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公开(公告)号：US11547849B2
公开(公告)日：2023-01-10
申请号：US16001866
申请日：2018-06-06
Applicant: NeuroNexus Technologies, Inc.
Inventor： Jamille Farraye Hetke , Rio J. Vetter , Carlos Rackham , Daryl R. Kipke
Abstract: Systems and methods for ruggedized neural probes are provided. Such probes may be adapted for penetrating tissue. An exemplary ruggedized penetrating electrode array system includes an elongate shank having one or more electrodes disposed on at least one exterior surface thereof and a backend structure. A proximal end of the elongate shank is secured to the backend structure. The exemplary array system further includes an elongate carrier secured to the backend structure and extending away from the backend structure toward the distal end of the elongate shank, the elongate carrier being more rigid than the elongate shank. Methods for fabricating such an array system are also provided.
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公开(公告)号：US10946187B2
公开(公告)日：2021-03-16
申请号：US15845611
申请日：2017-12-18
Applicant: NeuroNexus Technologies, Inc.
Inventor： Rio J. Vetter , Jamille Farraye Hetke , David S. Pellinen , Bencharong Suwarato , K C Kong
Abstract: A three-dimensional neural probe electrode array system is described. Planar probes are microfabricated and electrically connected to flexible micro-machined ribbon cables using a rivet bonding technique. The distal end of each cable is connected to a probe with the proximal end of the cable being customized for connection to a printed circuit board. Final assembly consists of combining multiple such assemblies into a single structure. Each of the two-dimensional neural probe arrays is positioned into a micro-machined platform that provides mechanical support and alignment for each array. Lastly, a micro-machined cap is placed on top of each neural electrode probe and cable assembly to protect them from damage during shipping and subsequent use. The cap provides a relatively planar surface for attachment of a computer controlled inserter for precise insertion into the tissue.
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公开(公告)号：US10173051B2
公开(公告)日：2019-01-08
申请号：US14519583
申请日：2014-10-21
Applicant: NeuroNexus Technologies, Inc.
Inventor： David S. Pellinen , Bencharong Suwarato , Rio J. Vetter , Jamille Farraye Hetke , Daryl R. Kipke
Abstract: A neural probe comprising an array of stimulation and/or recording electrodes supported on a tape spring-type carrier is described. The neural probe comprising the tape spring-type carrier is used to insert flexible electrode arrays straight into tissue, or to insert them off-axis from the initial penetration of a guide tube. Importantly, the neural probe is not rigid, but has a degree of stiffness provided by the tape spring-type carrier that maintains a desired trajectory into body tissue, but will subsequently allow the probe to flex and move in unison with movement of the body tissue.
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公开(公告)号：US20180345010A9
公开(公告)日：2018-12-06
申请号：US14519583
申请日：2014-10-21
Applicant: NeuroNexus Technologies, Inc.
Inventor： David S. Pellinen , Bencharong Suwarato , Rio J. Vetter , Jamille Farraye Hetke , Daryl R. Kipke
CPC classification number: A61N1/0558 , A61B5/04001 , A61B5/0478 , A61M25/003 , A61M25/007 , A61M2025/0031 , A61N1/0534 , A61N1/36017 , G03F7/40
Abstract: A neural probe comprising an array of stimulation and/or recording electrodes supported on a tape spring-type carrier is described. The neural probe comprising the tape spring-type carrier is used to insert flexible electrode arrays straight into tissue, or to insert them off-axis from the initial penetration of a guide tube. Importantly, the neural probe is not rigid, but has a degree of stiffness provided by the tape spring-type carrier that maintains a desired trajectory into body tissue, but will subsequently allow the probe to flex and move in unison with movement of the body tissue.
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公开(公告)号：US09656054B2
公开(公告)日：2017-05-23
申请号：US14676037
申请日：2015-04-01
Applicant: NeuroNexus Technologies, Inc.
Inventor： David S. Pellinen , Mayurachat Ning Gulari , Jamille Farraye Hetke , David J. Anderson , Daryl R. Kipke , Rio J. Vetter
CPC classification number: A61N1/05 , A61B5/04001 , A61B2562/0209 , A61N1/0529 , A61N1/0551 , H05K1/0393 , H05K1/113 , H05K3/4644 , H05K2201/09781 , H05K2201/2072 , Y10T29/49117
Abstract: The implantable electrode system of the preferred embodiments includes a conductor, an interconnect coupled to the conductor, an insulator that insulates the interconnect, and an anchor that overlaps a peripheral edge of the electrode layer. The anchor is mechanically interlocked with the insulator. This structure is particularly useful with the electrode layer being a neural interface that is configured to provide either a recording and stimulating function.
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Patent Agency Ranking
公开(公告)号：US09643027B2
公开(公告)日：2017-05-09
申请号：US14521552
申请日：2014-10-23
Applicant: NeuroNexus Technologies, Inc.
Inventor： John P. Seymour , Mayurachat Ning Gulari , Daryl R. Kipke , Kc Kong
CPC classification number: A61N5/0622 , A61B5/0084 , A61B5/04001 , A61B5/4076 , A61B2562/0233 , A61B2562/046 , A61N2005/0626 , A61N2005/0643 , Y10T29/49016
Abstract: A waveguide neural interface device including: a neural device implantable in tissue and including an array of electrode sites that electrically communicate with their surroundings, in which the array of electrode sites includes at least one recording electrode site; and a waveguide, coupled to the neural device, that carries light along a longitudinal axis and includes a light directing element that redirects the carried light from the waveguide to illuminate selectively targeted tissue, in which at least a portion of the redirected light is directed laterally away from the longitudinal axis and the recording electrode site is configured to sample illuminated tissue. A method for assembling a waveguide neural interface device is also described.
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公开(公告)号：US20150246219A1
公开(公告)日：2015-09-03
申请号：US14685661
申请日：2015-04-14
Applicant: NeuroNexus Technologies, Inc.
Inventor： John P. Seymour , Jamille Farraye Hetke , Rio J. Vetter , Daryl R. Kipke , David S. Pellinen , Kc Kong
CPC classification number: A61N1/0534 , A61B1/07 , A61M25/0009 , A61M25/0023 , A61N1/0553 , A61N5/0601 , A61N2005/0632 , H05K1/028 , H05K1/118 , H05K3/10 , H05K2201/051 , Y10T29/4913 , Y10T29/49147 , Y10T29/49155
Abstract: The neural interface system of one embodiment includes a cylindrical shaft, a lateral extension longitudinally coupled to at least a portion of the shaft and having a thickness less than a diameter of the shaft, and an electrode array arranged on the lateral extension and radially offset from the shaft, including electrode sites that electrically interface with their surroundings. The method of one embodiment for making the neural interface system includes forming a planar polymer substrate with at least one metallization layer, patterning on at least one metallization layer an electrode array on a first end of the substrate, patterning conductive traces on at least one metallization layer, rolling a portion of the substrate toward the first end of the substrate, and securing the rolled substrate into a shaft having the first end of the substrate laterally extending from the shaft and the electrode array radially offset from the shaft.
Abstract translation: 一个实施例的神经接口系统包括圆柱形轴，纵向耦合到轴的至少一部分并且具有小于轴的直径的厚度的横向延伸部和布置在横向延伸部上的径向偏移的电极阵列 轴，包括与其周围环境电接触的电极位置。 用于制造神经接口系统的一个实施例的方法包括：形成具有至少一个金属化层的平面聚合物衬底，在至少一个金属化层上图案化在衬底的第一端上的电极阵列，在至少一个金属化层 将基板的一部分朝向基板的第一端滚动，并且将轧制的基板固定到轴中，其中基板的第一端从轴横向延伸并且电极阵列从轴向径向偏移。
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公开(公告)号：US20150201855A1
公开(公告)日：2015-07-23
申请号：US14676037
申请日：2015-04-01
Applicant: NeuroNexus Technologies, Inc.
Inventor： David S. Pellinen , Mayurachat Ning Gulari , Jamille Farraye Hetke , David J. Anderson , Daryl R. Kipke , Rio J. Vetter
CPC classification number: A61N1/05 , A61B5/04001 , A61B2562/0209 , A61N1/0529 , A61N1/0551 , H05K1/0393 , H05K1/113 , H05K3/4644 , H05K2201/09781 , H05K2201/2072 , Y10T29/49117
Abstract: The implantable electrode system of the preferred embodiments includes a conductor, an interconnect coupled to the conductor, an insulator that insulates the interconnect, and an anchor that overlaps a peripheral edge of the electrode layer. The anchor is mechanically interlocked with the insulator. This structure is particularly useful with the electrode layer being a neural interface that is configured to provide either a recording and stimulating function.
Abstract translation: 优选实施例的可植入电极系统包括导体，耦合到导体的互连件，使互连绝缘的绝缘体和与电极层的外围边缘重叠的锚固件。 锚固体与绝缘体机械地互锁。 该结构对于被配置为提供记录和刺激功能的神经接口的电极层是特别有用的。
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39.发明申请公开(公告)号：US20150119673A1
公开(公告)日：2015-04-30
申请号：US14519583
申请日：2014-10-21
Applicant: NeuroNexus Technologies, Inc.
Inventor： David S. Pellinen , Bencharong Suwarato , Rio J. Vetter , Jamille Farraye Hetke , Daryl R. Kipke
CPC classification number: A61N1/0558 , A61B5/04001 , A61B5/0478 , A61M25/003 , A61M25/007 , A61M2025/0031 , A61N1/0534 , A61N1/36017 , G03F7/40
Abstract: A neural probe comprising an array of stimulation and/or recording electrodes supported on a tape spring-type carrier is described. The neural probe comprising the tape spring-type carrier is used to insert flexible electrode arrays straight into tissue, or to insert them off-axis from the initial penetration of a guide tube. Importantly, the neural probe is not rigid, but has a degree of stiffness provided by the tape spring-type carrier that maintains a desired trajectory into body tissue, but will subsequently allow the probe to flex and move in unison with movement of the body tissue.
Abstract translation: 描述了包括支撑在带状弹簧式载体上的刺激和/或记录电极阵列的神经探针。 包括带状弹簧式载体的神经探针用于将柔性电极阵列直接插入到组织中，或将它们从引导管的初始穿透轴线插入。 重要的是，神经探针不是刚性的，而是具有通过带弹簧型载体提供的一定程度的刚度，其保持期望的轨迹到身体组织中，但随后允许探针与身体组织的移动一致地弯曲并移动 。
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公开(公告)号：US20130184799A1
公开(公告)日：2013-07-18
申请号：US13740310
申请日：2013-01-14
Applicant: NEURONEXUS TECHNOLOGIES, INC.
Inventor： Daryl R. Kipke , Jamille Farraye Hetke , Rio J. Vetter , John P. Seymour
IPC: A61N1/05
CPC classification number: A61B5/0478 , A61B5/04001 , A61B5/686 , A61B5/6868 , A61B2562/187 , A61N1/05 , A61N1/0529 , A61N1/0539 , A61N1/0551 , A61N1/36
Abstract: An improved deformable carrier or connector for an implantable neural interface device is described. The neural interface device comprises a carrier supporting at least one electrode array. The carrier comprises a tubular sidewall extending from a proximal carrier portion to a distal carrier portion. At least one deformable segment is provided in the carrier sidewall.. The deformable segment is more pliable than the remainder of the carrier sidewall to preferably move in response to forces imparted on the carrier and the electrode array by the shifting forces in body tissue. The deformable segment takes the form of a thinned sidewall segment or a slitted wall segment.
Abstract translation: 描述了用于可植入神经接口装置的改进的可变形载体或连接器。 神经接口装置包括支撑至少一个电极阵列的载体。 载体包括从近端载体部分延伸到远端载体部分的管状侧壁。 至少一个可变形部分设置在承载器侧壁中。可变形部分比载体侧壁的其余部分更柔韧，优选地响应于通过身体组织中的移动力施加在载体和电极阵列上的力而移动。 可变形段采取变薄的侧壁段或切开的壁段的形式。
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