中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

30 records (took 0.016 seconds)

    BROADLY FOCUSED ULTRASONIC PROPULSION PROBES, SYSTEMS, AND METHODS
    22.
    发明申请
    BROADLY FOCUSED ULTRASONIC PROPULSION PROBES, SYSTEMS, AND METHODS 审中-公开

    公开(公告)号：US20170245874A1

    公开(公告)日：2017-08-31

    申请号：US15519821

    申请日：2015-10-19

    Applicant: University of Washington ,  Sonomotion, Inc.

    Inventor： Michael R. Bailey ,  Bryan Cunitz ,  Barbrina Dunmire ,  Adam Maxwell ,  Oren Levy

    IPC: A61B17/22 ,  A61B8/08

    Abstract: Disclosed herein are ultrasonic probes and systems incorporating the probes. The probes are configured to produce an ultrasonic therapy exposure that, when applied to a kidney stone, will exert an acoustic radiation force sufficient to produce ultrasonic propulsion. Unlike previous probes configured to produce ultrasonic propulsion, however, the disclosed probes are engineered to produce a relatively large (both wide and long) therapy region effective to produce ultrasonic propulsion. This large therapy region allows the probe to move a plurality of kidney stones (or fragments from lithotripsy) in parallel, thereby providing the user the ability to clear several stones from an area simultaneously. This “broadly focused” probe is, in certain embodiments, combined in a single handheld unit with a typical ultrasound imaging probe to produce real-time imaging. Methods of using the probes and systems to move kidney stones are also provided.

    METHOD TO CREATE PATTERNS IN TISSUE GROWTH FOR TISSUE ENGINEERING
    24.
    发明公开
    METHOD TO CREATE PATTERNS IN TISSUE GROWTH FOR TISSUE ENGINEERING 审中-公开

    公开(公告)号：US20240043825A1

    公开(公告)日：2024-02-08

    申请号：US18365094

    申请日：2023-08-03

    Applicant: UNIVERSITY OF WASHINGTON ,  University of Rochester

    Inventor： Michael R. Bailey ,  Adam D. Maxwell ,  Mohamed Abdalla Ghanem ,  Diane Dalecki

    IPC: C12N13/00

    CPC classification number: C12N13/00

    Abstract: Methods and systems for creating patterns in tissue growth for tissue engineering are disclosed. In one embodiment, a method for arranging biological cells along predetermined patterns using an ultrasound includes: emitting the ultrasound by an ultrasound transducer; transmitting the ultrasound through a holographic lens toward a plurality of cells; and generating a pressure field in the predetermined patterns. The predetermined pattern includes a plurality of mutually parallel transverse planes. The parallel transverse planes are configured to entrap groups of cells of the plurality of cells. The axial pressure gradients within the parallel transverse planes are smaller than a first predetermined threshold. The lateral pressure gradients within the parallel transverse planes are larger than a second predetermined threshold. In response to generating the pressure field, the groups of entrapped cells are aligned within parallel transverse planes.

    High intensity focused ultrasound systems for treating tissue
    25.
    发明授权
    High intensity focused ultrasound systems for treating tissue 有权

    公开(公告)号：US11857813B2

    公开(公告)日：2024-01-02

    申请号：US16927860

    申请日：2020-07-13

    Applicant: University of Washington

    Inventor： Yak-Nam Wang ,  Michael R. Bailey ,  Tatiana D. Khokhlova ,  Wayne Kreider ,  Adam D. Maxwell ,  George R. Schade ,  Vera A. Khokhlova

    IPC: A61N7/00 ,  A61N7/02

    CPC classification number: A61N7/02 ,  A61N2007/0004 ,  A61N2007/0091

    Abstract: High intensity focused ultrasound systems for treating tissue are disclosed herein. A system of treating tissue in a patient in accordance with an embodiment of the present technology can include, for example, an ultrasound source having a focal region and configured to deliver high intensity focused ultrasound energy to a target site in tissue of the patient. The system can further include a controller operably coupled to the ultrasound source. The controller comprises a pulsing protocol for delivering the high intensity focused ultrasound energy with the ultrasound source to the target site. The controller is configured to cause the ultrasound source to pulse high intensity focused ultrasound waves to lyse cells in a volume of the tissue of the subject while preserving an extracellular matrix in the volume of the tissue exposed to the high intensity focused ultrasound waves.

    HIGH INTENSITY FOCUSED ULTRASOUND SYSTEMS FOR TREATING TISSUE
    27.
    发明申请
    HIGH INTENSITY FOCUSED ULTRASOUND SYSTEMS FOR TREATING TISSUE 有权

    公开(公告)号：US20210038924A1

    公开(公告)日：2021-02-11

    申请号：US16927860

    申请日：2020-07-13

    Applicant: University of Washington

    Inventor： Yak-Nam Wang ,  Michael R. Bailey ,  Tatiana D. Khokhlova ,  Wayne Kreider ,  Adam D. Maxwell ,  George R. Schade ,  Vera A. Khokhlova

    IPC: A61N7/02

    Abstract: High intensity focused ultrasound systems for treating tissue are disclosed herein. A system of treating tissue in a patient in accordance with an embodiment of the present technology can include, for example, an ultrasound source having a focal region and configured to deliver high intensity focused ultrasound energy to a target site in tissue of the patient. The system can further include a controller operably coupled to the ultrasound source. The controller comprises a pulsing protocol for delivering the high intensity focused ultrasound energy with the ultrasound source to the target site. The controller is configured to cause the ultrasound source to pulse high intensity focused ultrasound waves to lyse cells in a volume of the tissue of the subject while preserving an extracellular matrix in the volume of the tissue exposed to the high intensity focused ultrasound waves.

    Broadly focused ultrasonic propulsion probes, systems, and methods
    28.
    发明授权
    Broadly focused ultrasonic propulsion probes, systems, and methods 审中-公开

    公开(公告)号：US10667831B2

    公开(公告)日：2020-06-02

    申请号：US15519821

    申请日：2015-10-19

    Applicant: University of Washington ,  Sonomotion, Inc.

    Inventor： Michael R. Bailey ,  Bryan Cunitz ,  Barbrina Dunmire ,  Adam Maxwell ,  Oren Levy

    IPC: A61B8/00 ,  A61B17/22 ,  A61N7/02 ,  A61B8/08 ,  A61B17/225 ,  A61B18/00

    Abstract: Disclosed herein are ultrasonic probes and systems incorporating the probes. The probes are configured to produce an ultrasonic therapy exposure that, when applied to a kidney stone, will exert an acoustic radiation force sufficient to produce ultrasonic propulsion. Unlike previous probes configured to produce ultrasonic propulsion, however, the disclosed probes are engineered to produce a relatively large (both wide and long) therapy region effective to produce ultrasonic propulsion. This large therapy region allows the probe to move a plurality of kidney stones (or fragments from lithotripsy) in parallel, thereby providing the user the ability to clear several stones from an area simultaneously. This “broadly focused” probe is, in certain embodiments, combined in a single handheld unit with a typical ultrasound imaging probe to produce real-time imaging. Methods of using the probes and systems to move kidney stones are also provided.

    METHODS AND SYSTEMS FOR SELECTIVELY DISRUPTING TISSUE WITH HIGH INTENSITY FOCUSED ULTRASOUND
    29.
    发明申请
    METHODS AND SYSTEMS FOR SELECTIVELY DISRUPTING TISSUE WITH HIGH INTENSITY FOCUSED ULTRASOUND 审中-公开
    用高强度聚焦超声波选择性组织的方法和系统

    公开(公告)号：US20170072228A1

    公开(公告)日：2017-03-16

    申请号：US15126131

    申请日：2015-03-30

    Applicant: University of Washington

    Inventor： Yak-Nam Wang ,  Michael R. Bailey ,  Tatiana D. Khokhlova ,  Wayne Kreider ,  Adam D. Maxwell ,  George R. Schade ,  Vera A. Khokhlova

    IPC: A61N7/02

    CPC classification number: A61N7/02 ,  A61N2007/0004 ,  A61N2007/0091

    Abstract: Methods and systems for selectively disrupting tissue using high intensity focused ultrasound (“HIFU”) therapy are disclosed herein. A method of treating tissue in accordance with an embodiment of the present technology can include, for example, pulsing HIFU waves from an ultrasound source toward a volume of tissue that includes an extracellular matrix (“ECM”) and generating, from nonlinear propagation of the HIFU waves, shock waves in the tissue to induce boiling in the volume of the tissue. The method can further include lysing cells in the volume of tissue while leaving the ECM at least substantially intact. The emulsification of cells can be to a sufficient degree to decellularize the tissue and form a decellularized scaffold for subsequent tissue growth.

    Abstract translation: 本文公开了使用高强度聚焦超声（“HIFU”）治疗选择性地破坏组织的方法和系统。 根据本技术的实施例的治疗组织的方法可以包括例如将来自超声源的HIFU波脉冲到包括细胞外基质（“ECM”）的组织体积，并从 HIFU波，组织中的冲击波诱导组织体积沸腾。 该方法可以进一步包括裂解组织体内的细胞，同时离开ECM至少基本完整。 细胞的乳化可以足够的程度使组织脱细胞并形成用于随后组织生长的脱细胞支架。

Patent Agency Ranking