公开(公告)号：US10722467B2

公开(公告)日：2020-07-28

申请号：US16454555

申请日：2019-06-27

Applicant: ZONEONE PHARMA, INC.

Inventor： Mark E. Hayes ,  Charles O. Noble ,  Francis C. Szoka, Jr.

IPC: A61K9/127 ,  A61K31/4196 ,  A61K31/496 ,  A61K38/07 ,  A61K31/5377 ,  A61K9/00 ,  B01J13/08 ,  A61K9/19

Abstract: The present invention provides liposome compositions containing sparingly soluble drugs that are used to treat life-threatening diseases. A preferred method of encapsulating a drug inside a liposome is by remote or active loading. Remote loading of a drug into liposomes containing a transmembrane electrochemical gradient is initiated by co-mixing a liposome suspension with a solution of drug, whereby the neutral form of the compound freely enters the liposome and becomes electrostatically charged thereby preventing the reverse transfer out of the liposome. There is a continuous build-up of compound within the liposome interior until the electrochemical gradient is dissipated or all the drug is encapsulated in the liposome. However, this process as described in the literature has been limited to drugs that are freely soluble in aqueous solution or solubilized as a water-soluble complex. This invention describes compositions and methods for remote loading drugs with low water solubility (

公开(公告)号：US10709645B2

公开(公告)日：2020-07-14

申请号：US15532900

申请日：2015-12-03

Applicant: BASF SE

Inventor： Ewelina Burakowska-Meise ,  Valeria Bem ,  Roland Hinrich Staff ,  Brigitte Lindemann ,  Helmut Witteler

IPC: A61K8/11 ,  B01J13/22 ,  A61K8/81 ,  A61Q17/04 ,  B01J13/08

Abstract: The present invention relates to microcapsules comprising a capsule core and a capsule shell wherein the capsule shell comprises a core surrounding layer of a polyvinyl alcohol and an adjacent layer of a polyoxazoline, a process of their production and their use.

公开(公告)号：US20200146987A1

公开(公告)日：2020-05-14

申请号：US16499408

申请日：2017-09-06

Applicant: UNIVERSITY OF SOUTH CAROLINA

Inventor： Morgan STEFIK ,  Hasala N. LOKUPITIYA

IPC: A61K9/107 ,  A61K47/32 ,  C08J5/00 ,  B01J13/08

Abstract: A method to quickly adjust the size of micelles and then return the micelles to a persistent state is provided. Specifically, the present invention is directed to a method for block copolymer micelle growth under high-χN solution conditions where ultrasonic cavitation facilitates rapid solution-gas interface production that accelerates micelle growth by an order of magnitude over other methods such as vortexing. The persistent micelles formed by the method of the present invention can then be used for controlled delivery of dispersions in organic electronic coatings, paint, or drug delivery applications and can also be used to control the pore size of films that include an oxide, a nitride, a carbide, a metal, or a carbon material.

公开(公告)号：US10584246B2

公开(公告)日：2020-03-10

申请号：US16043680

申请日：2018-07-24

Applicant: International Business Machines Corporation

Inventor： Dylan J. Boday ,  Jason T. Wertz

IPC: C08L89/00 ,  B01J13/10 ,  C11C3/00 ,  B01J13/14 ,  B01J13/08

Abstract: A renewable material for releasing a self-healing agent includes a renewable polymeric substrate with capsules and a reactant dispersed in the renewable polymeric substrate. The capsules may be formed from a first renewable shell polymer and may enclose the renewable self-healing agent. The reactant may be suitable for reacting with the renewable self-healing agent to form a polymer.

公开(公告)号：US10584245B2

公开(公告)日：2020-03-10

申请号：US16043650

申请日：2018-07-24

Applicant: International Business Machines Corporation

Inventor： Dylan J. Boday ,  Jason T. Wertz

IPC: C08L89/00 ,  B01J13/10 ,  C11C3/00 ,  B01J13/14 ,  B01J13/08

Abstract: A renewable material for releasing a self-healing agent includes a renewable polymeric substrate with capsules and a reactant dispersed in the renewable polymeric substrate. The capsules may be formed from a first renewable shell polymer and may enclose the renewable self-healing agent. The reactant may be suitable for reacting with the renewable self-healing agent to form a polymer.

公开(公告)号：US10454100B2

公开(公告)日：2019-10-22

申请号：US15311184

申请日：2015-05-14

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Ning Ding ,  Yanwei Lum ,  Tzi Sum Andy Hor ,  Zhao Lin Liu ,  Yun Zong

IPC: H01M4/36 ,  H01M4/62 ,  H01M4/58 ,  B01J13/08 ,  B01J13/20 ,  C01B17/20 ,  C01G9/08 ,  C01G1/12

Abstract: There is provided a method of forming a porous particle comprising an electrically conductive continuous shell encapsulating a core, said core comprising an elemental compound that reversibly reduces in the presence of a cation and oxidizes in the absence of said cation, said method comprising the steps of: a) encapsulating an elemental compound precursor with said electrically conductive shell; b) reacting said elemental compound precursor with an oxidation agent to oxidize said elemental compound precursor to form said elemental compound, thereby forming said electrically conductive shell encapsulating said core comprising said elemental compound.

公开(公告)号：US10439213B2

公开(公告)日：2019-10-08

申请号：US15317405

申请日：2015-06-05

Applicant: SUZHOU INSTITUTE OF NANO-TECH AND NANO-BIONICS, CHINESE ACADEMY OF SCIENCE

Inventor： Yuegang Zhang ,  Yongcai Qiu ,  Wanfei Li ,  Guizhu Li ,  Yuan Hou ,  Meinan Liu ,  Lisha Zhou ,  Fangmin Ye ,  Hongfei Li

IPC: H01M4/00 ,  H01M4/36 ,  B01J13/08 ,  H01M4/58 ,  H01M4/587 ,  H01M4/38 ,  H01M4/62 ,  H01M4/02

Abstract: The invention provides a nitrogen-doped graphene coated nano sulfur positive electrode composite material, a preparation method, and an application thereof. The composite material includes: an effective three-dimensional conductive network formed by overlapping of nitrogen-doped graphenes, and nano sulfur particles coated by nitrogen doped graphene layers evenly. The preparation method includes: dispersing nitrogen-doped graphenes in a liquid-phase reaction system including at least sulfur source and acid, and depositing nano sulfur particles by an in-situ chemical reaction of the sulfur source and the acid, thereby preparing the positive electrode composite material. The positive electrode composite material of the invention has a high conductivity, a high sulfur utilization rate, and a high rate, thereby restraining the dissolution and shuttle effect in the lithium sulfur batteries, and enhancing the cyclic performance of the batteries.

公开(公告)号：US10316199B2

公开(公告)日：2019-06-11

申请号：US15646421

申请日：2017-07-11

Applicant: Microtek Laboratories Inc.

Inventor： Carl M Lentz ,  Kayla L. M. Ryan

IPC: C09D5/14 ,  C09D179/04 ,  C09D161/28 ,  C09D133/00 ,  A01N59/26 ,  A01N59/20 ,  A01N25/28 ,  A01N59/06 ,  A01N59/16 ,  B01J13/22 ,  C09K5/06 ,  B01J13/08 ,  C09D5/00 ,  C09F9/00 ,  B01J13/02 ,  B01J13/14 ,  F28D20/02 ,  C09D7/61 ,  C09D7/40 ,  C09D161/34 ,  C08G14/08

Abstract: Microcapsules are disclosed that have a core composition encapsulated within a polymer wall, and an inorganic shell connected to an exterior surface of the polymer wall by a surfactant. The inorganic shell has a cation attracted to the surfactant and an anion or anion equivalent chemically bonded to the cation to form the shell or has the metal portion of a metal-containing compound attracted to the surfactant to form the shell. The shell may comprise a Ca, Mg, or Ag metal compound. The shell may be a graphene oxide-metal compound.

公开(公告)号：US20190125677A1

公开(公告)日：2019-05-02

申请号：US15854890

申请日：2017-12-27

Applicant: METAL INDUSTRIES RESEARCH & DEVELOPMENT CENTRE

Inventor： Zong-Hsin Liu ,  Cheng-Han Hung ,  Ying-Chieh Lin ,  Cheng-Tang Pan ,  Shiao-Wei Kuo ,  Yao-Kun Huang

IPC: A61K9/16 ,  B01J13/08

Abstract: A water-phase composition for producing microparticles includes a water-phase fluid, an amphiphilic polymer stabilizing agent, a water-phase surfactant, and an organic solvent. The amphiphilic polymer stabilizing agent can be polyvinyl alcohol. The water-phase surfactant can be polysorbate 20, polysorbate 80, poloxamer 188, or sodium dodecyl sulfate. The water-phase surfactant can be ethyl acetate, dichloromethane, chloroform, or dimethyl sulfoxide.

公开(公告)号：US10243114B2

公开(公告)日：2019-03-26

申请号：US15911960

申请日：2018-03-05

Applicant: Nanosys, Inc.

Inventor： Jason Hartlove ,  Veeral Hardev ,  Shihai Kan ,  Jian Chen ,  Jay Yamanaga ,  Christian Ippen ,  Wenzhuo Guo ,  Charles Hotz ,  Robert Wilson

IPC: H01L33/50 ,  B01J13/08 ,  C09K11/02 ,  C09K11/88 ,  H01L27/32 ,  H05B33/14 ,  H05B33/20 ,  B82Y20/00 ,  B82Y40/00

Abstract: Embodiments of a display device including barrier layer coated quantum dots and a method of making the barrier layer coated quantum dots are described. Each of the barrier layer coated quantum dots includes a core-shell structure and a hydrophobic barrier layer disposed on the core-shell structure. The hydrophobic barrier layer is configured to provide a distance between the core-shell structure of one of the quantum dots with the core-shell structures of other quantum dots that are in substantial contact with the one of the quantum dots. The method for making the barrier layer coated quantum dots includes forming reverse micro-micelles using surfactants and incorporating quantum dots into the reverse micro-micelles. The method further includes individually coating the incorporated quantum dots with a barrier layer and isolating the barrier layer coated quantum dots with the surfactants of the reverse micro-micelles disposed on the barrier layer.