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41.发明授权Omega 7 rich compositions and methods of isolating omega 7 fatty acids 有权富含Omega 7的丰富组合物和分离ω-7脂肪酸的方法公开(公告)号：US09200236B2
公开(公告)日：2015-12-01
申请号：US13680961
申请日：2012-11-19
Applicant: Heliae Development, LLC
Inventor： Sandip Shinde , Aniket Kale , Tom Kulaga , Jason D. Licamele , Anna Lee Tonkovich
IPC: A61K8/36 , A61K8/97 , C11B3/00 , C07C1/22 , C12P7/64 , C12N1/12 , A23D9/00 , A23D9/02 , A23K1/16 , C11B1/10 , C11B3/12 , C11B7/00 , C11C3/02 , A23L1/30 , C11C3/00 , C10L1/02 , A61Q19/00
CPC classification number: C11B3/001 , A23D9/00 , A23D9/02 , A23K20/158 , A23L33/12 , A61K8/361 , A61K8/9706 , A61Q19/00 , C07C1/22 , C10G2300/1014 , C10L1/026 , C11B1/10 , C11B3/006 , C11B3/12 , C11B7/00 , C11C3/00 , C11C3/003 , C11C3/02 , C12N1/12 , C12P7/6409 , Y02E50/13 , Y02P30/20
Abstract: Disclosed here are compositions rich in omega-7 fatty acids, including palmitoleic acid, and products rich in omega-7 fatty acids derived from algal biomass. The algae and/or compositions rich in omega-7 fatty acids may be used in products or as ingredients of products. Methods and systems for increasing the production or concentration of omega-7 fatty acids, and isolating omega-7 fatty acids from algal biomass are also disclosed herein.
Abstract translation: 这里公开的是富含ω-7脂肪酸的组合物，包括棕榈油酸和富含来自藻类生物质的ω-7脂肪酸的产物。 富含ω-7脂肪酸的藻类和/或组合物可用于产品或产品的成分。 本文还公开了用于增加ω-7脂肪酸的产生或浓度以及从藻类生物质分离ω-7脂肪酸的方法和系统。
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42.发明授权Direct transesterification of algal biomass for synthesis of fatty acid ethyl esters (FAEE) 有权用于合成脂肪酸乙酯（FAEE）的藻类生物质的直接酯交换公开(公告)号：US09187713B1
公开(公告)日：2015-11-17
申请号：US14804962
申请日：2015-07-21
Applicant: HELIAE DEVELOPMENT LLC
Inventor： Sandip Shinde
CPC classification number: C11C1/10 , C11B3/04 , C11B3/12 , C11C1/005 , C11C1/007 , C11C1/08 , C11C3/10
Abstract: Methods of producing fatty acid ethyl esters (FAEE) using a direct transesterification process are described. The direct transesterification process uses low levels of chemical solvents, acid catalysts, and heating energy to produce the FAEE in a method with increased efficiency in a co-solvent system. The FAEE produced may be used in a variety of products including health, beauty, nutraceutical, and cosmetic products.
Abstract translation: 描述了使用直接酯交换方法生产脂肪酸乙酯（FAEE）的方法。 直接酯交换方法使用低水平的化学溶剂，酸催化剂和加热能量，以在共溶剂系统中提高效率的方法产生FAEE。 所生产的FAEE可用于各种产品，包括健康，美容，营养保健品和化妆品。
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公开(公告)号：US09120987B2
公开(公告)日：2015-09-01
申请号：US13625483
申请日：2012-09-24
Applicant: Heliae Development, LLC
Inventor： Aniket Kale
IPC: B01D11/04 , C02F1/24 , C02F1/38 , C02F1/40 , C11B1/10 , C10L1/18 , C02F9/00 , C02F1/00 , C12P7/64
CPC classification number: C10L1/1802 , B01D11/0492 , C02F1/001 , C02F1/24 , C02F1/38 , C02F1/40 , C02F9/00 , C11B1/10 , C11B1/102 , C11B1/108 , C12P7/6463
Abstract: A method for separating neutral lipids from plant material, in particular, intact algal cells, using an amphipathic solvent set and a hydrophobic solvent set. Some embodiments include dewatering intact algal cells and then extracting neutral lipids from the algal cells. The methods provide for single and multistep extraction processes which allow for efficient separation of algal neutral lipids from a wet algal biomass while avoiding emulsification of extraction mixtures. The neutral lipids are removed after first removing a polar lipid fraction and a protein fraction. These neutral lipids can be used to generate renewable fuels as well as food products and supplements.
Abstract translation: 使用两亲性溶剂组和疏水性溶剂组从植物材料，特别是完整的藻类细胞中分离中性脂质的方法。 一些实施方案包括将完整的藻细胞脱水，然后从藻类细胞中提取中性脂质。 该方法提供单步和多步提取方法，其允许藻类中性脂质与湿藻类生物质的有效分离，同时避免提取混合物的乳化。 首先除去极性脂质部分和蛋白质级分后，除去中性脂质。 这些中性脂质可用于生产可再生燃料以及食品和补充剂。
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44.发明申请公开(公告)号：US20150118735A1
公开(公告)日：2015-04-30
申请号：US14585371
申请日：2014-12-30
Applicant: Heliae Development, LLC
Inventor： Eneko GANUZA , Anna Lee TONKOVICH , Jason D. LICAMELE
IPC: C12N1/12
Abstract: Methods of culturing microorganisms in non-axenic mixotrophic conditions are disclosed. A method of culturing microalgae mixotrophically and controlling bacterial contamination with an acetic acid/pH auxostat system is specifically described. Methods of culturing microalgae mixotrophically with an increased productivity through an increase in oxygen transfer to the culture, and controlling bacterial contamination with an oxidative agent are also described.
Abstract translation: 公开了在非旋转混合营养条件下培养微生物的方法。 具体描述了利用乙酸/ pH辅助促渗系统混合培养微藻并控制细菌污染的方法。 还描述了通过增加向培养物的氧转移以及用氧化剂控制细菌污染的方式，通过增加的生产力来混合培养微藻。
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公开(公告)号：US20140017759A1
公开(公告)日：2014-01-16
申请号：US13899873
申请日：2013-05-22
Applicant: Heliae Development, LLC
Inventor： Justin S. KNIEP , Aniket KALE
Abstract: Described herein are systems, methods, and apparatuses for aggregating microorganism in an aqueous suspension. In particular, are systems, methods, and apparatuses that apply an electrical field and/or acoustic energy to an aqueous suspension comprising microorganisms as the aqueous suspension follows a flow path to cause aggregation of the microorganisms. The electrical field may be continuous or pulsed. In some embodiments, the flow path for the aqueous suspension may vary.
Abstract translation: 本文描述了用于在水性悬浮液中聚集微生物的系统，方法和装置。 特别地，是当包含微生物的水性悬浮液伴随着流动路径引起微生物聚集时，将电场和/或声能施加到水性悬浮液的系统，方法和装置。 电场可以是连续的或脉冲的。 在一些实施方案中，水性悬浮液的流动路径可以变化。
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Patent Agency Ranking
公开(公告)号：US20140005422A1
公开(公告)日：2014-01-02
申请号：US13848479
申请日：2013-03-21
Applicant: Heliae Development, LLC
Inventor： Aniket KALE
IPC: C11B1/10
CPC classification number: C11B1/10 , B01D11/028 , B01D11/0288 , C10L2290/544 , C11B1/04 , C11B1/108 , C11C3/003 , C12N1/005 , Y02E50/10
Abstract: A method for separating neutral lipids from plant material, in particular, intact algal cells, using an amphipathic solvent set and a hydrophobic solvent set. Some embodiments include dewatering intact algal cells and then extracting neutral lipids from the algal cells. The methods provide for single and multistep extraction processes which allow for efficient separation of algal neutral lipids from a wet algal biomass while avoiding emulsification of extraction mixtures. These neutral lipids are high value products which can be used to generate renewable fuels.
Abstract translation: 使用两亲性溶剂组和疏水性溶剂组从植物材料，特别是完整的藻类细胞中分离中性脂质的方法。 一些实施方案包括将完整的藻细胞脱水，然后从藻类细胞中提取中性脂质。 该方法提供单步和多步提取方法，其允许藻类中性脂质与湿藻类生物质的有效分离，同时避免提取混合物的乳化。 这些中性脂质是可用于生产可再生燃料的高价值产品。
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47.发明申请公开(公告)号：US20130129775A1
公开(公告)日：2013-05-23
申请号：US13680961
申请日：2012-11-19
Applicant: Heliae Development, LLC
Inventor： Sandip SHINDE , Aniket KALE , Tom KULAGA , Jason D. LICAMELE , Anna Lee TONKOVICH
CPC classification number: C11B3/001 , A23D9/00 , A23D9/02 , A23K20/158 , A23L33/12 , A61K8/361 , A61K8/9706 , A61Q19/00 , C07C1/22 , C10G2300/1014 , C10L1/026 , C11B1/10 , C11B3/006 , C11B3/12 , C11B7/00 , C11C3/00 , C11C3/003 , C11C3/02 , C12N1/12 , C12P7/6409 , Y02E50/13 , Y02P30/20
Abstract: Disclosed here are compositions rich in omega-7 fatty acids, including palmitoleic acid, and products rich in omega-7 fatty acids derived from algal biomass. The algae and/or compositions rich in omega-7 fatty acids may be used in products or as ingredients of products. Methods and systems for increasing the production or concentration of omega-7 fatty acids, and isolating omega-7 fatty acids from algal biomass are also disclosed herein.
Abstract translation: 这里公开的是富含ω-7脂肪酸的组合物，包括棕榈油酸和富含来自藻类生物质的ω-7脂肪酸的产物。 富含ω-7脂肪酸的藻类和/或组合物可用于产品或产品的成分。 本文还公开了用于增加ω-7脂肪酸的产生或浓度以及从藻类生物质分离ω-7脂肪酸的方法和系统。
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公开(公告)号：US11771093B2
公开(公告)日：2023-10-03
申请号：US17838942
申请日：2022-06-13
Applicant: HELIAE DEVELOPMENT, LLC
Inventor： Sandip Shinde , Stephen Ventre , Nicholas Donowitz , Michael Rohlfsen , Laura Carney
CPC classification number: A01N65/03 , A01N63/00 , A01N65/00 , C12N1/12 , A01N65/03 , A01N25/00 , A01N65/03 , A01N63/20 , A01N63/22 , A01N63/25
Abstract: Liquid agricultural compositions comprising pasteurized Chlorella cells, as well as methods of preparation and use thereof, are disclosed. The compositions are formulated for application to a plant, seed, seedling, or soil and are effective in enhancing at least one plant characteristic including, but not limited to: seed germination, seedling emergence, seedling size, plant fresh weight, plant dry weight, utilization, leaf production, leaf formation, thatch height, plant maturation, plant yield, plant growth, plant quality, plant health, plant resistance to salt stress, plant resistance to heat stress, plant resistance to heavy-metal stress, plant resistance to drought, maturation time, yield, root length, root mass, color, fruit production, fruit yield, fruit growth, and fruit quality.
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公开(公告)号：US20220400723A1
公开(公告)日：2022-12-22
申请号：US17818772
申请日：2022-08-10
Applicant: HELIAE DEVELOPMENT, LLC
Inventor： Micheal LaMont , Magdalena Amezquita Ernult , Eneko Ganuza Taberna
IPC: A23L29/00 , C12N1/12 , C12P7/6409
Abstract: Disclosed are techniques and systems for producing microbials having anaplerotic oils that are rich in odd-chain fatty acids, and other beneficial components, at higher concentrations than those present in other natural dietary sources of OCFA, at lower cost, and higher production yield. Further, disclosed are examples of incorporation of these higher concentration OCFA products into food for human and non-human animal consumption.
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公开(公告)号：US20220159984A1
公开(公告)日：2022-05-26
申请号：US17531401
申请日：2021-11-19
Applicant: HELIAE DEVELOPMENT, LLC
Inventor： Magdalena Amezquita Ernult , Lawrence Johnson , Micheal J. LaMont , Eric Lichtenheld , Stephen Ventre , Yan Xu
Abstract: The present invention provides a method of preparing a defatted animal dairy product enriched with microbial anaplerotic oil and animal dairy products rich in odd-chain fatty acids for consumption by human and non-human animals. Also provided are animal dairy products rich in odd-chain fatty acids (OCFA) for consumption by human and non-human animals, the animal dairy product comprising defatted raw animal milk and microbial anaplerotic oil rich in OCFA.
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