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公开(公告)号：US20230287384A1
公开(公告)日：2023-09-14
申请号：US18059370
申请日：2022-11-28
Applicant: University Health Network , Sinai Health System
Inventor： Daniel DINIZ DE CARVALHO , Shu Yi SHEN , Rajat SINGHANIA
IPC: C12N15/10 , C12Q1/6806 , C12Q1/6804 , G01N33/53
CPC classification number: C12N15/1003 , C12N15/10 , C12N15/1093 , C12Q1/6804 , C12Q1/6806 , G01N33/5308 , C12Q1/6886
Abstract: There is described herein, a method of capturing cell-free methylated DNA from a sample having less than 100 mg of cell-free DNA, comprising the steps of: subjecting the sample to library preparation to permit subsequent sequencing of the cell-free methylated DNA; adding a first amount of filler DNA to the sample, wherein at least a portion of the filler DNA is methylated; denaturing the sample; and capturing cell-free methylated DNA using a binder selective for methylated polynucleotides.
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公开(公告)号：US20230158022A1
公开(公告)日：2023-05-25
申请号：US17916773
申请日：2021-04-01
Applicant: Repare Therapeutics Inc. , Sinai Health System
Inventor： Daniel DUROCHER , Jordan YOUNG , Frank SICHERI , Janek SZYCHOWSKI , Bingcan LIU , Evelyne DIETRICH , Frédéric VALLÉE , Alexander PERRYMAN , Jean-François TRUCHON , Robert PAPP , Theresa ZHANG , Artur VELOSO , Jimmy FOURTOUNIS , Patrick BEAULIEU
IPC: A61K31/4985 , A61K31/437 , A61K31/5377 , A61K31/496 , A61K31/506 , A61K31/541 , A61K31/55 , A61K31/501 , A61P35/00 , A61K31/444
CPC classification number: A61K31/4985 , A61K31/437 , A61K31/5377 , A61K31/496 , A61K31/506 , A61K31/541 , A61K31/55 , A61K31/501 , A61P35/00 , A61K31/444
Abstract: Disclosed are methods of using inhibitors of tyrosine and threonine-specific cdc2-inhibitory kinase (Myt1), e.g., in the treatment of subjects in need thereof.
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公开(公告)号：US20220119796A1
公开(公告)日：2022-04-21
申请号：US17353756
申请日：2021-06-21
Applicant: University Health Network , Sinai Health System
Inventor： Daniel Diniz De Carvalho , Shu Yi Shen , Rajat Singhania
IPC: C12N15/10 , C12Q1/6806 , C12Q1/6804 , G01N33/53
Abstract: There is described herein, a method of capturing cell-free methylated DNA from a sample having less than 100 mg of cell-free DNA, comprising the steps of: subjecting the sample to library preparation to permit subsequent sequencing of the cell-free methylated DNA; adding a first amount of filler DNA to the sample, wherein at least a portion of the filler DNA is methylated; denaturing the sample; and capturing cell-free methylated DNA using a binder selective for methylated polynucleotides.
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公开(公告)号：US20220073902A1
公开(公告)日：2022-03-10
申请号：US17519350
申请日：2021-11-04
Applicant: University Health Network , Sinai Health System
Inventor： Daniel Diniz De Carvalho , Shu Yi Shen , Rajat Singhania
IPC: C12N15/10 , C12Q1/6806 , C12Q1/6804 , G01N33/53
Abstract: There is described herein, a method of capturing cell-free methylated DNA from a sample having less than 100 mg of cell-free DNA, comprising the steps of: subjecting the sample to library preparation to permit subsequent sequencing of the cell-free methylated DNA; adding a first amount of filler DNA to the sample, wherein at least a portion of the filler DNA is methylated; denaturing the sample; and capturing cell-free methylated DNA using a binder selective for methylated polynucleotides.
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35.发明申请公开(公告)号：US20170360873A1
公开(公告)日：2017-12-21
申请号：US15536416
申请日：2015-12-15
Inventor： Benjamin J. Blencowe , Mathieu Quesnel-Vallieres , Manuel Irimia , Bushra Raj , Sabine P. Cordes
IPC: A61K38/05 , G01N33/68 , A01K67/027 , C12Q1/68 , A61K49/00 , A61K31/7088
Abstract: Methods for treatment and diagnosis of neurological disorders such as autism and autism spectrum disorder are disclosed. Also disclosed are modulators of alternative splicing regulators SRRM4 and/or SRRM3 for treating neurological disorders. Further disclosed are agents that modulate the expression of at least one splice variant for treating neurological disorders. Mouse models of neurological disorders having increased or decreased expression of SRRM4 and/or SRRM3 are also disclosed.
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Patent Agency Ranking
36.发明授权公开(公告)号：US12186401B2
公开(公告)日：2025-01-07
申请号：US17310837
申请日：2020-03-02
Inventor： Frank Sicheri , Ganna Posternak , Gennady Poda
IPC: A61K47/55 , A61K47/54 , A61P35/00 , C07D471/04
Abstract: The present application relates to novel compounds of Formula (I) containing a E3 ubiquitin ligase binding moiety linked to a Raf protein kinase binding moiety. The present application also includes methods and uses of the compounds, for example, for inhibiting and/or degrading V600E mutant B-Raf. I
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公开(公告)号：US20240352081A1
公开(公告)日：2024-10-24
申请号：US18426877
申请日：2024-01-30
Applicant: Sinai Health System
Inventor： Daniel Durocher , Salomé Adam , Silvia Emma Rossi , Yibo Xue
CPC classification number: C07K14/4703 , A61P35/00 , A61K38/00
Abstract: Disclosed are compounds, compositions, uses and methods using inhibitors of the CIP2A-TOPBP1 complex or agents that inhibit phosphopeptide recognition of TOPBP1 BRCT7/8, for treatment of a cancer associated with or characterized by a homologous recombination (HR) deficiency or treatment of cancer cells having HR deficiency.
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公开(公告)号：US11897925B2
公开(公告)日：2024-02-13
申请号：US17520638
申请日：2021-11-06
Applicant: Sinai Health System
Inventor： Daniel Durocher , Salomé Adam , Silvia Emma Rossi , Yibo Xue
CPC classification number: C07K14/4703 , A61P35/00 , A61K38/00
Abstract: Disclosed are compounds, compositions, uses and methods using inhibitors of the CIP2A-TOPBP1 complex or agents that inhibit phosphopeptide recognition of TOPBP1 BRCT7/8, for treatment of a cancer associated with or characterized by a homologous recombination (HR) deficiency or treatment of cancer cells having HR deficiency.
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公开(公告)号：US20220153793A1
公开(公告)日：2022-05-19
申请号：US17520638
申请日：2021-11-06
Applicant: Sinai Health System
Inventor： Daniel Durocher , Salomé Adam , Silvia Emma Rossi , Yibo Xue
Abstract: Disclosed are compounds, compositions, uses and methods using inhibitors of the CIP2A-TOPBP1 complex or agents that inhibit phosphopeptide recognition of TOPBP1 BRCT7/8, for treatment of a cancer associated with or characterized by a homologous recombination (HR) deficiency or treatment of cancer cells having HR deficiency.
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40.发明申请公开(公告)号：US20220125936A1
公开(公告)日：2022-04-28
申请号：US17310837
申请日：2020-03-02
Inventor： Frank Sicheri , Ganna Posternak , Gennady Poda
Abstract: The present application relates to novel compounds of Formula (I) containing a E3 ubiquitin ligase binding moiety linked to a Raf protein kinase binding moiety. The present application also includes methods and uses of the compounds, for example, for inhibiting and/or degrading V600E mutant B-Raf. I
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