公开(公告)号：US08182441B2

公开(公告)日：2012-05-22

申请号：US12136003

申请日：2008-06-09

Applicant: Christopher Paul Swain ,  Cole Chen ,  Mitchell Dann ,  Greg Fluet ,  John Hancock ,  Josiah Verkaik ,  Gerard von Hoffmann ,  James Wright

Inventor： Christopher Paul Swain ,  Cole Chen ,  Mitchell Dann ,  Greg Fluet ,  John Hancock ,  Josiah Verkaik ,  Gerard von Hoffmann ,  James Wright

IPC: A61M1/36

CPC classification number: A61F5/0076 ,  A61J15/0003 ,  A61J15/003 ,  A61J15/0049 ,  A61J15/0069 ,  A61J15/0084 ,  A61M31/00

Abstract: Disclosed herein are systems and methods for attaching or maintaining the position of a therapeutic or diagnostic device in a body lumen, such as the GI tract without necessarily requiring any penetrating attachments through any body walls. The system can include at least two elements: a proximal orientation element and a distal support element. The proximal orientation element can be configured to reside at least partially within the esophageal lumen and the distal support element can be configured to reside in the stomach, such as along the greater curve of the stomach. An intragastric support system can have a first configuration in which the long axis of the proximal orientation element is substantially parallel and/or substantially coaxial with the long axis of the distal support element, and a second configuration in which the long axis of the proximal orientation element is not substantially coaxial with the long axis of the distal support element. The second configuration can thus advantageously retain the intragastric support system in place and prevent unwanted proximal migration of the distal support element into the esophagus or distal migration into the intestine.

Abstract translation: 本文公开了用于将治疗或诊断装置的位置附接或维持在诸如GI道的体腔中的系统和方法，而不需要通过任何身体壁的任何穿透附着物。 该系统可以包括至少两个元件：近端定向元件和远侧支撑元件。 近端定向元件可被配置为至少部分地位于食管腔内，并且远端支撑元件可被配置为驻留在胃中，例如沿着胃的较大曲线。 胃内支持系统可以具有第一构造，其中近侧定向元件的长轴基本上与远侧支撑元件的长轴平行和/或基本上同轴，并且第二构造，其中近端定向的长轴 元件基本上与远侧支撑元件的长轴同轴。 因此，第二配置可以有利地将胃内支持系统保持在适当位置，并且防止远端支撑元件进入食道的不必要的近端迁移或远端移入肠内。

公开(公告)号：US20110275704A1

公开(公告)日：2011-11-10

申请号：US12965294

申请日：2010-12-10

Applicant: Greg Troiano ,  Young-Ho Song ,  Stephen E. Zale ,  James Wright ,  Tina Van Geen Hoven

Inventor： Greg Troiano ,  Young-Ho Song ,  Stephen E. Zale ,  James Wright ,  Tina Van Geen Hoven

IPC: A61K31/337 ,  A61P35/00 ,  A61K47/30 ,  B82Y5/00

CPC classification number: A61K31/337 ,  A61K9/0019 ,  A61K9/16 ,  A61K9/19 ,  A61K9/5123 ,  A61K9/5153 ,  A61K9/5161 ,  A61K9/5192 ,  A61K31/335 ,  A61K47/26 ,  A61K47/34 ,  A61K47/40 ,  C08G63/664 ,  Y10S977/906

Abstract: The present disclosure generally relates to lyophilized pharmaceutical compositions comprising polymeric nanoparticles which, upon reconstitution, have low levels of greater than 10 micron size particles. Other aspects of the invention include methods of making such nanoparticles.

Abstract translation: 本公开一般涉及包含聚合物纳米颗粒的冻干药物组合物，其在重构时具有低水平的大于10微米尺寸的颗粒。 本发明的其它方面包括制备这种纳米颗粒的方法。

公开(公告)号：US20110217377A1

公开(公告)日：2011-09-08

申请号：US13108361

申请日：2011-05-16

Applicant: Stephen E. Zale ,  Greg Troiano ,  Mir M. Ali ,  Jeff Hrkach ,  James Wright ,  Susan Low

Inventor： Stephen E. Zale ,  Greg Troiano ,  Mir M. Ali ,  Jeff Hrkach ,  James Wright ,  Susan Low

IPC: A61K9/14 ,  A61K31/337 ,  A61K31/436 ,  A61K31/519 ,  A61K31/437 ,  A61P35/00 ,  B82Y5/00

CPC classification number: A61K9/5153 ,  A61K9/0019 ,  A61K9/1641 ,  A61K31/337 ,  A61K31/436 ,  A61K31/475 ,  A61K31/519 ,  A61K47/542 ,  A61K47/593 ,  A61K47/60 ,  A61K47/6925 ,  A61K47/6937 ,  B82Y5/00

Abstract: The present disclosure is directed in part to a biocompatible nanoparticle composition comprising a plurality of non-colloidal long circulating nanoparticles, each comprising a α-hydroxy polyester-co-polyether and a therapeutic agent, wherein such disclosed compositions provide a therapeutic effect for at least 12 hours.

Abstract translation: 本公开部分地涉及生物相容性纳米颗粒组合物，其包含多个非胶体长循环纳米颗粒，每个非胶体长循环纳米颗粒包含α-羟基聚酯 - 共聚醚和治疗剂，其中所述公开的组合物至少提供治疗效果 12小时。

公开(公告)号：US20110193518A1

公开(公告)日：2011-08-11

申请号：US13023956

申请日：2011-02-09

Applicant: James Wright ,  Wang Ke Chun ,  Xia Guan Hao ,  Zhao Ding

Inventor： James Wright ,  Wang Ke Chun ,  Xia Guan Hao ,  Zhao Ding

IPC: H01M10/46 ,  H02J7/00

CPC classification number: H01M10/46 ,  H01M10/44 ,  H02J7/0029 ,  H02J7/0063

Abstract: A battery system is described. In one embodiment, the battery system uses a battery override. In another embodiment, the battery system has an integrated power management system having a charge controller and an inverter integrated into a single device.

Abstract translation: 描述电池系统。 在一个实施例中，电池系统使用电池超驰。 在另一个实施例中，电池系统具有集成电力管理系统，其具有集成到单个装置中的充电控制器和逆变器。

公开(公告)号：US20100069426A1

公开(公告)日：2010-03-18

申请号：US12485462

申请日：2009-06-16

Applicant: Stephen E. Zale ,  Greg Troiano ,  Mir Mukkaram Ali ,  Jeff Hrkach ,  James Wright

Inventor： Stephen E. Zale ,  Greg Troiano ,  Mir Mukkaram Ali ,  Jeff Hrkach ,  James Wright

IPC: A61K31/436 ,  A61K47/32 ,  A61P35/00 ,  A61P37/06

CPC classification number: A61K9/14 ,  A61K9/19 ,  A61K9/5146 ,  A61K9/5153 ,  A61K31/00 ,  A61K31/435 ,  A61K31/436 ,  C07C59/08 ,  Y10S977/773

Abstract: The present disclosure generally relates to therapeutic nanoparticles. Exemplary nanoparticles disclosed herein may include about 1 to about 20 weight percent of a mTOR inhibitor; and about 70 to about 99 weight percent biocompatible polymer.

Abstract translation: 本公开一般涉及治疗性纳米颗粒。 本文公开的示例性纳米颗粒可包括约1至约20重量％的mTOR抑制剂; 和约70至约99重量％的生物相容性聚合物。

公开(公告)号：US20090012553A1

公开(公告)日：2009-01-08

申请号：US12136003

申请日：2008-06-09

Applicant: Christopher Paul Swain ,  Mitchell Dann ,  Greg Fluet ,  John Hancock ,  Gerard von Hoffmann ,  James Wright

Inventor： Christopher Paul Swain ,  Mitchell Dann ,  Greg Fluet ,  John Hancock ,  Gerard von Hoffmann ,  James Wright

IPC: A61M29/00

CPC classification number: A61F5/0076 ,  A61J15/0003 ,  A61J15/003 ,  A61J15/0049 ,  A61J15/0069 ,  A61J15/0084 ,  A61M31/00

Abstract: Disclosed herein are systems and methods for attaching or maintaining the position of a therapeutic or diagnostic device in a body lumen, such as the GI tract without necessarily requiring any penetrating attachments through any body walls. The system can include at least two elements: a proximal orientation element and a distal support element. The proximal orientation element can be configured to reside at least partially within the esophageal lumen and the distal support element can be configured to reside in the stomach, such as along the greater curve of the stomach. An intragastric support system can have a first configuration in which the long axis of the proximal orientation element is substantially parallel and/or substantially coaxial with the long axis of the distal support element, and a second configuration in which the long axis of the proximal orientation element is not substantially coaxial with the long axis of the distal support element. The second configuration can thus advantageously retain the intragastric support system in place and prevent unwanted proximal migration of the distal support element into the esophagus or distal migration into the intestine.

Abstract translation: 本文公开了用于将治疗或诊断装置的位置附接或维持在诸如GI道的体腔中的系统和方法，而不需要通过任何身体壁的任何穿透附着物。 该系统可以包括至少两个元件：近端定向元件和远侧支撑元件。 近端定向元件可被配置为至少部分地位于食管腔内，并且远端支撑元件可被配置为驻留在胃中，例如沿着胃的较大曲线。 胃内支持系统可以具有第一构造，其中近侧定向元件的长轴基本上与远侧支撑元件的长轴平行和/或基本上同轴，并且第二构造，其中近端定向的长轴 元件基本上与远侧支撑元件的长轴同轴。 因此，第二配置可以有利地将胃内支持系统保持在适当位置，并且防止远端支撑元件进入食道的不必要的近端迁移或远端移入肠内。

公开(公告)号：US07413565B2

公开(公告)日：2008-08-19

申请号：US10948853

申请日：2004-09-23

Applicant: Yulun Wang ,  Modjtaba Ghodoussi ,  Darrin Uecker ,  James Wright ,  Amante Mangaser ,  Ranjan Mukherjee

Inventor： Yulun Wang ,  Modjtaba Ghodoussi ,  Darrin Uecker ,  James Wright ,  Amante Mangaser ,  Ranjan Mukherjee

IPC: A61B17/00 ,  G06F19/00

CPC classification number: G06F19/3418 ,  A61B34/30 ,  A61B34/35 ,  A61B34/37 ,  A61B34/70 ,  A61B34/75 ,  A61B34/76 ,  A61B34/77 ,  A61B90/361 ,  A61B2017/00707 ,  A61B2034/305 ,  A61B2090/064 ,  G06F19/00

Abstract: A medical system that allows a mentor to teach a pupil how to use a robotically controlled medical instrument. The system may include a first handle that can be controlled by a mentor to move the medical instrument. The system may further have a second handle that can be moved by a pupil to control the same instrument. Deviations between movement of the handles by the mentor and the pupil can be provided as force feedback to the pupil and mentor handles. The force feedback pushes the pupil's hand to correspond with the mentor's handle movement. The force feedback will also push the mentor's hand to provide information to the mentor on pupil's movements. The mentor is thus able to guide the pupil's hands through force feedback of the pupil handles to teach the pupil how to use the system.

Abstract translation: 允许导师教导学生如何使用机器人控制的医疗器械的医疗系统。 系统可以包括可由导师控制以移动医疗器械的第一手柄。 该系统还可以具有可由瞳孔移动以控制相同仪器的第二手柄。 指导者和瞳孔的手柄运动之间的偏差可以作为对瞳孔和导师手柄的力反馈来提供。 力反馈推动学生的手与导师的手柄运动相对应。 力量反馈还将推动导师的手向导师提供有关学生运动的信息。 导师因此能够引导学生的手通过瞳孔手柄的力反馈来教导学生如何使用系统。

公开(公告)号：US20080115136A1

公开(公告)日：2008-05-15

申请号：US11969075

申请日：2008-01-03

Applicant: Alan Smith ,  James Wright

Inventor： Alan Smith ,  James Wright

IPC: G06F9/46

CPC classification number: G06F11/1438 ,  G06F2201/80

Abstract: A transfer of control to a batch application is intercepted, wherein a batch front-end routine receives control in place of the batch application and performs initialization processing. This initialization processing comprises issuing a DLI restart call and issuing a DLI checkpoint call. If the DLI restart call returns a checkpoint ID, then one or more databases associated with the batch application are repositioned. The transfer of control to the batch application is then resumed, whereby the batch application restarts from the checkpoint ID, if the checkpoint ID was returned by the DLI restart call, in a manner transparent to the batch application.

Abstract translation: 拦截对批处理应用程序的控制转移，其中批量前端程序代替批处理应用程序接收控制并执行初始化处理。 该初始化处理包括发出DLI重启呼叫并发出DLI检查点呼叫。 如果DLI重新启动调用返回检查点ID，则重新定位与批处理应用程序关联的一个或多个数据库。 然后恢复对批处理应用程序的转移，如果检查点ID由DLI重新启动调用返回，批处理应用程序将以批处理应用程序透明的方式从检查点ID重新启动。

公开(公告)号：US20080104597A1

公开(公告)日：2008-05-01

申请号：US11969127

申请日：2008-01-03

Applicant: Alan Smith ,  James Wright

Inventor： Alan Smith ,  James Wright

IPC: G06F9/46

CPC classification number: G06F11/1438 ,  G06F2201/80

Abstract: A transfer of control to a batch application is intercepted, wherein a batch front-end routine receives control in place of the batch application and performs initialization processing. This initialization processing comprises issuing a DLI restart call and issuing a DLI checkpoint call. If the DLI restart call returns a checkpoint ID, then one or more databases associated with the batch application are repositioned. The transfer of control to the batch application is then resumed, whereby the batch application restarts from the checkpoint ID, if the checkpoint ID was returned by the DLI restart call, in a manner transparent to the batch application.

Abstract translation: 拦截对批处理应用程序的控制转移，其中批量前端程序代替批处理应用程序接收控制并执行初始化处理。 该初始化处理包括发出DLI重启呼叫并发出DLI检查点呼叫。 如果DLI重新启动调用返回检查点ID，则重新定位与批处理应用程序关联的一个或多个数据库。 然后恢复对批处理应用程序的转移，如果检查点ID由DLI重新启动调用返回，批处理应用程序将以批处理应用程序透明的方式从检查点ID重新启动。

公开(公告)号：US20080017552A1

公开(公告)日：2008-01-24

申请号：US11824230

申请日：2007-06-29

Applicant: James Wright ,  Carl White ,  Kurt Gabrielson ,  John Hines ,  Lisa Arthur ,  Michael Cousin

Inventor： James Wright ,  Carl White ,  Kurt Gabrielson ,  John Hines ,  Lisa Arthur ,  Michael Cousin

IPC: B03D1/02 ,  B03D1/00 ,  B03D3/02

CPC classification number: C08G2/02 ,  B03D1/0046 ,  B03D1/01 ,  B03D1/012 ,  B03D1/016 ,  B03D1/08 ,  B03D3/06 ,  B03D2201/06 ,  B03D2203/006 ,  B03D2203/02 ,  B03D2203/025 ,  C02F1/24 ,  C02F1/44 ,  C02F1/444 ,  C02F1/56 ,  C02F1/66 ,  C02F2101/10 ,  C02F2101/103 ,  C02F2101/20

Abstract: Modified resins are disclosed for removing a wide variety of solids and/or ionic species from the liquids in which they are suspended and/or dissolved. These modified resins are especially useful as froth flotation depressants in the beneficiation of many types of materials (e.g., mineral and metal ores), including the beneficiation of impure coal comprising clay impurities, as well as in the separation of valuable bitumen from solid contaminants such as sand. The modified resins are also useful for treating aqueous liquid suspensions to facilitate the removal of solid particulates, as well as the removal of metallic ions in the purification of water. The modified resins comprise a base resin that is modified with a coupling agent, which is highly selective for binding to solid contaminants and especially siliceous materials such as sand or clay.

Abstract translation: 公开了用于从悬浮和/或溶解的液体中除去多种固体和/或离子物质的改性树脂。 这些改性树脂在许多类型的材料（例如矿物和金属矿石）的选矿中特别可用作泡沫浮选抑制剂，包括选择含有粘土杂质的不纯的煤，以及将有价值的沥青从固体污染物分离出来 作为沙子。 改性树脂也可用于处理含水液体悬浮液以便于去除固体颗粒，以及在净化水中去除金属离子。 改性树脂包括用耦合剂改性的基础树脂，其对于结合固体污染物，特别是硅质材料如沙子或粘土是高选择性的。