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    Drug delivery after biodegradation of the stent scaffolding
    43.
    发明授权
    Drug delivery after biodegradation of the stent scaffolding 有权
    支架支架生物降解后的药物输送

    公开(公告)号：US08398706B2

    公开(公告)日：2013-03-19

    申请号：US13086308

    申请日：2011-04-13

    Applicant: David C. Gale ,  Bin Huang

    Inventor： David C. Gale ,  Bin Huang

    IPC: A61F2/82

    CPC classification number: A61L31/10 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/41 ,  A61L2300/416 ,  C08L67/04

    Abstract: Disclosed herein is a stent comprising: a bioabsorbable polymeric scaffolding; and a coating comprising a bioabsorbable material on at least a portion of the scaffolding, wherein the degradation rate of all or substantially all of the bioabsorbable polymer of the scaffolding is faster than the degradation rate of all or substantially all of the bioabsorbable material of the coating.

    Abstract translation: 本文公开了一种支架，其包括：生物可吸收聚合物支架; 以及在所述支架的至少一部分上包含生物可吸收材料的涂层，其中所述脚手架的全部或基本上全部所述生物可吸收聚合物的降解速度比所述涂层的所有或基本上全部所述生物可吸收材料的降解速度快 。

    Implantable medical devices fabricated from polymer blends with star-block copolymers
    46.
    发明授权
    Implantable medical devices fabricated from polymer blends with star-block copolymers 有权
    由具有星形嵌段共聚物的聚合物共混物制成的可植入医疗器械

    公开(公告)号：US08262723B2

    公开(公告)日：2012-09-11

    申请号：US11784925

    申请日：2007-04-09

    Applicant: Yunbing Wang ,  David C. Gale ,  Bin Huang

    Inventor： Yunbing Wang ,  David C. Gale ,  Bin Huang

    IPC: A61F2/82

    CPC classification number: A61L27/48 ,  A61F2/91 ,  A61F2210/0004 ,  A61L27/58 ,  A61L31/041 ,  A61L31/148

    Abstract: Implantable medical devices are fabricated from polymer blends with star-block copolymers. The polymer blends include a biodegradable matrix polymer blended with a biodegradable star-block copolymer. The copolymer has at least three arms and the arms include inner segments and outer segments. The inner segments form a discrete phase within a continuous phase, the continuous phase including the matrix polymer and the outer segments. The segments can include units having acidic degradation products that enhance the degradation rate of the blend.

    Abstract translation: 可植入医疗器械由具有星形嵌段共聚物的聚合物共混物制成。 聚合物共混物包括与可生物降解的星形嵌段共聚物共混的可生物降解的基质聚合物。 共聚物具有至少三个臂，并且臂包括内部段和外部段。 内部段在连续相中形成离散相，连续相包括基质聚合物和外部链段。 这些链段可以包括具有增强共混物降解速率的酸性降解产物的单元。

    Method of fabricating an implantable medical device with biaxially oriented polymers
    47.
    发明授权
    Method of fabricating an implantable medical device with biaxially oriented polymers 有权
    用双轴取向聚合物制造可植入医疗器械的方法

    公开(公告)号：US08192678B2

    公开(公告)日：2012-06-05

    申请号：US12806785

    申请日：2010-08-19

    Applicant: Bin Huang ,  Stephen Schalble ,  David C. Gale

    Inventor： Bin Huang ,  Stephen Schalble ,  David C. Gale

    IPC: B29C49/04

    CPC classification number: A61F2/82 ,  A61F2/91 ,  A61F2002/825 ,  A61L31/148 ,  B23K2103/42 ,  B23K2103/50 ,  B29C47/0023 ,  B29C47/0057 ,  B29C47/24 ,  B29C49/786 ,  B29L2031/7534

    Abstract: Methods and systems for manufacturing an implantable medical device, such as a stent, from a tube with desirable mechanical properties, such as improved circumferential strength and rigidity, are described herein. Improved circumferential strength and rigidity may be obtained by inducing molecular orientation in materials for use in manufacturing an implantable medical device. Some embodiments may include inducing molecular orientation by expansion of a molten annular polymer film. Other embodiments may include inducing circumferential molecular orientation by inducing circumferential flow in a molten polymer. In certain embodiments, circumferential orientation may be induced by expansion of a polymer tube. Further embodiments may include manufacturing an implantable medical device from a biaxially oriented planar polymer film.

    Abstract translation: 本文描述了用于制造可植入医疗装置（例如支架）的方法和系统，其具有期望的机械性质（例如改善的周向强度和刚度）的管。 可以通过在用于制造可植入医疗装置的材料中诱导分子取向来获得改善的周向强度和刚性。 一些实施方案可以包括通过膨胀熔融的环状聚合物膜诱导分子取向。 其它实施方案可以包括通过诱导熔融聚合物中的周向流动来诱导圆周分子取向。 在某些实施方案中，可以通过聚合物管的膨胀来引起圆周取向。 另外的实施例可以包括从双轴取向的平面聚合物膜制造可植入医疗装置。

    RGD PEPTIDE ATTACHED TO BIOABSORBABLE STENTS
    49.
    发明申请
    RGD PEPTIDE ATTACHED TO BIOABSORBABLE STENTS 审中-公开
    RGD肽连接到生物可溶性STENTS

    公开(公告)号：US20120135131A1

    公开(公告)日：2012-05-31

    申请号：US13366235

    申请日：2012-02-03

    Applicant: David C. Gale ,  Bin Huang ,  Kleine Klaus

    Inventor： David C. Gale ,  Bin Huang ,  Kleine Klaus

    IPC: B05D7/00 ,  B05D5/00

    CPC classification number: A61L31/047 ,  A61L31/10 ,  C08L71/02

    Abstract: Provided herein is a method of forming medical device that includes RGD attached to the device via a spacer compound. The method comprises providing a spacer compound comprising a hydrophobic moiety and a hydrophilic moiety, grafting or embedding the spacer compound to the surface layer of the polymer to cause the hydrophobic moiety to be grafted to or embedded within the surface layer of polymer, and attaching a chemo-attractant to the hydrophilic moiety.

    Abstract translation: 本文提供了一种形成医疗装置的方法，其包括通过间隔物化合物附着到装置的RGD。 该方法包括提供包含疏水部分和亲水部分的间隔化合物，将间隔化合物接枝或嵌入聚合物的表面层，以使疏水部分接枝到或嵌入聚合物的表面层中， 化学引诱剂到亲水部分。

    RGD peptide attached to bioabsorbable stents
    50.
    发明授权
    RGD peptide attached to bioabsorbable stents 有权
    附着于生物可吸收支架的RGD肽

    公开(公告)号：US08118863B2

    公开(公告)日：2012-02-21

    申请号：US12035392

    申请日：2008-02-21

    Applicant: David C. Gale ,  Bin Huang ,  Kleine Klaus

    Inventor： David C. Gale ,  Bin Huang ,  Kleine Klaus

    IPC: A61F2/06

    CPC classification number: A61L31/047 ,  A61L31/10 ,  C08L71/02

    Abstract: Provided herein is a method of forming medical device that includes RGD attached to the device via a spacer compound. The method comprises providing a spacer compound comprising a hydrophobic moiety and a hydrophilic moiety, grafting or embedding the spacer compound to the surface layer of the polymer to cause the hydrophobic moiety to be grafted to or embedded within the surface layer of polymer, and attaching a chemo-attractant to the hydrophilic moiety.

    Abstract translation: 本文提供了一种形成医疗装置的方法，其包括通过间隔物化合物附着到装置的RGD。 该方法包括提供包含疏水部分和亲水部分的间隔化合物，将间隔化合物接枝或嵌入聚合物的表面层，以使疏水部分接枝到或嵌入聚合物的表面层中， 化学引诱剂到亲水部分。

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