公开(公告)号：US20240253040A1

公开(公告)日：2024-08-01

申请号：US18427503

申请日：2024-01-30

Applicant: IDEXX Laboratories, Inc.

Inventor： Murthy Yerramilli ,  Jennifer Gagner ,  William Foster ,  Eugene Chan ,  Pradeep Sathyanarayana

IPC: B01L3/00

CPC classification number: B01L3/502761 ,  B01L2400/0427 ,  B01L2400/043

Abstract: A method for preparing for manipulating a droplet on a surface of a cartridge, wherein the droplet comprises at least one paramagnetic, bar-coded bead is disclosed. The method includes transporting, via a plurality of electrodes of the cartridge, the droplet on the surface of the cartridge, wherein the plurality of electrodes is configured to transport the droplet on the surface of the cartridge. The method also includes immobilizing, via at least one magnet of the cartridge, the droplet on the surface of the cartridge, wherein the at least one magnet is configured to immobilize the droplet on the surface of the cartridge.

公开(公告)号：US20240219379A1

公开(公告)日：2024-07-04

申请号：US18390970

申请日：2023-12-20

Applicant: IDEXX Laboratories, Inc.

Inventor： Murthy Yerramilli ,  Dustin Wride ,  Hongzhi Xie ,  William Foster ,  Jennifer Gagner

IPC: G01N33/53 ,  G01N33/543

CPC classification number: G01N33/5308 ,  G01N33/54388 ,  G01N2333/4353 ,  G01N2469/10

Abstract: Immunoassay devices, kits and methods for determining a first analyte in a sample. The device a membrane that supports lateral flow of a liquid, and a dried first detection reagent comprising a first gold nanoparticle having bound thereto (i) a first binding partner for the first analyte, and (ii) a first label, wherein the dried first detection reagent is dried on the membrane and solubilizable by a liquid. Methods using the device to determine analytes in liquid samples.

公开(公告)号：US20240218421A1

公开(公告)日：2024-07-04

申请号：US18541764

申请日：2023-12-15

Applicant: IDEXX LABORATORIES, INC.

Inventor： Arvind Dev ,  Adam St. Hilaire ,  Thomas Jordan ,  Paige Pomeroy

IPC: C12Q1/44

CPC classification number: C12Q1/44

Abstract: Methods and devices for determining pancreatic lipase in an animal sample are provided. In one aspect, the device includes a basic buffer layer comprising one or more bile salts and calcium; an isolation layer comprising colipase; an indicator layer comprising a chromogenic substrate such as DGGR. The device may also include and a system for optically determining the amount of a development of a color change. The methods include the use of the device to detect pancreatic lipase in animal samples.

公开(公告)号：US20240170141A1

公开(公告)日：2024-05-23

申请号：US18425540

申请日：2024-01-29

Applicant: IDEXX Laboratories, Inc.

Inventor： Jeremy Hammond ,  Timothy Butcher ,  Jui Ming Lin ,  James Russell

IPC: G16H40/40 ,  G01N15/14 ,  G01N15/1429 ,  G01N35/00 ,  G16H10/40 ,  G16H50/20

CPC classification number: G16H40/40 ,  G01N15/1425 ,  G01N15/1429 ,  G01N35/00623 ,  G01N35/00693 ,  G16H10/40 ,  G16H50/20 ,  G01N15/01

Abstract: The present disclosure relates to quality control for point-of-care medical diagnostic systems. In various embodiments, the system includes an on-board storage containing a synthetic quality control material, a plurality of sub-systems having a plurality of operating parameters and including a material analyzer, a database storing quality control results that include results of the material analyzer analyzing the synthetic quality control material over time, one or more processors, and at least one memory storing instructions which, when executed by the one or more processors, cause the system to, automatically without user intervention: generate a control chart based on the quality control results, determine that a parameter of the plurality of operating parameters is out-of-tolerance based on the control chart, and adjust at least one of the plurality of sub-systems without user intervention to bring the out-of-tolerance parameter to within tolerance.

公开(公告)号：US20240093308A1

公开(公告)日：2024-03-21

申请号：US18362238

申请日：2023-07-31

Applicant: IDEXX Laboratories, Inc.

Inventor： Robert Schaad Livingston ,  Sarah Ann Hansen ,  Marcus Jeremy Crim

IPC: C12Q1/6886 ,  C12Q1/686

CPC classification number: C12Q1/6886 ,  C12Q1/686 ,  C12Q2600/158 ,  C12Q2600/166

Abstract: Provided are assays that can provide the percentage of a first mammalian cell population (e.g., human cells) compared to a second mammalian cell population (e.g. mouse cells) in a mixed cell sample. The assays can be used to, for example, evaluate a wide variety of sample types, including humanized mice, humanized organs, passaged cell lines, and passaged tumors. These assays can be offered alone or in combination with, for example, cell line authentication and/or interspecies contamination testing.

公开(公告)号：US20230210473A1

公开(公告)日：2023-07-06

申请号：US18148163

申请日：2022-12-29

Applicant: IDEXX Laboratories, Inc.

Inventor： Regina Marie Hyson

IPC: A61B5/00 ,  A61B90/00 ,  G16H10/60

CPC classification number: A61B5/743 ,  A61B5/7425 ,  A61B5/7435 ,  A61B5/748 ,  A61B90/36 ,  G16H10/60 ,  A61B2090/367

Abstract: A patient information system is described. A virtual representation of a patient is generated using a captured image of the patient. A graphical user interface is displayed on the display, the graphical user interface including a first screen portion configured to display the virtual representation of the patient and a second screen portion configured to display information. A selection of an area of interest is received on the virtual representation of the patient. Clinical and diagnostic information associated with the selected area of interest is received and displayed in the second screen portion of the graphical user interface. The graphical user interface also includes a timeline that displays events of interest. A selection of an event of interest causes the second screen portion of the graphical user interface to display clinical and diagnostic information associated with the selected event of interest.

公开(公告)号：US20230184754A1

公开(公告)日：2023-06-15

申请号：US18078531

申请日：2022-12-09

Applicant: IDEXX Laboratories, Inc.

Inventor： Jason Cyr ,  Kevin Chamberland ,  Jennifer Cote ,  Arvind Dev ,  Julie Rollins ,  Andrey Asanov

IPC: G01N33/543 ,  G01N21/88

CPC classification number: G01N33/54326 ,  G01N21/8851

Abstract: A method for preparing for preparing a solution comprising a plurality of particles in a vial is disclosed. The method includes agitating the vial at a first predetermined mixing speed. The method also includes dispersing, into the vial, during the agitating, a first volume of buffer solution at a first predetermined dispensing rate to suspend the plurality of particles in the solution, wherein particles of the plurality of particles comprise a unique identifying feature.

公开(公告)号：US20230182143A1

公开(公告)日：2023-06-15

申请号：US18078510

申请日：2022-12-09

Applicant: IDEXX Laboratories, Inc.

Inventor： Kevin Chamberland ,  Jennifer Cote ,  Regina Lee Reif ,  Michael Thorpe ,  Jennifer Curtis ,  Arvind Dev ,  Julie Rollins ,  Andrey Asanov

IPC: B01L9/06 ,  B01L9/00

CPC classification number: B01L9/06 ,  B01L9/54 ,  B01L2200/022 ,  B01L2300/021 ,  B01L2200/0605

Abstract: A device comprising a base and a support structure is disclosed. The base includes a vial receptacle for holding a vial. The support structure is coupled to an upper portion of the base and is configured to align a pipette comprising a pipette tip vertically over the vial receptacle. The support structure is configured to support a pipette such that an end of a pipette tip is positioned one or more predetermined depths within a vial in the vial receptacle.

公开(公告)号：US20230102277A1

公开(公告)日：2023-03-30

申请号：US17877410

申请日：2022-07-29

Applicant: IDEXX LABORATORIES, INC.

Inventor： Honghzhi Xie ,  Sreenivasa Rao Ramisetty ,  Murthy VSN Yerramilli

IPC: G01N33/68 ,  G01N33/563 ,  G01N33/58 ,  G01N33/60

Abstract: The disclosure generally relates to the detection of symmetrical dimethylarginine (SDMA). More particularly, the disclosure relates to the detection of SDMA using a solid phase. The disclosure provides devices, reagents, kits and methods for detecting symmetrical dimethyl arginine (SDMA) in sample, such as a biological sample from an animal. The method includes detecting the presence or amount of SDMA in the sample by using an immunoassay format, such as a competitive immunoassay. The assay includes the use of antibodies to SDMA that are specific for SDMA and that have less affinity for other arginine derivatives.

公开(公告)号：US11551789B2

公开(公告)日：2023-01-10

申请号：US14283374

申请日：2014-05-21

Applicant: IDEXX Laboratories, Inc.

Inventor： Jonathan W. Ayers ,  Anestes G. Fotiades ,  Robert B. Brazell ,  David Dieffenbach

IPC: G16H10/60 ,  G16H15/00 ,  G06F16/248

Abstract: A method and system for reporting medical data including both current and past medical results for medical tests performed on a patient is provided. The medical data is output in columns, and the current results and past results of the same medical test are presented in the same row. In this manner, the report is provided in a layout that has rows and columns, so that all current results are presented in one column, and all past results are presented in a separate column. In addition, graphs of the medical results can be displayed to illustrate current and past medical results in a view that allows for trend and comparative diagnosis.