公开(公告)号：US09980951B2

公开(公告)日：2018-05-29

申请号：US15383983

申请日：2016-12-19

Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION

Inventor： Michael K. Schultz ,  Jessica Reedy ,  Christopher Pigge ,  Moustafa Tarek Ahmed Ibrahim Gabr ,  Mahboubeh Varmazyad ,  Prabhat C. Goswami

IPC: A61K31/44 ,  A61K31/444 ,  A61K31/4409 ,  A61K49/00

CPC classification number: A61K31/444 ,  A61K31/4409 ,  A61K49/0021

Abstract: The invention provides a method to treat cancer in an animal comprising administering a tetra-arylethylene cation to the animal.

公开(公告)号：US20170290929A1

公开(公告)日：2017-10-12

申请号：US15316585

申请日：2015-05-14

Applicant: University of Iowa Research Foundation

Inventor： Somya Kapoor ,  Michael K. Schultz

IPC: A61K49/00 ,  A61K31/16 ,  A61N5/00 ,  A61K51/08 ,  A61K33/24

CPC classification number: A61K49/0043 ,  A61K31/16 ,  A61K33/00 ,  A61K33/24 ,  A61K38/43 ,  A61K47/64 ,  A61K49/0056 ,  A61K51/088 ,  A61N5/00 ,  G01N33/68

Abstract: Accordingly, certain embodiments of the invention provide a conjugate of formula (I): P-(X-D)n, wherein P is a peptide that binds to a glucose regulated protein 78 (GRP78); X is a direct bond or a linking group; D is a detectable agent; and n is 1 to 4. Certain embodiments of the invention provide a pharmaceutical composition comprising a conjugate of formula (I) and a pharmaceutically acceptable excipient. Certain embodiments of the invention provide a method for treating or preventing cancer in an animal (e.g., a human) comprising administering a therapeutically effective amount of a conjugate of formula (I) (e.g., a conjugate comprising a therapeutic radionuclide) to the animal.

公开(公告)号：US20160303258A1

公开(公告)日：2016-10-20

申请号：US15100883

申请日：2014-12-03

Applicant: MILLENNIUM PHARMACEUTICALS, INC. ,  INVICRO LLC ,  UNIVERSITY OF IOWA RESEARCH FOUNDATION ,  STC.UNM

Inventor： Donna Cvet ,  Swapnil Raut ,  Michael K. Schultz ,  Jeffrey P. Norenberg ,  Tamara Anderson Daniels ,  John William Hoppin

IPC: A61K51/04 ,  A61K51/08 ,  G01N33/60 ,  A61K45/06 ,  G01N33/50 ,  C07K7/08 ,  C07K16/40

CPC classification number: A61K51/0482 ,  A61K38/50 ,  A61K45/06 ,  A61K51/08 ,  A61K51/1063 ,  C07K7/08 ,  C07K16/3046 ,  C07K16/40 ,  C12N9/88 ,  C12Y305/01001 ,  C12Y406/01002 ,  G01N33/5011 ,  G01N33/60 ,  Y02A50/473 ,  A61K2300/00

Abstract: This disclosure provides radiolabeled compounds that bind to guanylyl cyclase C (GCC) and which can bind cancer cells that express GCC. Exemplary compounds comprise a chelating moiety capable of binding a radioactive atom, a peptide capable of binding GCC, and a linker moiety connecting the two. This disclosure also provides methods of detecting and treating cancer using the compounds described herein.

Abstract translation: 本公开提供了结合鸟苷酸环化酶C（GCC）并且可以结合表达GCC的癌细胞的放射性标记的化合物。 示例性化合物包括能够结合放射性原子的螯合部分，能够结合GCC的肽和连接两者的连接体部分。 本公开还提供了使用本文所述的化合物检测和治疗癌症的方法。