公开(公告)号：US07063089B2

公开(公告)日：2006-06-20

申请号：US10629490

申请日：2003-07-29

Applicant: Mark B. Knudson ,  Timothy R. Conrad ,  Jerry C. Griffin

Inventor： Mark B. Knudson ,  Timothy R. Conrad ,  Jerry C. Griffin

IPC: A61B19/00

CPC classification number: A61F5/566

Abstract: A method and apparatus for treating snoring of a patient includes providing an implant for altering a dynamic response of a soft palate of the patient to airflow past the soft palate. The implant is embedded in the soft palate to alter the dynamic response. For example, the implant has a mass, stiffness or dampening sufficient to alter the dynamic response following the implantation without substantially impairing a function of the soft palate to close a nasal passage of the patient during swallowing.

Abstract translation: 用于治疗患者打鼾的方法和装置包括提供植入物，用于改变患者的软腭的动态响应以使气流通过软腭。 植入物嵌入软腭以改变动态反应。 例如，植入物具有足以改变植入后的动态响应的质量，刚度或阻尼，而基本上不会损伤软腭在吞咽期间关闭患者鼻通道的功能。

公开(公告)号：US07017582B2

公开(公告)日：2006-03-28

申请号：US10237149

申请日：2002-09-06

Applicant: Anja K. Metzger ,  Brian J. Erickson ,  John P. Sopp ,  Mark B. Knudson ,  Timothy R. Conrad

Inventor： Anja K. Metzger ,  Brian J. Erickson ,  John P. Sopp ,  Mark B. Knudson ,  Timothy R. Conrad

IPC: A61F13/00

CPC classification number: A61F5/56 ,  A61F2/04 ,  A61F2/20 ,  A61F2002/046 ,  A61M31/002 ,  A61M37/00

Abstract: A pharyngeal airway having a pharyngeal wall of a patient at least partially surrounding and defining the airway is treated by selecting an implant dimensioned so as to be implanted at or beneath a mucosal layer of the pharyngeal wall and extending transverse to said wall. The implant has mechanical characteristics for the implant, at least in combination with a fibrotic tissue response induced by the implant, to stiffen said pharyngeal wall to resist radial collapse. The implant is implanted into the pharyngeal wall transverse to a longitudinal axis of the airway.

公开(公告)号：US06860851B2

公开(公告)日：2005-03-01

申请号：US10306872

申请日：2002-11-27

Applicant: Mark B. Knudson ,  Timothy R. Conrad ,  Katherine S. Tweden

Inventor： Mark B. Knudson ,  Timothy R. Conrad ,  Katherine S. Tweden

IPC: A61B5/00

CPC classification number: A61B5/14546 ,  A61B5/14503 ,  A61B5/14539 ,  A61B5/1459 ,  A61B5/1473

Abstract: Vulnerable plaque is identified through a diagnostic method by identifying pathologic markers such as C-reactive proteins or pH change generated by the pathologic site. First and second detectors are advanced through a blood vessel with each of the detectors selected to detect the pathological marker. The detectors are spaced apart while seeking the marker. Differential concentration of the pathological marker as measured by the first and second detectors indicates a presence of the pathological site in proximity to at least one of the detectors.

Abstract translation: 通过诊断方法通过鉴定病理标志物如C反应蛋白或由病理部位产生的pH变化来鉴定易感斑。 第一和第二检测器通过血管前进，每个检测器被选择以检测病理学标记。 检测器在寻找标记物时间隔开。 通过第一和第二检测器测量的病理标志物的差异浓度表明在至少一个检测器附近存在病理部位。

公开(公告)号：US06626181B2

公开(公告)日：2003-09-30

申请号：US09872545

申请日：2001-06-01

Applicant: Mark B. Knudson ,  Timothy R. Conrad ,  Jerry C. Griffin

Inventor： Mark B. Knudson ,  Timothy R. Conrad ,  Jerry C. Griffin

IPC: A61B1900

CPC classification number: A61F5/566

Abstract: A method and apparatus for treating snoring of a patient includes providing an implant for altering a dynamic response of a soft palate of the patient to airflow past the soft palate. The implant is embedded in the soft palate to alter the dynamic response. For example, the implant has a mass, stiffness or dampening sufficient to alter the dynamic response following the implantation without substantially impairing a function of the soft palate to close a nasal passage of the patient during swallowing.

Abstract translation: 用于治疗患者打鼾的方法和装置包括提供植入物，用于改变患者的软腭的动态响应以使气流通过软腭。 植入物嵌入软腭以改变动态反应。 例如，植入物具有足以改变植入后的动态响应的质量，刚度或阻尼，而基本上不会损伤软腭在吞咽期间关闭患者鼻通道的功能。

公开(公告)号：US06513531B2

公开(公告)日：2003-02-04

申请号：US09814460

申请日：2001-03-21

Applicant: Mark B. Knudson ,  Timothy R. Conrad

Inventor： Mark B. Knudson ,  Timothy R. Conrad

IPC: A61B1900

CPC classification number: A61F2/00 ,  A61F2/0059 ,  A61F5/566

Abstract: A treatment for treating snoring of a patient attributable at least in part to motion of a soft palate of the patient includes forming a scar in the interior of the soft palate and extending in a direction toward the distal end of the soft palate with the scar limited to a proximal two-thirds of the soft palate

Abstract translation: 用于治疗至少部分地归因于患者的软腭运动的患者的打鼾的治疗包括在软腭内部形成瘢痕并且沿着具有瘢痕限制的朝向软腭远端的方向延伸 到近端三分之二的软腭

公开(公告)号：US06431174B1

公开(公告)日：2002-08-13

申请号：US09636803

申请日：2000-08-10

Applicant: Mark B. Knudson ,  Katherine S. Tweden ,  Timothy R. Conrad

Inventor： Mark B. Knudson ,  Katherine S. Tweden ,  Timothy R. Conrad

IPC: A61B1900

CPC classification number: A61F5/56 ,  A61F2/0059

Abstract: A patient's upper airway condition such as snoring and sleep apnea is treated by selecting a particulate material selected for limited migration within tissue and for encouraging a fibrotic response of tissue to the material. A bolus of the particulate material is injected into the tissue area to structurally stiffen the tissue.

Abstract translation: 患者的上呼吸道状况如打鼾和睡眠呼吸暂停通过选择在组织内选择用于有限迁移的颗粒材料并促进组织对该材料的纤维化反应来治疗。 将大量颗粒材料注入组织区域以使组织结构变硬。

公开(公告)号：US06401717B1

公开(公告)日：2002-06-11

申请号：US09434653

申请日：1999-11-05

Applicant: Timothy R. Conrad ,  Mark B. Knudson ,  Jerry C. Griffin

Inventor： Timothy R. Conrad ,  Mark B. Knudson ,  Jerry C. Griffin

IPC: A61B1900

CPC classification number: A61F5/566

Abstract: A method and apparatus for treating snoring of a patient includes providing an implant for altering a dynamic response of a soft palate of the patient to airflow past the soft palate. The implant is embedded in the soft palate to alter the dynamic response. For example, the implant has a mass, stiffness or dampening sufficient to alter the dynamic response following the implantation without substantially impairing a function of the soft palate to close a nasal passage of the patient during swallowing.

Abstract translation: 用于治疗患者打鼾的方法和装置包括提供植入物，用于改变患者的软腭的动态响应以使气流通过软腭。 植入物嵌入软腭以改变动态反应。 例如，植入物具有足以改变植入后的动态响应的质量，刚度或阻尼，而基本上不会损伤软腭在吞咽期间关闭患者鼻通道的功能。

公开(公告)号：US08617095B2

公开(公告)日：2013-12-31

申请号：US12898178

申请日：2010-10-05

Applicant: Mark B. Knudson ,  Timothy R. Conrad

Inventor： Mark B. Knudson ,  Timothy R. Conrad

IPC: A61M5/00

CPC classification number: A61F2/04 ,  A61F5/0003 ,  A61F2002/044

Abstract: A method and apparatus for treating a patient's health condition by diverting pancreatic exocrine secretions include a flow diverter of material compatible with chronic residence within a small intestine of the patient. The flow diverter has a cover end and a discharge end. The flow diverter is sized to be placed within the small intestine with the discharge end placed distally from said cover end and with said flow diverter further sized so permit passage of chyme through the small intestine and past the flow diverter. The cover end is sized to cover a discharge papilla of the pancreatic duct. The diverter is adapted to divert at least a portion of pancreatic exocrine secretion from the papilla to the distal discharge end.

Abstract translation: 通过转移胰腺外分泌分泌物治疗患者的健康状况的方法和装置包括与患者的小肠内的慢性住院相容的材料的分流器。 分流器具有盖端和排出端。 流量分配器的尺寸设置成放置在小肠内，排出端从所述盖端向远侧放置，并且所述分流器进一步尺寸使得食道通过小肠并经过分流器。 盖端的尺寸设置成覆盖胰管的排出乳头。 分流器适于将至少一部分胰腺外分泌分泌物从乳头转移到远端排出端。

公开(公告)号：US08424531B2

公开(公告)日：2013-04-23

申请号：US12798262

申请日：2010-03-30

Applicant: Mark B. Knudson ,  Timothy R. Conrad

Inventor： Mark B. Knudson ,  Timothy R. Conrad

IPC: A61F5/56

CPC classification number: A61F5/56 ,  A61F2/0077 ,  A61F2/20 ,  A61M31/002 ,  A61M37/00

Abstract: A patient's pharyngeal wall is treated by inserting an expander member into the airway and positioning an active portion of the expander member in opposition to portions of the pharyngeal wall to be treated. The expander member is activated to urge the wall portions outwardly to an outwardly displaced position. The expander member is then deactivated while leaving the wall portions in the outwardly placed position and the expander member is removed from said airway. A further aspect of the treatment includes stabilization of at least a portion of the pharyngeal wall after compression of portions of the wall.

公开(公告)号：US08037885B2

公开(公告)日：2011-10-18

申请号：US11179184

申请日：2005-07-12

Applicant: Anja K. Metzger ,  Brian J. Erickson ,  John P. Sopp ,  Mark B. Knudson ,  Timothy R. Conrad

Inventor： Anja K. Metzger ,  Brian J. Erickson ,  John P. Sopp ,  Mark B. Knudson ,  Timothy R. Conrad

IPC: A61F5/56

CPC classification number: A61F5/56 ,  A61F2/04 ,  A61F2/20 ,  A61F2002/046 ,  A61M31/002 ,  A61M37/00

Abstract: A pharyngeal airway having a pharyngeal wall of a patient at least partially surrounding and defining the airway is treated by selecting an implant dimensioned so as to be implanted at or beneath a mucosal layer of the pharyngeal wall and extending transverse to said wall. The implant has mechanical characteristics for the implant, at least in combination with a fibrotic tissue response induced by the implant, to stiffen said pharyngeal wall to resist radial collapse. The implant is implanted into the pharyngeal wall transverse to a longitudinal axis of the airway.

Abstract translation: 具有至少部分地围绕和限定气道的患者的咽壁的咽气道通过选择尺寸设置成植入在咽壁的粘膜层上或下方并且横向于所述壁延伸的植入物来治疗。 植入物具有用于植入物的机械特征，至少与由植入物引起的纤维化组织反应相结合，以加强所述咽壁以抵抗径向塌陷。 将植入物植入到垂直于气道纵轴的咽壁中。