-
公开(公告)号：US20060211694A1
公开(公告)日：2006-09-21
申请号：US11226556
申请日：2005-09-14
Applicant: Balekudru Devadas , John Walker , Shaun Selness , Terri Boehm , Richard Durley , Rajesh Devraj , Brian Hickory , Paul Rucker , Kevin Jerome , Heather Madsen , Edgardo Alvira , Michele Promo , Radhika Blevis-Bal , Laura Marruto , Jeff Hitchcock , Thomas Owen , Win Naing , Li Xing , Huey Shieh , Aruna Sambandam , Shuang Liu , Ian Scott , Kevin McGee
Inventor： Balekudru Devadas , John Walker , Shaun Selness , Terri Boehm , Richard Durley , Rajesh Devraj , Brian Hickory , Paul Rucker , Kevin Jerome , Heather Madsen , Edgardo Alvira , Michele Promo , Radhika Blevis-Bal , Laura Marruto , Jeff Hitchcock , Thomas Owen , Win Naing , Li Xing , Huey Shieh , Aruna Sambandam , Shuang Liu , Ian Scott , Kevin McGee
IPC: A61K31/53 , A61K31/506 , A61K31/498 , A61K31/497 , A61K31/501 , A61K31/4439 , A61K31/4747 , A61K31/4709 , A61K31/4412
CPC classification number: C07D213/64 , C07D213/69 , C07D213/70 , C07D213/74 , C07D213/75 , C07D213/79 , C07D213/84 , C07D213/85 , C07D215/22 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/06 , C07D409/14 , C07D413/10
Abstract: Disclosed are compounds Formula I and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, and R5 are defined herein. These compounds are useful for treating diseases and conditions caused or exacerbated by unregulated p38 MAP Kinase and/or TNF activity. Pharmaceutical compositions containing the compounds, methods of preparing the compounds and methods of treatment using the compounds are also disclosed.
Abstract translation: 公开了式I化合物及其药学上可接受的盐，其中R 1，R 2，R 3，R 4， >和R 5＆gt;在本文中定义。 这些化合物可用于治疗由不受调节的p38 MAP激酶和/或TNF活性引起或加重的疾病和病症。 还公开了含有化合物的药物组合物，制备化合物的方法和使用该化合物的治疗方法。
-
公开(公告)号：US07067540B2
公开(公告)日：2006-06-27
申请号：US10367987
申请日：2003-02-14
Applicant: Balekudru Devadas , John Walker , Shaun R. Selness , Terri L. Boehm , Richard C. Durley , Rajesh Devraj , Brian S. Hickory , Paul V. Rucker , Kevin D. Jerome , Heather M. Madsen , Edgardo Alvira , Michele A. Promo , Radhika M. Blevis-Bal , Laura D. Marruto , Jeff Hitchcock , Thomas Owen , Win Naing , Li Xing , Huey S. Shieh , Aruna Sambandam , Shuang Liu , Ian L. Scott , Kevin F. McGee
Inventor： Balekudru Devadas , John Walker , Shaun R. Selness , Terri L. Boehm , Richard C. Durley , Rajesh Devraj , Brian S. Hickory , Paul V. Rucker , Kevin D. Jerome , Heather M. Madsen , Edgardo Alvira , Michele A. Promo , Radhika M. Blevis-Bal , Laura D. Marruto , Jeff Hitchcock , Thomas Owen , Win Naing , Li Xing , Huey S. Shieh , Aruna Sambandam , Shuang Liu , Ian L. Scott , Kevin F. McGee
IPC: A61K31/44 , C07D213/02 , C07D401/02
CPC classification number: C07D213/64 , C07D213/69 , C07D213/70 , C07D213/74 , C07D213/75 , C07D213/79 , C07D213/84 , C07D213/85 , C07D215/22 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/06 , C07D409/14 , C07D413/10
Abstract: Disclosed are compounds Formula I and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, and R5 are defined herein. These compounds are useful for treating diseases and conditions caused or exacerbated by unregulated p38 MAP Kinase and/or TNF activity. Pharmaceutical compositions containing the compounds, methods of preparing the compounds and methods of treatment using the compounds are also disclosed.
Abstract translation: 公开了式I化合物及其药学上可接受的盐，其中R 1，R 2，R 3，R 4， >和R 5＆gt;在本文中定义。 这些化合物可用于治疗由不受调节的p38 MAP激酶和/或TNF活性引起或加重的疾病和病症。 还公开了含有化合物的药物组合物，制备化合物的方法和使用该化合物的治疗方法。
-
公开(公告)号：US07033187B2
公开(公告)日：2006-04-25
申请号：US10765313
申请日：2004-01-26
Applicant: Li Xing Wu , Liu Jun Zhang
Inventor： Li Xing Wu , Liu Jun Zhang
IPC: H01R12/00
CPC classification number: G11B33/122 , G11B5/4806 , G11B5/4853 , G11B5/486 , H01R12/62 , H01R43/0256 , H05K3/365 , H05K2201/10234 , H05K2203/041
Abstract: An electrical connection and a method of electrically coupling are disclosed. In one embodiment, a circuit substrate with a first set of circuitry has a bonding pad mounted to a surface of the circuit board. The bonding pad is electrically coupled to the first set of circuitry. A flexible circuit substrate with a second set of circuitry has a connecting pad mounted to a surface of the flexible circuit substrate facing the surface of the circuit board. The connecting pad is electrically coupled to the second set of circuitry. A ball of conductive material is mounted on the bonding pad. A clamping device presses the connecting pad to the ball of conductive material.
-
34.发明授权公开(公告)号：US06998236B2
公开(公告)日：2006-02-14
申请号：US10212917
申请日：2002-08-05
Applicant: Wei Shao , Junquan Xu , Wan-Li Xing , Jing Cheng
Inventor： Wei Shao , Junquan Xu , Wan-Li Xing , Jing Cheng
CPC classification number: B01L3/50851 , B01J19/0046 , B01J2219/00315 , B01J2219/00351 , B01J2219/00495 , B01J2219/00497 , B01J2219/00527 , B01J2219/00529 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/0063 , B01J2219/00659 , B01J2219/00662 , B01J2219/0072 , B01J2219/00722 , B01J2219/0074 , B01J2219/00743 , B01L3/502 , B01L7/00 , B01L9/52 , B81B7/04 , C40B40/06 , C40B60/14 , G01N33/54373 , G01N35/00029 , G01N2035/00158 , Y10S977/924
Abstract: This invention relates generally to the field of microarray technology. In particular, the invention provides an integrated microarray device, which device comprises a substrate comprising a plurality of distinct microlocations and a plurality of microarray chips, wherein the number of said microlocations equals to or is more than the number of said microarray chips. In preferred embodiments, the devices also comprises a temperature controller at some or all of the microlocations. The use of the integrated microarray devices for detecting interactions among various moieties in various fields, such as clinical diagnostics, drug discovery, environmental monitoring and forensic analysis, etc., are further provided.
-
公开(公告)号：US20050176775A1
公开(公告)日：2005-08-11
申请号：US10918826
申请日：2004-08-13
Applicant: Balekudru Devadas , John Walker , Shaun Selness , Terri Boehm , Richard Durley , Rajesh Devraj , Brian Hickory , Paul Rucker , Kevin Jerome , Heather Madsen , Edgardo Alvira , Michele Promo , Radhika Blevis-Bal , Laura Marrufo , Jeff Hitchcock , Thomas Owen , Win Naing , Li Xing , Huey Shieh , Aruna Sambandam , Shuang Liu , Ian Scott , Kevin McGee
Inventor： Balekudru Devadas , John Walker , Shaun Selness , Terri Boehm , Richard Durley , Rajesh Devraj , Brian Hickory , Paul Rucker , Kevin Jerome , Heather Madsen , Edgardo Alvira , Michele Promo , Radhika Blevis-Bal , Laura Marrufo , Jeff Hitchcock , Thomas Owen , Win Naing , Li Xing , Huey Shieh , Aruna Sambandam , Shuang Liu , Ian Scott , Kevin McGee
IPC: A61K20060101 , A61K31/4412 , A61K31/4415 , A61K31/4439 , A61P29/00 , C07D211/86 , C07D213/64 , C07D213/69 , C07D213/70 , C07D213/73 , C07D213/74 , C07D213/75 , C07D213/80 , C07D213/84 , C07D215/22 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/06 , C07D413/10 , C07D417/04 , C07D41/02
CPC classification number: C07D213/69 , C04B35/632 , C07D213/64 , C07D213/70 , C07D213/73 , C07D213/80 , C07D215/22 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/06 , C07D413/10 , C07D417/04
Abstract: Disclosed are compounds of Formula I and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, and R5 are defined herein. These compounds are useful for treating diseases and conditions caused or exacerbated by unregulated p38 MAP Kinase and/or TNF activity. Pharmaceutical compositions containing the compounds, methods of preparing the compounds and methods of treatment using the compounds are also disclosed.
Abstract translation: 公开了式I的化合物及其药学上可接受的盐，其中R 1，R 2，R 3，R 4， SUB＆gt;和R 5＆gt;在本文中定义。 这些化合物可用于治疗由不受调节的p38 MAP激酶和/或TNF活性引起或加重的疾病和病症。 还公开了含有化合物的药物组合物，制备化合物的方法和使用该化合物的治疗方法。
-
Patent Agency Ranking
公开(公告)号：US20050042894A1
公开(公告)日：2005-02-24
申请号：US10765313
申请日：2004-01-26
Applicant: Li Xing Wu , Liu Jun Zhang
Inventor： Li Xing Wu , Liu Jun Zhang
CPC classification number: G11B33/122 , G11B5/4806 , G11B5/4853 , G11B5/486 , H01R12/62 , H01R43/0256 , H05K3/365 , H05K2201/10234 , H05K2203/041
Abstract: An electrical connection and a method of electrically coupling are disclosed. In one embodiment, a circuit substrate with a first set of circuitry has a bonding pad mounted to a surface of the circuit board. The bonding pad is electrically coupled to the first set of circuitry. A flexible circuit substrate with a second set of circuitry has a connecting pad mounted to a surface of the flexible circuit substrate facing the surface of the circuit board. The connecting pad is electrically coupled to the second set of circuitry. A ball of conductive material is mounted on the bonding pad. A clamping device presses the connecting pad to the ball of conductive material.
-
公开(公告)号：US06703203B2
公开(公告)日：2004-03-09
申请号：US09898271
申请日：2001-07-02
Applicant: Wei Shao , Junquan Xu , Wan-Li Xing , Jing Cheng
Inventor： Wei Shao , Junquan Xu , Wan-Li Xing , Jing Cheng
IPC: C12Q168
CPC classification number: B01L3/50851 , B01J19/0046 , B01J2219/00315 , B01J2219/00351 , B01J2219/00495 , B01J2219/00497 , B01J2219/00527 , B01J2219/00529 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/0063 , B01J2219/00659 , B01J2219/00662 , B01J2219/0072 , B01J2219/00722 , B01J2219/0074 , B01J2219/00743 , B01L3/502 , B01L7/00 , B01L9/52 , B81B7/04 , C40B40/06 , C40B60/14 , G01N33/54373 , G01N35/00029 , G01N2035/00158 , Y10S977/924
Abstract: This invention relates generally to the field of microarray technology. In particular, the invention provides an integrated microarray device, which device comprises a substrate comprising a plurality of distinct microlocations and a plurality of microarray chips, wherein the number of said microlocations equals to or is more than the number of said microarray chips. In preferred embodiments, the devices also comprises a temperature controller at some or all of the microlocations. The use of the integrated microarray devices for detecting interactions among various moieties in various fields, such as clinical diagnostics, drug discovery, environmental monitoring and forensic analysis, etc., are further provided.
Abstract translation: 本发明一般涉及微阵列技术领域。 特别地，本发明提供了一种集成微阵列装置，该装置包括包含多个不同微位置和多个微阵列芯片的基板，其中所述微位置的数量等于或大于所述微阵列芯片的数量。 在优选实施例中，装置还包括位于微位置的部分或全部的温度控制器。 还提供了使用集成的微阵列装置来检测各个领域的各个部分之间的相互作用，诸如临床诊断，药物发现，环境监测和法医分析等。
-
38.发明申请公开(公告)号：US20120064169A1
公开(公告)日：2012-03-15
申请号：US13220356
申请日：2011-08-29
Applicant: R. Holland Cheng , Li Xing , Tatsuo Miyamura , Yasuhiro Yasutomi , Tian-Cheng Li , Naokazu Takeda
Inventor： R. Holland Cheng , Li Xing , Tatsuo Miyamura , Yasuhiro Yasutomi , Tian-Cheng Li , Naokazu Takeda
CPC classification number: A61K39/21 , A61K39/12 , A61K39/29 , A61K2039/5258 , A61K2039/541 , A61K2039/542 , C07K14/005 , C07K2319/40 , C12N2740/16122 , C12N2740/16134 , C12N2740/16234 , C12N2770/28123 , C12N2770/28134 , C12N2770/28142
Abstract: This invention provides a peptide/nucleic acid composition for oral/mucosal, dual-modal activation of immune protection systems.
Abstract translation: 本发明提供了用于免疫保护系统的口腔/粘膜，双重模态激活的肽/核酸组合物。
-
39.发明授权Electrical connection between a suspension flexure cable and a head stack assembly flexible circuit 失效悬挂式挠性电缆与磁头组合组装柔性电路之间的电气连接公开(公告)号：US07411763B2
公开(公告)日：2008-08-12
申请号：US10754203
申请日：2004-01-09
Applicant: Li Xing Wu , Yiu Sing Ho , Jeffery L. Wang , Liu Jun Zhang
Inventor： Li Xing Wu , Yiu Sing Ho , Jeffery L. Wang , Liu Jun Zhang
CPC classification number: G11B5/4846 , G11B5/486 , H05K1/189 , H05K3/325 , Y10T29/49027 , Y10T29/49147
Abstract: A method and apparatus for electrically coupling a slider to a controller circuit are disclosed. In one embodiment, a pre-amplifier with an integrated electrical connector (I-connector) may be connected via an electrical trace to a slider and via a head stack assembly flexible circuit to a control circuit. The pre-amplifier may have two parallel series of spring probe claws, two parallel series of contact pegs, two slots, or a slot and a rotary cam.
Abstract translation: 公开了一种用于将滑块电耦合到控制器电路的方法和装置。 在一个实施例中，具有集成电连接器（I型连接器）的前置放大器可以经由电气迹线连接到滑动器并且经由磁头堆叠组件柔性电路连接到控制电路。 前置放大器可以具有两个平行的一系列弹簧探针爪，两个平行的接触栓系列，两个槽或槽和旋转凸轮。
-
40.发明授权Process and apparatus for producing hydrocarbons from residential trash or waste and/or organic waste materials 失效从住宅垃圾或废物和/或有机废物生产碳氢化合物的工艺和设备
公开(公告)号：US06133491A
公开(公告)日：2000-10-17
申请号：US204078
申请日：1998-12-03
Applicant: Li Xing
Inventor： Li Xing
CPC classification number: C10G1/02 , C10B47/30 , C10G1/08 , F23G5/20 , F23G2203/211
Abstract: The invention provides a process and apparatus for producing hydrocarbons from residential trash or waste and/or organic waste materials. In particular, the invention provides a process and apparatus for producing hydrocarbons from residential trash or waste and/or organic waste materials in virtue of pyrolysis and catalytic cracking.
Abstract translation: 本发明提供了一种用于从住宅垃圾或废物和/或有机废物生产碳氢化合物的方法和装置。 特别地，本发明提供了由于热解和催化裂化而从住宅垃圾或废物和/或有机废物生产碳氢化合物的方法和装置。
-
-
-
-
-
-
-
-
-
Search Results
40
records
(took 0.058 seconds)
