公开(公告)号：US20040062774A1

公开(公告)日：2004-04-01

申请号：US10650369

申请日：2003-08-27

Applicant: University of Saskatchewan

Inventor： Andrew A. Potter ,  Jose Perez-Casal ,  Michael Fontaine

IPC: A61K039/00 ,  C07K014/705

CPC classification number: G01N33/56944 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/53 ,  C07K14/315 ,  C07K2319/00 ,  G01N2469/20

Abstract: The recombinant production of Gap4, a chimeric GapC plasmin binding protein comprising the entire amino acid sequence of the Streptococcus dysgalactiae GapC protein in addition to unique amino acid sequences from the Streptococcus parauberis and Streptococcus agalactiae GapC proteins, is described. Also described is the use of Gap4 chimeric GapC protein in vaccine compositions to prevent or treat streptococcal infections in general and mastitis in particular.

Abstract translation: 描述了除了来自婴儿链球菌和无乳链球菌GapC蛋白质的唯一氨基酸序列之外，重组产生包含除了乳酸链球菌GapC蛋白的全部氨基酸序列的嵌合GapC纤溶酶结合蛋白的Gap4。 还描述了Gap4嵌合GapC蛋白在疫苗组合物中的用途，特别是预防或治疗一般的链球菌感染和乳腺炎。

公开(公告)号：US20020106639A1

公开(公告)日：2002-08-08

申请号：US09935428

申请日：2001-08-20

Applicant: University of Saskatchewan

Inventor： Li Wang ,  Lorne A. Babiuk ,  Andrew A. Potter ,  Philip Willson

IPC: C12Q001/70 ,  C07H021/04 ,  C12N015/09 ,  C12N007/00 ,  C12N015/00 ,  C12N015/70 ,  C12N005/06 ,  C07K001/00 ,  C07K017/00 ,  C12P021/08 ,  C12Q001/68 ,  C12P021/04 ,  C12N015/63 ,  C12N005/16 ,  C07K016/00 ,  C12P021/06 ,  C12N007/01 ,  C12N015/74 ,  C07K014/00 ,  G01N033/53

CPC classification number: C07K14/005 ,  A61K38/00 ,  A61K39/00 ,  A61K39/12 ,  A61K2039/552 ,  C12N7/00 ,  C12N15/86 ,  C12N2750/10022 ,  C12N2750/10043 ,  C12Q1/701

Abstract: The cloning of a novel PCVII viral genome is described as is expression of proteins derived from the PCVII genome. These proteins can be used in vaccine compositions for the prevention and treatment of PCVII infections, as well as in diagnostic methods for determining the presence of PCVII infections in a vertebrate subject. Polynucleotides derived from the viral genome can be used as diagnostic primers and probes.

Abstract translation: 新型PCVII病毒基因组的克隆描述为源自PCVII基因组的蛋白质的表达。 这些蛋白质可用于预防和治疗PCVII感染的疫苗组合物中，以及用于确定脊椎动物受试者中PCVII感染存在的诊断方法。 衍生自病毒基因组的多核苷酸可用作诊断引物和探针。

公开(公告)号：US12063929B2

公开(公告)日：2024-08-20

申请号：US17309256

申请日：2019-11-19

Applicant: University of Saskatchewan

Inventor： Suzanne R. Abrams ,  Leon Lai ,  Naveen Diddi

IPC: C07C59/90 ,  A01N37/42 ,  A01P21/00 ,  C07C69/738

CPC classification number: A01N37/42 ,  A01P21/00 ,  C07C59/90 ,  C07C69/738

Abstract: The present application relates to novel 3′-unsaturated abscisic acid (ABA) derivatives of Formula (I) as ABA antagonists. For example, the present application relates to methods of using compounds of Formula (I) for reducing adverse effects of an ABA response in plants such as lentil and promoting germination. (I) The present application also relates to methods of using 3′-phenyl abscisic acid (ABA) derivatives of Formula (II) as ABA antagonists, for example, for reducing adverse effects of an ABA response in plants such as lentil and promoting germination. (II)

公开(公告)号：US20240237634A1

公开(公告)日：2024-07-18

申请号：US18513435

申请日：2023-11-17

Applicant: University of Saskatchewan

Inventor： Francois Eudes ,  Jaswant Singh ,  Kosala Rajapaksha ,  Muhammad Anzar ,  Gregg P. Adams

IPC: A01N1/02 ,  C12N5/076

CPC classification number: A01N1/0221 ,  A01N1/0278 ,  A01N1/0284 ,  C12N5/061

Abstract: This disclosure provides a preserving composition comprising a cholesterol:carrier complex, optionally a cholesterol:cyclodextrin complex (CC complex) and/or a cell permeable antioxidant peptide and a biological buffer and optionally a cryprotectant, wherein the preserving composition is optionally substantially free of animal phospholipid, animal protein and/or animal lipoprotein. The disclosure also provides methods for the use of the preserving composition in cryopreservation of semen or sperm cells. Also provided is a kit comprising the preserving composition having a CC complex, a biological buffer, a cryoprotectant, a carbohydrate, a pH stabilizer, an antibiotic or antibiotic cocktail and/or a cell permeable anti-oxidant peptide.

公开(公告)号：US11851459B2

公开(公告)日：2023-12-26

申请号：US17044602

申请日：2019-04-04

Applicant: University of Saskatchewan

Inventor： Troy Harkness ,  Terra Gayle Arnason

IPC: C07K14/47 ,  A61P35/00 ,  A61K38/00 ,  A61K45/06

CPC classification number: C07K14/4705 ,  A61P35/00 ,  A61K38/00 ,  A61K45/06

Abstract: Methods and uses of activators of the APC complex for treating cancer in a subject, inhibiting the growth of a cancer cell, increasing sensitivity to a cancer treatment in a cancer cell or a subject and/or reducing resistance to a cancer treatment in a cancer cell or a subject.

公开(公告)号：US20230218734A1

公开(公告)日：2023-07-13

申请号：US17996688

申请日：2021-04-19

Applicant: University of Saskatchewan ,  The University of British Columbia

Inventor： Antonio Facciuolo ,  Philip Griebel ,  Volker Gerdts ,  Andrew Potter ,  Neil Rawlyk ,  Jeffrey Chen ,  Elodie Pastural ,  Manjeet Bains ,  Michael Trimble ,  Amy Lee ,  Robert Hancock

IPC: A61K39/04 ,  A61K39/39 ,  A61P31/04 ,  G01N33/569

CPC classification number: A61K39/04 ,  A61K39/39 ,  A61P31/04 ,  G01N33/5695 ,  A61K2039/55566

Abstract: Mycobacterial antigens, such as MAP and M. bovis antigens, are described. The antigens can be used in subunit compositions to elicit immune responses in order to prevent and/or control mycobacterial infections, as well as in diagnostics in order to detect mammals infected with mycobacteria.

公开(公告)号：US20230161057A1

公开(公告)日：2023-05-25

申请号：US17908722

申请日：2021-03-04

Applicant: University of Saskatchewan

Inventor： Timothy Lewis Kelly ,  Yunlong Li ,  Richard Pettipas

IPC: G01T1/24 ,  C09D11/52 ,  C09D11/037 ,  C09D11/033 ,  C09D11/106

CPC classification number: G01T1/24 ,  C09D11/52 ,  C09D11/037 ,  C09D11/033 ,  C09D11/106

Abstract: A direct conversion x-ray detection apparatus having a planar x-ray detection layer having a detection layer upper surface and a detection layer lower surface, the planar x-ray detection layer including a lead halide perovskite material; a top electrode layer above the detection layer upper surface; a bottom electrode layer below the detection layer lower surface and in conductive communication with the top electrode layer through the x-ray detection layer to apply a bias voltage across the x-ray detection layer; and a blocking layer between the x-ray detection layer and the top electrode layer to inhibit a dark current, the blocking layer including a polymer selected from the group comprising polyacrylates, polyimides, polyamides, polysulfones, polystyrenes, and polycarbonates.

公开(公告)号：US11427886B2

公开(公告)日：2022-08-30

申请号：US15568245

申请日：2016-04-21

Applicant: UNIVERSITY OF SASKATCHEWAN

Inventor： Stephen Foley ,  Hiwa Salimi ,  Loghman Moradi

IPC: C22B11/00 ,  C22B3/16 ,  C22B3/26 ,  C22B3/06 ,  C22B3/44 ,  C07C335/26 ,  C07D207/06 ,  C07D211/16 ,  C07D295/215 ,  C22B1/00 ,  C25C1/20 ,  C25C7/06

Abstract: The present application relates to methods for the simultaneous leaching and extraction of precious metals. For example, the present application relates to methods of leaching and extracting gold and/or palladium from a substance comprising gold and/or palladium such as a gold- and/or palladium-containing ore in one step using a compound of Formula I:(I).

公开(公告)号：US20220024904A1

公开(公告)日：2022-01-27

申请号：US17368272

申请日：2021-07-06

Applicant: Research Foundation of the City University of New York ,  University of Saskatchewan

Inventor： Brian Zeglis ,  Guillaume Dewaele-Le Roi ,  Eric W. Price ,  Elaheh Khozeimeh Sarbisheh

IPC: C07D413/10 ,  A61K49/00 ,  A61K51/10 ,  A61K51/04 ,  A61K47/68 ,  A61K47/54

Abstract: A label that permits rebridging of disulfide linkages in antibodies or proteins. The label has a general formula given by wherein R1 is methyl, ethyl or propyl and R2 is a metal chelator, a fluorophore or a click-chemistry synthon.

公开(公告)号：US20210236667A1

公开(公告)日：2021-08-05

申请号：US17163145

申请日：2021-01-29

Applicant: University of Saskatchewan

Inventor： Humphrey Fonge ,  Clarence Ronald Geyer ,  Siddesh Vrushabendra swamy Hartimath

IPC: A61K51/10 ,  C07K16/28 ,  C07K16/32 ,  A61K47/68 ,  A61K47/60 ,  A61K47/64 ,  A61P35/00

Abstract: The disclosure provides radiolabeled and/or cytotoxin labelled antibodies and methods and uses of these antibodies. In one embodiment, provided is a cytotoxic agent comprising an antibody that specifically binds a target disease cell surface receptor, a cytotoxin, and a radiolabel, wherein the cytotoxin is linked directly or indirectly to the antibody, and wherein the radiolabel comprises a radionuclide and optionally a scaffold, wherein the scaffold is directly or indirectly coupled to the antibody. Also provided are methods of preparing the cytotoxic agent and methods of treating disease using the cytotoxic agent.