公开(公告)号：US20230324301A1

公开(公告)日：2023-10-12

申请号：US18202823

申请日：2023-05-26

Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE ,  UNIVERSITY HEALTH NETWORK

Inventor： Keith D. Paulsen ,  David W. Roberts ,  Dennis Wirth ,  Brian C. Wilson ,  Mira Sibai

IPC: G01N21/64 ,  G01N21/47 ,  G01B11/22 ,  G01N33/483

CPC classification number: G01N21/6456 ,  G01B11/22 ,  G01N21/4795 ,  G01N33/4833 ,  G01N2201/062

Abstract: A method and device for determining the depth and fluorophore concentration of a fluorophore concentration below the surface of an optically absorbing and scattering medium suitable for use in fluorescence-based surgical guidance such as in tumor resection is described. Long-wavelength stimulus light us used to obtain deep tissue penetration. Recovery of depth is performed by fitting measured modulation amplitudes for each spatial frequency to precomputed modulation amplitudes in a table of modulation amplitudes indexed by optical parameters and depth.

公开(公告)号：US11375898B2

公开(公告)日：2022-07-05

申请号：US14719493

申请日：2015-05-22

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： Ralph Sebastian Dacosta ,  Brian C. Wilson ,  Kai Zhang

IPC: A61B5/00 ,  A61B5/01 ,  A61B10/00 ,  G01N21/64

Abstract: A system for acquiring data regarding a wound in tissue comprises at least one light source configured to directly illuminate a target surface with a homogeneous field of excitation light. An optical sensor is configured to detect signals responsive to illumination of an illuminated portion of a wound and the area around the wound. A thermal sensor is configured to detect thermal information regarding the illuminated portion of the wound and the area around the wound. A processor receives the detected signals and the detected thermal information and outputs data regarding the illuminated portion of the wound and the area around the wound. The output data may include wound size of the illuminated portion of the wound, bacterial load of the illuminated portion of the wound, or at least one temperature associated with the illuminated portion of the wound and the area around the wound. The data output by the processor may be displayed on a display of the system.

公开(公告)号：US20210259552A1

公开(公告)日：2021-08-26

申请号：US17193318

申请日：2021-03-05

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： Ralph Sebastian Dacosta ,  Brian C. Wilson ,  Kai Zhang

IPC: A61B5/00 ,  G01N21/64 ,  A61B5/01

Abstract: A system for acquiring data regarding a wound in tissue comprises at least one excitation light source configured to directly illuminate a wound with excitation light; a spectral filtering mechanism configured to permit passage of optical signals responsive to illumination of the wound and having at least one wavelength corresponding to bacterial, fungal, and/or other microorganism autofluorescence and/or bacterial, fungal, viral, and/or microbial fluorescence, the spectral filtering mechanism including a plurality of selectable filters respectively corresponding to different discrete spectral bandwidths; an optical sensor configured to detect the spectrally filtered signals; and a processor configured to receive the detected, filtered signals and to identify a fluorescent signature of bacteria in the wound based at least in part on the detected, filtered signals and to output data regarding the bacterial, fungal, viral, and/or microbial fluorescent signature.

公开(公告)号：US20160045114A1

公开(公告)日：2016-02-18

申请号：US14719493

申请日：2015-05-22

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： Ralph Sebastian Dacosta ,  Brian C. Wilson ,  Kai Zhang

IPC: A61B5/00 ,  A61B5/01

Abstract: A system for acquiring data regarding a wound in tissue comprises at least one light source configured to directly illuminate a target surface with a homogeneous field of excitation light. An optical sensor is configured to detect signals responsive to illumination of an illuminated portion of a wound and the area around the wound. A thermal sensor is configured to detect thermal information regarding the illuminated portion of the wound and the area around the wound. A processor receives the detected signals and the detected thermal information and outputs data regarding the illuminated portion of the wound and the area around the wound. The output data may include wound size of the illuminated portion of the wound, bacterial load of the illuminated portion of the wound, or at least one temperature associated with the illuminated portion of the wound and the area around the wound. The data output by the processor may be displayed on a display of the system.

Abstract translation: 用于获取关于组织中的伤口的数据的系统包括被配置为用均匀的激发光场直接照射目标表面的至少一个光源。 光学传感器被配置为检测响应于伤口的照射部分和伤口周围区域的照明的信号。 热传感器被配置为检测关于伤口的照射部分和伤口周围区域的热信息。 处理器接收检测到的信号和检测到的热信息，并输出关于伤口的照射部分和伤口周围区域的数据。 输出数据可以包括伤口的照射部分的伤口尺寸，伤口的照射部分的细菌负荷或与伤口的照射部分和伤口周围区域相关联的至少一个温度。 处理器输出的数据可以显示在系统的显示器上。