公开(公告)号：US20220284603A1

公开(公告)日：2022-09-08

申请号：US17687283

申请日：2022-03-04

Applicant: CytoVeris Inc.

Inventor： David Fournier ,  Kevin Didden ,  Alan Kersey

IPC: G06T7/30 ,  G06T19/00 ,  G16H10/40

Abstract: A system and method of producing an image-based registration of an excised tissue specimen for histopathological examination is provided. The method includes: a) producing a three-dimensional image of an excised tissue specimen having a plurality of surfaces at a first location, the excised tissue specimen having an in-vivo orientation prior to being excised; b) producing orientation information relating to the orientation of the plurality of surfaces of the excised tissue specimen relative to the in-vivo orientation of the tissue specimen prior to being excised; c) wherein the excised tissue specimen is transported to a second location and is positioned; and d) using the three-dimensional image and the orientation information to confirm the excised tissue specimen positioned at the second location is in the in-vivo orientation.

公开(公告)号：US20220128477A1

公开(公告)日：2022-04-28

申请号：US17513824

申请日：2021-10-28

Applicant: CytoVeris Inc.

Inventor： David Fournier ,  Rishikesh Pandey

IPC: G01N21/65 ,  G01J3/44 ,  G01N33/543 ,  A61B5/00

Abstract: A system and method for assaying high and low abundant biomolecules within a biological fluid sample is provided. The method includes: a) placing a biological fluid sample in contact with a first nanostructure surface; b) interrogating the sample with a light source, the sample in contact with the first nanostructure surface, the interrogation using a SERS technique; c) detecting an enhanced Raman scattering from at least one high abundant biomolecule type and producing first signals representative thereof; d) placing the sample in contact with a second nanostructure surface having a targeting agent that targets a low abundant biomolecule; e) interrogating the sample with the light source using the SERS technique; f) detecting the enhanced Raman scattering from the low abundant biomolecules and producing second signals representative thereof; and g) assaying the biological fluid sample using the first signals and the second signals.