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    Information notification sample processing system and methods of biological slide processing
    42.
    发明授权
    Information notification sample processing system and methods of biological slide processing 有权

    公开(公告)号：US10156580B2

    公开(公告)日：2018-12-18

    申请号：US14959741

    申请日：2015-12-04

    Applicant: Dako Denmark A/S

    Inventor： Gordon Feingold ,  Marc Key ,  John Favuzzi ,  Rosanne Welcher

    IPC: G01N35/00 ,  G01N1/30 ,  G01N1/31 ,  G16H50/20

    Abstract: A sample processing system that may be automated and methods are disclosed where samples are arranged on a carrier element and a process operation control system automatically processes the samples perhaps robotically with an operationally-influential exteriorly-consequential information monitor or a data capture element. Significant process details as well as operationally-influential exteriorly-consequential information may be monitored and an automatic notice element may cause notification of a person at some display that may be remote. Various people may be notified, such as an administrator, a supplier, or a manufacturer of an opportunity for some action such as reagent reordering or the like. A simulated motion display may be included to “watch” simulated operation in real time or long after completion of the actual processing.

    RAPID AND SENSITIVE METHOD FOR DETECTION OF BIOLOGICAL TARGETS
    46.
    发明申请
    RAPID AND SENSITIVE METHOD FOR DETECTION OF BIOLOGICAL TARGETS 审中-公开
    用于检测生物目标的快速和敏感方法

    公开(公告)号：US20160370375A1

    公开(公告)日：2016-12-22

    申请号：US15165823

    申请日：2016-05-26

    Applicant: Dako Denmark A/S

    Inventor： Jesper Lohse ,  Kenneth Heesche Petersen

    IPC: G01N33/58 ,  C12Q1/68 ,  C12Q1/28

    CPC classification number: G01N33/581 ,  C12Q1/28 ,  C12Q1/6806 ,  G01N2333/908

    Abstract: The present invention relates to a method of biological labeling that occurs via a free radical chain reaction. The labeling occurs due to deposition of a detectable reporter molecule from a media comprising a substance comprising at least two moieties of a peroxidase enzyme substrate (termed herein ‘cross-linker’) in a target site comprising peroxidase activity and a biological marker. The labeling reaction described herein may generally be used to detect targets in a host of experimental schemes for detecting and visualizing a biological or chemical target, including immunohistochemistry (IHC), in situ hybridization (ISH), antibody-based staining methods such as ELISA, Southern, Northern, and Western blotting, and others.

    Abstract translation: 本发明涉及通过自由基链反应发生的生物标记方法。 标记发生是由于可检测的报道分子从包含过氧化物酶底物（称为“交联剂”）至少两个部分的物质的介质沉积在包含过氧化物酶活性的靶位点和生物标记物中。 本文描述的标记反应通常可用于检测用于检测和可视化生物或化学靶的主要实验方案中的靶标，包括免疫组织化学（IHC），原位杂交（ISH），基于抗体的染色方法如ELISA， 南，北，西印迹等。

    NON-MODAL INTERPLATE MICROWAVE HEATING SYSTEM AND METHOD OF HEATING
    47.
    发明申请
    NON-MODAL INTERPLATE MICROWAVE HEATING SYSTEM AND METHOD OF HEATING 审中-公开
    非模态相位微波加热系统及加热方法

    公开(公告)号：US20160252538A1

    公开(公告)日：2016-09-01

    申请号：US14940859

    申请日：2015-11-13

    Applicant: Dako Denmark A/S

    Inventor： Magnus Fagrell ,  Ian Christopher Ray

    IPC: G01N35/02 ,  G01N1/30 ,  G01N35/00 ,  H05B6/80

    CPC classification number: G01N35/026 ,  G01N1/30 ,  G01N35/0099 ,  H05B6/46 ,  H05B6/80 ,  H05B6/806

    Abstract: Disclosed is a microwave heater and a method of heating. The microwave heater includes a non-modal interplate microwave applicator and may include a nonresonant enclosure. The non-modal interplate microwave applicator is configured to receive therein a load to be heated by microwaves radiated from the non-modal interplate microwave applicator.

    Abstract translation: 公开了一种微波加热器和加热方法。 微波加热器包括非模态板间微波施加器，并且可以包括非共振外壳。 非模态板间微波施加器被构造成在其中容纳由非模态板间微波施加器辐射的微波加热的负载。

    Immunohistochemistry detection method
    48.
    发明授权
    Immunohistochemistry detection method 有权
    免疫组化检测方法

    公开(公告)号：US09340824B2

    公开(公告)日：2016-05-17

    申请号：US14251934

    申请日：2014-04-14

    Applicant: Dako Denmark A/S

    Inventor： Lars Winther ,  Jesper Lohse ,  Susanne Gabs ,  Kenneth Heesche Petersen

    IPC: C07H21/04 ,  C12Q1/68 ,  A61K47/48 ,  A61K49/00 ,  C07H19/06 ,  C07H19/10 ,  C07H19/16 ,  C07H19/20 ,  C07H21/00 ,  C08G69/02 ,  C07C231/02 ,  C07C233/36 ,  G01N33/53

    CPC classification number: C12Q1/6804 ,  A61K47/61 ,  A61K47/6843 ,  A61K47/6889 ,  A61K49/0041 ,  A61K49/0043 ,  A61K49/0056 ,  C07C231/02 ,  C07C233/36 ,  C07H19/06 ,  C07H19/10 ,  C07H19/16 ,  C07H19/20 ,  C07H21/00 ,  C08G69/02 ,  C12Q1/6876 ,  G01N33/5306

    Abstract: The invention provides compositions and methods for the detection of targets in a sample; in particular, an immunohistochemistry (IHC) sample. Probes and detectable labels may be provided in multiple layers in order to increase the flexibility of a detection system, and to allow for amplification to enhance the signal from a target. The layers may be created by incorporating probes and detectable labels into larger molecular units that interact through nucleic acids base-pairing, including peptide-nucleic acid (PNA) base-pairing. Optional non-natural bases allow for degenerate base pairing schemes. The compositions and methods are compatible with immunohistochemistry (IHC), but also could be used in immunocytochemistry (ICC), in situ hybridization (ISH), flow cytometry, enzyme immuno-assays (EIA), enzyme linked immuno-assays (ELISA), blotting methods (e.g. Western, Southern, and Northern), labeling inside electrophoresis systems or on surfaces or arrays, and precipitation, among other general detection assay formats. The invention is also compatible with many different types of targets, probes, and detectable labels.

    Abstract translation: 本发明提供用于检测样品中靶标的组合物和方法; 特别是免疫组织化学（IHC）样品。 可以以多层提供探针和可检测标记，以便增加检测系统的灵活性，并允许放大以增强来自靶的信号。 可以通过将探针和可检测标记掺入通过核酸碱基配对（包括肽 - 核酸（PNA）碱基配对）相互作用的较大分子单元中来产生层。 可选的非天然碱基允许简并碱基配对方案。 组合物和方法与免疫组织化学（IHC）相容，但也可用于免疫细胞化学（ICC），原位杂交（ISH），流式细胞术，酶免疫分析（EIA），酶联免疫分析（ELISA） 印迹方法（如西方，南方和北方），电泳系统或表面或阵列内标记，以及其他一般检测方法中的沉淀。 本发明还与许多​​不同类型的靶，探针和可检测标记相兼容。

    SYSTEMS AND METHODS FOR ANALYZING WORKFLOW ASSOCIATED WITH A PATHOLOGY LABORATORY
    49.
    发明申请
    SYSTEMS AND METHODS FOR ANALYZING WORKFLOW ASSOCIATED WITH A PATHOLOGY LABORATORY 审中-公开

    公开(公告)号：US20150006195A1

    公开(公告)日：2015-01-01

    申请号：US14454116

    申请日：2014-08-07

    Applicant: DAKO DENMARK A/S

    Inventor： Flemming Juncker ,  Mats Grahn ,  Nihad Hasagic

    IPC: G06Q10/06 ,  G06F19/00 ,  G06Q40/00 ,  G06Q50/22

    CPC classification number: G06Q10/0633 ,  G06Q40/12 ,  G06Q50/22 ,  G16H10/40

    Abstract: A computer system for analyzing a specimen processing workflow in a pathology laboratory including a display and a processor configured to provide a first interface, a second interface, and a third interface to the display, receive, via the first interface, a first set of parameters associated with an existing specimen processing workflow in a pathology laboratory, the first set of parameters including a workflow process and a workflow scale, and determine, based on the first set of parameters, current performance data of the existing specimen processing workflow having an associated current cost information and current time utilization. The processor may further be configured to receive, via the second interface, a second set of parameters associated with a proposed modification to the existing specimen processing workflow, the second set of parameters including parameters associated with at least one laboratory device, determine, based on the first and second sets of parameters, revised performance data having an associated revised cost information and revised time utilization, and provide an output comprising a comparison between revised performance data and the current performance data.

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