公开(公告)号：US20110034800A1

公开(公告)日：2011-02-10

申请号：US12535004

申请日：2009-08-04

Applicant: Shuki Vitek ,  Rita Schmidt ,  Amir Seginer

Inventor： Shuki Vitek ,  Rita Schmidt ,  Amir Seginer

IPC: A61B5/055 ,  A61N7/00

CPC classification number: A61N7/02 ,  A61B5/055 ,  A61B8/587 ,  A61B2017/00725 ,  A61B2090/374 ,  A61B2090/3954 ,  A61N2007/0065 ,  A61N2007/0078 ,  A61N2007/0095 ,  G01R33/4814

Abstract: A magnetic-resonance-guided focused ultrasound system may be calibrated by generating ultrasound foci using ultrasound transducers, establishing coordinates of the foci and of magnetic-resonance trackers associated with the transducers, and determining a geometric relationship between the trackers and the transducers.

Abstract translation: 可以通过使用超声换能器产生超声灶，建立焦点的坐标和与换能器相关联的磁共振跟踪器，以及确定跟踪器和换能器之间的几何关系来校准磁共振引导的聚焦超声系统。

公开(公告)号：US20100318002A1

公开(公告)日：2010-12-16

申请号：US12813016

申请日：2010-06-10

Applicant: Oleg Prus ,  Rita Schmidt ,  Eyal Zadicario ,  Shuki Vitek

Inventor： Oleg Prus ,  Rita Schmidt ,  Eyal Zadicario ,  Shuki Vitek

IPC: A61N7/00

CPC classification number: A61N7/00 ,  A61B8/0808 ,  A61B17/22004 ,  A61B17/22029 ,  A61B2017/00106 ,  A61B2017/22007 ,  A61B2017/22028 ,  A61N2007/0039 ,  A61N2007/0078

Abstract: Ultrasound energy is delivered to a patient in a controlled manner using a focused ultrasound system, thus maintaining the desired therapeutic effect without causing unwanted damage to surrounding tissue. An ultrasound transducer device includes multiple transducer elements, each of which is controlled by drive circuitry and a drive signal controller. An acoustic detector detects signals indicative of cavitation in tissue targeted by the transducer elements, and the drive signal controller manages the delivery of acoustic energy from the transducer elements based on the detected cavitation signals such that a therapeutic effect at the target tissue remains within an efficacy range.

Abstract translation: 使用聚焦超声系统以可控的方式将超声能量传送给患者，从而保持所需的治疗效果，而不会对周围组织造成不必要的损伤。 超声换能器装置包括多个换能器元件，每个换能器元件由驱动电路和驱动信号控制器控制。 声学检测器检测指示由换能器元件所针对的组织中的气蚀的信号，并且驱动信号控制器基于检测到的空化信号来管理来自换能器元件的声能的传递，使得靶组织上的治疗效果保持在功效 范围。

公开(公告)号：US07535794B2

公开(公告)日：2009-05-19

申请号：US11668321

申请日：2007-01-29

Applicant: Oleg Prus ,  Shuki Vitek

Inventor： Oleg Prus ,  Shuki Vitek

IPC: H04B17/00 ,  G01K11/32

CPC classification number: G10K11/346 ,  G01S7/52004

Abstract: Method for adjusting the output of a phased array ultrasonic transducer using surface mapping. The transducer surface is mapped using a sensor, such as a hydrophone, to determine the actual location of each transducer element relative to the expected location of each transducer element. Mapping can be performed by measuring a distance between a hydrophone and each transducer element. At least one of the hydrophone and the transducer are moveable relative to each other to map the transducer surface. A determination is made whether the actual location of a transducer element differs from the expected location. Drive signals of certain transducer elements having actual locations that differ from expected locations are adjusted to control the output of the transducer.

Abstract translation: 使用表面映射调整相控阵超声换能器的输出的方法。 使用诸如水听器的传感器来映射换能器表面，以确定每个换能器元件相对于每个换能器元件的预期位置的实际位置。 可以通过测量水听器和每个换能器元件之间的距离来执行映射。 水听器和换能器中的至少一个可相对于彼此移动以映射换能器表面。 确定换能器元件的实际位置是否与预期位置不同。 调整具有与预期位置不同的实际位置的某些换能器元件的驱动信号，以控制换能器的输出。

公开(公告)号：US06790180B2

公开(公告)日：2004-09-14

申请号：US10005845

申请日：2001-12-03

Applicant: Shuki Vitek

Inventor： Shuki Vitek

IPC: A61B800

CPC classification number: G01H3/10

Abstract: Apparatus, systems, and methods are provided for measuring the power of acoustic energy transmitted by an ultrasound transducer. The apparatus includes a container including a liquid therein, and a buoyant body floating at a first level in the liquid. When acoustic energy is transmitted by the ultrasound transducer towards the buoyant body, the buoyant body floats at a second, different level in the liquid. The displaced volume of the buoyant body from the first level to the second level is directly related to the power of the acoustic energy transmitted by the ultrasound transducer. The apparatus may output signals corresponding to the level at which the buoyant body floats. The signal may be routed to a controller for adjusting the power output by the ultrasound transducer.

Abstract translation: 提供了用于测量由超声换能器传输的声能的功率的装置，系统和方法。 该装置包括其中包含液体的容器和浮在液体中的第一级的浮力体。 当声能通过超声换能器朝向浮力体传递时，浮力体浮在液体中的第二个不同水平面上。 从第一级到第二级的浮力体的移位体积与由超声换能器传递的声能的功率直接相关。 该装置可以输出与浮力体浮起的水平相对应的信号。 信号可以被路由到控制器以调整超声换能器的功率输出。

公开(公告)号：US06645162B2

公开(公告)日：2003-11-11

申请号：US09879262

申请日：2001-06-11

Applicant: Zvi Friedman ,  Dov Maor ,  Shuki Vitek

Inventor： Zvi Friedman ,  Dov Maor ,  Shuki Vitek

IPC: A61N700

CPC classification number: A61B17/22012 ,  A61B2017/22007 ,  A61N7/00 ,  A61N2007/0008 ,  A61N2007/0078

Abstract: Cells are destroyed within a subcutaneous tissue region using a transducer disposed externally adjacent to a patient's skin. The transducer emits acoustic energy that is focused at a linear focal zone within the tissue region, the acoustic energy having sufficient intensity to rupture cells within the focal zone while minimizing heating. The transducer may include one or more transducer elements having a partial cylindrical shape, a single planar transducer element coupled to an acoustic lens, or a plurality of linear transducer elements disposed adjacent one another in an arcuate or planar configuration. The transducer may include detectors for sensing cavitation occurring with the focal zone, which is correlated to the extent of cell destruction. A frame may be provided for controlling movement of the transducer along the patient's skin, e.g., in response to the extent of cell destruction caused by the transducer.

公开(公告)号：US06626854B2

公开(公告)日：2003-09-30

申请号：US09753273

申请日：2000-12-27

Applicant: Zvi Friedman ,  Dov Maor ,  Shuki Vitek

Inventor： Zvi Friedman ,  Dov Maor ,  Shuki Vitek

IPC: A61N700

CPC classification number: A61B17/22012 ,  A61B2017/22007 ,  A61N7/00 ,  A61N2007/0008 ,  A61N2007/0078

Abstract: Cells are destroyed within a subcutaneous tissue region using a transducer disposed externally adjacent to a patient's skin. The transducer emits acoustic energy that is focused at a linear focal zone within the tissue region, the acoustic energy having sufficient intensity to rupture cells within the focal zone while minimizing heating. The transducer may include one or more transducer elements having a partial cylindrical shape, a single planar transducer element coupled to an acoustic lens, or a plurality of linear transducer elements disposed adjacent one another in an arcuate or planar configuration. The transducer may include detectors for sensing cavitation occurring with the focal zone, which is correlated to the extent of cell destruction. A frame may be provided for controlling movement of the transducer along the patient's skin, e.g., in response to the extent of cell destruction caused by the transducer.

公开(公告)号：US06613004B1

公开(公告)日：2003-09-02

申请号：US09557078

申请日：2000-04-21

Applicant: Shuki Vitek ,  Dov Maor

Inventor： Shuki Vitek ,  Dov Maor

IPC: A61N700

CPC classification number: G10K11/346 ,  A61B17/22004 ,  A61N7/02 ,  A61N2007/0065 ,  A61N2007/0078

Abstract: A system for performing a therapeutic procedure using focused ultrasound includes a transducer array including a plurality of transducer elements, drive circuitry coupled to the transducer elements, and a controller coupled to the drive circuitry. The controller controls the drive circuitry to alternatively provide sets of the transducer elements with respective drive signals. Each of the sets of transducer elements are alternatively driven with the respective drive signals for a predetermined duration during a sonication, while substantially continuously focusing ultrasonic energy produced by the transducer elements of each set at a desired focal zone. The controller also controls a phase component of the respective drive signals to provide a predetermined size, shape, and/or location of the focal zone, and thereby necrose a target tissue region at the focal zone.

Abstract translation: 用于使用聚焦超声波执行治疗程序的系统包括包括多个换能器元件的换能器阵列，耦合到换能器元件的驱动电路以及耦合到驱动电路的控制器。 控制器控制驱动电路以交替地提供具有各自的驱动信号的换能器元件组。 在超声处理期间，各组传感器元件中的每组换能器以相应的驱动信号驱动预定的持续时间，同时基本上连续地将由每组的换能器元件产生的超声能量聚焦在期望的焦点区域。 控制器还控制各个驱动信号的相位分量以提供焦点区域的预定尺寸，形状和/或位置，从而使焦点区域上的目标组织区域变暗。

公开(公告)号：US06543272B1

公开(公告)日：2003-04-08

申请号：US09557050

申请日：2000-04-21

Applicant: Shuki Vitek

Inventor： Shuki Vitek

IPC: G01V1300

CPC classification number: B06B1/0207 ,  A61B2017/00725 ,  A61N7/02 ,  B06B2201/40 ,  B06B2201/76

Abstract: Systems and methods for testing the performance of a focused ultrasound transducer array include transmitting ultrasonic energy from the transducer array towards an acoustic reflector, such as a planar air mirror, and receiving ultrasonic energy reflected off of the acoustic reflector using a sensing element. A characteristic of the reflected ultrasonic energy, such as amplitude and phase, is measured by processing circuitry, for example, by comparing the characteristic of the received ultrasonic energy to a corresponding characteristic of the transmitted ultrasonic energy to obtain an actual gain and phase shift for the received ultrasonic energy. A controller compares the actual gain and phase shift of the received ultrasonic energy to an expected gain and phase shift of the received ultrasonic energy. This information is used to calibrate the transducer array and/or to declare a system failure if the comparison indicates an error.

Abstract translation: 用于测试聚焦超声换能器阵列的性能的系统和方法包括将超声能量从换能器阵列传送到诸如平面空气反射镜的声反射器，以及使用感测元件接收从声反射器反射的超声波能量。 通过处理电路测量反射的超声波能量（例如振幅和相位）的特性，例如通过将接收到的超声能量的特性与发射的超声能量的相应特性进行比较，以获得实际的增益和相移 接收超声能量。 控制器将接收到的超声能量的实际增益和相移与所接收的超声能量的预期增益和相移进行比较。 该信息用于校准换能器阵列和/或如果比较指示错误则声明系统故障。

公开(公告)号：US11272904B2

公开(公告)日：2022-03-15

申请号：US15627922

申请日：2017-06-20

Applicant: Kobi Vortman ,  Shuki Vitek ,  Yoav Levy

Inventor： Kobi Vortman ,  Shuki Vitek ,  Yoav Levy

IPC: A61B8/00 ,  A61B5/01 ,  A61B5/055 ,  G01S7/52 ,  A61B8/08 ,  A61B17/22 ,  A61B17/00 ,  A61B18/00 ,  A61N7/02 ,  B06B1/02 ,  B06B1/06 ,  A61N7/00 ,  A61B90/00

Abstract: A system for delivering ultrasound energy to an internal anatomical target includes an ultrasound transducer having multiple transducer elements collectively operable as a phased array; multiple driver circuits, each being connected to at least one of the transducer elements; multiple phase circuits; a switch matrix selectably coupling the driver circuits to the phase circuits; and a controller configured for (i) receiving as input a target average intensity level and/or an energy level energy to be applied to the target and/or a temperature level in target, (ii) identifying multiple sets of the transducer elements, each of the sets corresponding to multiple transducer elements for shaping and/or focusing, as a phased array, ultrasound energy at the target across tissue intervening between the target and the ultrasound transducer, and (iii) sequentially operating the transducer-element sets to apply and maintain the target average energy level at the target. In various embodiments, the controller operates each of the transducer element sets in accordance with a pulse-width modulation pattern having a duty cycle selected to achieve the target average intensity level, energy level, and/or temperature level at the target in accordance with a time constant of the target tissue.

公开(公告)号：US10765892B1

公开(公告)日：2020-09-08

申请号：US15613940

申请日：2017-06-05

Applicant: Shuki Vitek ,  Yoav Levy

Inventor： Shuki Vitek ,  Yoav Levy

IPC: A61N7/00

Abstract: Systems and methods for predicting a phase correction of ultrasound waves transmitted from one or more transducer elements and traversing a patient's skull into a target region utilizing data of the patient's skull include predicting a first beam path of the ultrasound waves traversing the skull based at least in part on the target location; computationally determining structural characteristics of the skull along the first beam path based on the acquired imaging data; and predicting a second beam path of the ultrasound waves traversing the skull based at least in part on the determined structural characteristics, thereby accounting for refraction resulting from the skull.