公开(公告)号：US10094784B2

公开(公告)日：2018-10-09

申请号：US15200126

申请日：2016-07-01

Applicant: SamanTree Medical SA

Inventor： Bastien Rachet ,  Davor Kosanic ,  Etienne Shaffer

IPC: G01N21/77 ,  G02B21/00 ,  G01N21/64 ,  G02B21/26 ,  G02B21/34 ,  G02B21/36 ,  G01N33/483 ,  G02B21/16 ,  G02B21/24

Abstract: The disclosed technology brings histopathology into the operating theater, to enable real-time intra-operative digital pathology. The disclosed technology utilizes confocal imaging devices image, in the operating theater, “optical slices” of fresh tissue—without the need to physically slice and otherwise process the resected tissue as required by frozen section analysis (FSA). The disclosed technology, in certain embodiments, includes a simple, operating-table-side digital histology scanner, with the capability of rapidly scanning all outer margins of a tissue sample (e.g., resection lump, removed tissue mass). Using point-scanning microscopy technology, the disclosed technology, in certain embodiments, precisely scans a thin “optical section” of the resected tissue, and sends the digital image to a pathologist rather than the real tissue, thereby providing the pathologist with the opportunity to analyze the tissue intra-operatively. Thus, the disclosed technology provides digital images with similar information content as FSA, but faster and without destroying the tissue sample itself.

公开(公告)号：US20160313252A1

公开(公告)日：2016-10-27

申请号：US15200126

申请日：2016-07-01

Applicant: SamanTree Medical SA

Inventor： Bastien Rachet ,  Davor Kosanic ,  Etienne Shaffer

IPC: G01N21/77 ,  G01N33/483

CPC classification number: G01N21/77 ,  G01N21/6428 ,  G01N21/6458 ,  G01N33/4833 ,  G01N2021/6439 ,  G01N2021/6463 ,  G01N2021/7786 ,  G01N2201/0633 ,  G01N2201/068 ,  G02B21/0012 ,  G02B21/0032 ,  G02B21/004 ,  G02B21/0044 ,  G02B21/0076 ,  G02B21/0088 ,  G02B21/16 ,  G02B21/24 ,  G02B21/26 ,  G02B21/34 ,  G02B21/361

Abstract: The disclosed technology brings histopathology into the operating theatre, to enable real-time intra-operative digital pathology. The disclosed technology utilizes confocal imaging devices image, in the operating theatre, “optical slices” of fresh tissue—without the need to physically slice and otherwise process the resected tissue as required by frozen section analysis (FSA). The disclosed technology, in certain embodiments, includes a simple, operating-table-side digital histology scanner, with the capability of rapidly scanning all outer margins of a tissue sample (e.g., resection lump, removed tissue mass). Using point-scanning microscopy technology, the disclosed technology, in certain embodiments, precisely scans a thin “optical section” of the resected tissue, and sends the digital image to a pathologist rather than the real tissue, thereby providing the pathologist with the opportunity to analyze the tissue intra-operatively. Thus, the disclosed technology provides digital images with similar information content as FSA, but faster and without destroying the tissue sample itself.

Abstract translation: 所公开的技术将组织病理学带入手术室，以实现实时的手术中数字病理学。 所公开的技术在手术室中利用共聚焦成像装置，在新鲜组织的“光学切片”中，而不需要根据冷冻切片分析（FSA）的要求对切除的组织进行物理切片和处理。 在某些实施例中，所公开的技术包括简单的操作台式数字组织学扫描仪，具有快速扫描组织样本的所有外部边缘（例如，切除肿块，去除的组织块）的能力。 使用点扫描显微镜技术，在某些实施例中，所公开的技术精确地扫描被切除的组织的薄的“光学部分”，并将数字图像发送到病理学家而不是真实的组织，从而为病理学家提供机会 术中分析组织。 因此，所公开的技术提供具有与FSA相似的信息内容的数字图像，但是更快地提供并且不破坏组织样本本身的数字图像。