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公开(公告)号：US5315672A
公开(公告)日：1994-05-24
申请号：US764257
申请日：1991-09-23
Applicant: Francois A. Padovani
Inventor： Francois A. Padovani
CPC classification number: G01N21/7703 , G01N2201/0873
Abstract: A fiber optic sensor for detecting the presence or concentration of particular chemical or biological species in a zone to be monitored has light-emitting and detecting elements such as a gallium arsenide light-emitting diode and a Schottky diode light detector provided in a semiconductor body, and has an optical fiber formed in situ on a surface of the body to conduct light from the light-emitting diode to the detector. The fiber has a long light-transmitting core of a material such as silicon dioxide deposited on a semiconductor body surface and defined by photolithographic techniques and has a cladding deposited over and around the core of a material of relatively lower refractive index than the core. The cladding material reacts when contacted by the particular chemical or biological species to produce measurable changes in transmission of light through the fiber so that the detector provides an electrical signal representative of the presence or concentration of the species.
Abstract translation: 用于检测待监测区域中特定化学或生物物质的存在或浓度的光纤传感器具有发光和检测元件，例如设置在半导体主体中的砷化镓发光二极管和肖特基二极管光检测器， 并且在本体的表面上具有原位形成的光纤，以将来自发光二极管的光导入检测器。 光纤具有长的透光芯，例如沉积在半导体主体表面上的二氧化硅的材料，并通过光刻技术限定，并且具有沉积在比芯更低折射率的材料的芯上和周围的包层。 包层材料在被特定的化学或生物物质接触时反应，以产生通过纤维的光的透射变化，使得检测器提供代表物种的存在或浓度的电信号。
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42.发明公开公开(公告)号：US20240361264A1
公开(公告)日：2024-10-31
申请号：US18309692
申请日：2023-04-28
Applicant: SAUDI ARABIAN OIL COMPANY
Inventor： Damian Pablo San Roman Alerigi
CPC classification number: G01N25/18 , G01N21/65 , G01N1/08 , G01N2021/3595 , G01N2201/0826 , G01N2201/0873 , G06N3/08
Abstract: A method may include determining a thermal signal for a thermal analysis of a rock sample. The method may further include transmitting various commands to various thermal sources to produce various heat emissions. A respective command among the commands may cause a respective thermal source among the thermal sources to produce a respective heat emission based on the thermal signal. The method further includes determining distributed temperature data of the rock sample using various distributed temperature sensors in response to producing the heat emissions. The distributed temperature sensors may be coupled to the rock sample on a first rock surface and a second rock surface. The first rock surface may be on an opposite side of the rock sample from the second rock surface. The method may further include determining predicted thermal property data of the rock sample using the distributed temperature data and a machine-learning model.
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公开(公告)号：US20240035975A1
公开(公告)日：2024-02-01
申请号：US18265361
申请日：2021-12-17
Applicant: Carl Zeiss Jena GmbH
Inventor： Alexandre Gatto , Michael Totzeck
IPC: G01N21/64
CPC classification number: G01N21/645 , G01N2201/0873 , G01N2021/0346
Abstract: A lab-on-a-chip system (100) comprises an optical detection waveguide (122) that has an at least partially periodic structure (123, 501, 502, 503, 504) that is configured to couple light (152) from surroundings of the optical detection waveguide (122) into the optical detection waveguide (122). The lab-on-a-chip system (100) furthermore also comprises a microfluidic network (212), wherein the microfluidic network (212) has multiple lines and at least one reaction chamber (211, 211-1, 211-2, 211-3).
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44.发明授权公开(公告)号：US09989467B2
公开(公告)日：2018-06-05
申请号：US15432696
申请日：2017-02-14
Applicant: International Business Machines Corporation
Inventor： Yann A. N. Astier , Ning Li , Devendra K. Sadana , Joshua T. Smith , William T. Spratt
IPC: H01L31/16 , G01N21/64 , G02B6/132 , H01L33/32 , G02B6/122 , G02B6/12 , H01L33/00 , H01L31/0304 , H01L27/14 , H01L27/15
CPC classification number: G01N21/6454 , B01L3/502707 , B01L3/502715 , B01L2300/0654 , G01N15/1436 , G01N15/1459 , G01N15/1484 , G01N21/6428 , G01N21/645 , G01N2015/1006 , G01N2021/6439 , G01N2021/6482 , G01N2201/0873 , G02B6/12004 , G02B6/122 , G02B6/131 , G02B6/132 , G02B6/136 , G02B2006/12078 , G02B2006/12123 , H01L27/14 , H01L27/15 , H01L31/03044 , H01L31/16 , H01L33/007 , H01L33/32
Abstract: A semiconductor structure includes a first optical waveguide and a second optical waveguide located on a sapphire substrate. The first optical waveguide and the second optical waveguide each include a core portion of gallium nitride (GaN), and a cladding layer laterally surrounding the core portion. The cladding layer includes a material having a refractive index less than a refractive index of the sapphire substrate.
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公开(公告)号：US09915612B2
公开(公告)日：2018-03-13
申请号：US15451305
申请日：2017-03-06
Applicant: Pacific Biosciences of California, Inc.
Inventor： Annette Grot , Ravi Saxena , Paul Lundquist
CPC classification number: G01N21/6454 , G01N21/6428 , G01N21/648 , G01N21/7703 , G01N21/78 , G01N2021/6439 , G01N2021/6478 , G01N2021/7756 , G01N2021/7786 , G01N2201/068 , G01N2201/0873 , G02B5/1895 , G02B5/201 , G02B5/285 , G02B6/132 , G02B6/136 , G02B27/4238 , G02B27/4244 , G02B2006/12102 , G02B2006/12109 , H01L27/14621 , H01L27/14627 , H01L27/14685
Abstract: Arrays of integrated analytical devices and their methods for production are provided. The arrays are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The devices allow the highly sensitive discrimination of optical signals using features such as spectra, amplitude, and time resolution, or combinations thereof. The devices include an integrated diffractive beam shaping element that provides for the spatial separation of light emitted from the optical reactions.
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Patent Agency Ranking
公开(公告)号：US20170322156A1
公开(公告)日：2017-11-09
申请号：US15600668
申请日：2017-05-19
Applicant: Pacific Biosciences of California, Inc.
Inventor： Ravi SAXENA , Michael Tzu RU , Takashi Whitney ORIMOTO , Annette GROT , Mathieu FOQUET , Hou-Pu CHOU
IPC: G01N21/64 , G02B6/02 , G02B6/12 , G02B6/124 , G02B6/136 , G02B5/18 , B29D11/00 , C12Q1/68 , B29D17/00 , B29L11/00
CPC classification number: G02B6/12004 , B29D11/0073 , B29D17/007 , B29L2011/005 , B29L2011/0066 , B29L2011/0075 , C12Q1/6869 , G01N21/6454 , G01N21/648 , G01N2021/6478 , G01N2201/0873 , G02B5/189 , G02B6/02123 , G02B6/124 , G02B6/136 , G02B2006/12038 , G02B2006/12109
Abstract: Arrays of integrated analytical devices and their methods for production are provided. The arrays are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The integrated devices allow the highly sensitive discrimination of optical signals using features such as spectra, amplitude, and time resolution, or combinations thereof. The arrays and methods of the invention make use of silicon chip fabrication and manufacturing techniques developed for the electronics industry and highly suited for miniaturization and high throughput.
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公开(公告)号：US09739709B2
公开(公告)日：2017-08-22
申请号：US14889839
申请日：2014-05-08
Inventor： Kevin Lear , Timothy Erickson
CPC classification number: G01N21/4133 , G01M11/33 , G01N33/1833 , G01N2021/4166 , G01N2201/0873 , G02B6/028 , G02B6/12004 , G02B6/1221 , G02B6/4291 , G02B27/56 , G02B2006/12123 , G02B2006/12138 , Y02A20/206
Abstract: A chip-scale, reusable sensor can detect aromatic hydrocarbons, such as benzene, toluene, ethylbenzene, and xylenes (BTEX), rapidly in water without sample preparation. The device is capable of real-time, continuous monitoring for BTEX solutes, which diffuse into a film, such as a polymer, on the sensors surface. In operation, BTEX analytes concentrate in the film, causing an increase in refractive index, which modulates evanescent coupling into the chips integrated photodetector array. Integration of the photodetector array simplifies system instrumentation and permits incorporation of an on-chip photocurrent reference region in the immediate vicinity of the sensing region, reducing drift due to temperature fluctuations. In some examples, the chip responds linearly for BTEX concentrations between 1 ppm and 30 ppm, with a limit of detection of 359 ppb, 249 ppb, and 103 ppb for benzene, toluene, and xylene in water, respectively.
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48.发明申请公开(公告)号：US20170205350A1
公开(公告)日：2017-07-20
申请号：US15432719
申请日：2017-02-14
Applicant: International Business Machines Corporation
Inventor： Yann A. N. Astier , Ning Li , Devendra K. Sadana , Joshua T. Smith , William T. Spratt
IPC: G01N21/64 , G02B6/132 , G02B6/13 , H01L31/16 , G02B6/12 , H01L33/32 , H01L33/00 , H01L31/0304 , G02B6/136 , G02B6/122
CPC classification number: G01N21/6454 , B01L3/502707 , B01L3/502715 , B01L2300/0654 , G01N15/1436 , G01N15/1459 , G01N15/1484 , G01N21/6428 , G01N21/645 , G01N2015/1006 , G01N2021/6439 , G01N2021/6482 , G01N2201/0873 , G02B6/12004 , G02B6/122 , G02B6/131 , G02B6/132 , G02B6/136 , G02B2006/12078 , G02B2006/12123 , H01L27/14 , H01L27/15 , H01L31/03044 , H01L31/16 , H01L33/007 , H01L33/32
Abstract: A method of forming a semiconductor structure includes forming a first optical waveguide and a second optical waveguide on a sapphire substrate. The first optical waveguide and the second optical waveguide each include a core portion of gallium nitride (GaN), and a cladding layer laterally surrounding the core portion. The cladding layer includes a material having a refractive index less than a refractive index of the sapphire substrate. The method further includes etching a portion of the cladding layer to form a microfluidic channel therein and forming a capping layer on a top surface of the first optical waveguide, the second optical waveguide and the microfluidic channel.
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49.发明授权Cointegration of optical waveguides, microfluidics, and electronics on sapphire substrates 有权蓝宝石衬底上的光波导，微流体和电子的协整公开(公告)号：US09588289B1
公开(公告)日：2017-03-07
申请号：US15002041
申请日：2016-01-20
Applicant: International Business Machines Corporation
Inventor： Yann A. N. Astier , Ning Li , Devendra K. Sadana , Joshua T. Smith , William T. Spratt
CPC classification number: G01N21/6454 , B01L3/502707 , B01L3/502715 , B01L2300/0654 , G01N15/1436 , G01N15/1459 , G01N15/1484 , G01N21/6428 , G01N21/645 , G01N2015/1006 , G01N2021/6439 , G01N2021/6482 , G01N2201/0873 , G02B6/12004 , G02B6/122 , G02B6/131 , G02B6/132 , G02B6/136 , G02B2006/12078 , G02B2006/12123 , H01L27/14 , H01L27/15 , H01L31/03044 , H01L31/16 , H01L33/007 , H01L33/32
Abstract: A method of forming a semiconductor structure includes forming a first optical waveguide and a second optical waveguide on a sapphire substrate. The first optical waveguide and the second optical waveguide each include a core portion of gallium nitride (GaN), and a cladding layer laterally surrounding the core portion. The cladding layer includes a material having a refractive index less than a refractive index of the sapphire substrate. The method further includes etching a portion of the cladding layer to form a microfluidic channel therein and forming a capping layer on a top surface of the first optical waveguide, the second optical waveguide and the microfluidic channel.
Abstract translation: 形成半导体结构的方法包括在蓝宝石衬底上形成第一光波导和第二光波导。 第一光波导和第二光波导均包括氮化镓（GaN）的核心部分和横向包围核心部分的包层。 包覆层包括折射率小于蓝宝石衬底的折射率的材料。 该方法还包括蚀刻包层的一部分以在其中形成微流体通道，并在第一光波导，第二光波导和微流体通道的顶表面上形成覆盖层。
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公开(公告)号：US09372308B1
公开(公告)日：2016-06-21
申请号：US13920037
申请日：2013-06-17
Applicant: Pacific Biosciences of California, Inc.
Inventor： Ravi Saxena , Michael Tzu Ru , Takashi Whitney Orimoto , Annette Grot , Mathieu Foquet , Hou-Pu Chou
CPC classification number: G02B6/12004 , B29D11/0073 , B29D17/007 , B29L2011/005 , B29L2011/0066 , B29L2011/0075 , C12Q1/6869 , G01N21/6454 , G01N21/648 , G01N2021/6478 , G01N2201/0873 , G02B5/189 , G02B6/02123 , G02B6/124 , G02B6/136 , G02B2006/12038 , G02B2006/12109
Abstract: Arrays of integrated analytical devices and their methods for production are provided. The arrays are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The integrated devices allow the highly sensitive discrimination of optical signals using features such as spectra, amplitude, and time resolution, or combinations thereof. The arrays and methods of the invention make use of silicon chip fabrication and manufacturing techniques developed for the electronics industry and highly suited for miniaturization and high throughput.
Abstract translation: 提供了集成分析设备阵列及其生产方法。 阵列可用于高密度高分复用的光学反应，包括生化反应，如核酸测序反应。 集成器件允许使用诸如光谱，幅度和时间分辨率之类的特征或其组合来对光信号进行高灵敏度鉴别。 本发明的阵列和方法利用为电子工业开发的硅芯片制造和制造技术，并且非常适合于小型化和高吞吐量。
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