公开(公告)号：US20130139649A1

公开(公告)日：2013-06-06

申请号：US13512033

申请日：2010-12-02

Applicant: Michael Schelhaas ,  Pierre Vanhoorne ,  Reinhold Klipper ,  Georg Martin

Inventor： Michael Schelhaas ,  Pierre Vanhoorne ,  Reinhold Klipper ,  Georg Martin

IPC: B01J45/00

CPC classification number: B01J45/00 ,  C08F28/02

Abstract: The present invention relates to chelating resins containing methyleneaminoethylsulfonic acid groups, a process for producing them and also their use for removing heavy metals or metals of value from aqueous solutions having a pH of

Abstract translation: 本发明涉及含有亚甲基氨基乙基磺酸基团的螯合树脂，其制备方法，以及它们用于从pH值<4的水溶液中除去重金属或金属的用途，优选来自电子工业中的工艺用水， 电镀行业或采矿业。

公开(公告)号：US08357398B2

公开(公告)日：2013-01-22

申请号：US12925353

申请日：2010-10-20

Applicant: William Wayne Howard ,  Russell Francis Somma ,  Doreen Marie Frank

Inventor： William Wayne Howard ,  Russell Francis Somma ,  Doreen Marie Frank

IPC: A61K9/14 ,  A61K9/20 ,  A61K9/54 ,  A61K31/075 ,  A61K31/245 ,  B01J45/00

CPC classification number: A61K31/74 ,  A61K9/2027 ,  A61K9/2054 ,  A61K9/2081 ,  A61K9/4858 ,  A61K9/4866 ,  A61K9/5042 ,  A61K9/5084 ,  B01J39/18

Abstract: Oral dosage forms of benzonatate useful for anti-tussive and anti-tussive/combination applications.

Abstract translation: 用于抗咳嗽和抗咳嗽/组合应用的苯甲酸酯的口服剂型。

公开(公告)号：US20080314836A1

公开(公告)日：2008-12-25

申请号：US11766881

申请日：2007-06-22

Applicant: Andrew Michael Leach ,  Peter Miller ,  Eric Telfeyan ,  David Brandon Whitt

Inventor： Andrew Michael Leach ,  Peter Miller ,  Eric Telfeyan ,  David Brandon Whitt

IPC: B01J47/00 ,  B01D15/00 ,  B01D15/36 ,  B01J45/00

CPC classification number: A61M5/165 ,  B01D15/00 ,  B01D15/08 ,  B01D15/322 ,  B01D15/327 ,  B01J20/103 ,  B01J20/26 ,  B01J20/3242

Abstract: A device for dynamic filtration of a pharmaceutical product is provided. The device includes a resin configured to selectively retain one or more components from a mixture having the pharmaceutical product, where the resin is configured to be activated by a medium of the mixture. The device further includes at least one positioning material disposed adjacent to the resin, where the positioning material is configured to provide mechanical support to the resin to at least partially retain the resin in position. In certain embodiments, the device does not require conditioning immediately prior to filtration.

Abstract translation: 提供了用于药物动力过滤的装置。 该装置包括被配置为从具有药物产品的混合物中选择性地保持一种或多种组分的树脂，其中树脂被配置为由混合物的介质活化。 该装置还包括邻近树脂设置的至少一个定位材料，其中定位材料构造成为树脂提供机械支撑以至少部分地将树脂保持在适当位置。 在某些实施方案中，该装置在过滤之前不需要立即进行调节。

公开(公告)号：US20050272116A1

公开(公告)日：2005-12-08

申请号：US10861660

申请日：2004-06-04

Applicant: Michael Ellison ,  Albert Abbott ,  Darren Baker

Inventor： Michael Ellison ,  Albert Abbott ,  Darren Baker

IPC: B01J45/00 ,  C07K1/10 ,  C07K1/22 ,  C12P21/06

CPC classification number: B01J45/00 ,  C07K1/22 ,  Y02P20/582

Abstract: A polymer substrate for recombinant protein purification is provided. A process for purifying recombinant proteins is also provided. In general, the present invention is directed to a chelating composition which may be used in a self-supported purification medium for recombinant protein purification. In another embodiment, a process for removal of transition metals from environmental waste is also provided.

Abstract translation: 提供了用于重组蛋白纯化的聚合物底物。 还提供了一种纯化重组蛋白的方法。 通常，本发明涉及可用于重组蛋白纯化的自支撑纯化介质中的螯合组合物。 在另一个实施方案中，还提供了从环境废物中除去过渡金属的方法。

公开(公告)号：US20050209444A1

公开(公告)日：2005-09-22

申请号：US11032281

申请日：2005-01-10

Applicant: Tonny Johnson ,  Rebecca Godat ,  Laurie Engel

Inventor： Tonny Johnson ,  Rebecca Godat ,  Laurie Engel

IPC: B01D15/38 ,  B01J45/00 ,  C07K1/14 ,  C07K1/22 ,  C07K1/16

CPC classification number: B01J45/00 ,  C07K1/22

Abstract: Disclosed are methods of separating a target molecule from a non-target molecule using zinc- or cobalt-charged solid supports.

公开(公告)号：US06867295B2

公开(公告)日：2005-03-15

申请号：US09949010

申请日：2001-09-07

Applicant: L. Andy Woodruff ,  Andrei V. Bordunov ,  Christopher A. Pohl

Inventor： L. Andy Woodruff ,  Andrei V. Bordunov ,  Christopher A. Pohl

IPC: G01N30/02 ,  B01D15/08 ,  B01J20/281 ,  B01J20/285 ,  B01J41/14 ,  B01J45/00 ,  C08J5/20 ,  G01N30/26 ,  G01N30/34 ,  G01N30/64 ,  G01N30/88 ,  C08B37/16

CPC classification number: B01J45/00 ,  B01J41/14

Abstract: One embodiment of the invention comprises an ion exchange composition formed by reacting unsaturated carbon to carbon moieties pendant from derivatized ion binding cryptands with a support substrate under free radical activation conditions to form a covalent bond therebetween.In another embodiment, a cryptand ion exchange composition is made by covalently bonding unsaturated carbon to carbon moieties pendant from a derivatized ion binding cryptands with unsaturated carbon to carbon moieties pendant from a support substrate under free radical activation conditions to form covalent bond.

Abstract translation: 本发明的一个实施方案包括通过使自由基活化条件下的不饱和碳与衍生的离子结合穴状物侧基的碳部分与支持底物反应而形成的离子交换组合物，在其间形成共价键。在另一个实施方案中，穴状离子交换组合物是 通过共价键合不饱和碳与从不饱和碳衍生的衍生化离子结合穴状结构的碳部分与自由基激活条件下从载体底物侧基形成共价键的碳部分共价键合。

公开(公告)号：US6432313B2

公开(公告)日：2002-08-13

申请号：US83213901

申请日：2001-04-06

Applicant: IBC ADVANCED TECH INC

Inventor： BRUENING RONALD L ,  KRAKOWIAK KRZYSZTOF E

IPC: B01J20/32 ,  B01J45/00 ,  B01D15/00

CPC classification number: B01J45/00 ,  B01J20/3204 ,  B01J20/321 ,  B01J20/3219 ,  B01J20/3251 ,  B01J20/3255

Abstract: Compositions and methods for selectively binding metal ions from a source solution comprise using a polyhydroxypyridinone-containing ligand covalently bonded to a particulate solid support through a hydrophilic spacer of the formula SS-A-X-L (HOPO)n where SS is a particulate solid support such as silica or a polymeric bead, A is a covalent linkage mechanism, X is a hydrophilic spacer grouping, L is a ligand carrier, HOPO is a hydroxypyridinone appropriately spaced on the ligand carrier to provide a minimum of six functional coordination metal binding sites, and n is an integer of 3 to 6 with the proviso that when SS is a particulate organic polymer, A-X may be combined as a single covalent linkage. The separation is accomplished by passing a source solution containing the ions to be separated through a column containing the particulate composition, causing the selected ions to be complexed to the HOPO ligands and subsequently removing the selected ions from the column by passing an aqueous receiving solution through the column and quantitatively stripping the selected ions from the HOPO ligand.

Abstract translation: 用于选择性地结合来自源溶液的金属离子的组合物和方法包括使用通过式SS-AXL（HOPO）n的亲水间隔物共价键合到颗粒状固体载体上的聚羟基吡啶酮配体，其中SS是颗粒状固体载体如二氧化硅 或聚合物珠，A是共价连接机理，X是亲水间隔基，L是配体载体，HOPO是在配体载体上适当间隔开的羟基吡啶酮，以提供至少六个功能性配位金属结合位点，n是 3至6的整数，条件是当SS为颗粒状有机聚合物时，可将AX作为单一共价键组合。 通过将含有待分离的离子的源溶液通过含有颗粒组合物的柱，使所选择的离子与HOPO配体络合并随后通过使含水接收溶液通过而从柱中除去所选择的离子来实现分离 柱并定量地从HOPO配体中剥离选定的离子。

公开(公告)号：US6143569A

公开(公告)日：2000-11-07

申请号：US144106

申请日：1998-08-31

Applicant: Greg E. Collins ,  Ling-Siu Choi

Inventor： Greg E. Collins ,  Ling-Siu Choi

IPC: B01J45/00 ,  C07C255/58 ,  G01N33/20

CPC classification number: C07C255/58 ,  B01J45/00

Abstract: A polyfunctional amine, such as cyclam, substituted with 4-(N,N-dimethylao) benzonitrile, exhibits triple fluorescence and complexes with metal ions. The complexation of metal ions with the fluorophore changes the triple fluorescence characteristics of the fluorophore. Thus, this substituted polyfunctional amine provides an effective indicator for the qualitative and quantitative detection of metals.

Abstract translation: 用4-（N，N-二甲基氨基）苄腈取代的多官能胺，如环己烷，与金属离子呈现三重荧光和配合物。 金属离子与荧光团的络合改变荧光团的三重荧光特性。 因此，这种取代的多官能胺为金属的定性和定量检测提供了有效的指标。

公开(公告)号：US6133392A

公开(公告)日：2000-10-17

申请号：US147804

申请日：1999-03-11

Applicant: Jens Utecht ,  Martin Rubenacker ,  Claudia Nilz ,  Rainer Rahm

Inventor： Jens Utecht ,  Martin Rubenacker ,  Claudia Nilz ,  Rainer Rahm

IPC: B01J20/26 ,  B01J45/00 ,  C08F8/00 ,  C08F12/28

CPC classification number: B01J45/00 ,  B01J20/26 ,  C08F8/00

Abstract: An insoluble, only slight swellable, polymer having modified amino groups, which contain units of the formulae: ##STR1## or both (I) and (II), wherein R.sup.1, R.sup.2, R.sup.3 and Me are as defined herein.

Abstract translation: PCT No.PCT / EP97 / 04545 Sec。 371 1999年3月11日 102（e）1999年3月11日PCT PCT 1997年8月21日PCT公布。 公开号WO98 / 11145 日期1998年3月19日具有改性氨基的不溶性仅有轻微溶胀性聚合物，其含有下列式（I）和（II）的单元，其中R 1，R 2，R 3和Me如本文所定义。

公开(公告)号：US6103112A

公开(公告)日：2000-08-15

申请号：US295474

申请日：1999-04-19

Applicant: John E. Sutton ,  Douglas T. Gjerde ,  Paul D. Taylor

Inventor： John E. Sutton ,  Douglas T. Gjerde ,  Paul D. Taylor

IPC: B01D15/08 ,  B01D15/12 ,  B01D15/16 ,  B01D15/20 ,  B01D15/36 ,  B01D15/38 ,  B01J45/00 ,  C12N15/10 ,  C12Q1/68 ,  G01N30/14 ,  G01N30/30 ,  G01N30/52 ,  G01N30/54

CPC classification number: B01D15/125 ,  B01D15/161 ,  B01D15/20 ,  B01D15/366 ,  B01D15/38 ,  B01J45/00 ,  C12N15/101 ,  C12Q1/6827 ,  C12Q1/6834 ,  G01N30/30 ,  G01N30/54 ,  G01N2030/528 ,  G01N30/14

Abstract: A liquid chromatography apparatus with stationary and mobile phase temperature controls suitable for polynucleotide separations by MIPC and DMIPC processes. The apparatus includes heater means with a temperature control system; a matched ion polynucleotide chromatography separation column having an inlet end; a coil of capillary tubing having an inlet end and an outlet end. The outlet end of the capillary tubing is connected with the inlet end of the separation column. The inlet end of the capillary tubing comprising means for receiving process liquid, the tubing having a length of from 6 to 400 cm having a linear tubing length of heating means. The separation column and the coil of capillary tubing are enclosed in the heater means. The capillary tubing preferably is PEEK or titanium. The heater means can be an air batch oven. Preferably, it is a heat-conducting block having a first heat transfer surface, a separation column receptacle, and a capillary coil receptacle. A separation column is positioned within the separation column receptacle in heat conducting relationship with an inner wall thereof. A coil of capillary tubing is positioned in the capillary coil receptacle, the outer extremities of the coil being in heat conducting relationship with an inner wall of the capillary coil receptacle. Optimally, the heating means is a Peltier heating and cooling unit in heat conducting relationship with a heat transfer surface of the heating block.