公开(公告)号：US11332662B2

公开(公告)日：2022-05-17

申请号：US16591235

申请日：2019-10-02

Applicant: THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY

Inventor： Benzhong Tang ,  Jing Zhang

IPC: C09K11/06

Abstract: The present subject matter relates to a fluorescent compound having aggregation-induced emission (AIE) characteristics. The compound can undergo spontaneous hierarchical self-assembly from a vesicle to a helical fiber in the aggregate state. A composition capable of providing circularly polarized luminescence can include the fluorescent compound and at least one additional compound selected from the group consisting of an aggregation-caused quenching luminogen and an aggregation-induced emission luminogen.

公开(公告)号：US11320428B2

公开(公告)日：2022-05-03

申请号：US16604894

申请日：2018-04-18

Applicant: THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY

Inventor： Benzhong Tang ,  Meijuan Jiang ,  Xuesong Li ,  Jianan Qu

IPC: G01N33/543 ,  C07D213/57 ,  C09K11/06 ,  G01N21/64 ,  A61B5/00 ,  G01N33/533

Abstract: The present subject matter relates to compounds that have aggregation-induced emission (AIE) characteristics and are capable of generating Raman signals in the Raman cell-silent region (1800 cm−1-2800 cm−1). The compounds can be used in dual-mode cell imaging by fluorescence and Raman microscopes.

公开(公告)号：US11253592B2

公开(公告)日：2022-02-22

申请号：US16758697

申请日：2018-10-24

Applicant: THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY

Inventor： Benzhong Tang ,  Dong Wang

IPC: A61K41/00 ,  A61B90/20 ,  A61N5/06 ,  C07D409/06 ,  C09K11/07 ,  G01N21/64 ,  G01N21/76 ,  G02B21/00 ,  G02B21/16 ,  C07D215/12

Abstract: The present subject matter relates to water-soluble, fluorescent compounds that have aggregation-induced emission (AIE) characteristics and exhibit near infrared (NIR) absorption. The compounds can be utilized as plasma-membrane specific bio-probes in cell imaging through a wash-free and fast staining procedure. In addition, the compounds can efficiently generate reactive oxygen species (ROS) in vivo when irradiated with visible light. As such, the compounds can be effective in killing cancer cells through image-guided, photodynamic therapy (PDT) processes.

公开(公告)号：US11034709B2

公开(公告)日：2021-06-15

申请号：US15929797

申请日：2020-05-22

Applicant: The Hong Kong University of Science and Technology

Inventor： Benzhong Tang ,  Parvej Alam ,  Nelson Lik Ching Leung

IPC: C07F9/50 ,  B42D25/23 ,  B42D25/24 ,  B42D25/36 ,  B42D25/29 ,  C09K11/06

Abstract: Provided herein are organic long persistent luminescence compositions and methods of use and preparation thereof and articles comprising the same.

公开(公告)号：US09618453B2

公开(公告)日：2017-04-11

申请号：US13899070

申请日：2013-05-21

Applicant: THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY

Inventor： Benzhong Tang ,  Ka Ming Ng ,  Qian Luo ,  Yong Yu ,  Yuning Hong ,  Jianzhao Liu ,  Sijie Chen ,  Wing Yip Lam ,  Zhengke Wang ,  Wei Qin ,  Tsz Kin Kwok

IPC: C12Q1/04 ,  G01N21/64 ,  B82Y15/00 ,  G01N1/30 ,  C07F7/08

CPC classification number: G01N21/6486 ,  B82Y15/00 ,  C07F7/0805 ,  C07F7/0816 ,  G01N1/30 ,  G01N21/6428 ,  G01N21/6458 ,  G01N2021/6439

Abstract: Provided herein are fluorescent bioprobes comprising fluorogens that exhibit aggregation-induced emission (AIE) labeled on biomolecules. The present subject matter relates to a fluorescent bioprobe comprising one or more fluorogen labeled on chitosan. The present subject matter is also directed to methods of preparing the fluorescent bioprobes, methods of labeling and detecting DNA and/or proteins with the fluorescent bioprobe, and methods of cell imaging including live cell tracking.

公开(公告)号：US09518921B2

公开(公告)日：2016-12-13

申请号：US13728150

申请日：2012-12-27

Applicant: THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY

Inventor： Benzhong Tang ,  Wing Yip Lam ,  Jianzhao Liu ,  Faisal Mahtab ,  Yang Liu ,  Yong Yu

IPC: G01N21/64 ,  G01N33/543 ,  G01N33/533 ,  G01N33/58 ,  C07D207/448 ,  C09B69/00 ,  C07D207/46 ,  C07F7/08 ,  C07F7/18 ,  C09B23/14 ,  B82Y15/00

CPC classification number: G01N21/6428 ,  B82Y15/00 ,  C07D207/448 ,  C07D207/46 ,  C07F7/0807 ,  C07F7/1804 ,  C09B23/14 ,  C09B23/148 ,  C09B69/008 ,  G01N33/533 ,  G01N33/54326 ,  G01N33/54346 ,  G01N33/582 ,  G01N33/587 ,  Y10S977/773 ,  Y10S977/92

Abstract: Provided herein are magnetic silica fluorescent nanoparticles and fluorescent silica nanoparticles comprising an aggregation induced emission luminogen and magnetite nanoparticles and use of the same as a fluorescent bioprobe for intracellular imaging and a protein carrier. Also provided are processes for preparing and fabricating the same.

Abstract translation: 本文提供了磁性二氧化硅荧光纳米颗粒和包含聚集诱导发射发光体和磁铁矿纳米颗粒的荧光二氧化硅纳米颗粒，并且使用其作为荧光生物探针用于细胞内成像和蛋白质载体。 还提供了制备和制造它们的方法。

公开(公告)号：US09200121B2

公开(公告)日：2015-12-01

申请号：US14386972

申请日：2013-04-07

Applicant: THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY

Inventor： Benzhong Tang ,  Jie Li ,  Rongrong Hu ,  Wing Yip Lam

IPC: C08G77/52 ,  C09J183/14

CPC classification number: C08G77/52 ,  C09J183/14

Abstract: A poly(siloxane-diphenylbutadiyne) exhibiting thermosetting properties, a highly tunable glass transition temperature (Tg), and very high thermal and thermo-oxidative stability. In one embodiment, the poly(siloxane-diphenylbutadiyne) is a poly(tetrasiloxane-diphenylbutadiyne). The present subject matter also relates to a method of synthesizing the poly(tetrasiloxane-diphenylbutadiyne).

Abstract translation: 显示出热固性，高可调玻璃化转变温度（Tg）和非常高的热和热氧化稳定性的聚（硅氧烷 - 二苯基丁二炔）。 在一个实施方案中，聚（硅氧烷 - 二苯基丁二炔）是聚（四硅氧烷 - 二苯基丁二炔）。 本主题还涉及合成聚（四硅氧烷 - 二苯基丁二炔）的方法。

公开(公告)号：US09109155B2

公开(公告)日：2015-08-18

申请号：US13902120

申请日：2013-05-24

Applicant: THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY ,  National University of Singapore

Inventor： Benzhong Tang ,  Wing Yip Lam ,  Na Zhao ,  Min Li ,  Bin Liu ,  Haibin Shi ,  Dan Ding

IPC: A61B5/00 ,  A61B8/00 ,  A61B10/00 ,  C09K11/06 ,  C12Q1/37 ,  A61K9/00

CPC classification number: C09K11/06 ,  A61K9/0019 ,  C12Q1/37 ,  G01N2333/96469

Abstract: The development of a series of fluorescent materials including heterocycle-functionalized luminogens with aggregation-induced/enhanced emission (AIE/AEE), long wavelength emission, and high solid state fluorescence quantum efficiency is contemplated. The described fluorescent materials are promising candidates in selective luminescence-based chemosensor for Hg2+ or ATP, fluorescent staining for mitochondria in living cells with high photostability, stimuli-responsive luminescent materials, and materials for optical waveguides. In addition, these heterocycle-functionalized luminogens are particularly useful as fluorescent labels for biopolymers such as peptides, antibodies, or nucleic acids, making them useful as AIE-active biocompatible probes for clinical cancer imaging and diagnostics.

Abstract translation: 考虑了包括具有聚集诱导/增强发射（AIE / AEE）的杂环官能化发光体，长波长发射和高固态荧光量子效率的一系列荧光材料的开发。 所描述的荧光材料是用于Hg2 +或ATP的基于选择性发光的化学传感器中的有希望的候选物，具有高光稳定性，刺激响应性发光材料和光波导材料的活细胞中线粒体的荧光染色。 此外，这些杂环官能化发光体特别可用作生物聚合物如肽，抗体或核酸的荧光标记，使其成为用于临床癌症成像和诊断的AIE活性生物相容性探针。