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41.发明申请Implantable Neural Interface Device with a Connector having a Slitted Deformable Section 有权具有可切割变形部分的连接器的可植入神经接口装置公开(公告)号：US20130184795A1
公开(公告)日：2013-07-18
申请号：US13741864
申请日：2013-01-15
Applicant: NeuroNexus Technologies, Inc.
Inventor： Daryl R. Kipke , Jamille Farraye Hetke , Rio J. Vetter , John P. Seymour
IPC: A61N1/05
CPC classification number: A61B5/0478 , A61B5/04001 , A61B5/686 , A61B5/6868 , A61B2562/187 , A61N1/05 , A61N1/0529 , A61N1/0539 , A61N1/0551 , A61N1/36
Abstract: An improved deformable carrier or connector for an implantable neural interface device is described. The neural interface device comprises a carrier supporting at least one electrode array. The carrier comprises a tubular sidewall extending from a proximal carrier portion to a distal carrier portion. At least one deformable segment is provided in the carrier sidewall. The deformable segment is more pliable than the remainder of the carrier sidewall to preferably move in response to forces imparted on the carrier and the electrode array by the shifting forces in body tissue. The deformable segment takes the form of a thinned sidewall segment or a slitted wall segment.
Abstract translation: 描述了用于可植入神经接口装置的改进的可变形载体或连接器。 神经接口装置包括支撑至少一个电极阵列的载体。 载体包括从近端载体部分延伸到远端载体部分的管状侧壁。 至少一个可变形段设置在承载器侧壁中。 可变形部分比载体侧壁的其余部分更柔韧，优选地响应于通过身体组织中的移动力施加在载体和电极阵列上的力而移动。 可变形段采取变薄的侧壁段或切开的壁段的形式。
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42.发明申请Implantable Electrode Lead System with a Three Dimensional Arrangement and Method of Making the Same 有权具有三维布置的可植入电极引线系统及其制造方法公开(公告)号：US20130137955A1
公开(公告)日：2013-05-30
申请号：US13750420
申请日：2013-01-25
Applicant: NeuroNexus Technologies, Inc.
Inventor： Kc Kong , Jamille Farraye Hetke , James A. Wiler , David S. Pellinen , Mayurachat Ning Gulari
CPC classification number: A61B5/04 , A61B5/04001 , A61B5/0492 , A61B5/685 , A61B2562/125 , A61B2562/166 , A61B2562/227 , A61M25/0147 , A61N1/05 , A61N1/0529 , A61N1/0534 , H05K1/00 , H05K1/147
Abstract: One embodiment of the invention includes an implantable electrode lead system that includes a series of shims stacked upon each other, a series of first components, and a series of second components connected to the series of first components through a series of connectors. One of the first components extends from one of the shims, and another of the first components extends from another one of the shims. The shims position the first components in a three dimensional arrangement.
Abstract translation: 本发明的一个实施例包括可植入电极引线系统，其包括彼此堆叠的一系列垫片，一系列第一部件和通过一系列连接器连接到该系列第一部件的一系列第二部件。 第一部件中的一个部件从其中一个垫片延伸，另一个部件从另一个垫片延伸。 垫片将第一部件置于三维布置中。
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公开(公告)号：US11096614B2
公开(公告)日：2021-08-24
申请号：US15999381
申请日：2018-08-20
Applicant: NeuroNexus Technologies, Inc.
Inventor： John P. Seymour
Abstract: A method for providing a neural interface system. At least one primary metallization layer is deposited on a substrate. The primary metallization layer has a thickness. A monolayer of nanospheres is deposited in a substantially uniform distribution. The nanospheres contact an upper surface of the primary metallization layer. The upper surface of the primary metallization layer not contacted by the nanospheres is treated to form a plurality of undulating structures having a substantially uniform arrangement. The treating comprises etching recesses part-way through the thickness of exposed portions of the primary metallization layer from the upper surface thereof.
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公开(公告)号：US10758727B2
公开(公告)日：2020-09-01
申请号：US15629852
申请日：2017-06-22
Inventor： Emil Toader , Hubert Cécile François Martens , Michel Marcel Jose Decré , Franciscus Paulus Maria Budzelaar , Pieter Gerrit Blanken , David James Anderson
Abstract: A method and system are provided for determining a relation between stimulation settings for a brain stimulation probe and a corresponding V-field. The brain stimulation probe comprises multiple stimulation electrodes. The V-field is an electrical field in brain tissue surrounding the stimulation electrodes. The method comprises sequentially applying a test current to n stimulation electrodes, n being a number between 2 and the number of stimulation electrodes of the brain stimulation probe, for each test current at one of the n stimulation electrodes, measuring a resulting excitation voltage at m stimulation electrodes, m being a number between 2 and the number of stimulation electrodes of the brain stimulation probe, from the stimulation settings and the measured excitation voltages, deriving a coupling matrix, an element in the coupling matrix reflecting an amount of electrical impedance between two of the stimulation electrodes, and using the coupling matrix for determining the relation between the stimulation settings and the corresponding V-field.
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公开(公告)号：US10688298B2
公开(公告)日：2020-06-23
申请号：US15600877
申请日：2017-05-22
Applicant: NeuroNexus Technologies, Inc.
Inventor： David S. Pellinen , Mayurachat Ning Gulari , Jamille Farraye Hetke , David J. Anderson , Daryl R. Kipke , Rio J. Vetter
Abstract: An implantable electrode system of is disclosed that includes a conductive electrode layer, an interconnect coupled to the electrode layer, an insulator that insulates the interconnect, and an anchor that more securely fixes the electrode layer in place. This structure is particularly useful with the electrode layer being a neural interface that is configured to provide either a recording or stimulating function. A method for forming such an implantable electrode system includes forming an interconnect over a base layer, forming an anchoring structure over the base layer, depositing an insulating material layer over the interconnect structure and over the anchoring structure, exposing a portion of the interconnect structure, forming an electrode layer over the insulating layer, the electrode layer contacting the exposed portion of the interconnect structure.
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Patent Agency Ranking
公开(公告)号：US20200046239A1
公开(公告)日：2020-02-13
申请号：US16277334
申请日：2019-02-15
Applicant: Neuronexus Technologies, Inc.
Inventor： John P. Seymour , Jongeun Jeon , Nicholas Hewitt , Abeer Khurram
Abstract: An optical electrode having a plurality of electrodes, including a recording electrode having a roughened surface and an optical light source configured to emit light, wherein at least a portion of the light impinges on the recording electrode. Also disclosed are methods of producing an optical electrode and an opto-electronic neural interface system.
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公开(公告)号：US20190298993A1
公开(公告)日：2019-10-03
申请号：US16241230
申请日：2019-01-07
Applicant: NeuroNexus Technologies, Inc.
Inventor： David S. Pellinen , Bencharong Suwarato , Rio J. Vetter , Jamille Farraye Hetke , Daryl R. Kipke
Abstract: A neural probe comprising an array of stimulation and/or recording electrodes supported on a tape spring-type carrier is described. The neural probe comprising the tape spring-type carrier is used to insert flexible electrode arrays straight into tissue, or to insert them off-axis from the initial penetration of a guide tube. Importantly, the neural probe is not rigid, but has a degree of stiffness provided by the tape spring-type carrier that maintains a desired trajectory into body tissue, but will subsequently allow the probe to flex and move in unison with movement of the body tissue.
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公开(公告)号：US20180353753A1
公开(公告)日：2018-12-13
申请号：US16002992
申请日：2018-06-07
Applicant: NeuroNexus Technologies, Inc.
Inventor： Rio J. Vetter , Peter Gerow , David S. Pellinen , Carlos Rackham , Daryl R. Kipke , Jamille F. Hetke
CPC classification number: A61N1/0553 , A61B5/04001 , A61B5/0422 , A61B5/6869 , A61B5/6883 , A61B2562/0209 , A61B2562/046 , A61B2562/164 , A61B2562/166 , A61B2562/222 , A61N1/0558 , A61N1/059 , A61N1/0597 , A61N1/36114
Abstract: A medical electrode array system comprising a thin-film substrate, a plurality of electrode contacts disposed on the thin-film substrate, and a plurality of traces. The plurality of electrode contacts is configured to provide electrical contact points. The plurality of traces is electrically connected to the plurality of electrode contacts. A electrode contact of the plurality of electrode contacts has a dedicated trace of the plurality of traces that provides electrical connectivity to the electrode contact. The thin-film substrate is configured to flex to maintain continuous contact with contours of patient anatomy. The plurality of traces includes flexible spring-like portions to add flexibility to the thin-film substrate.
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公开(公告)号：US10118030B2
公开(公告)日：2018-11-06
申请号：US14519346
申请日：2014-10-21
Applicant: NeuroNexus Technologies, Inc.
Inventor： David S. Pellinen , Bencharong Suwarato , Rio J. Vetter , Jamille Farraye Hetke , Daryl R. Kipke
Abstract: A neural probe system having a single guide tube that is inserted into neural tissue and from which a number of neural probes can be deployed is described. Each probe is deployable into tissue along a desired trajectory. This is done by supporting the electrode array on a spring tape-type carrier that maintains axial stiffness once the neural probe has deployed out a channel in the guide tube. That way, a target neural tissue is bounded by an increased number of neural probes while minimizing trauma to surrounding body tissue.
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公开(公告)号：US20170281947A1
公开(公告)日：2017-10-05
申请号：US15629852
申请日：2017-06-22
Inventor： Emil Toader , Hubert Cécile François Martens , Michel Marcel Jose Decré , Franciscus Paulus Maria Budzelaar , Pieter Gerrit Blanken , David James Anderson
CPC classification number: A61N1/36139 , A61N1/00 , A61N1/0534 , A61N1/36185
Abstract: A method and system are provided for determining a relation between stimulation settings for a brain stimulation probe and a corresponding V-field. The brain stimulation probe comprises multiple stimulation electrodes. The V-field is an electrical field in brain tissue surrounding the stimulation electrodes. The method comprises sequentially applying a test current to n stimulation electrodes, n being a number between 2 and the number of stimulation electrodes of the brain stimulation probe, for each test current at one of the n stimulation electrodes, measuring a resulting excitation voltage at m stimulation electrodes, m being a number between 2 and the number of stimulation electrodes of the brain stimulation probe, from the stimulation settings and the measured excitation voltages, deriving a coupling matrix, an element in the coupling matrix reflecting an amount of electrical impedance between two of the stimulation electrodes, and using the coupling matrix for determining the relation between the stimulation settings and the corresponding V-field.
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