公开(公告)号：US06357285B1

公开(公告)日：2002-03-19

申请号：US09188497

申请日：1998-11-09

Applicant: Michael J. Allen

Inventor： Michael J. Allen

IPC: H01J314

CPC classification number: G01Q10/06 ,  Y10S977/853

Abstract: Local sensitive force detector output data, acquired from a cellular and sub-cellular structures (“biological structures”), are quantified in an objective format. Data are acquired from two axes of the biological structure at scan positions along a third axis of the biological structure, which is perpendicular to the two axes. Data are then quantified as a function of scan position along the third axis. The quantified data can be plotted and displayed to generate a two-dimensional representation of a biological structure's morphology, which contains quantified data points from along the third axis of the biological structure. The output can be used for morphology-based classification and typing of biological structures. The invention classifies and types biological structures by converting the local sensitive force detector data into a graphical fingerprint, which, for example, can be compared to standard data generated from known biological structures. Potential applications of the invention include (1) differentiating cells, such as malignant, premalignant, and benign cells in Pap smears, (2) typing cells into blood cell types, such as T-lymphocytes, B-lymphocytes, platelets, and red blood cells, and (3) identifying genetic variants among a group of macromolecules. Sub-cellular applications include classification of sperm nuclei. Advantages over and differences from previous methods include providing (1) data having higher resolution than confocal microscope data and (2) a measurement of biological structure's morphology as a function of scan position along a single axis, and (3) a method for objectively comparing the higher resolution data obtained from unknown biological structures to known biological structures.

Abstract translation: 从细胞和亚细胞结构（“生物结构”）获取的局部敏感力检测器输出数据以客观格式量化。 在垂直于两个轴的生物结构的第三轴的扫描位置从生物结构的两个轴获取数据。 然后将数据作为沿着第三轴的扫描位置的函数被量化。 可以绘制和显示量化的数据以产生生物结构形态的二维表示，其包含沿着生物结构的第三轴的量化数据点。 输出可用于基于形态学的分类和生物结构的分型。 本发明通过将局部敏感力检测器数据转换为图形指纹来分类和分类生物结构，其可以与已知生物结构产生的标准数据进行比较。 本发明的潜在应用包括（1）在巴氏涂片中区分细胞，如恶性，恶化前和良性细胞，（2）将细胞分为血细胞类型，如T淋巴细胞，B淋巴细胞，血小板和红血球 细胞，和（3）鉴定一组大分子之间的遗传变异。 亚细胞应用包括精子核分类。 与先前方法的优点和差异包括提供（1）具有比共聚焦显微镜数据更高分辨率的数据和（2）作为沿着单个轴的扫描位置的函数的生物结构形态的测量，以及（3）客观比较的方法 从未知生物结构到已知生物结构获得的较高分辨率数据。

公开(公告)号：US06297497B1

公开(公告)日：2001-10-02

申请号：US09194260

申请日：1998-11-25

Applicant: Bernhard Braunecker ,  Bernhard F. Gaechter ,  John Rice Rogers

Inventor： Bernhard Braunecker ,  Bernhard F. Gaechter ,  John Rice Rogers

IPC: H01J314

CPC classification number: G01S3/783

Abstract: The invention concerns a method and device for determining the direction of an object (10) which emits or reflects optical radiation. An optical element (14) which structures the wavefront of the radiation converts the conventional dot-type image (20) into an intensity distribution (14′) with more than one maximum on a locally resolving opto-electronic detector (13). From the intensity distribution (14′) and the structure function of the optical element (14), the direction of the object (10) can be determined with a high degree of accuracy over a wide measurement range. In addition, this gives a design with a shorter optical path length and very few optical components.

Abstract translation: 本发明涉及一种用于确定发射或反射光辐射的物体（10）的方向的方法和装置。 结构化辐射波前的光学元件（14）在局部分辨的光电检测器（13）上将传统的点型图像（20）转换为具有多于一个最大值的强度分布（14'）。 根据光学元件（14）的强度分布（14'）和结构功能，可以在宽的测量范围内以高精度确定物体（10）的方向。 此外，这给出了具有较短光程长度和非常少的光学部件的设计。

公开(公告)号：US06236040B1

公开(公告)日：2001-05-22

申请号：US08904632

申请日：1997-08-01

Applicant: Kouichi Takemura ,  Yoshitaka Murakawa ,  Hiroyuki Matsuo ,  Takao Sugano ,  Kazuki Ogawa ,  Fumio Kaneko ,  Yukihiro Matsushita

Inventor： Kouichi Takemura ,  Yoshitaka Murakawa ,  Hiroyuki Matsuo ,  Takao Sugano ,  Kazuki Ogawa ,  Fumio Kaneko ,  Yukihiro Matsushita

IPC: H01J314

CPC classification number: G02B26/123

Abstract: An image forming apparatus includes a plurality of light sources emitting beams of light, a photoconductor, a scanner for reflecting the beams of light emitted by the light sources to scan the photoconductor periodically, a light detector for receiving the beams of light from the scanner to determine a beam pitch between the beams of light, the light detector being provided in a part of an optical path between the scanner and the photoconductor, a beam shifter for shifting the beams of light incident on the scanner from the light sources, and a controller for operating the beam shifter so that the beam pitch determined by the light detector becomes a predetermined value.

Abstract translation: 图像形成装置包括发射光束的多个光源，光电导体，用于反射由光源发射的光束以周期性扫描光电导体的扫描器，用于接收来自扫描仪的光束的光检测器 确定光束之间的光束间距，光检测器设置在扫描器和光电导体之间的光路的一部分中;光束移动器，用于将入射在扫描仪上的光束从光源移位;以及控制器 用于操作光束移动器，使得由光检测器确定的光束间距变为预定值。

公开(公告)号：US06184521B2

公开(公告)日：2001-02-06

申请号：US09003224

申请日：1998-01-06

Applicant: James P. Coffin, IV ,  Thomas J. Gerhardt ,  Michael A. Mills ,  Massi E. Kiani

Inventor： James P. Coffin, IV ,  Thomas J. Gerhardt ,  Michael A. Mills ,  Massi E. Kiani

IPC: H01J314

CPC classification number: A61B5/6826 ,  A61B5/14552 ,  A61B5/6838 ,  A61B2562/182 ,  A61B2562/222

Abstract: A photodiode has integrated shields for the rejection of noise-producing electromagnetic interference and ambient light. The electromagnetic shield forms a conductive matrix which covers the photodiode active area. The matrix is deposited as a metallization layer onto the photodiode and provides exposed portions of the active area for light detection. A pad is electrically connected to the shield to allow external termination of the shield. The ambient-light shield is in the form of a colored encapsulant surrounding the photodiode. The encapsulant provides a high-pass light transmission characteristic which passes signal light and rejects out-of-band ambient light. The photodiode is particularly advantageous for use in pulse oximetry probes.

Abstract translation: 光电二极管具有集成屏蔽，用于抑制产生噪声的电磁干扰和环境光。 电磁屏蔽形成覆盖光电二极管有效区域的导电矩阵。 该基质作为金属化层沉积到光电二极管上，并提供有源区域的暴露部分用于光检测。 焊盘电连接到屏蔽件以允许屏蔽件的外部端接。 环境光屏蔽是围绕光电二极管的彩色密封剂的形式。 密封剂提供高通透光特性，其传递信号光并且抑制带外环境光。 光电二极管特别适用于脉搏血氧测定探针。

公开(公告)号：US06756583B2

公开(公告)日：2004-06-29

申请号：US09837213

申请日：2001-04-19

Applicant: Takeshi Yamawaki

Inventor： Takeshi Yamawaki

IPC: H01J314

CPC classification number: H04N1/053 ,  H04N1/1135 ,  H04N2201/02497 ,  H04N2201/0471 ,  H04N2201/04732 ,  H04N2201/04744

Abstract: An optical scanning device includes a first optical system, including a light source, for directing a light beam, emitted from the light source, to an optical deflector. A second optical system focuses the light beam deflected by the deflector on an effective scanning area of a scanning surface. The light source is continuously kept lit when scanning outside of the effective scanning area. A light shield member is positioned between the deflector and the scanning surface to block at least a portion of the light beam emitted during the period of time when the light source is continuously kept lit when scanning outside of the effective scanning area.

Abstract translation: 光学扫描装置包括：第一光学系统，包括光源，用于将从光源发射的光束引导到光学偏转器。 第二光学系统将由偏转器偏转的光束聚焦在扫描表面的有效扫描区域上。 扫描有效扫描区域外时，光源连续保持点亮。 遮光构件位于偏转器和扫描面之间，以阻挡当在有效扫描区域外扫描时光源连续保持点亮的时间段期间发射的光束的至少一部分。

公开(公告)号：US06723977B1

公开(公告)日：2004-04-20

申请号：US09556274

申请日：2000-04-24

Applicant: Joseph M. Fukumoto

Inventor： Joseph M. Fukumoto

IPC: H01J314

CPC classification number: G02F1/39 ,  G02F1/3551 ,  G02F1/3553 ,  G02F2201/16 ,  G02F2201/17 ,  G02F2201/18 ,  G02F2201/34 ,  G02F2203/05 ,  G02F2203/58 ,  H01S3/0809

Abstract: A chemical sensing system and method. The system (10) includes a transmitter having a laser for providing a collimated beam of electromagnetic energy at a first frequency and a Q switch in optical alignment with the beam. The system further includes a crystal for shifting the frequency of the beam from the first frequency to a second frequency. A mechanism is included for shifting the beam from the second frequency to a third frequency in the range of 8-12 microns. The system includes a mechanism for switching the polarization state of the second beam and providing third and fourth beams therefrom. The third beam has a first polarization and the fourth beam has a second polarization. The second polarization is orthogonal relative to the first polarization. The frequency shifted third and fourth beams are combined to provide an output beam in the range of 8-12 microns. The output beam is transmitted and a return signal is detected by a receiver in the illustrative chemical sensing application.

Abstract translation: 化学传感系统和方法。 系统（10）包括具有激光器的发射器，用于在第一频率处提供准直的电磁能量束和与光束对准的Q开关。 该系统还包括用于将光束的频率从第一频率转换到第二频率的晶体。 包括用于将光束从第二频率移动到8-12微米范围内的第三频率的机构。 该系统包括用于切换第二光束的偏振状态并从其提供第三和第四光束的机构。 第三光束具有第一偏振，第四光束具有第二偏振。 第二极化相对于第一极化正交。 频移的第三和第四光束被组合以提供在8-12微米范围内的输出光束。 传输输出光束并且在说明性化学感测应用中由接收器检测返回信号。

公开(公告)号：US06696681B2

公开(公告)日：2004-02-24

申请号：US09912538

申请日：2001-07-26

Applicant: Kenichi Kodama

Inventor： Kenichi Kodama

IPC: H01J314

CPC classification number: G02B13/0005

Abstract: An f-&thgr; lens is composed of a negative lens element of a negative power, and second and third lens elements of a positive power, arranged in this order from the side of a optical deflection device, wherein at least one surface of the lens elements is a cylindrical surface that has a refractive power only in the deflecting direction. The f-&thgr; lens satisfies the conditions: N1>N2=N3, v1>v2=v3, and 4 mm≦|f23/f1·D0|

Abstract translation: f-theta透镜由负功率的负透镜元件和正光焦度的第二和第三透镜元件组成，其从光学偏转装置的侧面依次布置，其中透镜元件的至少一个表面 是仅在偏转方向上具有屈光力的圆柱形表面。 f-θ透镜满足以下条件：N1> N2 = N3，v1> v2 = v3和4mm <= | f23 / f1.D0 | <16mm，其中N1，N2和N3表示折射率v1，v2 v3分别表示第一至第三透镜元件的阿贝常数，f1表示第一透镜元件的焦距，f23表示第二和第三透镜元件的复合焦距，D0表示从光学偏转装置到 第一透镜元件的透镜表面。

公开(公告)号：US06670603B2

公开(公告)日：2003-12-30

申请号：US10190685

申请日：2002-07-09

Applicant: Yasuhiro Shimada ,  Atsushi Kandori

Inventor： Yasuhiro Shimada ,  Atsushi Kandori

IPC: H01J314

CPC classification number: G01J1/32 ,  G03B21/008

Abstract: An image projector of the present invention which is capable of automatically adjusting a size of an image area and a focal distance has light sources with a device for modulating light for forming an image, a measuring light source for supplying measuring light, a mixing optical system for mixing the light for forming an image and the measuring light on one optical axis, a projection device for scanning the light mixed by the mixing optical system and projecting the mixed light onto a screen, a photodetector for detecting the measuring light reflected by the screen, and correction devices for correcting an image by controlling the projected light on the basis of a result of detection by the photodetector.

公开(公告)号：US06670602B1

公开(公告)日：2003-12-30

申请号：US09324896

申请日：1999-06-03

Applicant: Yoshiaki Kohama ,  Akihiro Goto ,  Muneki Hamashima ,  Yukiharu Okubo

Inventor： Yoshiaki Kohama ,  Akihiro Goto ,  Muneki Hamashima ,  Yukiharu Okubo

IPC: H01J314

CPC classification number: H01J37/28 ,  H01J2237/2817

Abstract: New and improved scanning device and corresponding method that include and involve a movable stage on which a specimen is positioned, irradiation means which irradiates an electron beam onto an irradiation region of the specimen, secondary beam detection means used in generating a picture of the irradiation region by detecting a secondary beam which consists of at least one of secondary electrons or reflected electrons from the irradiation region of the electron beam, an imaging electron optical system which causes imaging of the secondary beam on a detection surface of the secondary beam detection means, and which is arranged between the specimen and the secondary beam detection means. The secondary beam detection means is equipped with a fluorescent unit which is arranged on the detection surface, and which converts the secondary beam into light, and one-dimensional line sensors which have a structure arrayed in two dimensions forming electric charge by photoelectric conversion, an array imaging element which continuously adds up the electric charge of the accumulated image in a predetermined line of the line sensors, and the electric charge of the line of the image which moves accompanying the movement of the stage, and a two-dimensional imaging element which emits electric charge by means of photoelectric conversion. The scanning device and corresponding method further include and involve changeover means for selectively irradiating the light converted by means of the fluorescent unit to an imaging element which is either one of the array imaging elements and the two-dimensional imaging element.

Abstract translation: 新的改进的扫描装置及其相应的方法，其包括并涉及其上放置试样的可移动台，将电子束照射到试样的照射区域上的照射装置，用于产生照射区域的图像的二次束检测装置 通过检测由来自电子束的照射区域的二次电子或反射电子中的至少一种构成的次级光束，使次光束在二次光束检测装置的检测表面上成像的成像电子光学系统，以及 其布置在样本和次级束检​​测装置之间。 二次光束检测装置配备有布置在检测表面上并将次光束转换为光的荧光单元和具有通过光电转换形成电荷的二维排列的结构的一维线传感器， 阵列成像元件，其连续地将累积图像的电荷累积在行传感器的预定线中，以及伴随舞台移动移动的图像线的电荷，以及二维成像元件 通过光电转换发射电荷。 扫描装置和相应的方法还包括并包括切换装置，用于选择性地将通过荧光单元转换的光照射到作为阵列成像元件和二维成像元件之一的成像元件。

公开(公告)号：US06621070B2

公开(公告)日：2003-09-16

申请号：US09682660

申请日：2001-10-03

Applicant: Michael J. Ahten ,  James W. Ring

Inventor： Michael J. Ahten ,  James W. Ring

IPC: H01J314

CPC classification number: G06K7/10683 ,  G06K7/10702

Abstract: A scan module and an optical system such as for a bar code scanner wherein the optical system has an axis of outgoing (illumination) light offset from the axis of collected light, arranged to limit the dynamic range of the collected light and thus the dynamic range within which the bar code scanner detector and signal processor must function. Preferably, the outgoing axis and the collection lens axis are substantially parallel.

Abstract translation: 一种扫描模块和诸如用于条形码扫描器的光学系统，其中光学系统具有偏离收集的光轴的出射（照明）光轴，其被布置成限制所收集的光的动态范围，并且因此限制动态范围 条形码扫描仪检测器和信号处理器必须在其中工作。 优选地，输出轴和收集透镜轴线基本上平行。