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公开(公告)号：US20080233170A1
公开(公告)日：2008-09-25
申请号：US12038606
申请日：2008-02-27
Applicant: Hermann Oppermann , Engin Ozkaynak , Thangavel Kuberasampath , David C. Rueger , Roy H. L. Pang
Inventor： Hermann Oppermann , Engin Ozkaynak , Thangavel Kuberasampath , David C. Rueger , Roy H. L. Pang
CPC classification number: A61K38/1875
Abstract: Disclosed are (1) osteogenic devices comprising a matrix containing substantially pure natural-sourced mammalian osteogenic protein; (2) DNA and amino acid sequences for novel polypeptide chains useful as subunits of dimeric osteogenic proteins; (3) vectors carrying sequences encoding these novel polypeptide chains and host cells transfected with these vectors; (4) methods of producing these polypeptide chains using recombinant DNA technology; (5) antibodies specific for these novel polypeptide chains; (6) osteogenic devices comprising these recombinantly produced proteins in association with an appropriate carrier matrix; and (7) methods of using the osteogenic devices to mimic the natural course of endochondral bone formation in mammals.
Abstract translation: 公开的是（1）包含含有基本上纯天然来源的哺乳动物成骨蛋白质的基质的成骨装置; （2）可用作二聚成骨蛋白亚基的新型多肽链的DNA和氨基酸序列; （3）携带编码这些新型多肽链的序列的载体和用这些载体转染的宿主细胞; （4）使用重组DNA技术生产这些多肽链的方法; （5）对这些新型多肽链具有特异性的抗体; （6）包含这些重组产生的蛋白质与合适的载体基质相结合的成骨装置; 和（7）使用成骨装置来模拟哺乳动物软骨内骨形成的自然过程的方法。
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公开(公告)号：US20080179621A1
公开(公告)日：2008-07-31
申请号：US12009634
申请日：2008-01-18
Applicant: Hermann Oppermann , Julius Muschaweck , Jochen Kunze , Thomas Luce , Eike Krochmann , Walter Tews , Gundula Roth
Inventor： Hermann Oppermann , Julius Muschaweck , Jochen Kunze , Thomas Luce , Eike Krochmann , Walter Tews , Gundula Roth
CPC classification number: H01L33/58 , H01L33/20 , H01L33/507 , H01L33/641 , H01L2224/48091 , H01L2224/48227 , H01L2224/48471 , H01L2224/73265 , H01L2924/181 , H01L2924/00014 , H01L2924/00012
Abstract: A light-emitting semi-conductor diode comprising a light emitting chip at least partially surrounded by a transparent electronics protecting body on which a composite layer foil is disposed, the composite layer foil includes at its side facing away from the electronics protection body a carrier layer, which has a refraction index that is greater than the refraction index of the electronics protection body and, at the opposite side, an active layer of the same material of which the electronics protecting body consists.
Abstract translation: 一种发光半导体二极管，包括至少部分地被透明电子保护体围绕的发光芯片，所述透明电子保护体设置有复合层箔，所述复合层箔在其背离电子保护体的一侧包括载体层 其具有大于电子保护体的折射率的折射率，并且在相对侧具有电子保护体所构成的相同材料的有源层。
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43.发明申请Oral Formulations Comprising Bone Morphogenetic Proteins For Treating Metabolic Bone Diseases 审中-公开包含骨形态发生蛋白的口服制剂用于治疗代谢性骨病公开(公告)号：US20070265187A1
公开(公告)日：2007-11-15
申请号：US11568247
申请日：2005-04-28
Applicant: Slobodan Vukicevic , Petra Simic , Hermann Oppermann
Inventor： Slobodan Vukicevic , Petra Simic , Hermann Oppermann
CPC classification number: A61K38/1875 , A61K9/0053 , A61K38/05 , A61K38/23 , A61K38/55 , A61K38/57 , A61K45/06 , A61K2300/00
Abstract: Methods and formulations for the administration of a bone morphogenetic protein (BMP) anywhere along the alimentary canal of an individual are described for use in treating osteoporosis or other metabolic bone diseases.
Abstract translation: 描述了沿着个体消化道任何地方施用骨形态发生蛋白（BMP）的方法和制剂，用于治疗骨质疏松症或其它代谢性骨疾病。
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公开(公告)号：US20050058638A1
公开(公告)日：2005-03-17
申请号：US10683547
申请日：2003-10-10
Applicant: James Huston , Hermann Oppermann
Inventor： James Huston , Hermann Oppermann
CPC classification number: C07K16/464 , A61K51/08 , A61K2039/505 , C07K16/00 , C07K16/18 , C07K16/22 , C07K16/30 , C07K16/3015 , C07K16/3069 , C07K16/32 , C07K2317/24 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/624 , C07K2319/00 , C07K2319/02 , C07K2319/705
Abstract: Disclosed is a formulation for targeting an epitope on an antigen expressed in a mammal. The formulation comprises a pharmaceutically acceptable carrier together with a dimeric biosynthetic construct for binding at least one preselected antigen. The biosynthetic construct contains two polypeptide chains, each of which define single-chain Fv (sFv) binding proteins and have C-terminal tails that facilitate the crosslinking of two sFv polypeptides. The resulting dimeric constructs have a conformation permitting binding of a said preselected antigen by the binding site of each said polypeptide chain when administered to said mammal. The formulation has particular utility in in vivo imaging and drug targeting experiments.
Abstract translation: 公开了用于靶向在哺乳动物中表达的抗原上的表位的制剂。 该制剂包含药学上可接受的载体以及用于结合至少一种预选抗原的二聚生物合成构建体。 生物合成构建体含有两条多肽链，每条链定义单链Fv（sFv）结合蛋白，并具有促进两种sFv多肽交联的C末端尾。 所得的二聚体构建体具有允许所述预选抗原与所述哺乳动物施用时由每个所述多肽链的结合位点结合的构象。 该制剂在体内成像和药物靶向实验中具有特别的用途。
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45.发明授权Modified proteins of the TGF-β superfamily, including morphogenic proteins 失效TGF-β超家族的修饰蛋白，包括形态发生蛋白公开(公告)号：US06846906B1
公开(公告)日：2005-01-25
申请号：US09374936
申请日：1999-08-16
Applicant: Hermann Oppermann , Mei-Sheng Tai , John McCartney
Inventor： Hermann Oppermann , Mei-Sheng Tai , John McCartney
IPC: G01N33/50 , A61K38/00 , A61P1/02 , A61P1/16 , A61P19/00 , A61P43/00 , C07K14/47 , C07K14/495 , C07K14/51 , C07K19/00 , C12N5/06 , C12N15/09 , C12N15/12 , C12N15/62 , C12P21/02 , G01N33/15 , G01N33/53 , C07K14/00 , C12N15/00
CPC classification number: C07K14/47 , A61K38/00 , C07K2319/00 , C07K2319/75 , C12N15/62
Abstract: The invention provides modified proteins and DNAs of the TGF-β superfamily including modified morphogenic proteins. The proteins of the present invention display altered biological or biochemical attributes. Specifically, the modified proteins are designed through manipulation or exchange of subdomains among two or more members of the superfamily such that certain desired attributes are mixed-and-matched and then exploited therapeutically.
Abstract translation: 本发明提供TGF-β超家族包括修饰形态发生蛋白的修饰蛋白和DNA。 本发明的蛋白质显示改变的生物或生物化学属性。 具体地，通过在超家族的两个或更多个成员之间操纵或交换子域来设计修饰的蛋白质，使得某些所需属性被混合并匹配，然后在治疗上被利用。
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Patent Agency Ranking
46.发明授权Methods and compositions for the treatment of motor neuron injury and neuropathy 失效用于治疗运动神经元损伤和神经病变的方法和组合物公开(公告)号：US06723698B2
公开(公告)日：2004-04-20
申请号：US08937755
申请日：1997-09-25
Applicant: David C. Rueger , Kuber T. Sampath , Hermann Oppermann , Roy H. L. Pang , Charles M. Cohen
Inventor： David C. Rueger , Kuber T. Sampath , Hermann Oppermann , Roy H. L. Pang , Charles M. Cohen
IPC: A61K3800
CPC classification number: C07K16/22 , A01N1/0226 , A61F2310/00365 , A61K38/17 , A61K38/1703 , A61K38/1875 , A61L27/227 , A61L27/24 , C07K14/495 , C07K14/51 , G01N2500/10 , A61K2300/00
Abstract: Disclosed are therapeutic treatment methods, compositions and devices for maintaining neural pathways in a mammal, including enhancing survival of neurons at risk of dying, inducing cellular repair of damaged neurons and neural pathways, and stimulating neurons to maintain their differentiated phenotype. In one embodiment, the invention provides means for stimulating CAM expression in neurons. The invention also provides means for evaluating the status of nerve tissue, including means for detecting and monitoring neuropathies in a mammal. The methods, devices and compositions include a morphogen or morphogen-stimulating agent provided to the mammal in a therapeutically effective concentration.
Abstract translation: 公开了用于在哺乳动物中维持神经通路的治疗治疗方法，组合物和装置，包括增加有死亡风险的神经元的存活，诱导受损神经元和神经通路的细胞修复，以及刺激神经元维持其分化表型。 在一个实施方案中，本发明提供用于刺激神经元中的CAM表达的装置。 本发明还提供用于评估神经组织状态的手段，包括用于检测和监测哺乳动物神经病变的手段。 方法，装置和组合物包括以治疗有效浓度提供给哺乳动物的形态发生剂或形态发生剂。
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公开(公告)号：US06531445B1
公开(公告)日：2003-03-11
申请号：US09464206
申请日：1999-12-15
Applicant: Charles M. Cohen , Thangavel Kuberasampath , Roy H. L. Pang , Hermann Oppermann , David C. Rueger
Inventor： Charles M. Cohen , Thangavel Kuberasampath , Roy H. L. Pang , Hermann Oppermann , David C. Rueger
IPC: A61K3816
CPC classification number: A61K6/0032 , A01N1/0226 , A61F2310/00365 , A61K38/17 , A61K38/1703 , A61K38/1875 , A61L27/227 , A61L27/24 , A61L2430/28 , C07K14/495 , C07K14/51 , C07K16/22 , G01N2500/10 , A61K2300/00
Abstract: Disclosed are 1) amino acid sequence data, structural features, homologies and various other data characterizing morphogenic proteins, 2) methods of producing these proteins from natural and recombinant sources and from synthetic constructs, 3) morphogenic devices comprising these morphogenic proteins and a suitably modified tissue-specific matrix, and 4) methods of inducing non-chondrogenic tissue growth in a mammal.
Abstract translation: 公开了1）氨基酸序列数据，结构特征，同源性和表征形态发生蛋白质的各种其他数据，2）从天然和重组来源以及合成构建体产生这些蛋白质的方法，3）包含这些形态发生蛋白的形态发生装置和适当修饰的 组织特异性基质，以及4）在哺乳动物中诱导非软骨形成组织生长的方法。
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公开(公告)号：US06399569B1
公开(公告)日：2002-06-04
申请号：US08461113
申请日：1995-06-05
Applicant: Charles M. Cohen , Marc F. Charette , Thangavel Kuberasampath , David C. Rueger , Hermann Oppermann , Roy H. L. Pang , Engin Ozkaynak , John E. Smart
Inventor： Charles M. Cohen , Marc F. Charette , Thangavel Kuberasampath , David C. Rueger , Hermann Oppermann , Roy H. L. Pang , Engin Ozkaynak , John E. Smart
IPC: A61K3818
CPC classification number: G01N33/6872 , A61F2310/00365 , A61K38/17 , A61K38/1703 , A61K38/1875 , A61L27/227 , A61L27/24 , C07K14/495 , C07K14/51 , C07K16/22 , G01N2500/10 , G01N2800/06 , A61K2300/00
Abstract: Disclosed are methods and compositions for maintaining the integrity of the gastrointestinal tract luminal lining in a mammal, including (1) limiting epithelial cell proliferation, (2) inhibiting ulcerative lesion formation, (3) inhibiting inflammation normally associated with ulcerative diseases, and (4) stimulating the repair of ulcerative lesions and the regeneration of the luminal tissue. The methods and compositions include a therapeutically effective amount of a morphogen as defined herein.
Abstract translation: 公开了用于维持哺乳动物胃肠道腔内衬的完整性的方法和组合物，包括（1）限制上皮细胞增殖，（2）抑制溃疡性病变形成，（3）抑制通常与溃疡性疾病相关的炎症，和（4 ）刺激溃疡性病变的修复和管腔组织的再生。 方法和组合物包括治疗有效量的如本文所定义的形态发生素。
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公开(公告)号：US6090776A
公开(公告)日：2000-07-18
申请号：US480515
申请日：1995-06-07
Applicant: Thangavel Kuberasampath , Roy H. L. Pang , Hermann Oppermann , David C. Rueger , Charles M. Cohen , John E. Smart
Inventor： Thangavel Kuberasampath , Roy H. L. Pang , Hermann Oppermann , David C. Rueger , Charles M. Cohen , John E. Smart
CPC classification number: A61L27/3687 , A01N1/0226 , A61L27/227 , A61L27/24 , A61L27/3604 , G01N2500/10
Abstract: The present invention is directed to methods and compositions for enhancing viability of organs and living tissues to be transplanted in a mammal. The methods and compositions provide a therapeutically effective concentration of a morphogen or morphogen-stimulating agent to the tissue or organ to be transplanted, sufficient to substantially protect the tissue or organ from tissue damage.
Abstract translation: 本发明涉及用于增强要移植到哺乳动物中的器官和活组织活力的方法和组合物。 所述方法和组合物向要移植的组织或器官提供治疗有效浓度的形态发生剂或形态发生剂刺激剂，足以基本上保护组织或器官免受组织损伤。
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公开(公告)号：US5837846A
公开(公告)日：1998-11-17
申请号：US461386
申请日：1995-06-05
Applicant: James S. Huston , L. L. Houston , David B. Ring , Hermann Oppermann
Inventor： James S. Huston , L. L. Houston , David B. Ring , Hermann Oppermann
IPC: C12N15/09 , A61K39/395 , A61K49/00 , A61K51/00 , A61K51/08 , A61P35/00 , C07H21/04 , C07K16/22 , C07K16/28 , C07K16/30 , C07K16/32 , C07K16/46 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/13 , C12N15/62 , C12N15/66 , C12P21/02 , C12P21/08 , C12R1/19
CPC classification number: C07K16/32 , C07K16/22 , C07K16/30 , C07K16/3015 , C07K16/3069 , A61K2039/505 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2319/00 , C07K2319/02 , C07K2319/33 , C07K2319/55
Abstract: Disclosed is a formulation for targeting an epitope on an antigen expressed in a mammal. The formulation comprises a pharmaceutically acceptable carrier together with a dimeric biosynthetic construct for binding at least one preselected antigen. The biosynthetic construct contains two polypeptide chains, each of which define single-chain Fv (sFv) binding proteins and have C-terminal tails that facilitate the crosslinking of two sFv polypeptides. The resulting dimeric constructs have a conformation permitting binding of a said preselected antigen by the binding site of each said polypeptide chain when administered to said mammal. The formulation has particular utility in in vivo imaging and drug targeting experiments.
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