公开(公告)号：US20220323739A1

公开(公告)日：2022-10-13

申请号：US17850174

申请日：2022-06-27

Applicant: University of Iowa Research Foundation

Inventor： Steven Richard Mickelsen

IPC: A61M39/10 ,  A61B5/0538 ,  A61B5/00 ,  A61B18/14 ,  A61B18/12 ,  A61M25/01 ,  A61M25/06 ,  A61B34/00 ,  A61M25/09

Abstract: A percutaneous catheter system for use within the human body and an ablation catheter for ablating a selected tissue region within the body of a subject. The percutaneous catheter system can include two catheters that are operatively coupled to one another by magnetic coupling through a tissue structure. The ablation catheter can include electrodes positioned within a central portion. The ablation catheter is positioned such that the central portion of a flexible shaft at least partially surrounds the selected tissue region. Each electrode of the ablation catheter can be activated independently to apply ablative energy to the selected tissue region. The ablation catheter can employ high impedance structures to change the current density at specific points. Methods of puncturing through a tissue structure using the percutaneous catheter system are disclosed. Also disclosed are methods for ablating a selected tissue region using the ablation catheter.

公开(公告)号：US20220280535A1

公开(公告)日：2022-09-08

申请号：US17321923

申请日：2021-05-17

Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION ,  THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS

Inventor： Christopher M. ADAMS ,  Steven D. KUNKEL ,  Michael WELSH

IPC: A61K31/58 ,  A61K31/215 ,  A61K31/352 ,  A61K31/36 ,  A61K31/382 ,  A61K31/404 ,  A61K31/4164 ,  A61K31/4166 ,  A61K31/4355 ,  A61K31/4365 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/438 ,  A61K31/4706 ,  A61K31/56 ,  G01N33/50 ,  A61K31/353 ,  A61K31/407 ,  A61K31/435 ,  A61K31/473 ,  A61K31/565 ,  C12Q1/6809 ,  A61K31/436

Abstract: The invention provides a method for (a) increasing skeletal muscle mass; (b) reducing skeletal muscle atrophy; (c) increasing muscular strength; (d) promoting muscle growth; (e) decreasing muscle wasting; or (f) increasing strength per unit of muscle mass in an animal identified or having been identified to be in need of one or more of (a)-(f), the method comprising administering to the animal an effective amount of a compound of formula: or a stereoisomer, solvate, or pharmaceutically acceptable salt thereof, thereby accomplishing one or more of (a)-(f).

公开(公告)号：US20220241436A1

公开(公告)日：2022-08-04

申请号：US17603831

申请日：2020-04-15

Applicant: University of Iowa Research Foundation ,  Spirovant Sciences, Inc.

Inventor： John F. Engelhardt ,  Ziying Yan ,  Yinghua Tang ,  Eric Yuen ,  Shen Lin

IPC: A61K48/00 ,  C12N15/86

Abstract: Provided herein are polynucleotides, rAAV vectors, pharmaceutical compositions, and methods of making and using the same, e.g., for treatment of cystic fibrosis (CF). For example, the disclosure provides a recombinant adeno-associated vims (rAAV) that includes, in one embodiment, an AV.TL65 capsid protein and a polynucleotide that includes an F5 enhancer and a tg83 promoter operably linked to a CFTRΔR minigene, pharmaceutical compositions thereof, and methods of use thereof, e.g., for treatment of CF.

公开(公告)号：US20220154213A1

公开(公告)日：2022-05-19

申请号：US17470560

申请日：2021-09-09

Applicant: University of Iowa Research Foundation ,  University of Kansas

Inventor： Ziying Yan ,  John F. Engelhardt ,  Jianming Qiu ,  Zekun Wang

IPC: C12N15/86 ,  A61P31/20 ,  A61K39/23 ,  C12N7/00

Abstract: Vectors having a nucleotide sequence having SEQ ID NO:1 or a nucleotide sequence having at least 85% identity to SEQ ID NO:1, or a portion thereof, that is capable of regulating bocaparvovirus replication, or vectors having the complement of the nucleotide sequence, and methods of using the vectors, are provided.

公开(公告)号：US11325967B2

公开(公告)日：2022-05-10

申请号：US16388184

申请日：2019-04-18

Applicant: H. LUNDBECK A/S ,  THE UNIVERSITY OF IOWA RESEARCH FOUNDATION

Inventor： Andrew F. Russo ,  Eric A. Kaiser ,  Ana Recober ,  Adisa Kuburas ,  Ann C. Raddant ,  Brian R. Kovacevich ,  John Latham ,  Jeffrey T. L. Smith ,  Leon F. Garcia-Martinez

IPC: C07K16/18 ,  A61K39/00

Abstract: The present invention is directed to methods of inhibiting or preventing photophobia in subjects in need thereof using anti-CGRP antibodies or antibody fragments that inhibit photophobia, especially CGRP-associated photophobia. These antibodies and fragments are useful in treating different disorders associated with photophobia such as migraine, cluster headaches and the like.
The present invention also provides assays using transgenic Nestin/Ramp1 rodents, utilizing a CGRP model light aversive behavior model for identifying therapeutically effective anti-CGRP antibodies and fragments thereof having binding specificity for CGRP which inhibit or prevent photophobia in subjects in need thereof. The present invention is specifically directed to methods for identifying therapeutically effective antibodies and fragments thereof having binding specificity for CGRP that may be used to treat CGRP associated disorders such as migraine. Specifically, this invention relates to assays and therapies using the antibodies described herein to inhibit or prevent photophobia, and binding fragments thereof, comprising the sequences of the VH, VL and CDR polypeptides described herein, and the polynucleotides encoding them.

公开(公告)号：US11307314B2

公开(公告)日：2022-04-19

申请号：US16061533

申请日：2016-12-20

Applicant: University of Iowa Research Foundation

Inventor： Ugur Akgun ,  Yasar Onel

IPC: G01T1/203 ,  C09K11/02 ,  C09K11/06 ,  G01T1/20

Abstract: A scintillating material that is a radiation hardened plastic and flexible elastomer is disclosed. The material is useful in a wide range of high energy particle environments and can be used to create detectors. Such detectors can be used in physics experiments or in medical treatment or imaging. The scintillator can be radiation hardened so as to allow for an extended lifetime over other materials.

公开(公告)号：US20220093823A1

公开(公告)日：2022-03-24

申请号：US17539260

申请日：2021-12-01

Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION

Inventor： JOHN P. PRINEAS ,  DENNIS NORTON ,  THOMAS F. BOGGESS ,  RUSSELL J. RICKER

IPC: H01L33/06 ,  H01L33/30 ,  H01L33/00

Abstract: A method and a device for cascading broadband emission is described. The device may comprise a substrate, a bottom contact layer above at least a portion of the substrate, and a plurality of emission regions above the bottom contact layer. The plurality of emission regions may be disposed one above another. Each of the plurality of emission regions may be configured with different respective bandgaps to emit radiation of different wavelengths. The device may comprise a plurality of tunnel junctions and a top contact layer above the plurality of emission regions. The plurality of emission regions may comprise a W-superlattice comprising an electron-well layer, a hole-well layer and an electron confinement layer. Semiconductor layers of the W-superlattice may include AlAsSb, InAs, InGaSb, and InAs. Exemplary embodiments of the W-superlattice may comprise a W-quantum well.

公开(公告)号：US20210401562A1

公开(公告)日：2021-12-30

申请号：US17360808

申请日：2021-06-28

Applicant: University of Iowa Research Foundation

Inventor： Syed M. A. Muqsit Hashmi ,  Leela Raghava Jaidev Chakka ,  Aliasger K. Salem

IPC: A61F2/00 ,  A61F2/14 ,  A01N1/02

Abstract: A Descemet Membrane Endothelial Keratoplasty (DMEK) holder for placement within a vial for supporting a corneal tissue inserter is provided. The DMEK holder includes a top and an opposite bottom, at least one support member extending between the top and the bottom, with a bottom portion of the at least one support member sized and shaped to fit against a bottom inner surface of the vial to thereby support the corneal tissue inserter within the vial, and a first annular member having an opening sized and shaped such that a bottom end of the corneal tissue inserter is insertable through the opening and the first annular member separates the corneal tissue inserter from an inner surface of the vial and positions the corneal tissue inserter within the vial away from inner surfaces of the vial to thereby improve retrieval of the corneal tissue inserter by a surgeon.

公开(公告)号：US20210369742A1

公开(公告)日：2021-12-02

申请号：US17331366

申请日：2021-05-26

Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION

Inventor： Anil Chauhan ,  Manasa K. Nayak

IPC: A61K31/63 ,  A61K31/5025 ,  A61K45/06 ,  A61P7/02

Abstract: The present invention provides in certain embodiments methods of inhibiting platelet function or thrombosis, inhibiting pyruvate kinase M2 (PKM2) dimerization, and/or treating a disease associated with thrombosis by administering a composition comprising a dimeric pyruvate kinase M2 (PKM2) inhibitor in a patient in need thereof.

公开(公告)号：US11155882B2

公开(公告)日：2021-10-26

申请号：US16794677

申请日：2020-02-19

Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION

Inventor： James O. McNamara ,  Katie R. Flenker ,  Hyeon Kim ,  Alexander R. Howswill ,  Frank J. Hernandez ,  Mark Behlke ,  Lingyan Huang ,  Richard Owczarzy ,  Elliott Burghardt ,  Karen Clark

IPC: C12Q1/689 ,  C07H21/00 ,  C07H21/02 ,  C07H21/04 ,  A61K49/00 ,  C12Q1/70 ,  G01N21/64 ,  G01N33/58

Abstract: The present invention relates to a rapid detection of microbial-associated nuclease activity with chemically modified nuclease (e.g., endonuclease) substrates, and probes and compositions useful in detection assays.