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公开(公告)号：US11623078B2
公开(公告)日：2023-04-11
申请号：US17072392
申请日：2020-10-16
Applicant: ELECTROCORE, INC.
Inventor： Bruce J. Simon , Joseph P. Errico , John T. Raffle
Abstract: Devices and methods for non-invasive stimulation of nerves, such as the vagus nerve, include a housing and an electrode spaced from the housing. The electrode is configured to be positioned adjacent to, or in contact with, an outer skin surface of a patient. A source of energy is positioned within the housing and operably coupled to the electrode, either wirelessly or via a lead or other wired connection. The source of energy emits an electrical impulse to the electrode such that the electrical impulse passes through the outer skin surface of the patient to a nerve at a target region in the patient sufficient to modulate the nerve. The electrical impulse comprises bursts each with a frequency from about 1 Hz to about 100 Hz, wherein each of the bursts comprises 2 pulses to 20 pulses.
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公开(公告)号：US20230005626A1
公开(公告)日：2023-01-05
申请号：US17944131
申请日：2022-09-13
Applicant: ELECTROCORE, INC
Inventor： Joseph P. Errico , Bruce J. Simon , Peter Staats , Thomas Errico
Abstract: Systems and methods are provided for treating blood clots associated with a replicating pathogen, such as a virus in the coronaviridae family. The methods include emitting an electrical impulse near a vagus nerve within the patient sufficient to inhibit or reduce an inflammatory or allergic response in the patient, provide relief for bronchoconstriction that results in the tightening of airways and the inability to breath without ventilator support and/or lessen the abnormal blot clotting that develops in some patients. The systems and methods are particularly useful for treating post-COVID conditions or post-acute sequelae of COVID-19 that develop in “long-haul” or COVID patients.
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公开(公告)号：US11517742B2
公开(公告)日：2022-12-06
申请号：US16540476
申请日：2019-08-14
Applicant: ElectroCore, Inc.
Inventor： Bruce J. Simon , Joseph P. Errico , John T. Raffle
Abstract: Devices, systems and methods are disclosed for treating a variety of diseases and disorders that are primarily or at least partially driven by an imbalance in neurotransmitters in the brain, such as asthma, COPD, depression, anxiety, epilepsy, fibromyalgia, and the like. The invention involves the use of an energy source comprising magnetic and/or electrical energy that is transmitted non-invasively to, or in close proximity to, a selected nerve to temporarily stimulate, block and/or modulate the signals in the selected nerve such that neural pathways are activated to release inhibitory neurotransmitters in the patient's brain.
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公开(公告)号：US11439818B2
公开(公告)日：2022-09-13
申请号：US16599285
申请日：2019-10-11
Applicant: ElectroCore, Inc.
Inventor： Bruce J. Simon , Joseph P. Errico , John T. Raffle
Abstract: Devices, systems and methods are disclosed for treating or preventing gastroparesis, functional dyspepsia, and other functional gastrointestinal disorders. The devices comprise a housing and an energy source for generating an electric current and transmitting the electric current from the electrode through an interface and the outer skin surface of the patient to a selected nerve fiber within the patient as the interface contacts the outer skin surface. The electric current is sufficient to modulate the selected nerve fiber to at least one of treat or prevent at least one of gastroparesis, functional dyspepsia, or ileus in the patient.
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公开(公告)号：US20220266015A1
公开(公告)日：2022-08-25
申请号：US17694655
申请日：2022-03-14
Applicant: ELECTROCORE, INC
Inventor： Bruce J. Simon , Joseph P. Errico , John T. Raffle
Abstract: Devices, systems and methods for treating various disorders and medical conditions through noninvasive stimulation of a nerve. A system comprises a stimulator including an electrode configured to contact an outer skin surface of a patient and an energy source coupled to the housing, The energy source generates an electrical impulse and the stimulator transmits the electrical impulse from the electrode transcutaneously through an outer skin surface of the patient to a selected nerve within the patient. The system further includes an application on a mobile device that receives data from a remote source. The mobile device couples to the stimulator and the application causes the mobile device to transmit the data to the stimulator.
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Patent Agency Ranking
公开(公告)号：US20220088382A1
公开(公告)日：2022-03-24
申请号：US17542390
申请日：2021-12-04
Applicant: electroCore, Inc.
Inventor： Joseph P. Errico , Steven Mendez , Bruce J. Simon
Abstract: Devices, systems and methods are disclosed for treating seizures, such as epileptic seizures, by electrical non-invasive stimulation of a nerve, such as the vagus nerve. A stimulator comprises a contact surface, such as an electrode, for contacting an outer skin surface of a patient. The stimulator is configured for coupling to a mobile device configured to receive a wireless signal. The stimulator is configured to transmit the electrical impulse through the contact surface and the outer skin surface sufficient to modulate a nerve within a patient and to ameliorate one or more symptoms of a seizure in the patient.
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公开(公告)号：US20220062622A1
公开(公告)日：2022-03-03
申请号：US17491313
申请日：2021-09-30
Applicant: electroCore, Inc.
Inventor： J. P. Errico , Bruce J. Simon , Peter Staats
Abstract: Devices, systems and methods are provided for treating post-operative symptoms following major surgery and/or for treating patients in critical or intensive care. A method includes positioning a contact surface of a device in contact with an outer skin surface of patient and applying an electrical impulse transcutaneously from the device through the outer skin surface of the patient to a vagus nerve in the patient for about 60 seconds to about 5 minutes. The electrical impulse is sufficient to modify the vagus nerve such that the symptoms are reduced. A stimulation protocol is provided that includes two or more doses administered per day for a period of time sufficient to relieve the symptoms. The doses may be administered before and after the patient's surgery, or while the patient is being treating in intensive care.
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公开(公告)号：US20220023619A1
公开(公告)日：2022-01-27
申请号：US17402690
申请日：2021-08-16
Applicant: ELECTROCORE, INC
Inventor： Bruce J. Simon , Joseph P. Errico
Abstract: Devices, systems and methods are disclosed for electrical stimulation of the vagus nerve to treat or prevent symptoms of headache in a patient. The headache may include primary headache, such as migraine and cluster headache, or secondary headache resulting from an underlying medical condition, such as post-concussion headache. The methods comprise transmitting impulses of energy to the vagus nerve according to a treatment paradigm that includes single doses of between about 30 seconds to about 5 minutes. The electrical impulses may have a frequency of about 1 kHz to about 20 kHz.
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公开(公告)号：US20210402173A1
公开(公告)日：2021-12-30
申请号：US17472061
申请日：2021-09-10
Applicant: ElectroCore, Inc.
Inventor： Bruce J. Simon , Joseph P. Errico , John T. Raffle
Abstract: Methods and devices for stimulating a nerve in a patient include emitting an electrical signal near a spinal nerve within the patient. The electrical signal is generated within the housing and comprises bursts of pulses. Each burst of pulses comprises a burst period and a constant period, Each burst period comprises 2 to 20 pulses and at least a portion of each constant period comprises zero pulses. At least one of the pulses has a duration of about 50 microseconds to about 1000 microseconds.
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公开(公告)号：US11141582B2
公开(公告)日：2021-10-12
申请号：US17010634
申请日：2020-09-02
Applicant: ElectroCore, Inc.
Inventor： Bruce J. Simon , Joseph P. Errico , John T. Raffle
Abstract: Methods and devices for stimulating a nerve in a patient include emitting an electrical signal near a spinal nerve within the patient such that the patient experiences at least some pain relief. The methods include varying an electric field such that burst periods and constant periods are created. The electric field has a charge that alternates between positive and negative during the burst periods and a charge with a magnitude of zero during the constant periods.
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