公开(公告)号：US11802284B2

公开(公告)日：2023-10-31

申请号：US16918520

申请日：2020-07-01

Applicant: NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSITY ,  TOKYO INSTITUTE OF TECHNOLOGY

Inventor： Kanako Niimori

IPC: A61K48/00 ,  A61K31/713 ,  A61P35/00 ,  C12N15/113 ,  A61K45/00 ,  C07K16/18 ,  C07K16/30 ,  A61K39/00

CPC classification number: C12N15/1135 ,  A61K31/713 ,  A61K45/00 ,  A61K48/00 ,  A61P35/00 ,  C07K16/18 ,  C07K16/30 ,  A61K2039/505 ,  C12N2310/14

Abstract: An object of the present invention is to reveal a role of a stem cell control factor including Matrin-3 in cancer exhibiting neural differentiation including small cell lung cancer, and develop a medicine useful for treating cancer and the like based on the role. Among cancers having the cancer stem cell controlling mechanism, in cancer exhibiting the differentiation potency, the peculiar balance where both of expression of a stem cell maintenance factor and expression of a differentiation promoting factor are higher as compared with normal cells is retained. Additionally, in undifferentiated cancer, the peculiar balance where expression of a stem cell maintenance factor is higher as compared with normal cells is retained. In cancer in which the cancer stem cell controlling mechanism exists, these peculiar balances of a stem cell control factor different from the balance of normal cells exist. In the medicine for treating cancer and the method for treating cancer of the present invention, proliferativeness of cancer is suppressed by breaking down this balance of a stem cell control factor.

公开(公告)号：US20230343997A1

公开(公告)日：2023-10-26

申请号：US18325970

申请日：2023-05-30

Applicant: FUJIFILM Corporation ,  TOKYO INSTITUTE OF TECHNOLOGY

Inventor： Yosuke SHIRATORI ,  Yukihiro OKUNO ,  Shintaro YASUI ,  Kengo SAITO ,  Kenta WATANABE

IPC: H01M10/0562

CPC classification number: H01M10/0562 ,  H01M2300/0068

Abstract: The present invention provides a lithium-based solid electrolyte excellent in ion conductivity, an inorganic solid electrolyte, a production method for a lithium-based solid electrolyte, a modified positive electrode active material, a modified negative electrode active material, an all-solid state secondary battery, an electrode sheet for an all-solid state secondary battery, a solid electrolyte sheet, and an electrode for an all-solid state secondary battery. The lithium-based solid electrolyte according to the present invention contains lithium tetraborate in a noncrystalline state, water, and a lithium salt.

公开(公告)号：US11767545B2

公开(公告)日：2023-09-26

申请号：US17272862

申请日：2019-09-06

Applicant: HIROSHIMA UNIVERSITY ,  TOKYO INSTITUTE OF TECHNOLOGY ,  MAZDA MOTOR CORPORATION

Inventor： Atsushi Sakamoto ,  Kumiko Okazaki ,  Takashi Yamamoto ,  Hiroyuki Ohta ,  Koichi Hori ,  Shinsuke Shimizu ,  Akihide Takami ,  Seiji Nomura ,  Fumihiko Saito

IPC: C12P7/6463 ,  C12N1/12 ,  C12R1/89

CPC classification number: C12P7/6463 ,  C12N1/12 ,  C12R2001/89

Abstract: A microorganism having at least one SPX gene encoding SPX protein responsive to phosphorus deficiency, and characterized in that a function of the SPX protein is decreased or lost by introducing gene mutation into the SPX gene.

公开(公告)号：US11750204B2

公开(公告)日：2023-09-05

申请号：US17692742

申请日：2022-03-11

Applicant: National Institute of Information and Communications Technology ,  Tokyo Institute of Technology

Inventor： Motoaki Hara ,  Yuichiro Yano ,  Masatoshi Kajita ,  Tetsuya Ido ,  Hiroyuki Ito

IPC: H03L7/26 ,  G04F5/14

CPC classification number: H03L7/26 ,  G04F5/145

Abstract: This atomic resonator for causing a resonance frequency by CPT resonance includes: a gas cell having alkali metal atoms enclosed; a photodetector configured to detect light having passed through the gas cell and convert the light to an electric signal; a high-frequency oscillator configured to receive the electric signal and output the signal after a frequency thereof is divided by two; and a laser light source configured to modulate and introduce, into the gas cell, light based on the signal output from the high-frequency oscillator. The high-frequency oscillator has an injection-locked frequency divider circuit including an acoustic resonator as an oscillation element.

公开(公告)号：US20230233132A1

公开(公告)日：2023-07-27

申请号：US17927481

申请日：2021-04-30

Applicant: TOKYO INSTITUTE OF TECHNOLOGY

Inventor： Natsue YOSHIMURA ,  Yasuharu KOIKE

IPC: A61B5/38 ,  A61B5/00

CPC classification number: A61B5/38 ,  A61B5/7267

Abstract: An estimation apparatus is configured to be capable of accessing a model storage unit that stores a model built by machine learning, using, as training data, information on a predetermined sound and information relating to a signal source of a signal indicating a brain activity of a first subject presented with the predetermined sound, the model outputting information on a sound estimated to be recognized by the subject. The estimation apparatus acquires a brain wave of a second subject presented with the predetermined sound. The estimation apparatus estimates, based on a mode of the brain wave acquired, a signal source of the brain wave, from among a plurality of regions in a brain of the second subject. The estimation apparatus inputs the information relating to the signal source estimated to the model and acquires information on a sound estimated to be recognized by the second subject.

公开(公告)号：US11667609B2

公开(公告)日：2023-06-06

申请号：US17434139

申请日：2020-02-20

Applicant: ADEKA CORPORATION ,  TOKYO INSTITUTE OF TECHNOLOGY

Inventor： Hideyuki Otsuka ,  Daisuke Aoki ,  Daisuke Sawamoto ,  Atsushi Kobayashi ,  Satoyuki Chikaoka

IPC: C07D211/96 ,  C09D7/63 ,  C08K5/43 ,  C09J11/06 ,  H01M4/62

CPC classification number: C07D211/96 ,  C08K5/43 ,  C09D7/63 ,  C09J11/06 ,  H01M4/622

Abstract: Provided is a compound, which is represented by the following general formula (1):




where X1 and X2 each independently represent an acrylic group or a methacrylic group, R1 to R8 each independently represent a hydrogen atom or a hydrocarbon group having 1 to 6 carbon atoms, and “n” represents an integer of from 1 to 10.

公开(公告)号：US20230160683A1

公开(公告)日：2023-05-25

申请号：US18098911

申请日：2023-01-19

Applicant: JAPAN AVIATION ELECTRONICS INDUSTRY, LIMITED ,  TOKYO INSTITUTE OF TECHNOLOGY

Inventor： Mikio KOZUMA ,  Ryotaro INOUE ,  Toshiyuki HOSOYA ,  Atsushi TANAKA

IPC: G01B9/02015 ,  G21K1/02 ,  G01C19/62

CPC classification number: G01B9/02016 ,  G21K1/025 ,  G01C19/62 ,  G01C19/58

Abstract: An atomic beam is irradiated with a first, a second, and a third laser beam. The first laser beam and the third laser beam each have a wavelength corresponding to a transition between a ground state and a first excited state. The second laser beam has a wavelength corresponding to a transition between the ground state and a second excited state. First, atoms each having a smaller velocity component than a predetermined velocity in a direction orthogonal to the traveling direction of the atomic beam are changed from the ground state to the first excited state by the first laser beam. Subsequently, a momentum is provided for individual atoms in the ground state by the second laser beam, which removes the atoms from the atomic beam. Finally, atoms in the first excited state are returned from the first excited state to the ground state by the third laser beam.

公开(公告)号：US20230152258A1

公开(公告)日：2023-05-18

申请号：US17915987

申请日：2021-03-17

Applicant: TOKYO INSTITUTE OF TECHNOLOGY

Inventor： Yuji HATANO ,  Takayuki IWASAKI ,  Mutsuko HATANO

IPC: G01N24/10 ,  G01N24/00

CPC classification number: G01N24/10 ,  G01N24/006

Abstract: A physical state measurement apparatus includes a main solid material which generates fluorescence by excitation light from a light source part. A microwave application part applies microwaves to the main solid material so as to control an electron state of the main solid material. A detection part detects the physical state of an object to be measured by the fluorescence from the main solid material. A feedback part has a solid material for feedback and a control part and detects a difference in amplitude between operating points on a low-frequency side and a high-frequency side of a lowering portion of a spectrum amplitude centered on a resonance frequency of an electron spin resonance spectrum of fluorescence from the solid material for feedback and feedback-controls the microwave application part such that the difference becomes zero.

公开(公告)号：US20230147287A1

公开(公告)日：2023-05-11

申请号：US17917188

申请日：2021-04-05

Applicant: Logomix, Inc. ,  Tokyo Institute of Technology

Inventor： Yasunori AIZAWA ,  Tomoyuki OHNO

IPC: C12N15/90 ,  C12N15/11 ,  C12N9/22 ,  C12N5/09

CPC classification number: C12N15/907 ,  C12N15/11 ,  C12N9/22 ,  C12N5/0693 ,  C12N2310/20 ,  C12N2800/80

Abstract: Provided are a genome engineering method and a genome engineering kit which can efficiently engineer two or more alleles and are capable of engineering a relatively large region. The present invention provides a genome engineering method for engineering two or more alleles, comprising the steps of: (a) introducing the following (i) and (ii) to a cell comprising the chromosome: (i) a genome engineering system comprising a sequence-specific nucleic acid cleaving molecule targeting a target region in the chromosomal genome, or a polynucleotide encoding the sequence-specific nucleic acid cleaving molecule, and (ii) two or more donor DNAs for selective markers respectively having different selective marker genes (the number of types of the donor DNAs for selective markers are equal to or more than the number of the alleles that are subject to genome engineering); and (b) selecting the cell on the basis of all the selective marker genes carried by the two or more donor DNAs for selective markers.

公开(公告)号：US11601074B2

公开(公告)日：2023-03-07

申请号：US17211279

申请日：2021-03-24

Applicant: DENSO CORPORATION ,  TOKYO INSTITUTE OF TECHNOLOGY ,  NATIONAL UNIVERSITY CORPORATION TOKAI NATIONAL HIGHER EDUCATION AND RESEARCH SYSTEM

Inventor： Daichi Sakurai ,  Seiichiro Washino ,  Shota Chatani ,  Haruhiko Watanabe ,  Masatoshi Shioya ,  Daisuke Kimura ,  Toshihira Irisawa ,  Kentaro Takagi ,  Takashi Hasegawa

IPC: H02N10/00 ,  F03G7/06

Abstract: An actuator capable of attaining high output. The actuator includes a frame structure part that forms a frame structure surrounding a housing part, and a volume change part housed in the housing part. The volume change part increases a volume thereof by input of external energy. The frame structure part has a higher Young's modulus than a Young's modulus of the volume change part. The housing part has an anisotropic shape, with a maximum width in first direction of the housing part longer than a maximum width in second direction different from the first direction of the housing part.