N-Myc-Interactor protein as a marker for chronic lung disease and uses thereof

    公开(公告)号:US11851707B1

    公开(公告)日:2023-12-26

    申请号:US17215249

    申请日:2021-03-29

    Abstract: A method of predicting the development of chronic lung allograft dysfunction (CLAD) in lung transplant patients using N-myc-interactor (NMI) as a biomarker and associated treatment thereof is presented. Also presented is a method of reducing the risk of CLAD by administering a therapeutic agent capable of increasing NMI in the patient. NMI is a critical regulator of epithelial-to-mesenchymal transition (EMT) and an important precursor to development of CLAD. NMI expression is reduced in CLAD patients and can be used as an early diagnostic biomarker to predict the development of CLAD. NMI can also be used as a drug target for a therapeutic to increase expression of NMI and treat chronic lung disease such as CLAD. Therapeutics comprising NMI protein or NMI gene can be used as potential treatments for chronic lung diseases such as CLAD.

    Systems and methods for generating tactile 3D maps

    公开(公告)号:US11840107B1

    公开(公告)日:2023-12-12

    申请号:US17202045

    申请日:2021-03-15

    CPC classification number: B41M3/16 B33Y50/02 B33Y80/00 G06T11/203 G06T17/20

    Abstract: A method for generating three dimensional indicators for the visually impaired. The method includes selecting one or more pre-designed symbols from a plurality of pre-designed symbols. The pre-designed symbols represent standard building layout features and are sized to be readable via a physical touch. The method further includes inserting the one or more selected symbols into a two dimensional digital layout, and generating one or more of an orientation object and a legend object into the two dimensional digital layout. The method further includes converting the two dimensional digital layout into a three dimensional digital model, and generating an output file including the three dimensional model in a format compatible with a three dimensional printing device.

    SYSTEMS AND METHODS FOR PREDICTIVE SAFETY ASSESSMENT

    公开(公告)号:US20230394962A1

    公开(公告)日:2023-12-07

    申请号:US18034369

    申请日:2021-10-28

    Inventor: Mouyid ISLAM

    CPC classification number: G08G1/0137 G08G1/0125 G08G1/164

    Abstract: A method for generating a predictive safety assessment of at least one existing facility and at least one proposed facility includes obtaining data about an existing facility and each proposed facility, receiving user input data regarding local conditions for the existing facility and each proposed facility, determining a predicted crash frequency for the existing facility and each proposed facility based at least on a set of Safety Performance Function (SPFs) associated with a facility type for the existing facility and each proposed facility respectively, determining a conversion factor for each proposed facility based on the predicted crash frequency of the existing facility and the predicted crash frequency of each proposed facility, determining a crash severity distribution by crash types, determining an impact of local traffic volume for each proposed facility, and generating a user interface to render a graphical representation of at least each conversion factor for each proposed facility.

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