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公开(公告)号：US20100074936A9
公开(公告)日：2010-03-25
申请号：US11894781
申请日：2007-08-20
Applicant: Slobodan Vukicevic , Vladimir Katic , Kuber T. Sampath
Inventor： Slobodan Vukicevic , Vladimir Katic , Kuber T. Sampath
CPC classification number: A61L27/20 , A61K9/0024 , A61K38/1875 , A61L27/227 , A61L27/24 , A61L27/3612 , A61L27/3616 , A61L27/3654 , A61L27/3662 , A61L27/54 , A61L2300/252 , A61L2300/414 , A61L2430/06 , C08L5/00
Abstract: Provided herein are methods and devices for inducing the formation of functional replacement nonarticular cartilage tissues and ligament tissues. These methods and devices involve the use of osteogenic proteins, and are useful in repairing defects in the larynx, trachea, interarticular menisci, intervertebral discs, ear, nose, ribs and other fibrocartilaginous tissues in a mammal.
Abstract translation: 本文提供用于诱导功能性替代性非关节软骨组织和韧带组织形成的方法和装置。 这些方法和装置涉及使用成骨蛋白，并且可用于修复哺乳动物的喉，气管，关节内半月状突起，椎间盘，耳，鼻，肋骨和其他纤维软骨组织中的缺陷。
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公开(公告)号：US07306903B1
公开(公告)日：2007-12-11
申请号：US09613177
申请日：2000-07-10
Applicant: Kuber T. Sampath , Shun-ichi Harada , Gideon A. Rodan
Inventor： Kuber T. Sampath , Shun-ichi Harada , Gideon A. Rodan
IPC: C12Q1/68
CPC classification number: C07K14/4705 , A61K38/00 , C07K14/51
Abstract: Disclosed herein are methods and compositions for identifying morphogen analogs. The preferred methods and compositions relate to the discovery that morphogen upregulation of the mouse type X collagen promoter activity is mediated by a MEF-2 like sequence and requires an adjacent AP-1 sequence. Certain methods rest on the use of test cells comprising DNA defining a morphogen-responsive transcription activating element operatively associated with a reporter gene. Other methods rest on the use of DNAs for measuring morphogen-inducible DNA-binding. In certain preferred embodiments, the methods and DNAs involve an osteogenic protein 1 (OP-1) responsive transcription activating element. Substances that mediate interaction with and/or activate the OP-1 responsive transcription activating element are considered herein likely to be useful for reproducing in vivo effects of morphogens such as OP-1.
Abstract translation: 本文公开了用于鉴定形态发生类似物的方法和组合物。 优选的方法和组合物涉及小鼠X型胶原启动子活性的形态发生上调由MEF-2样序列介导并需要相邻的AP-1序列的发现。 某些方法依赖于使用测试细胞，其包括定义与报告基因可操作地相关的形态发生反应性转录激活元件的DNA。 其他方法依赖于使用DNA来测量形态发生诱导型DNA结合。 在某些优选的实施方案中，所述方法和DNA涉及成骨蛋白1（OP-1）响应转录激活元件。 介导与OP-1反应性转录激活元件的相互作用和/或激活的物质在本文中被认为可能用于再现诸如OP-1的形态发生体的作用。
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3.发明授权Methods and compositions for the treatment of motor neuron injury and neuropathy 失效用于治疗运动神经元损伤和神经病变的方法和组合物公开(公告)号：US06723698B2
公开(公告)日：2004-04-20
申请号：US08937755
申请日：1997-09-25
Applicant: David C. Rueger , Kuber T. Sampath , Hermann Oppermann , Roy H. L. Pang , Charles M. Cohen
Inventor： David C. Rueger , Kuber T. Sampath , Hermann Oppermann , Roy H. L. Pang , Charles M. Cohen
IPC: A61K3800
CPC classification number: C07K16/22 , A01N1/0226 , A61F2310/00365 , A61K38/17 , A61K38/1703 , A61K38/1875 , A61L27/227 , A61L27/24 , C07K14/495 , C07K14/51 , G01N2500/10 , A61K2300/00
Abstract: Disclosed are therapeutic treatment methods, compositions and devices for maintaining neural pathways in a mammal, including enhancing survival of neurons at risk of dying, inducing cellular repair of damaged neurons and neural pathways, and stimulating neurons to maintain their differentiated phenotype. In one embodiment, the invention provides means for stimulating CAM expression in neurons. The invention also provides means for evaluating the status of nerve tissue, including means for detecting and monitoring neuropathies in a mammal. The methods, devices and compositions include a morphogen or morphogen-stimulating agent provided to the mammal in a therapeutically effective concentration.
Abstract translation: 公开了用于在哺乳动物中维持神经通路的治疗治疗方法，组合物和装置，包括增加有死亡风险的神经元的存活，诱导受损神经元和神经通路的细胞修复，以及刺激神经元维持其分化表型。 在一个实施方案中，本发明提供用于刺激神经元中的CAM表达的装置。 本发明还提供用于评估神经组织状态的手段，包括用于检测和监测哺乳动物神经病变的手段。 方法，装置和组合物包括以治疗有效浓度提供给哺乳动物的形态发生剂或形态发生剂。
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公开(公告)号：US5906827A
公开(公告)日：1999-05-25
申请号：US253398
申请日：1994-06-03
Applicant: Roger K. Khouri , Kuber T. Sampath , David C. Rueger
Inventor： Roger K. Khouri , Kuber T. Sampath , David C. Rueger
CPC classification number: A61L27/3604 , A61L27/227 , A61L27/3608 , A61L27/3612 , A61L27/3641 , A61L27/3645 , A61L27/3654 , A61L27/3683 , A61L2430/06
Abstract: Disclosed are matrices, devices and methods for the manufacture of live autogenous skeletal replacement parts comprising plural different tissues.
Abstract translation: 公开了用于制造包含多个不同组织的活自体骨骼替代部件的基质，装置和方法。
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公开(公告)号：US08354375B2
公开(公告)日：2013-01-15
申请号：US11894781
申请日：2007-08-20
Applicant: Slobodan Vukicevic , Vladimir Katic , Kuber T. Sampath
Inventor： Slobodan Vukicevic , Vladimir Katic , Kuber T. Sampath
CPC classification number: A61L27/20 , A61K9/0024 , A61K38/1875 , A61L27/227 , A61L27/24 , A61L27/3612 , A61L27/3616 , A61L27/3654 , A61L27/3662 , A61L27/54 , A61L2300/252 , A61L2300/414 , A61L2430/06 , C08L5/00
Abstract: Provided herein are methods and devices for inducing the formation of functional replacement nonarticular cartilage tissues and ligament tissues. These methods and devices involve the use of osteogenic proteins, and are useful in repairing defects in the larynx, trachea, interarticular menisci, intervertebral discs, ear, nose, ribs and other fibrocartilaginous tissues in a mammal.
Abstract translation: 本文提供用于诱导功能性替代性非关节软骨组织和韧带组织形成的方法和装置。 这些方法和装置涉及使用成骨蛋白，并且可用于修复哺乳动物的喉，气管，关节内半月状突起，椎间盘，耳，鼻，肋骨和其他纤维软骨组织中的缺陷。
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Patent Agency Ranking
公开(公告)号：US20100105621A1
公开(公告)日：2010-04-29
申请号：US12583013
申请日：2009-08-11
Applicant: Charles M. Cohen , Kuber T. Sampath , Slobodan Vukicevic
Inventor： Charles M. Cohen , Kuber T. Sampath , Slobodan Vukicevic
CPC classification number: A61K38/1875 , A61K2300/00
Abstract: The present invention provides methods for the treatment, and pharmaceuticals for use in the treatment, of mammalian subjects in, or at risk of, acute renal failure, or subject to, or at risk of, inflammation, neutrophil-mediated cell damage, and apoptosis resulting from tissue damage or injury. The methods involve the administration of certain proteins of the osteogenic protein/bone morphogenetic protein (OP/BMP) family within the TGF-β superfamily of proteins.
Abstract translation: 本发明提供了用于治疗和/或处于急性肾功能衰竭或患有或处于炎症，嗜中性粒细胞介导的细胞损伤和凋亡风险中的哺乳动物受试者和用于治疗的药物的方法 造成组织损伤或损伤。 该方法包括在TGF-β1中施用成骨蛋白/骨形态发生蛋白（OP / BMP）家族的某些蛋白质; 蛋白质超家族
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公开(公告)号：US20080220043A1
公开(公告)日：2008-09-11
申请号：US11894781
申请日：2007-08-20
Applicant: Slobodan Vukicevic , Vladimir Katic , Kuber T. Sampath
Inventor： Slobodan Vukicevic , Vladimir Katic , Kuber T. Sampath
CPC classification number: A61L27/20 , A61K9/0024 , A61K38/1875 , A61L27/227 , A61L27/24 , A61L27/3612 , A61L27/3616 , A61L27/3654 , A61L27/3662 , A61L27/54 , A61L2300/252 , A61L2300/414 , A61L2430/06 , C08L5/00
Abstract: Provided herein are methods and devices for inducing the formation of functional replacement nonarticular cartilage tissues and ligament tissues. These methods and devices involve the use of osteogenic proteins, and are useful in repairing defects in the larynx, trachea, interarticular menisci, intervertebral discs, ear, nose, ribs and other fibrocartilaginous tissues in a mammal.
Abstract translation: 本文提供用于诱导功能性替代性非关节软骨组织和韧带组织形成的方法和装置。 这些方法和装置涉及使用成骨蛋白，并且可用于修复哺乳动物的喉，气管，关节内半月状突起，椎间盘，耳，鼻，肋骨和其他纤维软骨组织中的缺陷。
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公开(公告)号：US06958149B2
公开(公告)日：2005-10-25
申请号：US09828607
申请日：2001-04-06
Applicant: Slobodan Vukicevic , Vladimir Katic , Kuber T. Sampath
Inventor： Slobodan Vukicevic , Vladimir Katic , Kuber T. Sampath
CPC classification number: A61L27/20 , A61K9/0024 , A61K38/1875 , A61L27/227 , A61L27/24 , A61L27/3612 , A61L27/3616 , A61L27/3654 , A61L27/3662 , A61L27/54 , A61L2300/252 , A61L2300/414 , A61L2430/06 , C08L5/00
Abstract: Provided herein are methods and devices for inducing the formation of functional replacement nonarticular cartilage tissues and ligament tissues. These methods and devices involve the use of osteogenic proteins, and are useful in repairing defects in the larynx, trachea, interarticular menisci, intervertebral discs, ear, nose, ribs and other fibrocartilaginous tissues in a mammal.
Abstract translation: 本文提供用于诱导功能性替代性非关节软骨组织和韧带组织形成的方法和装置。 这些方法和装置涉及使用成骨蛋白，并且可用于修复哺乳动物的喉，气管，关节内半月状突起，椎间盘，耳，鼻，肋骨和其他纤维软骨组织中的缺陷。
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公开(公告)号：US06498142B1
公开(公告)日：2002-12-24
申请号：US08643321
申请日：1996-05-06
Applicant: Kuber T. Sampath , Charles M. Cohen
Inventor： Kuber T. Sampath , Charles M. Cohen
IPC: A61K3804
CPC classification number: A61K38/1875
Abstract: The present invention provides methods for the treatment, and pharmaceuticals for use in the treatment, of mammalian subjects at risk chronic renal failure, or at risk of a need for renal replacement therapy. The methods involve the administration of certain morphogens, inducers of those morphogens, or agonists of the corresponding morphogen receptors, or implantation of renal cells induced with those morphogens. The morphogens useful in the invention include osteogenic protein-1 (OP-1) and other members of the OP-1 subfamily of the TGF-&bgr; superfamily of growth factors.
Abstract translation: 本发明提供用于治疗患有风险慢性肾功能衰竭的哺乳动物受试者的治疗方法和用于治疗需要肾脏替代疗法的风险的药物。 所述方法包括施用某些形态发生剂，那些形态发生物的诱导剂或相应形态发生受体的激动剂，或用这些形态发生体诱导的肾细胞的植入。 可用于本发明的形态发生物包括成骨蛋白-1（OP-1）和生长因子的TGF-β超家族的OP-1亚家族的其它成员。
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公开(公告)号：US6110482A
公开(公告)日：2000-08-29
申请号：US459129
申请日：1995-06-02
Applicant: Roger K. Khouri , Kuber T. Sampath , David C. Rueger
Inventor： Roger K. Khouri , Kuber T. Sampath , David C. Rueger
CPC classification number: A61L27/3604 , A61L27/227 , A61L27/3608 , A61L27/3612 , A61L27/3641 , A61L27/3645 , A61L27/3654 , A61L27/3683 , A61L2430/06
Abstract: Disclosed are matrix materials, methods, and devices for manufacture in vivo of autogenous replacement body parts comprising plural distinct tissues. In one embodiment, the replacement body part is a skeletal joint and the new plural distinct tissues include bone and articular cartilage.
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