Patent search caee:"Pfizer Inc." Page 5

41.

发明公开
SOLID STATE FORMS OF (S)-2-(((S)-6,8-DIFLUORO-1,2,3,4-TETRAHYDRONAPHTHALEN-2-YL)AMINO)-N-(1-(2-METHYL-1-(NEOPENTYLAMINO)PROPAN-2-YL)-1H-IMIDAZOL-4-YL)PENTANAMIDE AND USES THEREOF 审中-公开

公开(公告)号：US20230406827A1

公开(公告)日：2023-12-21

申请号：US18157592

申请日：2023-01-20

Applicant: Pfizer Inc.

Inventor： Elaine GREER , Stephen ANDERSON , Mark MALONEY , Shu YU , Ekaterina ALBERT , Emily RIGSBEE

IPC: C07D233/88

CPC classification number: C07D233/88 , C07B2200/13 , A61K31/40

Abstract: The present disclosure relates to: a) solid state forms of hydrobromide salts of Compound 1; b) pharmaceutical compositions comprising one or more solid state forms of hydrobromide salts of Compound 1, and, optionally, a pharmaceutically acceptable carrier; c) methods of treating tumors or cancers by administering one or more solid state forms of hydrobromide salts of Compound 1 to a subject in need thereof; and d) methods for the preparation of solid state forms of Compound 1.

42.

发明公开
Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof 审中-公开

公开(公告)号：US20230405137A1

公开(公告)日：2023-12-21

申请号：US18252124

申请日：2021-11-04

Applicant: Pfizer Inc.

Inventor： Paul Wayne Brown , Kaushik Dutta , Jason Arnold Lotvin , Kelly Jeffrey Sackett

IPC: A61K47/64 , A61K39/09 , A61P31/04

CPC classification number: A61K47/646 , A61K39/092 , A61P31/04 , A61K2039/6037

Abstract: The present invention relates to new immunogenic compositions comprising conjugated Streptococcus pneumoniae capsular saccharide antigens (glycoconjugates), kits comprising said immunogenic compositions and uses thereof. Immunogenic compositions of the present invention will typically comprise at least one glycoconjugate from a S. pneumoniae serotype not found in PREVNAR®, SYNFLORIX® and/or PREVNAR 13®. The invention also relates to vaccination of human subjects, in particular infants and elderly, against pneumococcal infections using said novel immunogenic compositions.

43.

发明公开
COMBINATIONS OF DIACYLGLYCEROL ACYLTRANSFERASE 2 INHIBITORS AND ACETYL-COA CARBOXYLASE INHIBITOR 审中-公开

公开(公告)号：US20230405002A1

公开(公告)日：2023-12-21

申请号：US17904554

申请日：2021-02-22

Applicant: Pfizer Inc.

Inventor： Neeta Balkrishan Amin , Arthur James Bergman , Roberto Arnaldo Calle , Robert Gregory Dullea , David James Edmonds , William Paul Esler , Kevin James Filipski , James Richard Gosset , Albert Myung Kim , Jeffrey Allen Pfefferkorn , Patrick Robert Verhoest

IPC: A61K31/506 , A61K31/4545 , A61P1/16 , A61P3/04

CPC classification number: A61K31/506 , A61K31/4545 , A61P1/16 , A61P3/04

Abstract: Described herein are pharmaceutical compositions comprising 2-{5-[(3-ethoxypyridin-2-yl)oxy]pyridin-3-yl}-N-[(3S,5S)-5-fluoropiperidin-3-yl]pyrimidine-5-carboxamide, or pharmaceutically acceptable salt thereof, for treatment of liver disease and diseases related thereto. Also described are compositions comprising 2-{5-[(3-ethoxypyridin-2-yl)oxy]pyridin-3-yl}-N-[(3S,5S)-5-fluoropiperidin-3-yl]pyrimidine-5-carboxamide, or pharmaceutically acceptable salt thereof and 4-(4-(1-Isopropyl-7-oxo-1,4,6,7-tetrahydrospiro[indazole-5,4′-piperidine]-1′-carbonyl)-6-methoxypyridin-2-yl)benzoic acid, or pharmaceutically acceptable salt thereof, for treatment of liver disease and diseases related thereto.

44.

发明公开
Methods for Purification of AAV Vectors by Anion Exchange Chromatography 审中-公开

公开(公告)号：US20230399656A1

公开(公告)日：2023-12-14

申请号：US18250252

申请日：2021-11-01

Applicant: Pfizer Inc.

Inventor： Alexander BERRILL , William S. KISH , John R. LIGHTHOLDER , Matthew K. ROACH , William B. WELLBORN , Tamara ZEKOVIC

IPC: C12N15/86 , B01D15/36 , B01D15/42 , B01D15/16

CPC classification number: C12N15/86 , B01D15/363 , B01D15/424 , B01D15/166 , C12N2750/14151 , C12N2750/14143

Abstract: The present disclosure provides methods for purifying a recombinant AAV (rAAV) vector from a solution by anion-exchange chromatography (AEX) to produce an eluate enriched for full capsids and depleted of empty capsids.

45.

发明公开
Methods for purifying bacterial polysaccharides 审中-公开

公开(公告)号：US20230383324A1

公开(公告)日：2023-11-30

申请号：US18249411

申请日：2021-10-19

Applicant: Pfizer Inc.

Inventor： Elizabeth BARANYI , Wei CHEN , Zecheng CHEN , Justin Keith MORAN , Yonghui YUAN

IPC: C12P19/04

CPC classification number: C12P19/04 , C12R2001/46

Abstract: The present invention relates to methods for purifying bacterial polysaccharides, in particular for removing impurities from cellular lysates of bacteria producing polysaccharides.

46.

发明公开
Cyclopentane-Based Modulators of STING (Stimulator of Interferon Genes) 审中-公开

公开(公告)号：US20230382932A1

公开(公告)日：2023-11-30

申请号：US18225589

申请日：2023-07-24

Applicant: PFIZER INC.

Inventor： Martin James WYTHES , Indrawan James MCALPINE , Ryan PATMAN , Eugene Yuanjin RUI , Andrew FENSOME , Andreas MADERNA , Mehran JALAIE , Ketan S. GAJIWALA

IPC: C07F9/6574 , A61K47/68 , A61P35/00 , C07H19/213

CPC classification number: C07F9/65744 , A61K47/6801 , A61P35/00 , C07H19/213

Abstract: Compounds of the general formula (I):

or a pharmaceutically acceptable salt thereof, processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.

47.

发明公开
Chemical Compounds 审中-公开

公开(公告)号：US20230382892A1

公开(公告)日：2023-11-30

申请号：US18322844

申请日：2023-05-24

Applicant: Pfizer Inc.

Inventor： Ariamala Gopalsamy , Shawn Cabral , Agustin Casimiro Garcia , Ming Zhu Chen , Chulho Choi , Robert Lee Dow , Olugbeminiyi Omezia Fadeyi , David Hepworth , Jayasankar Jasti , Lyn Howard Jones , Arjun Venkat Narayanan , Mihir Dineshkumar Parikh , David Walter Piotrowski , Lee Richard Roberts , Ralph Pelton Robinson, Jr. , Hatice Gizem Yayla

IPC: C07D401/14 , A61P7/06 , C07D471/04

CPC classification number: C07D401/14 , A61P7/06 , C07D471/04 , A61K45/06

Abstract: The invention relates to pyrazole derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes.
More particularly the invention relates to HbS modulators of formula (I)

or tautomers thereof, or pharmaceutically acceptable salts of said modulators or tautomers thereof, wherein X, Y, R2 and R3 are as defined in the description.

HbS modulators are potentially useful in the treatment of a wide range of disorders, including sickle cell disease (SCD).

48.

发明授权
Solid state forms of (S)-2-(((S)-6,8-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl)amino)-N-(1-(2-methyl-1-(neopentylamino)propan-2-yl)-1H-imidazol-4-yl)pentanamide and uses thereof 有权

公开(公告)号：US11820748B2

公开(公告)日：2023-11-21

申请号：US18160442

申请日：2023-01-27

Applicant: Pfizer Inc.

Inventor： Elaine Greer , Stephen Anderson , Mark Maloney , Shu Yu , Ekaterina Albert , Emily Rigsbee

IPC: C07D233/88 , A61K31/40

CPC classification number: C07D233/88 , A61K31/40 , C07B2200/13

Abstract: The present disclosure relates to: a) solid state forms of hydrobromide salts of Compound 1; b) pharmaceutical compositions comprising one or more solid state forms of hydrobromide salts of Compound 1, and, optionally, a pharmaceutically acceptable carrier; c) methods of treating tumors or cancers by administering one or more solid state forms of hydrobromide salts of Compound 1 to a subject in need thereof; and d) methods for the preparation of solid state forms of Compound 1.

49.

发明授权
Therapeutic antibodies and their uses 有权

公开(公告)号：US11814435B2

公开(公告)日：2023-11-14

申请号：US17005073

申请日：2020-08-27

Applicant: PFIZER INC.

Inventor： Tracy Chia-Chien Kuo , Javier Fernando Chaparro Riggers , Wei Chen , Amy Shaw-Ru Chen , Edward Derrick Pascua , Thomas John Van Blarcom , Leila Marie Boustany , Weihsien Ho , Yik Andy Yeung , Pavel Strop , Arvind Rajpal

IPC: C07K16/00 , C07K16/28 , A61K39/395 , A61K31/454 , A61K31/704 , A61K31/69 , A61K47/68 , A61K39/00

CPC classification number: C07K16/2878 , A61K31/454 , A61K31/69 , A61K31/704 , A61K39/3955 , A61K39/39558 , A61K47/6801 , A61K47/6849 , C07K16/2803 , C07K16/2809 , A61K2039/505 , C07K2317/21 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/92 , A61K31/69 , A61K2300/00 , A61K31/704 , A61K2300/00 , A61K31/454 , A61K2300/00

Abstract: The present invention relates to antibodies, e.g., full length antibodies or antigen binding fragments thereof, that specifically bind to BCMA (B-Cell Maturation Antigen) and/or CD3 (Cluster of Differentiation 3). The invention also relates to antibody conjugates (e.g., antibody-drug-conjugates) comprising the BCMA antibodies, compositions comprising the BCMA antibodies, and methods of using the BCMA antibodies and their conjugates for treating conditions associated with cells expressing BCMA (e.g., cancer or autoimmune disease). The invention further relates to heteromultimeric antibodies that specifically bind to CD3 and a tumor cell antigen, (e.g., bispecific antibodies that specifically bind to CD3 and BCMA). Compositions comprising such heteromultimeric antibodies, methods for producing and purifying such heterodimeric antibodies, and their use in diagnostics and therapeutics are also provided.