公开(公告)号：US11851447B2

公开(公告)日：2023-12-26

申请号：US16814423

申请日：2020-03-10

Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION

Inventor： Christopher Pigge ,  Moustafa Tarek Ahmed Ibrahim Gabr

IPC: G01N21/76 ,  C07F15/00 ,  C07H21/04 ,  G01N21/359 ,  C12N15/11 ,  C12Q1/34 ,  C12Q1/68

CPC classification number: C07F15/0086 ,  C07H21/04 ,  C12N15/11 ,  C12Q1/34 ,  G01N21/359 ,  G01N21/76 ,  C12Q1/68 ,  G01N2333/916 ,  C12Q1/68 ,  C12Q2563/103 ,  C12Q2521/301

Abstract: The invention provides a compound of formula (Ia) or (Ib):




or a salt thereof, wherein A, B, C, D, E, F, J, K, L, M, Q, V, X, Y, W and Z have any of the values described in the specification, as well as compositions comprising a compound of formula (Ia) or (Ib) or a salt thereof, and methods of use thereof.

公开(公告)号：US12128115B2

公开(公告)日：2024-10-29

申请号：US17051037

申请日：2019-04-25

Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION

Inventor： Michael K. Schultz ,  Christopher Pigge ,  Mengshi Li ,  Moustafa Gabr ,  Edwin Sagastume

IPC: A61K51/04 ,  A61K45/06 ,  A61K51/08

CPC classification number: A61K51/0482 ,  A61K45/06 ,  A61K51/0497 ,  A61K51/083

Abstract: A method of performing a chelating reaction comprising contacting a divalent metal with a compound of Formula (I): or a salt thereof wherein: each of R1-R4 is independently selected from the group consisting of CH2COORa and CH2C(═O)NHRa; each of R5-R12 is independently selected from the group consisting of H and -L-X; each Ra is independently selected from the group consisting of H and -L-X; each L is independently selected from the group consisting of absent and a linking group; and each X is a biological agent; and wherein the contacting occurs at a temperature below about 40° C. to form a chelated composition.

公开(公告)号：US20210228749A1

公开(公告)日：2021-07-29

申请号：US17051037

申请日：2019-04-25

Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION

Inventor： Michael K. Schultz ,  Christopher Pigge ,  Mengshi Li ,  Moustafa Gabr ,  Edwin Sagastume

IPC: A61K51/04 ,  A61K51/08 ,  A61K45/06

Abstract: A method of performing a chelating reaction comprising contacting a divalent metal with a compound of Formula (I): or a salt thereof wherein: each of R1-R4 is independently selected from the group consisting of CH2COORa and CH2C(═O)NHRa; each of R5-R12 is independently selected from the group consisting of H and -L-X; each Ra is independently selected from the group consisting of H and -L-X; each L is independently selected from the group consisting of absent and a linking group; and each X is a biological agent; and wherein the contacting occurs at a temperature below about 40° C. to form a chelated composition.

公开(公告)号：US20250009912A1

公开(公告)日：2025-01-09

申请号：US18896069

申请日：2024-09-25

Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION

Inventor： Michael K. Schultz ,  Christopher Pigge ,  Mengshi Li ,  Moustafa Gabr ,  Edwin Sagastume

IPC: A61K51/04 ,  A61K45/06 ,  A61K51/08

Abstract: A method of performing a chelating reaction comprising contacting a divalent metal with a compound of Formula (I): or a salt thereof wherein: each of R1-R4 is independently selected from the group consisting of CH2COORa and CH2C(═O)NHRa; each of R5-R12 is independently selected from the group consisting of II and -L-X; each Ra is independently selected from the group consisting of H and -L-X; each L is independently selected from the group consisting of absent and a linking group; and each X is a biological agent; and wherein the contacting occurs at a temperature below about 40° C. to form a chelated composition.

公开(公告)号：US20170172991A1

公开(公告)日：2017-06-22

申请号：US15383983

申请日：2016-12-19

Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION

Inventor： Michael K. Schultz ,  Jessica Reedy ,  Christopher Pigge ,  Moustafa Tarek Ahmed Ibrahim Gabr

IPC: A61K31/444 ,  A61K31/4409 ,  A61K49/00

CPC classification number: A61K31/444 ,  A61K31/4409 ,  A61K49/0021

Abstract: The invention provides a method to treat cancer in an animal comprising administering a tetra-arylethylene cation to the animal.

公开(公告)号：US20200308208A1

公开(公告)日：2020-10-01

申请号：US16814423

申请日：2020-03-10

Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION

Inventor： Christopher Pigge ,  Moustafa Tarek Ahmed Ibrahim Gabr

IPC: C07F15/00 ,  C12N15/11 ,  C12Q1/44 ,  G01N21/76

Abstract: The invention provides a compound of formula (Ia) or (Ib): or a salt thereof, wherein A, B, C, D, E, F, J, K, L, M, Q, V, X, Y, W and Z have any of the values described in the specification, as well as compositions comprising a compound of formula (Ia) or (Ib) or a salt thereof, and methods of use thereof.

公开(公告)号：US09980951B2

公开(公告)日：2018-05-29

申请号：US15383983

申请日：2016-12-19

Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION

Inventor： Michael K. Schultz ,  Jessica Reedy ,  Christopher Pigge ,  Moustafa Tarek Ahmed Ibrahim Gabr ,  Mahboubeh Varmazyad ,  Prabhat C. Goswami

IPC: A61K31/44 ,  A61K31/444 ,  A61K31/4409 ,  A61K49/00

CPC classification number: A61K31/444 ,  A61K31/4409 ,  A61K49/0021

Abstract: The invention provides a method to treat cancer in an animal comprising administering a tetra-arylethylene cation to the animal.