公开(公告)号：US11200536B2

公开(公告)日：2021-12-14

申请号：US16575401

申请日：2019-09-19

Applicant: Texas Tech University System

Inventor： Weston Mauldin ,  Ryan Litsey ,  Scott Luker

IPC: G06Q10/08 ,  G06N20/00

Abstract: Libraries are collections of books, periodicals, and other items that can be read in situ, checked out by patrons, and shared with other libraries. Collections are more useful when the items in the collection reflect user interests. Cluster analysis of the collection can be juxtaposed with cluster analysis of items taken from, borrowed from, or requested from the collection. The juxtaposition reveals differences between the collection and the user's desired collection. The collection can also be adapted to meet expected future needs by predicting future user needs based on past user behavior.

公开(公告)号：US20210347092A1

公开(公告)日：2021-11-11

申请号：US17268428

申请日：2019-08-14

Applicant: Texas Tech University System

Inventor： Serdar GORUMLU ,  Burak AKSAK

IPC: B29C33/38 ,  B29C39/02 ,  B29C39/26 ,  B29C39/38

Abstract: A method, system, and apparatus for an improved gripping device comprises a substrate and a curved microplate formed on the substrate. In certain embodiments, the system further comprises an array of curved microplates formed on the substrate further comprising a plurality of aligned rows of the curved microplates formed on the substrate and a plurality of aligned columns of the curved microplates formed on the substrate. The curved microplate has a gripping direction, being substantially opposite the direction of the curve in the curved microplate and the curved microplate has a releasing direction, substantially in line with the direction of the curve in the curved microplate.

公开(公告)号：US20210309607A1

公开(公告)日：2021-10-07

申请号：US17267439

申请日：2019-08-09

Applicant: Texas Tech University System

Inventor： Nadezhda German ,  Ruwein Zhang ,  Wei Wang ,  Constantinos Mikelis ,  Luca Cucullo

IPC: C07C275/30 ,  A61K45/06

Abstract: Disclosed is a composition and method for a therapeutic treatment that is able to combat triple negative breast cancers (TNBCs). The class of urea compounds acts by blocking at inhibiting the mTOR signaling pathway, which, as a central regulator of mammalian metabolism and physiology that when inhibited leads to the induction of autophagocytosis. The disclosed compounds are further capable of reinitiating the p53 cycle as well as inhibition of the BNIP3/BNIP3L pathway. The disclosed compounds also shows the ability to cross the blood-brain-barrier where metastases can form. This new drug has the potential to be a powerful new treatment to combat invasive TNBCs.

公开(公告)号：US20210238593A1

公开(公告)日：2021-08-05

申请号：US17049041

申请日：2019-04-18

Applicant: TEXAS TECH UNIVERSITY SYSTEM

Inventor： P. Hemachandra REDDY ,  Murali VIJAYAN

IPC: C12N15/113 ,  A61P9/10 ,  C12Q1/6883

Abstract: The present invention includes methods for detecting and reducing or inhibiting ischemic stroke in a mammal, the method comprising: (a) selecting microRNAs to downregulate selected from the group consisting of hsa-miR-96-5p, hsa-miR-99a-5p, hsa-miR-122-5p, hsa-miR-186-5p, hsa-miR-211-5p, hsa-mir-760, PC-3p-57664, orPC-5p-12969, (b) selecting microR-NAs to upregulate selected from the group consisting of ggo-miR-139, hsa-miR-30d-5p, hsa-miR-22-3p, hsa-miR-23a-3p, mmu-miR-5124a, mmu-mir-6240-5p, PC-3p-32463, or PC-5p-211, and combinations thereof, and (c) administering an agent that: downregulates that targets in (a), upregulates the targets in (b), or both, to the subject in an amount sufficient to reduce or inhibit ischemic stroke in the mammal. The present invention also includes the detection of the markers for use with stroke patients.

公开(公告)号：US20210230552A1

公开(公告)日：2021-07-29

申请号：US17231495

申请日：2021-04-15

Applicant: Texas Tech University System

Inventor： Harvinder Singh Gill ,  Chang Hyun Lee

IPC: C12N5/077 ,  C12N5/00 ,  C07K7/06 ,  C07K14/52 ,  C07K14/475

Abstract: The present invention includes a polypeptide for use in a three dimensional (3D) culture system for the growth of cells comprising one or more repeats of a sequence n1-(X1X2GXP)-n2 (SEQ ID NO:8), wherein X1 and X2 are any amino acids except proline, wherein X1 and X2 can be the same or different amino acid in solution or coated on a substrate, wherein n1 and n2 are equal to or greater than one, and wherein X is an aliphatic amino acid.

公开(公告)号：US10958295B2

公开(公告)日：2021-03-23

申请号：US16335217

申请日：2017-09-20

Applicant: TEXAS TECH UNIVERSITY SYSTEM

Inventor： Zhengyu Peng ,  Changzhi Li ,  Lixin Ran

IPC: H04B7/08 ,  H01Q3/24 ,  H04B1/00 ,  H01Q3/26

Abstract: Disclosed is a system and method for a complex domain radio frequency (RF) frontend, adaptive beamforming can separate the relatively slowly changed waveform delay information required from wideband RF signals, upon which a self-contained beamforming system is implemented with a low-speed baseband. By introducing vector RF multipliers in the frontend of the present invention, the amplitude and phase of RF signals are simultaneously controlled by the real and imaginary parts of complex numbers, such that beamforming algorithms derived in complex domain can be directly applied without any form of transformation. By doing so, the massive use of conventional T/R modules and high-speed baseband devices can be avoided, thus simplifying the realization and decreasing the cost of wideband digital beamforming systems for use in low cost, power efficient beamforming applications.

公开(公告)号：US20210023064A1

公开(公告)日：2021-01-28

申请号：US16630522

申请日：2018-07-13

Applicant: Texas Tech University System

Inventor： Paul Trippier ,  Nihar Kinarivala ,  Rose-Mary Boustany

IPC: A61K31/44 ,  A61K31/325 ,  A61K31/5377 ,  A61K31/4436

Abstract: The present invention includes compositions and methods for treating a subject afflicted with a neurodegenerative disorder or disease by determining that the subject is in need of treatment for the neurodegenerative disorder or disease; and administering to the subject an amount of an effective amount of a compound comprising a flupirtine derivative as disclosed herein.

公开(公告)号：US10830261B2

公开(公告)日：2020-11-10

申请号：US14774767

申请日：2014-03-12

Applicant: Texas Tech University System ,  nanoGriptech, Inc.

Inventor： Luciano Castillo ,  Burak Aksak ,  Metin Sitti

IPC: F15D1/00 ,  B64C21/10 ,  B63B1/36

Abstract: An aerodynamic or hydrodynamic wall surface has an array of fibrillar structures disposed on and extending from the wall surface, wherein each fibrillar structure comprises a stalk and a tip. The stalk has a first end and a second end, wherein the first end is attached to the wall surface, and the stalk is oriented with respect to the wall surface at a stalk angle between approximately 1 degrees and 179 degrees. The tip has a first side and a second side, wherein the first side is attached proximate to the second end of the stalk, the tip has a larger cross-sectional area than the stalk, and the second side comprises a substantially planar surface that is oriented with respect to the stalk at a tip angle between approximately 0 degrees and 90 degrees.

公开(公告)号：US20200341051A1

公开(公告)日：2020-10-29

申请号：US16758810

申请日：2018-10-26

Applicant: Texas Tech University System

Inventor： Shelby LACOUTURE ,  Stephen BAYNE

IPC: G01R31/26

Abstract: A system, method and apparatus for measuring carrier lifetime of a device comprises subjecting a test device to a voltage via a voltage source associated with the test system, disconnecting the test device from the voltage source, measuring the voltage as a function of time, measuring the current as a function of time, and determining a carrier lifetime of the test piece according to the slope of the measured voltage and the measured current.

公开(公告)号：US20200309708A1

公开(公告)日：2020-10-01

申请号：US16831545

申请日：2020-03-26

Applicant: Texas Tech University System

Inventor： Gregory Fernandes

IPC: G01N21/76 ,  G01N21/64

Abstract: A system, method, and apparatus for sensing analytes comprises assembling a sensor of at least one polymer and at least one fluorophore by mixing the polymer with the fluorophore, exposing the sensor to an analyte, and identifying the presence of the analyte according to a change in fluorescence of the sensor. The sensor can comprise a non-covalent complex of the at least one fluorophore and the at least one polymer. The at least one polymer can comprise a polymer capable of binding a metal ion. The at least one polymer is capable of binding a metal ion comprising an imidazole-containing polymer such as an N-vinylimidazole homo polymer and/or an N-vinylimidazole co-polymer.