公开(公告)号：US11346822B2

公开(公告)日：2022-05-31

申请号：US16409463

申请日：2019-05-10

Applicant: Agilent Technologies, Inc.

Inventor： Thomas Ortmann ,  Daniel Thielsch

IPC: G01N30/20 ,  B01D15/14 ,  G01N30/04 ,  G01N30/10 ,  G01N30/36 ,  G01N30/32

Abstract: A sample management device which comprises a source flow path in which a fluidic sample can flow, a volume flow adjustment unit configured for adjusting a volume flow of the fluidic sample to be branched off from the source flow path at a fluidic coupling point, and a fluidic valve fluidically coupled with the source flow path and with the volume flow adjustment unit, wherein the fluidic valve is switchable into a branch off state in which the fluidic coupling point is established within the source flow path to branch off an adjustable volume of the fluidic sample from the source flow path via the fluidic coupling point while a flow of the fluidic sample in the source flow path continues.

公开(公告)号：US11275062B2

公开(公告)日：2022-03-15

申请号：US16833181

申请日：2020-03-27

Applicant: Agilent Technologies, Inc.

Inventor： Daniel Thielsch ,  Thomas Ortmann ,  Sam Wouters

IPC: G01N30/20 ,  G01N30/32 ,  G01N30/02

Abstract: An injector, for injecting a fluidic sample into a flow path between a fluid drive and a sample separation unit, includes a sample accommodation volume, a sample drive, and a fluidic valve switchable to selectively couple the volume with the flow path or decouple the volume from the flow path. In an injection switching state, the fluid drive, the separation unit and the sample drive are coupled by the valve so that fluid driven by the sample drive and flowing from the volume to the separation unit and further fluid driven by the fluid drive and flowing from the fluid drive to the separation unit are combined at a fluidic connection upstream of the separation unit. A control unit controls a pressure of the fluid and/or the further fluid during injecting.

公开(公告)号：US20210389282A1

公开(公告)日：2021-12-16

申请号：US17288478

申请日：2018-10-26

Applicant: Agilent Technologies, Inc.

Inventor： Thomas Ortmann

IPC: G01N30/20 ,  B01D15/18 ,  G01N30/22 ,  G01N30/46 ,  G01N30/60

Abstract: An injector, for injecting a fluidic sample in at least one selected one of a first sample separation apparatus and a second sample separation apparatus, includes a valve arrangement fluidically connectable to the first sample separation apparatus and the second sample separation apparatus, a sample accommodation volume for accommodating the fluidic sample, and a control unit configured for controlling the valve arrangement so that fluidic sample in the sample accommodation volume is selectively injectable into the selected first sample separation apparatus and/or second sample separation apparatus.

公开(公告)号：US20190265207A1

公开(公告)日：2019-08-29

申请号：US16409463

申请日：2019-05-10

Applicant: Agilent Technologies, Inc.

Inventor： Thomas Ortmann ,  Daniel Thielsch

IPC: G01N30/20 ,  G01N30/10 ,  G01N30/36 ,  G01N30/04 ,  B01D15/14

Abstract: A sample management device which comprises a source flow path in which a fluidic sample can flow, a volume flow adjustment unit configured for adjusting a volume flow of the fluidic sample to be branched off from the source flow path at a fluidic coupling point, and a fluidic valve fluidically coupled with the source flow path and with the volume flow adjustment unit, wherein the fluidic valve is switchable into a branch off state in which the fluidic coupling point is established within the source flow path to branch off an adjustable volume of the fluidic sample from the source flow path via the fluidic coupling point while a flow of the fluidic sample in the source flow path continues.

公开(公告)号：US20170322187A1

公开(公告)日：2017-11-09

申请号：US15525674

申请日：2014-11-10

Applicant: Agilent Technologies, Inc.

Inventor： Daniel Thielsch ,  Thomas Ortmann

IPC: G01N30/20 ,  B01D15/14 ,  B01D15/16 ,  B01D15/26 ,  B01D15/12 ,  G01N30/02

CPC classification number: G01N30/20 ,  B01D15/12 ,  B01D15/14 ,  B01D15/163 ,  B01D15/265 ,  G01N2030/027 ,  G01N2030/207

Abstract: A sample injector configured to introduce a sample fluid into a mobile phase, wherein the mobile phase is to be driven by a mobile phase drive through a separation unit for separating compounds of the sample fluid in the mobile phase, wherein the sample injector comprises a metering device being operable for displacing fluid and for intaking a metered amount of the sample fluid into the sample injector, an injector valve being switchable for operating the sample injector selectively in a sample intake mode in which the metering device is operable to intake the sample fluid from a sample container, or a separation mode in which intaken sample fluid is driven between the mobile phase drive and the separation unit for separating the compounds, and a flow direction controller configured for defining an enabled flow direction of fluid displaced by the metering device and for defining a disabled flow direction.

公开(公告)号：US20250164452A1

公开(公告)日：2025-05-22

申请号：US19030737

申请日：2025-01-17

Applicant: Agilent Technologies, Inc.

Inventor： Daniel Thielsch ,  Thomas Ortmann ,  Sam Wouters

IPC: G01N30/20 ,  G01N30/02 ,  G01N30/32

Abstract: An injector, for injecting a fluidic sample into a flow path between a fluid drive and a sample separation unit, includes a sample accommodation volume, a sample drive, and a fluidic valve switchable to selectively couple the volume with the flow path or decouple the volume from the flow path. In an injection switching state, the fluid drive, the separation unit and the sample drive are coupled by the valve so that fluid driven by the sample drive and flowing from the volume to the separation unit and further fluid driven by the fluid drive and flowing from the fluid drive to the separation unit are combined at a fluidic connection upstream of the separation unit. In that same injection switching state, the sample drive can branch off at least a portion of an amount of mobile phase into the sampling path from such fluidic connection to flush at least a portion of the sampling path with mobile phase. A control unit controls the operation of the injector in the switching states.

公开(公告)号：US20250060340A1

公开(公告)日：2025-02-20

申请号：US18932488

申请日：2024-10-30

Applicant: Agilent Technologies, Inc.

Inventor： Thomas Ortmann

IPC: G01N30/24 ,  F16K11/074 ,  G01N30/02 ,  G01N30/06 ,  G01N30/18 ,  G01N30/20 ,  G01N30/22 ,  G01N30/32

Abstract: A configurable injector for injecting a fluidic sample in a separation path of a sample separation apparatus includes a sample accommodation volume for accommodating the fluidic sample to be injected into the separation path, a valve arrangement fluidically couplable with the separation path, fluidically coupled with the sample accommodation volume, and being controllable for injecting the fluidic sample into the separation path, an input interface configured for receiving input data indicative of an injection profile of an injector to be emulated by the configurable injector, and a control unit configured for controlling the configurable injector, in particular the valve arrangement, so that the configurable injector is operated in accordance with the injection profile to thereby emulate the injector to be emulated.

公开(公告)号：US12174160B2

公开(公告)日：2024-12-24

申请号：US17631924

申请日：2020-07-30

Applicant: Agilent Technologies, Inc.

Inventor： Dwight Robert Stoll ,  Konstantin Shoykhet ,  Thomas Ortmann ,  Stephan Buckenmaier ,  Sascha Lege

IPC: G01N30/46 ,  G01N30/02 ,  G01N30/34

Abstract: A fluid processing apparatus includes a first fluid processing unit and a second fluid processing unit. A fluid unit is fluidically coupled to the first fluid processing unit and includes a first buffering unit configured for buffering fluid, and/or a mask flow source configured for providing a mask fluid or a flow thereof. A first coupling point is fluidically coupled between the first fluid processing unit and the fluid unit. A modulation unit is configured, selectively, for withdrawing fluid from the first coupling point, or for transferring withdrawn fluid into the second fluid processing unit. The apparatus may be utilized for chromatography.

公开(公告)号：US12140575B2

公开(公告)日：2024-11-12

申请号：US17826018

申请日：2022-05-26

Applicant: Agilent Technologies, Inc.

Inventor： Thomas Ortmann ,  Daniel Thielsch

IPC: G01N30/20 ,  B01D15/14 ,  G01N30/04 ,  G01N30/10 ,  G01N30/36 ,  G01N30/32

Abstract: A sample management device which comprises a source flow path in which a fluidic sample can flow, a volume flow adjustment unit configured for adjusting a volume flow of the fluidic sample to be branched off from the source flow path at a fluidic coupling point, and a fluidic valve fluidically coupled with the source flow path and with the volume flow adjustment unit, wherein the fluidic valve is switchable into a branch off state in which the fluidic coupling point is established within the source flow path to branch off an adjustable volume of the fluidic sample from the source flow path via the fluidic coupling point while a flow of the fluidic sample in the source flow path continues.

公开(公告)号：US20240077460A1

公开(公告)日：2024-03-07

申请号：US18369739

申请日：2023-09-18

Applicant: Agilent Technologies, Inc.

Inventor： Daniel Thielsch ,  Thomas Ortmann ,  Sam Wouters

IPC: G01N30/20 ,  G01N30/32

CPC classification number: G01N30/20 ,  G01N30/32 ,  G01N2030/027 ,  G01N2030/201 ,  G01N2030/202 ,  G01N2030/328

Abstract: An injector, for injecting a fluidic sample into a flow path between a fluid drive and a sample separation unit, includes a sample accommodation volume, a sample drive, and a fluidic valve switchable to selectively couple the volume with the flow path or decouple the volume from the flow path. In an injection switching state, the fluid drive, the separation unit and the sample drive are coupled by the valve so that fluid driven by the sample drive and flowing from the volume to the separation unit and further fluid driven by the fluid drive and flowing from the fluid drive to the separation unit are combined at a fluidic connection upstream of the separation unit. A control unit controls a pressure of the fluid and/or the further fluid during injecting.