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    TISSUE SHAPING DEVICE
    31.
    发明申请
    TISSUE SHAPING DEVICE 审中-公开

    公开(公告)号：US20200008943A1

    公开(公告)日：2020-01-09

    申请号：US16576025

    申请日：2019-09-19

    Applicant: Mark L. MATHIS ,  Leonard KOWALSKY ,  David G. REUTER ,  Cruz BEESON

    Inventor： Mark L. MATHIS ,  Leonard KOWALSKY ,  David G. REUTER ,  Cruz BEESON

    IPC: A61F2/24

    Abstract: An anchor anchors a therapeutic device having an elongated body within a body lumen. The anchor includes a fixation member carried on the device which is adjustable from a first configuration that permits placement of the device in the body lumen to a second configuration that anchors the device within the body lumen. The anchor further includes a lock that locks the fixation member in the second configuration. The fixation member may be locked in any one of a plurality of intermediate points between the first configuration and a maximum second configuration.

    FIXED ANCHOR AND PULL MITRAL VALVE DEVICE AND METHOD
    33.
    发明申请
    FIXED ANCHOR AND PULL MITRAL VALVE DEVICE AND METHOD 审中-公开
    固定式锚栓和拉力阀装置及方法

    公开(公告)号：US20160338833A1

    公开(公告)日：2016-11-24

    申请号：US15230093

    申请日：2016-08-05

    Applicant: Mark L. MATHIS ,  Gregory D. NIEMINEN ,  David G. REUTER

    Inventor： Mark L. MATHIS ,  Gregory D. NIEMINEN ,  David G. REUTER

    IPC: A61F2/24

    CPC classification number: A61F2/2451 ,  A61B2017/00243 ,  A61F2/24 ,  A61F2/2442 ,  A61F2/2466 ,  A61F2210/0014 ,  A61F2220/0008 ,  A61F2250/0012 ,  A61F2310/00017 ,  A61F2310/00023 ,  A61N1/057 ,  A61N2001/0585

    Abstract: Devices for treating mitral valve regurgitation, including a distal expandable anchor, a proximal expandable anchor, and a fixed length connecting member extending from the proximal expandable anchor to the distal expandable anchor, where at least one of the proximal and distal anchors includes first and second arm segments that extend from one end of the device toward the connecting member and the other anchor when in a collapsed delivery configuration, and where the at least one of the proximal and distal anchors that comprises the first and second arm segments has an expanded configuration in which the first and second arm segments extend radially outwardly such that the first and second arm segments extend away from one another toward the connector, and meet one another at a location axially spaced from the end of the device.

    Abstract translation: 用于治疗二尖瓣反流的装置，包括远端可扩张锚固件，近端可扩张锚固件和从近端可扩张锚固件延伸到远侧可扩张锚固件的固定长度连接构件，其中近端锚固件和远端锚固件中的至少一个包括第一和第二 臂部分在装置的一端延伸到连接构件，而另一个锚固件处于塌缩的输送构型时，并且其中包括第一和第二臂段的近端和远端锚固件中的至少一个具有扩展构型 其中第一和第二臂部段径向向外延伸，使得第一和第二臂部分彼此远离连接器延伸，并且在与装置的端部轴向间隔开的位置处彼此相遇。

    Device and method for modifying the shape of a body organ
    38.
    发明授权
    Device and method for modifying the shape of a body organ 有权
    用于改变身体器官形状的装置和方法

    公开(公告)号：US08172898B2

    公开(公告)日：2012-05-08

    申请号：US12719758

    申请日：2010-03-08

    Applicant: Clifton A. Alferness ,  John M. Adams ,  Mark L. Mathis ,  David G. Reuter ,  Cruz Beeson ,  Leonard Kowalsky

    Inventor： Clifton A. Alferness ,  John M. Adams ,  Mark L. Mathis ,  David G. Reuter ,  Cruz Beeson ,  Leonard Kowalsky

    IPC: A61F2/24 ,  A61F2/06

    CPC classification number: A61F2/2451 ,  A61F2250/001 ,  A61F2250/0059

    Abstract: An intravascular support device includes a support or reshaper wire, a proximal anchor and a distal anchor. The support wire engages a vessel wall to change the shape of tissue adjacent the vessel in which the intravascular support is placed. The anchors and support wire are designed such that the vessel in which the support is placed remains open and can be accessed by other devices if necessary. The device provides a minimal metal surface area to blood flowing within the vessel to limit the creation of thrombosis. The anchors can be locked in place to secure the support within the vessel.

    Abstract translation: 血管内支持装置包括支撑件或再生线，近端锚和远端锚。 支撑线接合血管壁以改变邻近其中放置血管内支架的血管的组织的形状。 锚和支撑线被设计成使得放置支撑件的容器保持打开，并且如果需要可以被其他装置访问。 该装置为在血管内流动的血液提供最小的金属表面积，以限制血栓形成。 锚固件可以锁定到位以将支撑件固定在容器内。

    Percutaneous Mitral Valve Annuloplasty Delivery System
    39.
    发明申请
    Percutaneous Mitral Valve Annuloplasty Delivery System 审中-公开
    经皮二尖瓣瓣膜成形术输送系统

    公开(公告)号：US20110066234A1

    公开(公告)日：2011-03-17

    申请号：US12952057

    申请日：2010-11-22

    Applicant: Lucas S. Gordon ,  Mark L. Mathis ,  Gregory Nieminen ,  Leonard Kowalsky ,  Ryan Braxtan ,  Brian J. Doll

    Inventor： Lucas S. Gordon ,  Mark L. Mathis ,  Gregory Nieminen ,  Leonard Kowalsky ,  Ryan Braxtan ,  Brian J. Doll

    IPC: A61F2/24

    CPC classification number: A61B17/3468 ,  A61F2/2451 ,  A61F2/95 ,  A61F2002/9511 ,  A61F2002/9517

    Abstract: The invention is a tissue shaping system, including a tissue shaping device with an expandable anchor and a lock; a delivery catheter; a delivery mechanism adapted to deliver the tissue shaping device from outside a patient to a target site within a lumen within the patient via the delivery catheter; and an actuator adapted to deliver an actuation force to the lock to lock the anchor in an expanded configuration. The invention is also a system adapted to percutaneously deliver and deploy a tissue shaping device at a target site within a lumen of a patient. The system includes: a handle; a delivery mechanism supported by the handle and adapted to deliver the tissue shaping device from outside the patient to the treatment site via a delivery catheter; and an actuator supported by the handle and adapted to deliver an actuation force to lock an anchor of the tissue shaping device in an expanded configuration.

    Abstract translation: 本发明是一种组织成形系统，包括具有可扩张锚和锁的组织成形装置; 输送导管; 输送机构，其适于经由输送导管将患者外部的组织成形装置输送到患者体内的内腔内的目标部位; 以及致动器，其适于将致动力传递到所述锁以将所述锚固件锁定在扩展构型中。 本发明也是适于在患者的内腔内的目标部位经皮输送和部署组织整形装置的系统。 该系统包括：手柄; 由手柄支撑并适于经由输送导管将组织成形装置从患者外部递送到治疗部位的递送机构; 以及致动器，其由所述手柄支撑并且适于递送致动力以将所述组织整形装置的锚固件以扩展构型锁定。

    Mitral Valve Device Using Conditioned Shape Memory Alloy
    40.
    发明申请
    Mitral Valve Device Using Conditioned Shape Memory Alloy 审中-公开
    二尖瓣装置使用条状形状记忆合金

    公开(公告)号：US20100280602A1

    公开(公告)日：2010-11-04

    申请号：US12838189

    申请日：2010-07-16

    Applicant: Mark L. Mathis

    Inventor： Mark L. Mathis

    IPC: A61F2/24

    CPC classification number: A61F2/2451 ,  A61F2210/0023

    Abstract: A mitral valve annulus reshaping device includes at least a portion that is formed of a biocompatible shape memory alloy SMA having a characteristic temperature, Af, that is preferably below body temperature. The device is constrained in an unstable martensite (UM) state while being introduced through a catheter that passes through the venous system and into the coronary sinus of the heart. The reshaping device is deployed adjacent to the mitral valve annulus of the heart as it is forced from the catheter. When released from the constraint of the catheter, the SMA of the device at least partially converts from the UM state to an austenitic state and attempts to change to a programmed shape that exerts a force on the adjacent tissue and modifies the shape of the annulus. The strain of the SMA can be varied when the device is within the coronary sinus.

    Abstract translation: 二尖瓣环重塑装置至少包括由具有特征温度Af的生物相容性形状记忆合金SMA形成的部分，其优选低于体温。 该装置被限制在不稳定的马氏体（UM）状态，同时通过导管穿过静脉系统并进入心脏的冠状窦。 当从导管被迫时，整形装置邻近心脏的二尖瓣环部署。 当从导管的约束释放时，该装置的SMA至少部分地从UM状态转变为奥氏体状态，并尝试改变为在相邻组织上施加力并且修改环形的形状的编程形状。 当器件在冠状窦内时，SMA的应变可以变化。

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