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    Article comprising a multi-channel dispensing head
    41.
    发明申请
    Article comprising a multi-channel dispensing head 失效
    包括多通道分配头的物品

    公开(公告)号：US20040045626A1

    公开(公告)日：2004-03-11

    申请号：US10660251

    申请日：2003-09-11

    Inventor： Ilya Feygin

    IPC: B65B001/08 ,  B65B003/10

    CPC classification number: B01L3/0265 ,  B01J3/002 ,  B01J3/03 ,  B01J4/02 ,  B01J2219/00274 ,  B01J2219/00315 ,  B01J2219/00317 ,  B01J2219/0036 ,  B01J2219/00369 ,  B01J2219/00585 ,  B01L2200/025 ,  B01L2200/146 ,  B01L2400/0633 ,  B01L2400/082 ,  C40B60/14 ,  G01N35/1065 ,  G01N2035/1041 ,  G01N2035/1044

    Abstract: A multi-channel fluid dispenser includes a reservoir with multiple internal chambers, a multi-channel liquid dispensing head, a plurality of fluid-delivery conduits, and support and positioning elements. The fluid-delivery conduits receive liquid from the chambers in the reservoir and deliver it to the dispensing head. The support and positioning elements are operable to support and position the dispensing head so that it can deliver the liquid from the reservoir to an underlying receiver. The fluid-delivery conduits include one or more optional flow control features that improve the accuracy of the dispensing operation. The multi-channel liquid dispensing head, which includes a valve-support member, a plurality of valves and a plurality of nozzles, is advantageously movable in three directions to facilitate alignment with an underlying receiver. Movement of the dispensing head along two axes is provided by the simple expedient of elongate holes having their long axes aligned in mutually orthogonal directions. In some embodiments, the valves are tiltable away from the vertical so that liquid dispensed from such tilted valves is directed at a non-normal angle into a receiver.

    Abstract translation: 多通道流体分配器包括具有多个内部腔室的储存器，多通道液体分配头，多个流体输送导管以及支撑和定位元件。 流体输送管道从储存器中的腔室接收液体并将其输送到分配头部。 支撑和定位元件可操作以支撑和定位分配头，使得其可以将液体从储存器输送到下面的接收器。 流体输送管道包括一个或多个可选的流量控制特征，其提高分配操作的准确性。 包括阀支撑构件，多个阀和多个喷嘴的多通道液体分配头有利地可在三个方向上移动以便于与下面的接收器对准。 分配头沿着两个轴的移动通过其长轴在相互正交的方向上对齐的细长孔的简单方法来提供。 在一些实施例中，阀可从垂直方向倾斜，使得从这种倾斜阀分配的液体以非正常角度被引导到接收器中。

    Dosing form for reagents, use of said dosing form in organic chemical synthesis and production of said dosing form
    42.
    发明申请
    Dosing form for reagents, use of said dosing form in organic chemical synthesis and production of said dosing form 审中-公开
    用于试剂的剂量形式，在有机化学合成中使用所述给药形式并生产所述给药形式

    公开(公告)号：US20030138376A1

    公开(公告)日：2003-07-24

    申请号：US10245836

    申请日：2002-09-16

    Applicant: H. Lundbeck A/S

    Inventor： Thomas Ruhland ,  Per Holm ,  Kirsten Schultz ,  Jannie Egeskov Holm ,  Kim Andersen

    IPC: A61K049/00 ,  G01N033/543

    CPC classification number: C07K1/023 ,  B01J4/02 ,  B01J19/0046 ,  B01J2219/00351 ,  B01J2219/00459 ,  B01J2219/00497 ,  B01J2219/005 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00592 ,  C07K1/04 ,  C07K1/1077 ,  C40B60/14

    Abstract: A dosing form for at least one solid reagent for use in conventional organic and inorganic synthesis, in parallel synthesis, and in split and mix synthesis in combinatorial chemistry is provided as compressed tablets each containing the same predetermined amount of said at least one reagent embedded in a polymer matrix comprising beads of a polymer insoluble in the solvents for the intended synthesis, which tablets are capable of disintegrating in said solvent for release of the at least one reagent and disperse the matrix as polymer beads into the solvent. The polymer beads forming the matrix and the reagents of the dosing form can easily be removed by filtration in order to separate these from a formed soluble product. In a method for producing the dosing form, beads of one or more polymers are mixed with the reagents and compressed into tablets after pre-treatment with an aprotic organic solvent.

    Abstract translation: 提供用于常规有机和无机合成，并行合成和组合化学中的分离和混合合成中的至少一种固体试剂的给药形式，其为包含相同预定量的所述至少一种试剂 聚合物基质，其包含不溶于用于预期合成的溶剂中的聚合物的珠粒，该片剂能够在所述溶剂中分解以释放至少一种试剂并将基质作为聚合物珠分散到溶剂中。 形成基质的聚合物珠粒和剂型的试剂可以通过过滤容易地除去，以将它们与形成的可溶性产物分离。 在制备给药形式的方法中，将一种或多种聚合物的珠粒与试剂混合，并用非质子有机溶剂预处理后压制成片剂。

    Method and system for optimizing batch process of preparing solution
    43.
    发明授权
    Method and system for optimizing batch process of preparing solution 失效
    优化批量制备溶液的方法和系统

    公开(公告)号：US06527018B2

    公开(公告)日：2003-03-04

    申请号：US09874357

    申请日：2001-06-06

    Applicant: Shingo Yamauchi ,  Shinichiro Kuwabara

    Inventor： Shingo Yamauchi ,  Shinichiro Kuwabara

    IPC: B65B304

    CPC classification number: G05D11/133 ,  B01J4/02 ,  B01J19/0006 ,  B01J2219/00049 ,  G03C1/015

    Abstract: Each of the batch processing lines has its exclusive one set material processing line independent from others and is operated according to the special algorithm which changes an amount to be prepared in the batch process in a few batches in the final stage of the downstream process based on a calculated total amount required by the downstream process to complete manufacturing. The method for preparing is capable of easily coping with the change of raw materials or prescriptions for the product without increasing or changing existing pipe lines or chemical liquid stock vessels and almost completely avoiding a waste of material.

    Abstract translation: 每批批处理生产线具有独立的一套材料处理生产线，独立于其他生产线，并根据特殊算法进行操作，该特殊算法在下游过程的最后阶段，以批量过程中批量进行批量改变， 下游流程完成制造所需的计算总金额。 制备方法能够容易地应对产品的原料或处方的变化，而不会增加或改变现有的管线或化学液体储存容器，几乎完全避免了材料的浪费。

    Chemical feeder
    45.
    发明授权
    Chemical feeder 失效
    化学进料器

    公开(公告)号：US6138703A

    公开(公告)日：2000-10-31

    申请号：US449258

    申请日：1999-11-24

    Applicant: Richard H. Ferguson ,  Stanley R. Pickens ,  Marilyn D. Higgins

    Inventor： Richard H. Ferguson ,  Stanley R. Pickens ,  Marilyn D. Higgins

    IPC: B01F1/00 ,  B01F5/04 ,  B01J4/02 ,  C02F1/68 ,  C02F1/76 ,  F16K3/02

    CPC classification number: B01F5/0496 ,  B01F1/0027 ,  B01J4/02 ,  C02F1/688 ,  F16K3/0227 ,  C02F1/76 ,  Y10T137/0318 ,  Y10T137/4891

    Abstract: Describes a chemical feeder for supplying chemical treating agents, e.g., calcium hypochlorite, to a liquid stream, e.g., an aqueous stream. The chemical feeder includes (a) a housing 11 having a chamber 12 therein for receiving solid chemical material, and a single principal opening 33 in the base 87 of the housing, (b) a valve casing 42 positioned below housing 11 and having a single first opening 36, a single second opening 39, a valve chamber 90 that provides fluid communication between openings 36 and 39, and a valve body 57 that is moveable within valve chamber 90 for selectively regulating the flow of fluid between openings 36 and 39, and (c) a fluid conduit 69 positioned below valve casing 42 and having a fluid inlet 72, a fluid outlet 75 and a feeder opening 84. First opening 36 of valve casing 42 is in fluid communication with opening 33 in base 87 of housing 11, and feeder opening 84 of fluid conduit 69 is in fluid communication with second opening 39 of valve casing 42. Fluid both enters and leaves chamber 12 through principal opening 33 in base 87 of housing 11.

    Abstract translation: 描述一种用于向液体物流例如含水物流供应化学处理剂（例如次氯酸钙）的化学进料器。 化学进料器包括（a）壳体11，其中具有用于接收固体化学材料的室12，以及在壳体的底座87中的单个主开口33，（b）位于壳体11下方并具有单个 第一开口36，单个第二开口39，提供开口36和39之间的流体连通的阀室90以及可在阀室90内移动的阀体57，用于选择性地调节开口36和39之间的流体流动，以及 （c）位于阀壳体42下方并具有流体入口72，流体出口75和进料口84的流体导管69.阀壳体42的第一开口36与壳体11的底座87中的开口33流体连通， 流体导管69的进料器开口84与阀壳体42的第二开口39流体连通。流体二通过壳体11的底座87中的主开口33进入和离开室12。

    Dull1 coding for a novel starch synthase and uses thereof
    47.
    发明授权
    Dull1 coding for a novel starch synthase and uses thereof 失效
    Dull1编码新型淀粉合成酶及其用途

    公开(公告)号：US5981728A

    公开(公告)日：1999-11-09

    申请号：US968542

    申请日：1997-11-12

    Applicant: Alan M. Myers ,  Martha G. James

    Inventor： Alan M. Myers ,  Martha G. James

    IPC: A01H5/00 ,  B01J4/02 ,  C07H21/04 ,  C12N5/10 ,  C12N9/00 ,  C12N9/10 ,  C12N15/09 ,  C12N15/29 ,  C12N15/82 ,  C12N15/84 ,  C12P19/04 ,  C12N5/04

    CPC classification number: C12N9/1051 ,  B01J4/02 ,  C07H21/04 ,  C12N15/8245 ,  C12N15/8261 ,  C12Y204/01011 ,  C07K2319/00

    Abstract: The maize gene dull1 (du1) of the present invention is a determinant of the structure of endosperm starch. Mutations of du1 affect the activity of at least two enzymes involved in starch biosynthesis, namely the starch synthase, SSII, and the starch branching enzyme, SBEIIa. Du1 codes for a predicted 1674 residue protein, and is expressed with a unique temporal pattern in endosperm but is undetectable in leaf or root. The size of the Du1 product and its expression pattern match precisely the known characteristics of maize SSII. The Du1 product contains two different repeated regions in its unique amino terminus, one of which is identical to a conserved segment of the starch debranching enzymes. The cDNA provided for in the present invention encodes SSII, and mutations within this gene affect multiple aspects of starch biogenesis by disrupting an enzyme complex containing starch synthase(s), starch branching enzyme(s), and possibly starch debranching enzyme(s).

    Abstract translation: 本发明的玉米基因dull1（du1）是胚乳淀粉结构的决定因素。 du1的突变影响淀粉生物合成中至少两种酶的活性，即淀粉合成酶，SSII和淀粉分支酶SBEIIa。 Du1编码预测的1674残基蛋白，并且在胚乳中以独特的时间模式表达，但在叶或根中是不可检测的。 Du1产品的大小及其表达模式与玉米SSII的已知特征精确匹配。 Du1产品在其独特的氨基末端含有两个不同的重复区域，其中之一与淀粉脱支酶的保守区段相同。 本发明中提供的cDNA编码SSII，并且该基因内的突变通过破坏含有淀粉合成酶，淀粉分支酶和可能的淀粉脱支酶的酶复合物影响淀粉生物发生的多个方面。

    Analytical and dosing system
    50.
    发明授权
    Analytical and dosing system 失效
    分析和计量系统

    公开(公告)号：US5833926A

    公开(公告)日：1998-11-10

    申请号：US547454

    申请日：1995-10-24

    Applicant: Christian Wurzel ,  Brigitte Wittmann-Liebold

    Inventor： Christian Wurzel ,  Brigitte Wittmann-Liebold

    IPC: B01J4/02 ,  B01J19/00 ,  B01L3/00 ,  G01N1/00 ,  G01N33/48

    CPC classification number: G01N35/1097 ,  B01J19/0046 ,  B01J19/0093 ,  B01J4/02 ,  B01L3/502707 ,  B01L3/502738 ,  B01L2200/12

    Abstract: This invention describes a new analysis and dosing system and a method to manufacture such devices based on the latest microelectronic and micromachining working methods. On chip or wafer 1 which consists of the one- or multilayer substrate 2 and one- or multilayer cover 3, are arranged the essential construction components as reactor 6a, detector 6b, converter/collector 6c, injection valve 6d, micropumps, sensors, and valves V1 to V30, of the system, and the connection(s) to a detecting/metering device. The substrate 2 and/or the cover 3 show depressions 4 to build cavities and the co-operation of the elements 6a . . . 6n.

    Abstract translation: 本发明描述了一种基于最新的微电子和微加工工作方法的新的分析和计量系统和制造这种装置的方法。 由单层或多层基板2和单层或多层盖3构成的芯片或晶片1布置成基本结构部件作为反应器6a，检测器6b，转换器/收集器6c，注射阀6d，微型泵，传感器和 系统的阀V1至V30，以及与检测/计量装置的连接。 衬底2和/或盖3显示凹陷4以构成腔体和元件6a的配合。 。 。 6n。

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