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公开(公告)号：US20220257634A1
公开(公告)日：2022-08-18
申请号：US17733640
申请日：2022-04-29
Inventor： Steven DOW , Kathryn WOTMAN , Lyndah CHOW
IPC: A61K31/713 , A61K9/00 , A61K9/127 , A61K31/711 , A61K47/38 , A61P37/04 , A61P27/02
Abstract: Embodiments of the present invention generally relate to novel immunostimulatory compositions of use to stimulate non-specific immune responses in a subject. In certain embodiments, immunogenic compositions disclosed herein can be directed to use in the eye of a subject. In some embodiments, the immunogenic compositions disclosed herein enhance non-specific immune responses in the eye of a subject to treat or reduce the risk of onset of an eye condition. In other embodiments, compositions disclosed herein can be used to treat eye infections due to a microorganism, tumors of the eye, as well as, chronic wounds or infections of the eye. In some embodiments, immunogenic ocular formulations disclosed herein include combinations of agents for prolonged exposure to the eye for improved outcomes.
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42.发明授权公开(公告)号：US11407979B2
公开(公告)日：2022-08-09
申请号：US16119399
申请日：2018-08-31
Inventor： Salman R. Khetani , Matthew D. Davidson
Abstract: The present disclosure relates to compositions and methods for culturing a population of hepatocytes in vitro, comprising co-culturing the population of hepatocytes with at least one non-parenchymal cell population and incubating the co-culture in culture medium, wherein the co-culture is periodically incubated in culture medium that does not comprise serum (serum-free culture medium).
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公开(公告)号：US20220236549A1
公开(公告)日：2022-07-28
申请号：US17648923
申请日：2022-01-25
Inventor： Randy A. Bartels , Jeffrey J. Field
Abstract: In an embodiment, a method includes obtaining radiation emitted from a radiation source. The method includes modulating the radiation with a time-varying modulation to generate a time-varying illumination pattern with a known modulation. The illumination pattern includes a time-varying intensity for each of a plurality of spatial locations. The method includes illuminating a target volume with the illumination pattern. The method includes collecting a signal generated by one or more objects within the target volume in response to illumination by the illumination pattern. The method includes estimating a location of each of the one or more objects based on the collected signal and the known modulation.
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公开(公告)号：US11299523B2
公开(公告)日：2022-04-12
申请号：US16315258
申请日：2017-07-06
Inventor： Daniel R. Bush , Amanda K. Broz , Bettina E. Broeckling , Michael M. Friedman
IPC: C07K14/415 , C12N15/82
Abstract: The invention provides methods for improving plant yield, biomass accumulation and stress tolerance. A novel AP2-like transcription factor MPG1, which when modulated impacts grain yield, biomass and abiotic and biotic stress tolerance when compared to non-modulated plants. The invention further provides methods using recombinant expression cassettes, host cells, transgenic plants and breeding methods using the same.
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公开(公告)号：US20220000674A1
公开(公告)日：2022-01-06
申请号：US17367191
申请日：2021-07-02
Inventor： Kevin Brewer
IPC: A61F13/04
Abstract: An orthopedic cast splitter apparatus for splitting an orthopedic cast may include a frame, a handle pivotally coupled to the frame, a drive rod configured to translate relative to the frame, and a jaws. The jaws may include a first plate coupled to the frame, and a second plate coupled to the drive rod and extending parallel to the first plate, with the second plate being configured to translate relative to the first plate. The jaws also may include a first tooth removably coupled to the first plate and extending beyond an end of the first plate, and a second tooth removably coupled to the second plate and extending beyond an end of the second plate, with the first tooth and the second tooth being configured to be inserted within a fissure formed in the orthopedic cast.
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Patent Agency Ranking
公开(公告)号：US20210386542A1
公开(公告)日：2021-12-16
申请号：US17458745
申请日：2021-08-27
Inventor： Kemal Schankereli , E. Christopher Orton
IPC: A61F2/24
Abstract: This invention relates to the design and function of a compressible valve replacement prosthesis which can be deployed into a beating heart without extracorporeal circulation using a transcatheter delivery system. The design as discussed focuses on the deployment of a device via a minimally invasive fashion and by way of example considers a minimally invasive surgical procedure preferably utilizing the intercostal or subxyphoid space for valve introduction. In order to accomplish this, the valve is formed in such a manner that it can be compressed to fit within a delivery system and secondarily ejected from the delivery system into the annulus of a target valve such as a mitral valve or tricuspid valve.
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公开(公告)号：US20210318286A1
公开(公告)日：2021-10-14
申请号：US17225809
申请日：2021-04-08
Inventor： Thomas W. Chen , Caleb R. Begly , Michael Siegel
IPC: G01N33/483 , B01L3/00 , G01N27/04
Abstract: An Ussing chamber assembly for assessing a tissue sample and for receiving a first fluid and a second fluid during such assessment is disclosed. The Ussing chamber assembly includes an Ussing chamber configured to be separated by the tissue sample into a first chamber portion and a second chamber portion. The assembly includes a first channel in fluidic communication with the first chamber portion, a second channel in fluidic communication with the second chamber portion, and at least three electrical conductors in fluidic communication with the first chamber portion.
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公开(公告)号：US20210311066A1
公开(公告)日：2021-10-07
申请号：US17266734
申请日：2019-08-09
Inventor： Christopher J. ACKERSON , Zachary BUTZ , Richard NEMETH , Ryan RISKOWSKI , Kanda BORGOGNONI
Abstract: Enzymes that reduce specific metal or metalloid ions to insoluble form are important to science. Peptides isolated from yeast- and phage-display libraries can affect the size and morphology of inorganic materials during their synthesis. Herein, an Se binding peptide was fused to an enzyme capable of reducing selenite (SeO32−) to a Se0 nanoparticle (SeNP). The fusion of the Se binding peptide to the metalloid reductase provided size control of the resulting SeNP. The SeNP product also remains associated to the enzyme fusion. The Se binding peptide fusion to the enzyme increases the enzyme's SeO32− reductase activity. Modification of enzyme activity was absent, and the size control of particles was diminished when the Se binding peptide was added exogenously to the reaction mixture. Binding of the peptide is attributed to His based ligation that results in a conformational change to the peptide.
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公开(公告)号：US20210196244A1
公开(公告)日：2021-07-01
申请号：US17127520
申请日：2020-12-18
Inventor： David Leith , John Volckens , Christian L'Orange , Daniel D. Miller-Lionberg
IPC: A61B10/00
Abstract: A portable sampler, the sampler including a sampler assembly having a housing that includes a receiver defined therein for interchangeably receiving a number of removable inlet assemblies, the removable inlet assemblies including a respirable inlet assembly and a thoracic inlet assembly. The respirable inlet assembly includes a hybrid cyclone assembly, the hybrid cyclone assembly including an impaction stage and a cyclone in series. The thoracic inlet assembly includes an inlet slot configured to function as a size-selective inlet. Another thoracic inlet assembly includes a housing having a number of openings configured to receive a sample airflow; an inlet insert through which an inlet aperture is defined; a prequalification chamber defined between a lower surface of the housing and an upper surface of the inlet insert; and a protrusion extending downward from the lower surface of the housing into the inlet aperture of the inlet insert to from an inlet slot.
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公开(公告)号：US20210169082A1
公开(公告)日：2021-06-10
申请号：US16630264
申请日：2018-07-11
Inventor： Melissa M. Reynolds , Megan J. Neufeld , Bella H. Neufeld , Alec Lutzke
Abstract: A substrate having an antibacterial surface includes a chitosan matrix and water-stable metal-organic frameworks dispersed throughout the chitosan matrix. The water-stable metal-organic frame-works are present in an amount of 5% wt/wt to 20% wt/wt based on total solids of the substrate
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