公开(公告)号：US20160243282A1

公开(公告)日：2016-08-25

申请号：US15061065

申请日：2016-03-04

Applicant: CLEMSON UNIVERSITY

Inventor： Dan Simionescu ,  Jeremy J. Mercuri

IPC: A61L27/26 ,  A61L27/38 ,  A61L27/54 ,  A61L27/52

CPC classification number: A61L27/26 ,  A61F2/441 ,  A61F2/442 ,  A61F2002/30075 ,  A61F2002/444 ,  A61L27/3804 ,  A61L27/3834 ,  A61L27/52 ,  A61L27/54 ,  A61L27/56 ,  A61L2300/414 ,  A61L2300/64 ,  A61L2400/16 ,  A61L2430/38 ,  C08L89/06

Abstract: A hydrogel biomaterial that can be utilized as a nucleus pulposus replacement material is described. The hydrogel biomaterial can is an elastin-glycosaminoglycan-collagen composite hydrogel biomaterial that can mimic the biochemical and functional characteristics of the human nucleus pulposus. Methods for forming the hydrogel biomaterial are also described as are methods for use of the hydrogel biomaterial, one of which is as an in vivo nucleus pulposus replacement material, another of which is a scaffolding material for use in nucleus pulposus tissue engineering applications.

Abstract translation: 描述了可用作髓核替代材料的水凝胶生物材料。 水凝胶生物材料罐可以是可以模拟人髓核的生物化学和功能特征的弹性蛋白 - 糖胺聚糖 - 胶原复合水凝胶生物材料。 形成水凝胶生物材料的方法也被描述为使用水凝胶生物材料的方法，其中之一是作为体内髓核替代材料，其中另一种是用于髓核组织工程应用中的支架材料。

公开(公告)号：US20160235158A1

公开(公告)日：2016-08-18

申请号：US15046661

申请日：2016-02-18

Applicant: CLEMSON UNIVERSITY

Inventor： John DesJardins ,  Scott Edward Stanley ,  Breanne Przestrzelski ,  Timothy C. Pruett ,  Steve L. Hoeffner ,  Brian Daryl Kaluf

IPC: A43B7/28 ,  A43B17/02 ,  A61F5/01 ,  A43B17/00

CPC classification number: A43B7/28 ,  A43B1/0009 ,  A43B7/146 ,  A43B13/188 ,  A43B13/20 ,  A43B17/006 ,  A43B17/02 ,  A43B17/03 ,  A43B17/14 ,  A61F5/0111 ,  B33Y10/00

Abstract: Orthotics and methods for forming orthotics are described. The orthotics can be designed with a patient-specific design and can include variation in hardness across the orthotic so as to satisfy clinical need. An orthotic can be a custom-designed orthotic formed according to an additive manufacturing process such as a 3-D printing methodology. Through utilization of on-site formation methods such as 3-D printing, an orthotic can be designed, formed and fit at the point of care in a much shorter time period than traditional orthotics. The orthotics can include a layer that includes a plurality of cells across the layer. The layer can exhibit variable hardness across the layer through variation in cell void volume and optionally material of formation across the layer.

Abstract translation: 描述矫形器和形成矫形器的方法。 矫形器可以设计为具有患者特定设计，并且可以包括矫形器上的硬度变化，以满足临床需要。 矫正器可以是根据添加剂制造工艺形成的定制设计的矫正器，例如3-D印刷方法。 通过利用诸如3-D印刷的现场形成方法，可以在比传统矫形器更短的时间段内在护理点设计，形成和配合矫形器。 矫形器可以包括跨越层的多个细胞的层。 该层可以通过细胞空隙体积的变化和任选的层的形成材料在整个层上显示出可变的硬度。

公开(公告)号：US20160146735A1

公开(公告)日：2016-05-26

申请号：US14555151

申请日：2014-11-26

Applicant: The Curators of the University of Missouri ,  Clemson University

Inventor： Yinfa Ma ,  Honglan Shi ,  Qingbo Yang ,  Hai Xiao

IPC: G01N21/64 ,  G01N33/543 ,  G01N31/22

CPC classification number: G01N21/6428 ,  G01N21/645 ,  G01N21/7703 ,  G01N21/80 ,  G01N31/221 ,  G01N2021/772 ,  G01N2021/7786 ,  G01N2201/0636

Abstract: A pH micro-probe, a temperature micro-probe, and an immuno-based micro-probe each include a shaft for transmitting an input light signal and a tip for inserting into a cell or other substance for measuring pH, temperature, and/or antigens. The pH micro-probe and the temperature micro-probe each include a luminescent material positioned on the tip of the micro-probe. The light signal excites the luminescent material so that the luminescent material emits a luminescent light signal. The luminescent light signal has a property value dependent on the pH or temperature being measured and reflects back through the shaft for being measured by a light signal measuring device. The immuno-based micro-probe includes a reflective material that has an effective refractive index dependent on the number of antigen-antibody bonds present on the reflective material.

Abstract translation: pH微探针，温度微探针和基于免疫的微探针各自包括用于传输输入光信号的轴和用于插入电池或用于测量pH，温度和/或 抗原。 pH微探针和温度微探针各自包括位于微探针尖端上的发光材料。 光信号激发发光材料，使得发光材料发出发光光信号。 发光光信号具有取决于被测量的pH或温度的特性值，并通过轴反射以便由光信号测量装置测量。 基于免疫的微探针包括具有取决于存在于反射材料上的抗原 - 抗体结合数目的有效折射率的反射材料。

公开(公告)号：US20160120133A1

公开(公告)日：2016-05-05

申请号：US14895104

申请日：2014-06-03

Applicant: SMITHERS-OASIS COMPANY ,  CLEMSON UNIVERSITY

Inventor： Jeffrey Adelberg ,  Jacqueline Naylor-Adelberg ,  Vijay Rapaka

IPC: A01G9/02 ,  A01G9/10 ,  A01G1/00

CPC classification number: A01G9/021 ,  A01G9/02 ,  A01G9/026 ,  A01G22/00 ,  A01G24/00 ,  A01H4/001

Abstract: Plant propagation systems are described that includes a flexible, self-standing container and a support that can be held within the container during one or more of sterilization, storage, shipping, and use of the system.

Abstract translation: 描述了植物繁殖系统，其包括柔性的自立式容器和在系统的灭菌，储存，运输和使用的一个或多个期间可以保持在容器内的支撑件。

公开(公告)号：US09320635B2

公开(公告)日：2016-04-26

申请号：US13971410

申请日：2013-08-20

Applicant: Clemson University Research Foundation

Inventor： Chelsea Lea Ex-Lubeskie ,  Meredith Cole Donaldson ,  Riley Morgan Csernica ,  Kaitlin Kathleen Grove ,  Charles Alden Thigpen

IPC: A61F5/00 ,  A61F5/01 ,  A61L15/14 ,  A61F5/37

CPC classification number: A61F5/0102 ,  A61F5/3723 ,  A61L15/14

Abstract: Shoulder braces for inhibiting secondary anterior shoulder dislocations that are configured to allow for a wide range of motion for mobility and stabilization, include a brace body with a single arm portion configured to reside about a shoulder of a user and a torso portion, a plurality of shoulder straps extending over the single arm portion shoulder, a substantially rigid thermoplastic insert releasably held by the arm portion of the brace body. The insert can have a user-specific custom shape that substantially conforms to shoulder anatomy of the shoulder of the user. The brace can also include at least one adjustable length laterally extending torso strap attached to the torso portion.

Abstract translation: 用于抑制被配置为允许移动性和稳定性的宽范围运动的继发性前肩脱位的肩撑包括具有单个臂部分的构架，其配置成围绕使用者的肩部和躯干部分驻留，多个 在单臂部分肩部上延伸的肩带，由支架主体的臂部可释放地保持的基本上刚性的热塑性插件。 插入物可以具有基本上符合使用者肩部的肩部解剖结构的用户特定的定制形状。 支架还可以包括附接到躯干部分的至少一个可调节长度的横向延伸的躯干带。

公开(公告)号：US20150290344A1

公开(公告)日：2015-10-15

申请号：US14683775

申请日：2015-04-10

Applicant: Clemson University ,  College of Charleston

Inventor： Frank Alexis ,  Daniel C. Whitehead ,  Brooke A. Van Horn

IPC: A61K49/04 ,  C08L67/04 ,  A61L31/18 ,  A61L17/14 ,  A61L29/08 ,  A61L29/18 ,  A61L27/50 ,  A61L27/34 ,  C08G63/91 ,  A61L31/10

CPC classification number: A61K49/0442 ,  A61L17/145 ,  A61L27/34 ,  A61L27/50 ,  A61L29/085 ,  A61L29/18 ,  A61L31/10 ,  A61L31/18 ,  A61L2300/44 ,  C08G63/08 ,  C08G63/91 ,  C08G63/912 ,  C08L67/04 ,  C08L101/00

Abstract: Biodegradable, radio-opaque polyesters and poly(ester amides) are described herein. The polyesters contain a plurality of radio-opaque agents or radio-opaque agent-containing moieties that are covalently bound along or from the polymer backbone. The agents/moieties may be bound to the termini of the polymer provided they are bound within the polyester backbone as well. The polyester can be aliphatic or aromatic. The polyester and poly(ester amide) is substituted with a plurality of radio-opaque graft agents or prepared from an appropriate radio-opaque monomer agent. The materials can be used for any application where a radio-opaque material is desired or necessary. The materials can be used to form, in whole or in part, a medical device, or coating thereon or therein.

Abstract translation: 可生物降解的，不透射线的聚酯和聚（酯酰胺）在本文中描述。 聚酯包含多个不透射线剂或含聚合物主链共价键共价结合的不透射线剂。 所述试剂/部分可以结合到聚合物的末端，只要它们在聚酯骨架内结合即可。 聚酯可以是脂肪族或芳族的。 聚酯和聚（酯酰胺）被多个不透射线的接枝剂取代或者由适当的不透射线的单体剂制备。 这些材料可用于需要或不需要不透射线材料的任何应用。 这些材料可以全部或部分地用于形成医疗装置，或其上或其上的涂层。

公开(公告)号：US09067273B1

公开(公告)日：2015-06-30

申请号：US13893617

申请日：2013-05-14

Applicant: Clemson University

Inventor： Sung-O Kim ,  Jae-Young Kim

IPC: B23K10/00

CPC classification number: H05H1/2406 ,  H05H2001/2462

Abstract: Disclosed is an atmospheric pressure plasma jet device for use in a variety of applications. The disclosed system can include a conduit tubing array that includes multiple individual tubes configured in a honeycomb structure. By altering the linear velocity of the system's gas source, the system can produce multiple non-thermal atmospheric plasma jets that can interact in such a way as to create a single plasma jet as opposed to multiple collimated plasma jets. The single jet formed by the interaction of the multiple conduits can exhibit an increased optical intensity and energy compared to either a plasma jet emitted from a single conduit or well-collimated plasma jets emitted from multiple conduits.

Abstract translation: 公开了一种用于各种应用的大气压等离子体喷射装置。 所公开的系统可以包括导管管阵列，其包括配置在蜂窝结构中的多个单独的管。 通过改变系统气源的线速度，该系统可以产生多个非热大气等离子体射流，其可以以与多个准直等离子体射流相反的方式相互作用来产生单个等离子体射流。 与从多个导管发射的单个导管发射的等离子体射流或者准直的等离子体射流相比，通过多个导管的相互作用形成的单个射流可以表现出增加的光学强度和能量。

公开(公告)号：US09034354B2

公开(公告)日：2015-05-19

申请号：US13900942

申请日：2013-05-23

Applicant: MUSC Foundation for Research Development ,  Clemson University

Inventor： Walter George Renne ,  Anthony Samuel Mennito ,  Michael Gerard Schmidt ,  Jompobe Vuthiganon ,  George Chumanov

IPC: A61K33/34 ,  C01G3/04 ,  A61K6/00 ,  C01G3/02 ,  C01G3/12 ,  A61K6/083 ,  A61C5/08

CPC classification number: A61K33/34 ,  A61C5/70 ,  A61K6/0017 ,  A61K6/0023 ,  A61K6/007 ,  A61K6/0835 ,  C01G3/02 ,  C01G3/04 ,  C01G3/12 ,  Y10S977/773

Abstract: Provided are antibacterial and antimicrobial surface coatings and dental materials by utilizing the antimicrobial properties of copper chalcogenide and/or copper halide (CuQ, where Q=chalcogens including oxygen, or halogens, or nothing). An antimicrobial barrier is created by incorporation of CuQ nanoparticles of an appropriate size and at a concentration necessary and sufficient to create a unique bioelectrical environment. The unique bioelectrical environment results in biocidal effectiveness through a multi-factorial mechanism comprising a combination of the intrinsic quantum flux of copper (Cu0, Cu1+, Cu2+) ions and the high surface-to-volume electron sink facilitated by the nanoparticle. The result is the constant quantum flux of copper which manifests and establishes the antimicrobial environment preventing or inhibiting the growth of bacteria. The presence of CuQ results in inhibiting or delaying bacterial destruction and endogenous enzymatic breakdown of the zone of resin inter-diffusion, the integrity of which is essential for dental restoration longevity.

Abstract translation: 通过利用铜硫属化物和/或铜卤化物（CuQ，其中Q =包括氧或卤素的硫属元素，或任何物质）的抗微生物性质，提供抗菌和抗微生物表面涂层和牙科材料。 通过掺入适当尺寸的CuQ纳米颗粒并以必要和足够的浓度产生独特的生物电气环境来产生抗微生物屏障。 独特的生物电气环境通过包含铜（CuO，Cu1 +，Cu2 +）的固有量子通量和由纳米颗粒促进的高表面 - 体积电子吸收的组合的多因素机制产生杀生物效果。 结果是铜的恒定量子通量显示并建立了防止或抑制细菌生长的抗微生物环境。 CuQ的存在导致抑制或延迟细菌破坏和树脂互扩散区域的内源性酶分解，其完整性对于牙齿修复寿命至关重要。

公开(公告)号：US20140094701A1

公开(公告)日：2014-04-03

申请号：US14034756

申请日：2013-09-24

Applicant: Clemson University

Inventor： David Kwartowitz ,  Erika Trent ,  Fuad Mefleh ,  Vipul Pai Raikar ,  Delphine Dean

IPC: A61B8/08

CPC classification number: A61B8/485 ,  A61B6/463 ,  A61B8/0875 ,  A61B8/4209 ,  A61B8/429 ,  A61B8/5223

Abstract: Adaptors for ultrasound probes can have an adaptor body can have an open lower end that allows a distal end of the ultrasound probe to extend therethrough to contact skin of a patient. The adaptor can include a plurality of spaced apart resilient members held by the adaptor body that, in operation, are able to change in length such that the resilient members translate from a first longer length to a second shorter length when the probe applies compressive force to the target tissue.

Abstract translation: 用于超声探头的适配器可以具有适配器主体，其可以具有允许超声波探头的远端延伸穿过其以接触患者皮肤的敞开的下端。 适配器可以包括由适配器主体保持的多个间隔开的弹性构件，其在操作中能够改变长度，使得当探针施加压缩力时弹性构件从第一较长长度平移到第二较短长度 目标组织。

公开(公告)号：US20140046191A1

公开(公告)日：2014-02-13

申请号：US13960881

申请日：2013-08-07

Applicant: CLEMSON UNIVERSITY

Inventor： Jeffrey Anker ,  Melissa Rogalski ,  Dakota Anderson ,  Jonathon Heath

IPC: A61B5/11 ,  A61B6/00 ,  A61B17/68 ,  A61B5/00

CPC classification number: A61B5/1127 ,  A61B5/0075 ,  A61B5/0077 ,  A61B5/0084 ,  A61B5/45 ,  A61B5/4504 ,  A61B5/686 ,  A61B5/6867 ,  A61B6/00 ,  A61B17/68 ,  A61B17/86 ,  A61B2562/0261 ,  G01L1/25

Abstract: Strain gauges that can provide information with regard to the state of implantable devices are described. The strain gauges can exhibit luminescence that is detectable through living tissue, and the detectable luminescent emission can vary according to the strain applied to the gauge. A change in residual strain of the device can signify a loss of mechanical integrity and/or loosening of the implant, and this can be non-invasively detected either by simple visual detection of the luminescent emission or through examination of the emission with a detector such as a spectrometer or a camera.

Abstract translation: 描述了可以提供关于可植入装置的状态的信息的应变计。 应变计可以显示可通过活组织检测的发光，并且可检测的发光发射可以根据施加到量规的应变而变化。 器件的残余应变的变化可以表示植入物的机械完整性和/或松动的损失，并且可以通过简单的视觉检测发光发射或通过用检测器检查发射来非侵入性地检测 作为光谱仪或相机。