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    Devices And Methods For Non-Invasive Vagal Nerve Stimulation
    41.
    发明申请
    Devices And Methods For Non-Invasive Vagal Nerve Stimulation 有权

    公开(公告)号：US20250117545A1

    公开(公告)日：2025-04-10

    申请号：US18983670

    申请日：2024-12-17

    Applicant: ElectroCore, Inc.

    Inventor： Bruce J. Simon ,  Joseph P. Errico ,  John T. Raffle

    IPC: G06F30/20 ,  G06F9/54 ,  G06Q10/10 ,  G09B5/12 ,  G09B5/14 ,  G09B9/08 ,  H04L67/60

    Abstract: Devices and methods are described to produce therapeutic effects in a patient by utilizing an energy source that transmits energy non-invasively to nervous tissue. A device for modulating a nerve within a body of a patient comprises a housing comprising a power supply and a signal generator for generating an electrical impulse. The electrical impulse comprises bursts of 2 to 20 pulses, wherein each of the bursts has a frequency of 15 to 50 Hz. The device further comprises first and second electrodes coupled to the housing and having a contact surface configured for contacting an outer skin surface of a neck of a user. The energy source is configured to transmit the electrical impulse from the first and second electrodes through the outer skin surface of the user to a vagus nerve.

    VAGAL NERVE STIMULATION
    42.
    发明申请
    VAGAL NERVE STIMULATION 有权

    公开(公告)号：US20240374889A1

    公开(公告)日：2024-11-14

    申请号：US18779141

    申请日：2024-07-22

    Applicant: ELECTROCORE, INC

    Inventor： Bruce J. Simon ,  Joseph P. Errico ,  John T. Raffle

    IPC: A61N1/04 ,  A61N1/36 ,  A61N1/40 ,  A61N2/00 ,  A61N2/02 ,  H04R25/00

    Abstract: Vagal nerve stimulation devices and methods are provided herein. A device comprises one or more electrodes having a contact surface for contacting an outer skin surface of a patient and an energy source coupled to the electrodes. The energy source generates one or more electrical impulses and transmits the electrical impulses to the electrodes and transcutaneously through the outer skin surface of the patient at or near a vagus nerve. The one or more electrical pulses comprise bursts of 2 to 20 pulses within each burst with each burst having a frequency of about 5 Hz to about 100 Hz.

    DEVICES AND METHODS FOR NON-INVASIVE NERVE STIMULATION
    47.
    发明申请
    DEVICES AND METHODS FOR NON-INVASIVE NERVE STIMULATION 有权

    公开(公告)号：US20220233845A1

    公开(公告)日：2022-07-28

    申请号：US17713832

    申请日：2022-04-05

    Applicant: electroCore, Inc.

    Inventor： Bruce J. Simon ,  Joseph P. Errico ,  John T. Raffle

    IPC: A61N1/04 ,  A61N2/00 ,  A61N1/36

    Abstract: Devices and methods for the non-invasive stimulation of nerves, such as the vagus nerve, include a housing and an electrode coupled to the housing. The electrode is configured to be positioned adjacent to, or in contact with, an outer skin surface of a patient. A source of energy is coupled to the housing and operably coupled to the electrode. The source of energy emits an electrical impulse to the electrode such that the electrical impulse passes through the outer skin surface of the patient to a nerve at a target region in the patient sufficient to modulate the nerve. The electrical impulse comprises burst periods and constant periods, wherein each burst period includes 2 to 20 pulses and has a duration of less than 20,000 microseconds

    Nerve stimulation devices and methods for treating cardiac arrhythmias
    48.
    发明授权
    Nerve stimulation devices and methods for treating cardiac arrhythmias 有权

    公开(公告)号：US11351363B2

    公开(公告)日：2022-06-07

    申请号：US17510320

    申请日：2021-10-25

    Applicant: electroCore, Inc.

    Inventor： Bruce J. Simon ,  Joseph P. Errico ,  John T. Raffle

    IPC: A61N1/04 ,  A61N1/362 ,  A61N1/36 ,  A61N1/375 ,  A61N2/00 ,  A61N2/02

    Abstract: Systems and methods for treating and/or averting cardiac arrhythmias, such as atrial fibrillation, are provided. A device comprises a housing including an energy source, a contact surface and an electrode. The energy source is configured to transmit an electrical impulse to the electrode through the outer skin surface to a vagus nerve of the patient. The electrical impulse comprises bursts of about 2 pulses to about 20 pulses with each of the bursts having a frequency of about 3 Hz to about 100 Hz. The electrical impulse modulates the vagus nerve to treat a cardiac arrhythmia of the patient. A system includes a sensor for detecting a physiological parameter of a patient's heart, such as heart rate variability, and a controller configured to activate the stimulator based on the physiological parameter to cause the stimulator to generate the electrical impulse.

    Devices and methods for vagal nerve stimulation
    49.
    发明授权
    Devices and methods for vagal nerve stimulation 有权

    公开(公告)号：US11324943B2

    公开(公告)日：2022-05-10

    申请号：US16942953

    申请日：2020-07-30

    Applicant: ELECTROCORE, INC.

    Inventor： Bruce J. Simon ,  Joseph P. Errico ,  John T. Raffle

    IPC: A61N1/04 ,  A61N2/00 ,  A61N1/36 ,  A61N1/40

    Abstract: Methods and devices for stimulating a nerve in a patient include positioning a device adjacent an outer skin surface of the patient and emitting an electrical field near the vagus nerve within the patient. The electric field is varied to create burst periods and constant periods. The charge of the electric field emitted during the burst periods alternates between positive and negative. The charge of the electric field emitted during the constant periods has a magnitude of zero.

    Methods and devices for treating primary headache
    50.
    发明授权
    Methods and devices for treating primary headache 有权

    公开(公告)号：US11297445B2

    公开(公告)日：2022-04-05

    申请号：US16540435

    申请日：2019-08-14

    Applicant: ElectroCore, Inc.

    Inventor： Bruce J. Simon ,  Joseph P. Errico ,  John T. Raffle

    IPC: A61N1/36 ,  H04R25/00 ,  A61N1/04 ,  A61N1/40 ,  A61N2/00 ,  A61N2/02

    Abstract: Non-invasive electrical nerve stimulation devices and magnetic stimulation devices are disclosed, along with methods of treating medical disorders using energy that is delivered noninvasively by such devices. The disorders comprise migraine and other primary headaches such as cluster headaches, including sinus symptoms that resemble an immune-mediated response (“sinus” headaches), irrespective of whether those symptoms arise from an allergy that is co-morbid with the headache. The disclosed methods may also be used to treat other disorders that may be co-morbid with migraine headaches, such as anxiety disorders. In preferred embodiments of the disclosed methods, one or both of the patient's vagus nerves are stimulated non-invasively. In other embodiments, parts of the sympathetic nervous system and/or the adrenal glands are stimulated.

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