公开(公告)号：US20190078985A1

公开(公告)日：2019-03-14

申请号：US16129581

申请日：2018-09-12

Applicant: Worcester Polytechnic Institute

Inventor： Dirk Albrecht ,  Ross Lagoy ,  Kyra Burnett

IPC: G01N1/30 ,  G01N1/44 ,  G01N1/36 ,  G01N33/483

Abstract: Devices and methods for capturing and imaging a specimen, such as a living organism, are disclosed. In some embodiments, a method for imaging a living organism in vivo includes placing at least one specimen into a hydrogel polymer on a substrate, and curing the hydrogel to embed the at least one specimen within the cured hydrogel such that the at least one specimen is kept alive and the movement of the at least one specimen within the cured hydrogel is restricted. The at least one embedded specimen can be imaged.

公开(公告)号：US20190054275A1

公开(公告)日：2019-02-21

申请号：US16107184

申请日：2018-08-21

Applicant: WORCESTER POLYTECHNIC INSTITUTE

Inventor： Gregory S. FISCHER ,  Hao SU

IPC: A61M25/01 ,  A61M5/32 ,  A61B34/37 ,  A61B34/30 ,  A61M5/46 ,  A61B34/00

Abstract: A needle steering system and apparatus provides active, semi-autonomous control of needle insertion paths while still enabling a clinician ultimate control over needle insertion. The present teaching describes a method and system for controlling needle path as the needle is inserted by precisely controlling the rotation of the needle as it continuously rotates during insertion. This enables underactuated 2 degree-of-freedom (DOF) control of the direction and the curvature of the needle from a single rotary actuator. Control of the rotary motion is therefore decoupled from the needle insertion. The rotary motion controls steering effort and direction, while the insertion controls needle depth or insertion speed. In one implementation, the proposed method does not require constant velocity insertion, interleaved insertion and rotation, or known insertion position or speed. The insertion may be provided by a robot or other automated method, may be a manual insertion, or may be a teleoperated insertion.

公开(公告)号：US20190024045A1

公开(公告)日：2019-01-24

申请号：US16070368

申请日：2017-01-22

Applicant: The Board of Trustees of the Leland Stanford Junio University ,  Worcester Polytechnic Institute

Inventor： Utkan Demirci ,  Erkan Tüzel ,  James Leonard Kingsley ,  Thiruppathiraja Chinnasamy

IPC: C12N5/071 ,  B01L3/00

Abstract: A microfluidic chip is provided for self-sorting highly motile, morphologically normal sperm cell with high DNA integrity from a fresh semen sample. The sperm self-sorting microfluidic chip has one or more inlet chambers, and sperm collection outlet chamber(s), and the middle of the channel features various micro-fabricated structures in different geometrical shapes and orientations, with varying periodicities and patterns, such as an array of micro-fabricated pillars that facilitate the transport of the active and healthy sperm into the outlet chamber.

公开(公告)号：US10119758B2

公开(公告)日：2018-11-06

申请号：US14726803

申请日：2015-06-01

Applicant: Worcester Polytechnic Institute

Inventor： Jamal Yagoobi ,  Yasmin Khakpour

IPC: F26B3/32 ,  F26B3/18 ,  F26B13/26

Abstract: Drying a planar substrate such as paper sheet goods for packing materials includes layering a phase change material (PCM) on a substrate, in which the substrate has a moisture content and adapted for moisture removal to form a planar medium. A drying process disposes the substrate adjacent to a plurality of rollers and heat the layered substrate to a predetermined temperature based on a specific heat of the PCM. The rollers advance the layered substrate in series through pocket ventilation regions between the heat transfer elements, such that the pocket ventilation regions permit drying of the substrate enhanced by the specific heat of the temperature sensitive material. Upon drying, the layered substrate forms the planar medium suitable for use as a packing medium or other suitable application. The pocket ventilation regions are based on the PCM to facilitate drying and eradication of moisture from the paper planar substrate.

公开(公告)号：US20180284100A1

公开(公告)日：2018-10-04

申请号：US15783414

申请日：2017-10-13

Applicant: WORCESTER POLYTECHNIC INSTITUTE

Inventor： Emmanuel AGU ,  Christina AIELLO

IPC: G01N33/497 ,  G01N33/98 ,  A61B5/00

Abstract: In a mobile sensing device, a method of detecting blood alcohol content includes receiving time-series gait data from at least one sensor of the mobile sensing device as a user walks and detecting a set of attributes associated with the time-series gait data, each attribute of the set of attributes related to the user's gait. The method includes comparing the set of attributes with a machine learning classification model learned from a training data set of attributes to determine at least one of a blood alcohol content range of the user and an impairment level of the user and outputting a notification associated with the at least one of the blood alcohol content range of the user and the impairment level of the user.

公开(公告)号：US20180256070A1

公开(公告)日：2018-09-13

申请号：US15916628

申请日：2018-03-09

Applicant: Worcester Polytechnic Institute

Inventor： Lucy Garvey ,  Lubna Hassan ,  Kyla Nichols ,  Allison Paquin ,  Robert J. Daniello ,  Marsha Rolle

IPC: A61B5/087 ,  A61B5/085 ,  A61B5/091

CPC classification number: A61B5/0878 ,  A61B5/0809 ,  A61B5/085 ,  A61B5/091 ,  A61B5/1135 ,  A61B2503/40 ,  A61B2562/0271 ,  A61B2562/029

Abstract: An equine respiratory detection device provides an inexpensive, portable appliance for evaluating equine health. A muzzle or mouthpiece attaches to the equine mouth region for sealably engaging with the respiratory pathway. The mouthpiece attached to a tubular vessel having a volumetric sensing apparatus for measuring respiratory inflow and outflow rates. The sensing apparatus includes a hot wire anemometer and sensing circuit for sensing flow rates based on changing electrical characteristics of a sensing element resulting from a temperature and humidity of the respiratory gases. Inhaling results in inflow gases having a cooling effect on a thermistor which affects the current flow in the sensor circuit. Similarly, exhaled outflow gases have increased temperature and humidity which allow identification of bidirectional flow and computation of an overall respiration volume to the equine patient subject.

公开(公告)号：US10061012B2

公开(公告)日：2018-08-28

申请号：US14701977

申请日：2015-05-01

Applicant: Worcester Polytechnic Institute

Inventor： Antti E. Koski ,  David Cyganski ,  R. James Duckworth

IPC: G01S5/06 ,  G01S5/02 ,  G01S5/22 ,  G01S1/02

CPC classification number: G01S5/0278 ,  G01S1/02 ,  G01S5/0252 ,  G01S5/06 ,  G01S5/22

Abstract: A ranging and tracking system and method employs a Coherent Array Reconciliation Tomography (CART) approach that benefits from a series of samples gathered from deployed receivers in an area of interest, and applies a sequence of matrix operations and transformations to data defining locations in a Cartesian grid space for summing constructive characteristics in a received waveform for identifying a leading edge indicative of a time of arrival (TOA) from a signal source, and computing a metric based on the distance to the signal source. Sampled waveform information (data) from multiple locations in the area of interest allows computation of a likelihood metric for each location in the grid space of containing the signal source. Rendering of the grid space location having the highest likelihood metric illustrates a position of the signal source, and may be graphically depicted clustering of the locations depicting a high likelihood.

公开(公告)号：US20180064851A1

公开(公告)日：2018-03-08

申请号：US15698429

申请日：2017-09-07

Applicant: Case Western Reserve University ,  Worcester Polytechnic Institute

Inventor： Eben Alsberg ,  Anna D. Dikina ,  Marsha W. Rolle ,  Hannah A. Strobel

IPC: A61L27/38 ,  A61K35/42 ,  A61L27/58 ,  A61K35/32

CPC classification number: A61L27/3817 ,  A61K35/28 ,  A61K35/32 ,  A61K35/42 ,  A61K35/44 ,  A61L27/3804 ,  A61L27/3839 ,  A61L27/3886 ,  A61L27/54 ,  A61L27/58 ,  A61L2300/414 ,  A61L2300/62 ,  A61L2400/12 ,  A61L2430/02 ,  C12M21/08 ,  C12M25/14 ,  C12N5/0655 ,  C12N5/0697 ,  C12N2533/30

Abstract: A modular engineered tissue construct includes a plurality of fused self-assembled, scaffold-free, high-density cell aggregates. At least one cell aggregate includes a plurality of cells and a plurality of biocompatible and biodegradable nanoparticles and/or microparticles that are incorporated within the cell aggregates. The nanoparticles and/or microparticles acting as a bulking agent within the cell aggregate to increase the cell aggregate size and/or thickness and improve the mechanical properties of the cell aggregate as well as to deliver bioactive agents.

公开(公告)号：US09846042B2

公开(公告)日：2017-12-19

申请号：US14940704

申请日：2015-11-13

Applicant: Worcester Polytechnic Institute

Inventor： Benzun Wisely Babu ,  David Cyganski ,  R. James Duckworth

IPC: G01C21/20 ,  G01C21/18 ,  G05D1/02 ,  G06T7/80 ,  G06T7/246

CPC classification number: G01C21/206 ,  G01C21/18 ,  G05D1/0251 ,  G05D1/027 ,  G05D1/0274 ,  G06T7/246 ,  G06T7/85 ,  G06T2207/10012 ,  G06T2207/30244

Abstract: An indoor localization system uses Visual Simultaneous Localization and Mapping (VSLAM) aided by gyroscope sensor information. Indoor environments pose several challenges which could cause a vision only system to fail due to tracking errors. Investigation revealed significant feature loss in a vision only system when traversing plain walls, windows and staircases. However, the addition of a gyroscope helps in handling such difficult conditions by providing additional rotational information. A portable system consisting of an Inertial Measurement Unit (IMU) and a stereo camera has been developed for indoor mapping. The images and gyroscope rates acquired by the system are stored and post-processed using Gyroscope Assisted Scalable Visual Simultaneous Localization and Mapping Algorithm.

公开(公告)号：US20170322629A1

公开(公告)日：2017-11-09

申请号：US15586684

申请日：2017-05-04

Applicant: Worcester Polytechnic Institute

Inventor： Saraj Pirasmepulkul ,  Alexander Caracappa ,  Peerapat Luxsuwong ,  Cagdas D. Onal ,  William Michalson ,  Tri Khuu ,  Ming Luo

IPC: G06F3/01 ,  G06F3/0484

CPC classification number: G06F3/016 ,  G06F3/011 ,  G06F3/014 ,  G06F3/017 ,  G06F3/0346 ,  G06F3/0484 ,  G06F2203/0383 ,  G10H2220/311 ,  G10H2220/321

Abstract: A toroidal actuator is responsive to a teleoperator for providing haptic feedback responsive to a curvature or articulated movement applied to a gripped object. The toroidal actuator surrounds an operator member such as a finger, and is responsive to pneumatic pressure for increasing telepresence force defined by resistance encounter against a teleoperated robotic claw. As the teleoperated claw grips an object, increased pneumatic pressure in the toroidal actuator tends to elongate the toroidal shape in a linear manner and oppose a curvature force applied by an inserted operator finger. Resistive force is based on soft sensing of the gripped object, thus the toroidal actuator applies an increasing resistive force to curvature as the robotic claw closes around a gripped object by solenoid regulated air pressure. A typical assembly includes at least 3 toroidal actuators for two digits and a thumb of an operator.