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公开(公告)号：US20190049711A1
公开(公告)日：2019-02-14
申请号：US16078024
申请日：2017-02-21
Applicant: Leica Microsystems CMS GmbH
Inventor： Christian Schumann
Abstract: A light sheet microscope includes an illumination optical system configured to generate a light sheet in an intermediate image space. A transport optical system, which is telecentric on both sides, is configured to image the light sheet generated in the intermediate image space into a sample and to image a region of the sample illuminated by the light sheet as an intermediate image into the intermediate image space. A detection optical system is configured to image the intermediate image generated in the intermediate image space onto a detector. The optical axes of the illumination optical system, the transport optical system and the detection optical system intersect one another in the intermediate image space. The microscope further includes a scanning element, which is arranged in the transport optical system and through which the light sheet is moveable in the sample transversely to the optical axis of the transport optical system.
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公开(公告)号：US10133063B2
公开(公告)日：2018-11-20
申请号：US15327659
申请日：2015-07-21
Applicant: Leica Microsystems CMS GmbH
Inventor： Christian Schulz , Christian Schumann , Cornell Gonschior , Tobias Bauer
Abstract: A microscope includes at least one correction unit arranged in a beam path for correcting a variable spherical aberration. The correction unit has at least one optical correction element that is arranged in a convergent or divergent area of the beam path such that the optical correction element is movable along an optical axis. The at least one optical correction element has at least one correction surface. A part of the at least one correction surface through which the convergent or divergent area of the beam path passes forms a correction-effective surface section whose radial extension crosswise to the optical axis is adjustable by moving the correction element along the optical axis.
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公开(公告)号：US09709788B2
公开(公告)日：2017-07-18
申请号：US14420905
申请日：2013-08-06
Applicant: LEICA MICROSYSTEMS CMS GMBH
Inventor： Christian Schumann
CPC classification number: G02B21/06 , G02B21/0032 , G02B21/0076 , G02B21/18 , G02B21/367
Abstract: An optical arrangement in a microscope includes an illumination device configured to generate an illuminating light beam extending on an illumination side. A splitting device is configured to split the illuminating light beam into at least two partial beams. A mirror arrangement is configured to reflect the partial beams into an illumination region for plane illumination of a specimen. Detection optics are arranged on a side of the illumination region facing away from the illumination side.
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公开(公告)号：US11586027B2
公开(公告)日：2023-02-21
申请号：US16964209
申请日：2019-01-29
Applicant: LEICA MICROSYSTEMS CMS GMBH
Inventor： Theo Larrieu , Christian Schumann
Abstract: A method for imaging a sample using a light-sheet microscope includes illuminating the sample from two different illumination directions using two light sheets, which have different polarization states and are superimposed on one another in a coplanar manner in a target region of the sample. An image of the illuminated target region is generated using an imaging optical unit of the light-sheet microscope. An interference pattern is generated using the two light sheets in the illuminated target region, whereby an image modulation corresponding to the interference pattern is applied to the image of the target region. The image modulation is evaluated. The illuminated target region is aligned in dependence on the evaluated image modulation in relation to a focal region of the imaging optical unit.
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35.发明申请公开(公告)号：US20230035107A1
公开(公告)日：2023-02-02
申请号：US17788783
申请日：2020-01-09
Applicant: LEICA MICROSYSTEMS CMS GMBH
Inventor： Christian Schumann
Abstract: An oblique plane microscope includes an optical imaging system configured to form an image of an object. The optical imaging system includes a telescope system with an optical zoom system, which is adjustable for adapting a magnification of the telescope system to a ratio between two refractive indices, one of which being associated with an object side of the telescope system and the other being associated with an image side of the telescope system. The oblique plane microscope further includes a control unit. The control unit is configured to evaluate an image quality of the image formed by the optical imaging system and to adjust the optical zoom system based on the evaluation.
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Patent Agency Ranking
公开(公告)号：US20220317429A1
公开(公告)日：2022-10-06
申请号：US17638213
申请日：2019-09-02
Applicant: Leica Microsystems CMS GmbH
Inventor： Christian Schumann
Abstract: A microscope includes: a motorized object stage for moving an object; an optical imaging system for forming an optical image of a plane (OE) in which the object is to be optically imaged; an optical scanning unit for moving the plane (OE) to be optically imaged by the optical imaging system relative to the optical imaging system; an image sensor for detecting the optical image of the plane (OE) formed by the optical imaging system; and a controller for controlling the motorized object stage and the optical scanning unit for simultaneously moving the object and the plane (OE) in a same direction relative to the optical imaging system while the optical image is being detected by the image sensor.
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公开(公告)号：US20210356720A1
公开(公告)日：2021-11-18
申请号：US16325729
申请日：2017-08-03
Applicant: Leica Microsystems CMS GmbH
Inventor： Christian Schumann
Abstract: A changing system for a microscope includes multiple afocal enlargement changing modules of different enlargement levels that are optionally introducible into an infinite beam path running along an optical axis of the microscope. Each of the enlargement changing modules contain a light deflection system. The light deflection systems are designed to adjust the path length of the infinite beam path passing through the respective enlargement changing module in such a way that all of the enlargement changing modules, regardless of the different enlargement levels of the enlargement changing modules, map an exit pupil of a lens of the microscope onto the same location along the optical axis.
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公开(公告)号：US20210341735A1
公开(公告)日：2021-11-04
申请号：US17285479
申请日：2019-10-11
Applicant: Leica Microsystems CMS GmbH
Inventor： Christian Schumann , Ronja Capellmann , Alexander Weiss
Abstract: A method is useable for correcting a spherical aberration of a microscope having an objective and a cover slip or object carrier, the objective having a correction element for correcting the spherical aberration. The method includes: ascertaining, by the microscope, an index of refraction of an optical medium bordering the cover slip or object carrier and/or a thickness of the cover slip or object carrier along an optical axis of the objective, ascertaining the spherical aberration based on the index of refraction of the optical medium and/or the thickness of the cover slip or object carrier, and ascertaining, based on the spherical aberration, a positioning variable, by which the correction element is adjusted so that the spherical aberration is corrected.
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公开(公告)号：US20210341721A1
公开(公告)日：2021-11-04
申请号：US17285481
申请日：2019-10-11
Applicant: Leica Microsystems CMS GmbH
Inventor： Alexander Weiss , Christian Schumann , Ronja Capellmann
Abstract: A method is useable for determining a refractive index of an optical medium in a microscope, which has an objective facing toward a sample chamber. The optical medium is one of two optical media, which border two opposing surfaces of a cover slip or object carrier in the sample chamber and form two partially reflective interfaces, which are arranged at different distances from the objective. The method includes: deflecting a measurement light beam by the objective with oblique incidence on the cover slip or object carrier; generating two reflection light beams spatially separated from one another by the measurement light beam being partially reflected at each of the interfaces; receiving the two reflection light beams by the objective and conducting them onto a position-sensitive detector; registering intensities by the position-sensitive detector; and determining the refractive index of the optical medium based on the registered intensities.
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公开(公告)号：US20200319445A1
公开(公告)日：2020-10-08
申请号：US16300966
申请日：2017-05-12
Applicant: Leica Microsystems CMS GmbH
Inventor： Christian Schumann , Albrecht Weiss , Tobias Bauer , Cornell Peter Gonschior
Abstract: An optical scanning microscope includes an illumination system having a light source portion emanating from a light source, first and second polarizing beam splitters, and first and second optical channels disposed between the beam splitters. The light source portion is configured to emit a first illumination light beam comprising light of a first and of a second main polarization direction. The first beam splitter is configured to guide the light of the first and second main polarization direction primarily into the first and channels, respectively. The second beam splitter is configured to form a second illumination light beam from light of the first and second main polarization directions from the first channel and second channels, respectively. The first and second channels are configured to emit the light of the first and second main polarization directions from the first and second channels, respectively, so as to have different convergence angles.
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