公开(公告)号：US11248259B2

公开(公告)日：2022-02-15

申请号：US16317518

申请日：2017-07-12

Applicant: Imperial College of Science, Technology and Medicine

Inventor： Michael Levin ,  Myrsini Kaforou ,  Jethro A. Herberg ,  Victoria J. Wright ,  Lachlan J. M. Coin

IPC: C12Q1/68 ,  C12P19/34 ,  C12Q1/686 ,  C12Q1/6883 ,  C12Q1/6806 ,  C12Q1/6851 ,  C12Q1/689

Abstract: A method of identifying a subject having a bacterial infection, which includes discriminating said subject from a subject having a viral infection or an inflammatory disease. Also provided is a gene signature employed in the method and to a bespoke gene chip for use in the method. Further provided are probes and/or primers specific to genes in a signature of the present disclosure.

公开(公告)号：US20220010500A1

公开(公告)日：2022-01-13

申请号：US17293314

申请日：2019-11-13

Applicant: Imperial College of Science, Technology and Medicine

Inventor： Alalea Kia ,  Hong S. Wong ,  Christopher R. Cheeseman

IPC: E01C11/22 ,  E01C5/06

Abstract: Method of forming a cement-based material pad (3) comprising a plurality of drainage holes and forms for use in such a method.

公开(公告)号：US20210400980A1

公开(公告)日：2021-12-30

申请号：US17289677

申请日：2019-10-31

Applicant: Imperial College Innovations Limited

Inventor： Laura BARTER ,  Nicholas LONG ,  Jonathan RAINS ,  Rudiger WOSCHOLSKI

IPC: A01N55/02 ,  A01N43/52 ,  A01N43/78 ,  A01P21/00

Abstract: A method of promoting growth in a photosynthetic organism comprising treating the photosynthetic organism with a metal complex or a precursor thereof, wherein the metal complex comprises a metal selected from the group consisting of zinc (Zn), cobalt (Co), copper (Cu), nickel (Ni) and iron (Fe), and a ligand, which is a bidentate or tridentate ligand. Metal complexes and their ligands are also described.

公开(公告)号：US20210315509A1

公开(公告)日：2021-10-14

申请号：US17270361

申请日：2019-08-23

Applicant: Imperial College of Science, Technology and Medicine ,  University of Maribor

Inventor： Dario FARINA ,  Deren Yusuf BARSAKCIOGLU ,  Ales HOLOBAR

IPC: A61B5/395 ,  A61B5/397

Abstract: Surface electromyography signals of a nervous system are obtained; a separation matrix is generated based on electromyography signals obtained over a first time period using a training module; one or more motor neuron action potentials for single motor neurones are detected based on said electromyography signals and said separation matrix, wherein said electromyography signals are provided over a second time period shorter than said first time period; and an output is generated in the form of a time-series indicative of motor neuron activity.

公开(公告)号：US20210301393A1

公开(公告)日：2021-09-30

申请号：US17214092

申请日：2021-03-26

Applicant: Imperial College Innovations Limited

Inventor： Milo Sebastian Peter Shaffer ,  David Benbow Anthony

IPC: C23C16/26 ,  C23C16/02 ,  C23C16/44 ,  C01B32/16 ,  C01B32/162 ,  C23C16/455 ,  C23C16/50 ,  D06M11/74

Abstract: The present invention relates to a process for producing a carbon nanotube-grafted substrate, the process comprising: providing a substrate having catalytic material deposited thereon; and synthesising carbon nanotubes on the substrate by a chemical vapour deposition process in a reaction chamber; characterised in that the process comprises providing a counter electrode, applying a potential difference to the substrate in relation to the counter electrode and maintaining the potential difference of the substrate in relation to the counter electrode during the chemical vapour deposition process.

公开(公告)号：US20210291383A1

公开(公告)日：2021-09-23

申请号：US17260511

申请日：2019-07-29

Applicant: IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE

Inventor： Ferdinando Rodriguezy BAENA ,  Arnau Garriga CASANOVAS

IPC: B25J15/00 ,  B25J19/00 ,  B25J15/12

Abstract: A soft robotic manipulator adapted to be activated by a pressurised fluid having a first end, a second end, an outer wall and an axis, and comprising a plurality of segments extending co-axially along the manipulator, such that the outer wall of each segment forms part of the outer wall of the manipulator, each segment having a first end and a second end and an outer wall and further comprising a plurality of chambers contained within the outer wall, each of which chambers extends from the first end to the second end, wherein each manipulator segment further comprises a central element extending along the axis of the manipulator segment, and a plurality of partition walls extending from the central element to the outer wall, the chambers being defined by the partition walls and the outer wall, wherein the outer wall of the manipulator comprises the outer wall of each segment.

公开(公告)号：US20210277441A1

公开(公告)日：2021-09-09

申请号：US17253314

申请日：2019-06-19

Applicant: IMPERIAL COLLEGE INNOVATIONS LIMITED

Inventor： Lara Vidal ,  John Heap

IPC: C12Q1/32 ,  C12N9/04 ,  C12N9/06 ,  C12N9/02

Abstract: The invention relates to methods for identifying polypeptides and polynucleotides of interest, be they novel or variant polypeptides and polynucleotides, by expressing a plurality of polypeptides in an obligate or facultative anaerobe that is incapable of, or displays a reduction in, the oxidation of NADH and/or NADPH under anaerobic fermentation conditions and selecting an obligate or facultative anaerobe that grows or displays a growth advantage under said conditions. The invention is also concerned with novel enzymes per se, and their use in enzymatic production processes.

公开(公告)号：US20210251496A1

公开(公告)日：2021-08-19

申请号：US17169013

申请日：2021-02-05

Applicant: PHILIPS IMAGE GUIDED THERAPY CORPORATION ,  MEDSOLVE LIMITED ,  IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE

Inventor： Justin DAVIES ,  Joseph BURNETT ,  Neil HATTANGADI ,  David ANDERSON ,  Helen DAVIES

IPC: A61B5/02 ,  A61B34/10 ,  A61B5/00 ,  A61B5/0215

Abstract: Embodiments of the present disclosure are configured to assess the severity of a blockage in a vessel and, in particular, a stenosis in a blood vessel. In some particular embodiments, the devices, systems, and methods of the present disclosure are configured to assess the severity of a stenosis in the coronary arteries without the administration of a hyperemic agent.

公开(公告)号：US20210238667A1

公开(公告)日：2021-08-05

申请号：US16973415

申请日：2019-06-07

Applicant: IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE

Inventor： Pantelis GEORGIOU ,  Ling-Shan YU ,  Kenny Malpartida CARDENAS ,  Matthew C. FISHER ,  Jesus Rodriguez MANZANO ,  Nicolas MOSER

IPC: C12Q1/6858 ,  C12Q1/6876

Abstract: The present application relates to methods for detecting a first allele of a single nucleotide polymorphism (SNP) in a nucleic acid sequence under isothermal conditions using primers specific for said first allele, in particular using Loop mediated isothermal amplification (LAMP), wherein the amplification of a second allele is prevented by using blocking primers.

公开(公告)号：US20210233637A1

公开(公告)日：2021-07-29

申请号：US17050677

申请日：2019-04-24

Applicant: IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY & MEDICINE

Inventor： Pantelis GEORGIOU ,  Amparo GÜEMES

IPC: G16H20/17 ,  G16H20/30

Abstract: There is provided apparatus for controlling the delivery of insulin to a subject. The apparatus comprises a first input (18) for receiving neural information from the subject indicative of prospective or actual food and/or drink intake and a second input (15) for receiving a signal indicative of the subject's blood glucose level (BG). The apparatus further comprises a processor or processors (10) configured to determine food and/or drink characteristics based on the received neural information and to determine an amount of insulin to be delivered based on the measured blood glucose levels (BG) and the determined food and/or drink characteristics, and an output for providing an insulin pump control signal (12) indicative of the determined amount of insulin.