公开(公告)号：US08390804B2

公开(公告)日：2013-03-05

申请号：US12697136

申请日：2010-01-29

Applicant: Michael J. Stuke ,  Alexandre M. Bratkovski ,  Min Hu ,  Huei Pei Kuo ,  Jingjing Li ,  Zhiyong Li ,  Fung Suong Ou ,  Shih-Yuan (Sy) Wang ,  Wei Wu

Inventor： Michael J. Stuke ,  Alexandre M. Bratkovski ,  Min Hu ,  Huei Pei Kuo ,  Jingjing Li ,  Zhiyong Li ,  Fung Suong Ou ,  Shih-Yuan (Sy) Wang ,  Wei Wu

IPC: G01J3/44

CPC classification number: G01J3/44 ,  G01N21/658

Abstract: A surface enhanced Raman spectroscopy (SERS) apparatus, system and method employ a plurality of nanorods configured to vibrate. The apparatus includes the nanorods having tips at free ends opposite an end attached to a substrate. The tips are configured to adsorb an analyte and to vibrate at a vibration frequency. The apparatus further includes a vibration source configured to vibrate the free ends of the nanorods at the vibration frequency in a back-and-forth motion. Vibration of the nanorods is configured to facilitate detection of a Raman scattering signal emitted by the analyte adsorbed on the nanorod tips. The system further includes a synchronous detector configured to receive the Raman signal and to be gated cooperatively with the vibration of the nanorods. The method includes inducing a vibration of the nanorods, illuminating the vibrating tips to produce a Raman signal, and detecting the Raman signal using the detector.

Abstract translation: 表面增强拉曼光谱（SERS）装置，系统和方法采用配置成振动的多个纳米棒。 该装置包括纳米棒，其具有与连接到基底的端部相对的自由端处的尖端。 尖端被配置为吸附分析物并以振动频率振动。 该装置还包括一个振动源，其构造成以往复运动的振动频率使纳米棒的自由端振动。 纳米棒的振动被配置为便于检测由吸附在纳米棒尖端上的分析物发射的拉曼散射信号。 该系统还包括一个同步检测器，其被配置为接收拉曼信号并与纳米棒的振动协同地门控。 该方法包括诱导纳米棒的振动，照亮振动尖端以产生拉曼信号，以及使用检测器检测拉曼信号。

公开(公告)号：US20130040862A1

公开(公告)日：2013-02-14

申请号：US13636799

申请日：2010-04-20

Applicant: Zhiyong Li ,  Min Hu ,  Fung Suong Ou ,  Wei Wu ,  R. Stanley Williams

Inventor： Zhiyong Li ,  Min Hu ,  Fung Suong Ou ,  Wei Wu ,  R. Stanley Williams

IPC: C40B40/14 ,  C40B50/14 ,  C40B40/18 ,  C40B40/04 ,  B82Y15/00

CPC classification number: G01N21/658

Abstract: A multi-pillar structure for molecular analysis is provided. The structure comprises at least two nanopoles, each nanopole attached at one end to a substrate and freely movable along its length. The opposite ends of the at least two nanopoles are each capable of movement toward each other to trap at least one analyte molecule at their opposite ends. Each nanopole is coated with a metal coating. An array of such multi-pillar structures is also provided. A method for preparing the multi-pillar structure is further provided.

Abstract translation: 提供了一种用于分子分析的多支柱结构。 该结构包括至少两个纳米微粒，每个纳米孔一端连接到基底上，并可沿其长度自由移动。 至少两个纳米球的相对端各自能够相互移动以在其相对端捕获至少一种分析物分子。 每个纳米孔涂有金属涂层。 还提供了这种多支柱结构的阵列。 还提供了一种制备多支柱结构的方法。

公开(公告)号：US08314932B2

公开(公告)日：2012-11-20

申请号：US12771440

申请日：2010-04-30

Applicant: Fung Suong Ou ,  Zhiyong Li ,  Min Hu ,  Wei Wu

Inventor： Fung Suong Ou ,  Zhiyong Li ,  Min Hu ,  Wei Wu

IPC: G01J3/44

CPC classification number: G02B1/12 ,  G01N21/658

Abstract: A surface-enhanced Raman spectroscopy device includes a substrate, and an ultraviolet cured resist disposed on the substrate. The ultraviolet cured resist has a pattern of cone-shaped protrusions, where each cone-shaped protrusion has a tip with a radius of curvature equal to or less than 10 nm. The ultraviolet cured resist is formed of a predetermined ratio of a photoinitiator, a cross-linking agent, and a siloxane based backbone chain. A Raman signal-enhancing material is disposed on each of the cone-shaped protrusions.

Abstract translation: 表面增强拉曼光谱装置包括基板和设置在基板上的紫外线固化抗蚀剂。 紫外线固化抗蚀剂具有锥形突起的图案，其中每个锥形突起具有等于或小于10nm的曲率半径的尖端。 紫外线固化的抗蚀剂由光引发剂，交联剂和基于硅氧烷的主链以预定比例形成。 拉曼信号增强材料设置在每个锥形突起上。

公开(公告)号：US20120013902A1

公开(公告)日：2012-01-19

申请号：US12836097

申请日：2010-07-14

Applicant: Min Hu ,  Alexandre M. Bratkovski ,  Huel Pei Kuo ,  Jingjing Li ,  Zhiyong Li ,  Fung Suong Ou ,  Michael Josef Stuke ,  Michael Renne Ty Tan ,  Shih-Yuan Wang ,  Wei Wu

Inventor： Min Hu ,  Alexandre M. Bratkovski ,  Huel Pei Kuo ,  Jingjing Li ,  Zhiyong Li ,  Fung Suong Ou ,  Michael Josef Stuke ,  Michael Renne Ty Tan ,  Shih-Yuan Wang ,  Wei Wu

IPC: G01J3/44

CPC classification number: G01J3/18 ,  G01J3/44 ,  G01N21/65 ,  G01N2021/651

Abstract: An apparatus for detecting at least one species using Raman light detection includes at least one laser source for illuminating a sample containing the at least one species. The apparatus also includes a modulating element for modulating a spatial relationship between the sample and the light beams to cause relative positions of the sample and the light beams to be oscillated, in which Raman light at differing intensity levels are configured to be emitted from the at least one species based upon the different wavelengths of the light beams illuminating the sample. The apparatus also includes a Raman light detector and a post-signal processing unit configured to detect the at least one species.

Abstract translation: 用于使用拉曼光检测来检测至少一种物质的装置包括用于照亮含有至少一种物质的样品的至少一个激光源。 该装置还包括用于调制样品与光束之间的空间关系的调制元件，以使得样品和光束的相对位置发生振荡，其中以不同强度水平的拉曼光被配置为从at 基于照射样品的光束的不同波长的至少一种物质。 该装置还包括拉曼光检测器和被配置为检测至少一种物种的后信号处理单元。

公开(公告)号：US20110188033A1

公开(公告)日：2011-08-04

申请号：US12696853

申请日：2010-01-29

Applicant: Min Hu ,  Alexandre M. Bratkovski ,  Jingjing Li ,  Huei Pei Kuo ,  Zhiyong Li ,  Fung Suong Ou ,  Michael Josef Stuke ,  Michael Renne Ty Tan ,  Shih-Yuan Wang ,  Wei Wu

Inventor： Min Hu ,  Alexandre M. Bratkovski ,  Jingjing Li ,  Huei Pei Kuo ,  Zhiyong Li ,  Fung Suong Ou ,  Michael Josef Stuke ,  Michael Renne Ty Tan ,  Shih-Yuan Wang ,  Wei Wu

IPC: G01J3/44

CPC classification number: G01J3/44

Abstract: An apparatus for detecting at least one molecule using Raman light detection includes a substrate for supporting a sample containing the at least one molecule, a laser source for emitting a laser beam to cause Raman light emission from the at least one molecule, a modulating element for modulating a spatial relationship between the laser beam and the substrate at an identified frequency to cause the Raman light to be emitted from the at least one molecule at the identified frequency, at least one detector for detecting the Raman light emitted from the at least one molecule, and a post-signal processing unit configured to process the detected Raman light emission at the identified frequency to detect the at least one molecule.

Abstract translation: 用于使用拉曼光检测检测至少一个分子的装置包括用于支撑含有至少一个分子的样品的基底，用于发射激光束以产生来自至少一个分子的拉曼光发射的激光源， 以识别的频率调制激光束和衬底之间的空间关系，以使所述拉曼光以所识别的频率从所述至少一个分子发射;至少一个检测器，用于检测从所述至少一个分子发射的拉曼光 以及后信号处理单元，被配置为处理所识别的频率处的所检测的拉曼光发射以检测所述至少一个分子。

公开(公告)号：US09244015B2

公开(公告)日：2016-01-26

申请号：US13636784

申请日：2010-04-20

Applicant: Zhiyong Li ,  Min Hu ,  Fung Suong Ou ,  Wei Wu

Inventor： Zhiyong Li ,  Min Hu ,  Fung Suong Ou ,  Wei Wu

IPC: G01J3/44 ,  B05D5/06 ,  B44C1/22 ,  C23C16/48 ,  C25D5/02 ,  G02B5/08 ,  G01N21/65

CPC classification number: G01N21/658 ,  G01N21/648

Abstract: A self-arranging, luminescence-enhancement device 101 for surface-enhanced luminescence. The self-arranging, luminescence-enhancement device 101 for surface-enhanced luminescence includes a substrate 110, and a plurality 120 of flexible columnar structures. A flexible columnar structure 120-1 of the plurality 120 includes a flexible column 120-1A, and a metallic cap 120-1B coupled to the apex 120-1 C of the flexible column 120-1A. At least the flexible columnar structure 120-1 and a second flexible columnar structure 120-2 are configured to self-arrange into a close-packed configuration with at least one molecule 220-1 disposed between at least the metallic cap 120-1B and a second metallic cap 120-2B of respective flexible columnar structure 120-1 and second flexible columnar structure 120-2.

Abstract translation: 用于表面增强发光的自配置发光增强装置101。 用于表面增强发光的自配置发光增强装置101包括基板110和多个120个柔性柱状结构。 多个120的柔性柱状结构120-1包括柔性柱120-1A以及耦合到柔性柱120-1A的顶点120-1C的金属盖120-1B。 至少柔性柱状结构120-1和第二柔性柱状结构120-2构造成自配置成紧密堆积构造，其中至少一个分子220-1设置在至少金属盖120-1B和 各个柔性柱状结构120-1的第二金属盖120-2B和第二柔性柱状结构120-2。

公开(公告)号：US08665432B2

公开(公告)日：2014-03-04

申请号：US12915148

申请日：2010-10-29

Applicant: Min Hu ,  Michael Josef Stuke ,  Zhiyong Li ,  Wei Wu ,  Fung Suong Ou ,  Shih-Yuan Wang ,  Lars Helge Thylen

Inventor： Min Hu ,  Michael Josef Stuke ,  Zhiyong Li ,  Wei Wu ,  Fung Suong Ou ,  Shih-Yuan Wang ,  Lars Helge Thylen

IPC: G01N21/65

CPC classification number: G01J3/44 ,  G01N21/658

Abstract: An apparatus for performing surface enhanced Raman spectroscopy (SERS) includes a substrate and a plurality of nano-pillars, each of the plurality of nano-pillars having a first end attached to the substrate, a second end located distally from the substrate, and a body portion extending between the first end and the second end, in which the plurality of nano-pillars are arranged in an array on the substrate, and in which each of the plurality of nano-pillars is formed of a polymer material that is functionalized to expand in the presence of a fluid to cause gaps between the plurality of nano-pillars to shrink when the fluid is supplied onto the nano-pillars.

Abstract translation: 用于进行表面增强拉曼光谱（SERS）的设备包括基底和多个纳米柱，多个纳米柱中的每一个具有连接到基底的第一端，位于远离基底的第二端，以及 主体部分在所述第一端和所述第二端之间延伸，其中所述多个纳米柱以阵列布置在所述基底上，并且所述多个纳米柱中的每一个由聚合物材料形成，所述聚合物材料被官能化为 在存在流体的情况下膨胀，以便当将流体供应到纳米支柱上时，使多个纳米柱之间的间隙收缩。

公开(公告)号：US08559003B2

公开(公告)日：2013-10-15

申请号：US13384456

申请日：2009-09-17

Applicant: Huei Pei Kuo ,  Shih-Yuan Wang ,  Min Hu ,  Zhiyong Li ,  Alexandre M. Bratkovski

Inventor： Huei Pei Kuo ,  Shih-Yuan Wang ,  Min Hu ,  Zhiyong Li ,  Alexandre M. Bratkovski

IPC: G01J3/44

CPC classification number: G01N21/658 ,  B82Y15/00 ,  B82Y30/00

Abstract: An electrically driven device for surface enhanced Raman spectroscopy includes a first electrode, a substrate positioned proximate to the first electrode, a plurality of cone shaped protrusions formed integrally with or on a substrate surface, a Raman signal-enhancing material coated on each protrusion, and a second electrode positioned relative to the first electrode at a predetermined distance. Each of the protrusions has a tip with a radius of curvature ranging from about 0.1 nm to about 100 nm. The second electrode is positioned relative to the first electrode such that the electrodes together produce an electric field when a voltage bias is applied therebetween. The electric field has a field distribution that creates a stronger field gradient at a region proximate to the tips than at other portions of the substrate.

Abstract translation: 用于表面增强拉曼光谱的电驱动装置包括第一电极，靠近第一电极定位的基板，与基底表面一体地形成的多个锥形突起，涂覆在每个突起上的拉曼信号增强材料，以及 相对于第一电极以预定距离定位的第二电极。 每个突起具有具有约0.1nm至约100nm范围的曲率半径的尖端。 第二电极相对于第一电极定位，使得当在其之间施加电压偏置时，电极一起产生电场。 电场具有场分布，其在靠近尖端的区域处产生比在衬底的其它部分更强的场梯度。

公开(公告)号：US20130194570A1

公开(公告)日：2013-08-01

申请号：US13363006

申请日：2012-01-31

Applicant: Wei WU ,  Michael Josef Stuke ,  Zhiyong Li ,  James Elmer Abbott, JR. ,  Min Hu ,  Ansoon Kim

Inventor： Wei WU ,  Michael Josef Stuke ,  Zhiyong Li ,  James Elmer Abbott, JR. ,  Min Hu ,  Ansoon Kim

IPC: G01J3/44 ,  G01J3/28

CPC classification number: G01J3/44 ,  G01J3/0205 ,  G01J3/26

Abstract: An apparatus for performing spectroscopy includes an optical waveguide comprising a fluidic channel to receive a fluid sample, in which the optical waveguide is to propagate lightwaves at a set of frequencies. The apparatus also includes a wavelength selective device coupled to the optical waveguide, in which the wavelength selective device comprises a predetermined bandwidth and is to capture frequencies of light within the predetermined bandwidth. The apparatus further includes a detector coupled to the wavelength selective device to generate signals that identify the frequencies captured by the wavelength selective device.

Abstract translation: 用于执行光谱学的装置包括光波导，其包括用于接收流体样品的流体通道，其中光波导将以一组频率传播光波。 该装置还包括耦合到光波导的波长选择装置，其中波长选择装置包括预定带宽并且捕获预定带宽内的光的频率。 该装置还包括耦合到波长选择装置的检测器，以产生识别由波长选择装置捕获的频率的信号。

公开(公告)号：US20130027698A1

公开(公告)日：2013-01-31

申请号：US13636784

申请日：2010-04-20

Applicant: Zhiyong Li ,  Min Hu ,  Fung Suong Ou ,  Wei Wu

Inventor： Zhiyong Li ,  Min Hu ,  Fung Suong Ou ,  Wei Wu

IPC: G01J3/44 ,  C25D5/02 ,  C23C16/48 ,  B44C1/22 ,  G02B5/08 ,  B05D5/06

CPC classification number: G01N21/658 ,  G01N21/648

Abstract: A self-arranging, luminescence-enhancement device 101 for surface-enhanced luminescence. The self-arranging, luminescence-enhancement device 101 for surface-enhanced luminescence includes a substrate 110, and a plurality 120 of flexible columnar structures. A flexible columnar structure 120-1 of the plurality 120 includes a flexible column 120-1A, and a metallic cap 120-1B coupled to the apex 120-1 C of the flexible column 120-1A. At least the flexible columnar structure 120-1 and a second flexible columnar structure 120-2 are configured to self-arrange into a close-packed configuration with at least one molecule 220-1 disposed between at least the metallic cap 120-1B and a second metallic cap 120-2B of respective flexible columnar structure 120-1 and second flexible columnar structure 120-2.

Abstract translation: 用于表面增强发光的自配置发光增强装置101。 用于表面增强发光的自配置发光增强装置101包括基板110和多个120个柔性柱状结构。 多个120的柔性柱状结构120-1包括柔性柱120-1A以及耦合到柔性柱120-1A的顶点120-1C的金属盖120-1B。 至少柔性柱状结构120-1和第二柔性柱状结构120-2构造成自配置成紧密堆积构造，其中至少一个分子220-1设置在至少金属盖120-1B和 各个柔性柱状结构120-1的第二金属盖120-2B和第二柔性柱状结构120-2。