公开(公告)号：US12205723B2

公开(公告)日：2025-01-21

申请号：US17788055

申请日：2020-12-25

Applicant: JAPANESE FOUNDATION FOR CANCER RESEARCH

Inventor： Noriko Yamamoto

IPC: G16H50/20 ,  G06V10/26 ,  G06V10/764 ,  G06V10/77 ,  G06V10/774 ,  G06V10/82 ,  G06V20/69 ,  G16H10/40 ,  G16H30/40

Abstract: Diagnosis is assisted by acquiring microscopical observation image data while specifying the position, classifying the image data into histological types with the use of AI, and reconstructing the classification result in a whole lesion. There is provided a pathological diagnosis assisting method that can provide an assistance technology which performs a pathological diagnosis efficiently with satisfactory accuracy by HE staining which is usually used by pathologists. Furthermore, there are provided a pathological diagnosis assisting system, a pathological diagnosis assisting program, and a pre-trained model.

公开(公告)号：US20240418733A1

公开(公告)日：2024-12-19

申请号：US18703972

申请日：2022-10-26

Applicant: The University of Tokyo ,  Japanese Foundation for Cancer Research

Inventor： Yutaka HARITA ,  Keiichi TAKIZAWA ,  Koji UEDA

IPC: G01N33/68

Abstract: A method for detecting a kidney dysfunction diagnostic marker, the method including measurement of an expression amount of MUC1 and/or MGAM in urinary extracellular vesicles derived from a subject.

公开(公告)号：US20240385152A1

公开(公告)日：2024-11-21

申请号：US18287424

申请日：2022-06-28

Applicant: JAPANESE FOUNDATION FOR CANCER RESEARCH ,  Shimadzu Corporation

Inventor： Koji UEDA ,  Yoshimi HAGA ,  Masaki YAMADA

IPC: G01N30/72 ,  C12Q1/34 ,  G01N30/02 ,  G01N30/88 ,  H01J49/42

Abstract: A sugar chain analysis method is a method for analyzing a sugar chain structure bound to an antibody, the method including: a releasing step of adding a sugar cleavage enzyme to a sample containing an antibody, so that a sugar chain bound to the antibody is specifically released to obtain a free sugar chain; a recovery step of recovering the free sugar chain by affinity purification; a hydrophobization step of hydrophobizing the free sugar chain to obtain a hydrophobized sugar chain; and a measurement step of performing supercritical liquid chromatography and tandem mass spectrometry in this order on the hydrophobized sugar chain.

公开(公告)号：US20230323475A1

公开(公告)日：2023-10-12

申请号：US18314267

申请日：2023-05-09

Applicant: JAPANESE FOUNDATION FOR CANCER RESEARCH

Inventor： Kengo Takeuchi ,  Kana Sakamoto ,  Ryohei Katayama ,  Seiji Sakata

IPC: C12Q1/6886 ,  A61K31/167 ,  G01N33/50 ,  G01N33/48 ,  A61K31/551 ,  G01N33/574 ,  A61K31/4745 ,  A61K45/00 ,  C12Q1/68 ,  A61P35/02 ,  A61P43/00 ,  A61K31/4045 ,  A61K31/55 ,  A61K31/635 ,  A61K31/675

CPC classification number: C12Q1/6886 ,  A61K31/167 ,  G01N33/5023 ,  G01N33/48 ,  G01N33/5011 ,  G01N33/5047 ,  A61K31/551 ,  G01N33/57426 ,  A61K31/4745 ,  A61K45/00 ,  G01N33/5748 ,  C12Q1/68 ,  A61P35/02 ,  A61P43/00 ,  A61K31/4045 ,  A61K31/55 ,  A61K31/635 ,  A61K31/675 ,  G01N2333/82 ,  C12Q2600/158 ,  G01N2800/56 ,  C12Q2600/16

Abstract: The diagnostic markers that provide novel diagnostic criteria to blastic plasmacytoid dendritic cell neoplasm (BPDCN) has been searched, and the presence of immunoblastoid cytomorphology, 8q24 rearrangement, and MYC expression were established as novel markers for subtyping BPDCN. It has been further found that the inhibitors which directly or indirectly inhibit the expression, functions, or signaling pathways of MYC, such as BET bromodomain-selective inhibitors or aurora kinase inhibitors, are effective in MYC-positive BPDCN, and HDAC inhibitors or BCL2 family protein inhibitors are effective as therapeutic drugs for BPDCN.

公开(公告)号：US20230237818A1

公开(公告)日：2023-07-27

申请号：US17928735

申请日：2021-03-08

Applicant: HITACHI HIGH-TECH CORPORATION ,  JAPANESE FOUNDATION FOR CANCER RESEARCH

Inventor： Hideharu HATTORI ,  Yasuki KAKISHITA ,  Kenko UCHIDA ,  Toshinari SAKURAI ,  Futoshi AKIYAMA

IPC: G06V20/69 ,  G06T7/00 ,  G06V10/77 ,  G06V10/764 ,  G16H50/20 ,  G16H30/40

CPC classification number: G06V20/698 ,  G06T7/0012 ,  G06V10/7715 ,  G06V10/764 ,  G16H50/20 ,  G16H30/40 ,  G06T2207/30096

Abstract: An image diagnosis method comprises a step of acquiring an image including at least one of a tissue and a cell as an element, a step of classifying, for each partial image that is a part of the image, a property of the element included in the partial image, and a step of sorting the image into any one of benign indicating that no lesion element is present, malignant indicating that a lesion element is present, and follow-up based on classification results of the plurality of partial images.

公开(公告)号：US11633084B2

公开(公告)日：2023-04-25

申请号：US16760458

申请日：2018-10-30

Applicant: JAPANESE FOUNDATION FOR CANCER RESEARCH ,  AI Medical Service Inc.

Inventor： Toshiaki Hirasawa ,  Tomohiro Tada ,  Kazuharu Aoyama ,  Tsuyoshi Ozawa ,  Toshiyuki Yoshio

IPC: A61B1/045 ,  A61B1/273 ,  A61B1/31 ,  G06K9/00 ,  A61B1/00 ,  G06V20/80 ,  G06T7/00

Abstract: Provided are: an image diagnosis assistance apparatus capable of assisting diagnosis of an endoscopic image captured by an endoscopist; a data collection method; an image diagnosis assistance method; and an image diagnosis assistance program. The image diagnosis assistance apparatus is provided with: a lesion assessment unit that assesses, by a convolutional neural network, the denomination and the position of a lesion which is present in a digestive system endoscopic image of a patient captured by a digestive system endoscopic imaging device and information about accuracies thereof; and a display control unit that performs control for generating an analysis result image in which the denomination and the position of the lesion and the accuracies thereof are displayed and for displaying the image on the digestive system endoscopic image.

公开(公告)号：US20220384037A1

公开(公告)日：2022-12-01

申请号：US17639062

申请日：2020-08-27

Applicant: JAPANESE FOUNDATION FOR CANCER RESEARCH ,  KONINKLIJKE PHILIPS N.V. ,  FINGGAL LINK CO., LTD.

Inventor： Naoko Tsuyama ,  Kengo Takeuchi ,  Sayuri Nakamura ,  Masayuki Hayashi ,  Takuya Sato

IPC: G16H50/20 ,  G16H70/60 ,  G16H30/40 ,  G16H30/20 ,  G16H10/40 ,  G16H15/00

Abstract: A laboratory information system (LIS) is linked with a whole slide image (WSI) management system to build a pathology image management system that can efficiently manage and utilize a digitized pathology image. A scan notification notifying that an image of a glass slide is scanned by a scanner is delivered to the LIS from the WSI management system to form a WSI link in the LIS, so that the LIS is linked with the WSI management system. By linking two systems with each other can eliminate the problem of mixing up specimens, for example, and hence, a pathologist can easily grasp the status of a pathology sample for which the pathologist is responsible.

公开(公告)号：US11415584B2

公开(公告)日：2022-08-16

申请号：US16473712

申请日：2017-12-27

Applicant: JAPANESE FOUNDATION FOR CANCER RESEARCH

Inventor： Tetsuo Mashima ,  Takeru Wakatsuki ,  Hiroyuki Seimiya ,  Kensei Yamaguchi

IPC: G01N33/68

Abstract: The therapeutic effect of and/or prognosis after administration of an anti-VEGFR-2 antibody drug, in particular, ramucirumab can be predicted by measuring VEGF-A, VEGF-D, sVEGFR-2, SDF-1α, and/or cNRP1. Provided is a biomarker for predicting the effect of administration of the anti-VEGFR-2 antibody drug, in particular, ramucirumab, and a test method and a test kit using the marker.

公开(公告)号：US20210407654A1

公开(公告)日：2021-12-30

申请号：US17474676

申请日：2021-09-14

Applicant: Sony Group Corporation ,  Japanese Foundation For Cancer Research

Inventor： Takeshi Ohashi

IPC: G16H30/20 ,  G06T11/00 ,  G02B21/36 ,  G06T3/00 ,  G06T5/50

Abstract: Provided is an information processing apparatus including an image supply unit that supplies a plurality of input images showing corresponding objects to an image processing unit and obtains a plurality of object images as an image processed result from the image processing unit, and a display control unit that synchronously displays the plurality of object images that have been obtained. The object images are regions including the corresponding objects extracted from the plurality of input images, and orientations, positions, and sizes of the corresponding objects of the plurality of object images are unified.

公开(公告)号：US20210278410A1

公开(公告)日：2021-09-09

申请号：US17259264

申请日：2019-07-05

Applicant: JAPANESE FOUNDATION FOR CANCER RESEARCH

Inventor： Koji Ueda ,  Yoshimi Haga

IPC: G01N33/574

Abstract: Provided is a test method for identifying prostate cancer by analyzing a sugar chain modifying PSA in a specimen, and detecting an abundance of a multisialylated LacdiNAc structure, in particular Glycan ID: 7512, Glycan ID: 7603, Glycan ID: 7612, and/or Glycan ID: 7613. Furthermore, calculation of PSA G-index from relative abundance(s) of Glycan ID: 7512 and/or Glycan ID: 7603 enables detection of prostate cancer with good specificity even in a patient having a PSA value in a gray zone.