公开(公告)号：US20180218512A1

公开(公告)日：2018-08-02

申请号：US15748532

申请日：2016-08-01

Applicant: VERSITECH LIMITED

Inventor： Shing Chow CHAN ,  Jia-fei WU

IPC: G06T7/593 ,  H04N19/82 ,  H04N19/122 ,  H04N19/11 ,  H04N19/59

Abstract: A method for encoding depth map image involves dividing the image into blocks. These blocks are then classified into smooth blocks without large depth discontinuities and discontinuous blocks with large depth discontinuities. In the discontinuous blocks, depth discontinuities are represented by line segments and partitions. Interpolation-based intra prediction is used to approximate and compress the depth values in the smooth blocks and partitions. Further compression can be achieved with of depth-aware quantization, adaptive de-blocking filtering, scale adaptive block size, and resolution decimation schemes.

公开(公告)号：US20170143788A1

公开(公告)日：2017-05-25

申请号：US15341949

申请日：2016-11-02

Applicant: Massachusetts Institute of Technology ,  Versitech Limited

Inventor： Rutledge Ellis-Behnke ,  Yu-Xiang Liang ,  Gerald E. Schneider ,  Kwok-Fai So ,  David K.C. Tay

IPC: A61K38/10 ,  A61K31/167

CPC classification number: A61K38/10 ,  A61K31/167 ,  A61L15/42 ,  A61L26/0061

Abstract: Compositions which self-assemble under physiological conditions are formulated for application to wounds. The formulations include a pharmaceutically acceptable carrier or are provided as part of a medical device or coating. The formulations may also include other therapeutic, prophylactic or diagnostic agents. The formulation can be administered as appropriate for treatment of one or more disorders or conditions. For example, the formulation may be applied to repair an injury or during surgery of the lung, eye or dura, or following an epidural or spinal tap, to stop leakage of blood, interstitial fluid, or cerebrospinal fluid. The formulation may be administered to a burn or ulcer. The formulation may be dispersed in a suture or adhesive for administration at the time of or as released following suturing or gluing of a wound, thereby limiting bleeding, loss of tissue fluids, or other fluids such as those produced by parenchymal tissues such as the liver, pancreas, and gastrointestinal tract. The formulation may be applied to any site of bleeding, in a bandage, gauze, sponge, or other material, for immediate control of bleeding, or released later to control bleeding if the initial treatment such as suturing or pressure is insufficient. In one embodiment, the formulation is provided as a dry or lyophilized powder. In another embodiment, the material is provided in water. In another embodiment, the material is provided in combination with an oil and forms a laminate. In another embodiment, the formulation is provided as a coating on a device, for example a stent or a catheter. The material is also useful to isolate tissue, for preservation of tissue for subsequent transplantation or reattachment, and as a bulking, stabilizing or hydrating agent.

公开(公告)号：US09464271B2

公开(公告)日：2016-10-11

申请号：US14183260

申请日：2014-02-18

Applicant: Versitech Limited

Inventor： Barbara Pui Chan ,  Godfrey Chi-Fung Chan ,  Hoi Ling Wong ,  Pik To Cheung ,  Song-Eng Kathryn Cheah ,  Danny Chan

IPC: C12N5/00 ,  C12N11/04 ,  C12N5/071 ,  C12N5/077 ,  C12N5/0775 ,  C12M1/12 ,  A61K35/12

CPC classification number: C12N5/0602 ,  A61K35/12 ,  C12M25/14 ,  C12N5/0012 ,  C12N5/0655 ,  C12N5/0663 ,  C12N2510/02 ,  C12N2533/54 ,  C12N2533/90

Abstract: A method has been developed to produce stable cell-matrix microspheres with up to 100% encapsulation efficiency and high cell viability, using matrix or biomaterial systems with poor shape and mechanical stability for applications including cell therapeutics via microinjection or surgical implantation, 3D culture for in vitro expansion without repeated cell splitting using enzymatic digestion or mechanical dissociation and for enhanced production of therapeutic biomolecules, and in vitro modeling for morphogenesis studies. The modified droplet generation method is simple and scalable and enables the production of cell-matrix microspheres when the matrix or biomaterial system used has low concentration, with slow phase transition, with poor shape and mechanical stability.

Abstract translation: 已经开发了一种方法来生产具有高达100％包封效率和高细胞活力的稳定的细胞基质微球，使用具有差的形状和机械稳定性的基质或生物材料体系，包括通过显微注射或手术植入的细胞治疗剂，3D培养物 使用酶消化或机械解离并且用于增强治疗性生物分子的产生的体外扩增而不重复细胞分裂，以及用于形态发生研究的体外模拟。 改进的液滴生成方法简单可伸缩，当使用的基质或生物材料系统具有低浓度，缓慢的相变，形状和机械稳定性差时，能够生产细胞基质微球。

公开(公告)号：US20160114028A1

公开(公告)日：2016-04-28

申请号：US14921323

申请日：2015-10-23

Applicant: VERSITECH LIMITED ,  Center for Public Health Research, Nanjing University

Inventor： Zhiwei CHEN ,  Xilin WU ,  Zhiwei WU

IPC: A61K39/21

CPC classification number: A61K39/21 ,  A61K39/12 ,  A61K2039/53 ,  A61K2039/575 ,  C12N2740/16034 ,  C12N2740/16234

Abstract: The present invention relates to the field of applied immunotechnology and medicine. More specifically, it relates to DNA motif vaccine design, glyco-DNA motif vaccine design, and immunogen design for producing antibodies against an epitope of arbitrary sequences or polysaccharide epitope, particularly those epitopes against which it is otherwise very difficult to induce antibodies, such as those of HIV-1. The present invention also relates to immunogen design to induce robust cellular and humoral immunity.

Abstract translation: 本发明涉及应用免疫技术和医学领域。 更具体地说，本发明涉及DNA序列疫苗设计，糖基DNA基因疫苗设计和免疫原设计，用于产生针对任意序列或多糖表位的抗原表位的抗体，特别是那些抗原非常难以诱导抗体的抗原决定簇，例如 那些HIV-1。 本发明还涉及诱导鲁棒细胞和体液免疫的免疫原设计。

公开(公告)号：US20150098477A1

公开(公告)日：2015-04-09

申请号：US14045258

申请日：2013-10-03

Applicant: VERSITECH LIMITED ,  THE HONG KONG POLYTECHNIC UNIVERSITY

Inventor： Chun-Yin Li ,  Ping-Kong Alexander Wai ,  Victor On-Kwok Li

IPC: H04B10/25 ,  H04Q11/00 ,  H04J14/02

CPC classification number: H04B10/2503 ,  H04J14/0215 ,  H04Q11/0005 ,  H04Q2011/0011 ,  H04Q2011/0016

Abstract: An optical transmission system comprises at least one first connection point and one second connection point arranged to transmit and receive at least one channel signal transmitted via at least one optical means connecting the first connection point and the second connection, wherein each of the at least one channel signal is reversibly configurable to be transmitted in either a first direction or a second direction between the first connection point and the second connection point. A method of transmitting at least one channel signal between a first connection point and a second connection point via at least one optical media in an optical transmission system, wherein each of the at least one channel signals is reversibly configurable to be transmitted in either a first direction or a second direction between the first and the second connection points.

Abstract translation: 一种光传输系统包括至少一个第一连接点和一个第二连接点，其布置成发送和接收经由连接第一连接点和第二连接的至少一个光学装置传输的至少一个信道信号，其中至少一个 通道信号可逆地配置为在第一连接点和第二连接点之间沿第一方向或第二方向传输。 一种在光传输系统中经由至少一个光介质在第一连接点和第二连接点之间传送至少一个信道信号的方法，其中所述至少一个信道信号中的每一个可逆地配置为以第一 方向或第二方向。

公开(公告)号：US20130274333A1

公开(公告)日：2013-10-17

申请号：US13804103

申请日：2013-03-14

Applicant: PURAPHARM COMPANY LIMITED ,  VERSITECH LIMITED

Inventor： ALLAN SIK YIN LAU ,  LAI HUNG CINDY YANG ,  STANLEY CHI CHUNG CHIK

IPC: C11B1/10

CPC classification number: A61K31/231 ,  C11B1/10 ,  C11C1/002 ,  Y02A50/463 ,  Y02P20/582

Abstract: The subject invention provides efficient and convenient methods of isolating 9-oxo-10E, 12E-octadecadienoic acid methyl ester (9-KODE methyl ester) from C. versicolor. In addition, the subject invention provides therapeutic uses of Coriolus versicolor extracts, biologically-active chemical substituents isolated from C. versicolor, as well as 9-KODE methyl ester and related compounds. In a preferred embodiment, the subject invention can be used to inhibit the metastatic spread of cancer cells.

Abstract translation: 本发明提供从C. versicolor分离9-氧代-10E，12E-十八碳二烯酸甲酯（9-KODE甲酯）的有效和方便的方法。 此外，本发明提供了Coriolus versicolor提取物，从C. versicolor分离的生物活性化学取代基以及9-KODE甲酯和相关化合物的治疗用途。 在优选的实施方案中，本发明可用于抑制癌细胞的转移扩散。

公开(公告)号：US12213955B2

公开(公告)日：2025-02-04

申请号：US16757312

申请日：2018-10-16

Applicant: VERSITECH LIMITED

Inventor： Shuofeng Yuan ,  Fuk Woo Jasper Chan ,  Hin Chu ,  Johnson Yiu-Nam Lau ,  Kwok Yung Yuen

IPC: A61K31/192 ,  A61P31/14 ,  A61P31/16 ,  A61P31/20

Abstract: AM580 and structurally related compounds have been found to be useful in treating infection by a wide range of RNA and DNA viruses, and also in reducing associated inflammation. This activity is independent of RAR-α signaling, and is not a result of activation of the hosts innate immune response. Broad antiviral activity of AM580 and structurally related compounds is a due to modulation of lipogenesis so as to correct disregulation of this pathway in virus-infected cells, via inhibition of nSREPBP.

公开(公告)号：US20250002581A1

公开(公告)日：2025-01-02

申请号：US18710523

申请日：2022-11-15

Applicant: Versitech Limited

Inventor： Zhiwei Chen ,  Dongyan Zhou ,  Li Liu

IPC: C07K16/28 ,  A61K39/00 ,  A61P37/04

Abstract: Provided are two fully humanized Δ42PD1-specific mAbs, specifically huCH101 and huCH34 at 97.0% humanness by CDR grafting. Provided is a method of using huCH101 and/or huCH34 to treat subjects in need of Δ42PD1-specific mAb, including subjects with cancer and/or infection.

公开(公告)号：US20240431215A1

公开(公告)日：2024-12-26

申请号：US18686153

申请日：2022-08-19

Applicant: Versitech Limited

Inventor： Jitae Kim ,  Zhaoyi Xu ,  Zhiqin Chu ,  Lingzhi Wang

IPC: H10N50/01 ,  B41J2/04 ,  B82Y30/00 ,  H10B69/00 ,  H10N50/20

Abstract: A method of fabricating a nitrogen-vacancy (NV) center quantum sensing device based on electrohydrodynamic (EHD) printing. A nanopipette with an aperture at one end is filled with nanodiamond suspension ink so the ink is present in a meniscus at The aperture, the nanodiamond suspension ink comprises nanodiamonds and solvent. The nanopipette is supported above a substrate having a back electrode. A DC is applied pulse between the nanopipette and the back electrode so as to generate an electrostatic attractive force resulting in the ejection of nano-diamond-laden droplets with sub-attoliter volume. The droplet lands on the substrate and is allowed to dry due to solvent evaporation. Using the method, the control of the number of printed nano-diamonds is at will, attaining single-particle level precision. This printing approach, therefore, enables printing NV center arrays with a controlled number directly on the substrate without any lithographic process.

公开(公告)号：US20240415956A1

公开(公告)日：2024-12-19

申请号：US18704050

申请日：2022-10-27

Applicant: The Chinese University of Hong Kong ,  Versitech Limited

Inventor： Siew Chien NG ,  Ka Leung Francis CHAN ,  Hein Min TUN

IPC: A61K39/39 ,  A61K35/00 ,  A61K35/741 ,  A61K35/745 ,  A61K39/00 ,  A61K45/06 ,  A61P37/04

Abstract: Probiotic compositions and methods for enhancing efficacy of COVID-19 vaccination or for reducing adverse effects of COVID-19 vaccination.