METHODS FOR MAKING DRUG-CONTAINING POROUS SILICONE STRUCTURES
    52.
    发明申请
    METHODS FOR MAKING DRUG-CONTAINING POROUS SILICONE STRUCTURES 审中-公开
    制备含多孔硅酮结构的方法

    公开(公告)号:US20160310644A1

    公开(公告)日:2016-10-27

    申请号:US15135034

    申请日:2016-04-21

    Abstract: The invention provides methods for making silicone structures, drug delivery devices and active pharmaceutical agent delivery systems and medical devices containing one or more active pharmaceutical ingredients. The invention provides silicone structures, drug delivery devices and active pharmaceutical agent delivery systems containing one or more active pharmaceutical ingredients. The silicones used in the invention are foaming silicones, which generate void-forming gases which completely volatilize during curing. The silicone structures, drug delivery devices and active pharmaceutical agent delivery systems can be of any shape or size, and are porous, and are capable of being loaded with high doses of the desired drug or drugs. The active pharmaceutical ingredients can be incorporated into the silicone prior to curing, or subsequent to curing, via a soaking process. Additionally, the rate of drug release from the silicone structures, drug delivery devices and active pharmaceutical agent delivery systems of the invention can be controlled by a post-curing membrane or sheath surrounding the structures. Further provided are methods of treating disease in mammals, preventing the onset of disease in mammals and lessening the severity of disease in mammals, by implanting one or more structures, drug delivery devices and active pharmaceutical agent delivery systems into the mammal.

    Abstract translation: 本发明提供了制备硅酮结​​构,药物递送装置和活性药剂递送系统以及含有一种或多种活性药物成分的医疗装置的方法。 本发明提供了含有一种或多种活性药物成分的硅酮结构,药物递送装置和活性药剂递送系统。 本发明中使用的硅氧烷是发泡硅氧烷,其产生在固化期间完全挥发的形成空气的气体。 硅氧烷结构,药物递送装置和活性药物递送系统可以是任何形状或尺寸,并且是多孔的,并且能够装载高剂量的所需药物或药物。 活性药物成分可以在固化之前或通过浸泡过程固化后并入硅氧烷中。 此外,本发明的硅氧烷结构,药物递送装置和活性药物递送系统的药物释放速率可以通过围绕结构的后固化膜或鞘来控制。 还提供了通过将哺乳动物中的一种或多种结构,药物递送装置和活性药物递送系统植入哺乳动物中来治疗哺乳动物疾病的方法,防止哺乳动物疾病发作并减轻哺乳动物疾病的严重性。

    Urethane foam molded product and method for producing the same
    56.
    发明授权
    Urethane foam molded product and method for producing the same 有权
    聚氨酯泡沫成型体及其制造方法

    公开(公告)号:US09399706B2

    公开(公告)日:2016-07-26

    申请号:US14044157

    申请日:2013-10-02

    Abstract: To provide a urethane foam molded product having high thermal conductivity and electric insulation and a method for producing the same. A urethane foam molded product includes a base material made of a polyurethane foam and composite particles that are blended in the base material and oriented in a mutually connected state, in which each of the composite particles includes a thermally conductive particle made of a non-magnetic body, and a magnetic particle and an insulating inorganic particle that are adhered to the surface of the thermally conductive particle through a binder. A powder of the composite particles can be produced by stirring a powder raw material containing a powder of the thermally conductive particle, a powder of the magnetic particle, a powder of the insulating inorganic particle, and the binder using a stirring granulator.

    Abstract translation: 提供具有高导热性和电绝缘性的聚氨酯泡沫成型体及其制造方法。 聚氨酯泡沫成型体包括由聚氨酯泡沫制成的基材和混合在基材中并以相互连接的方式取向的复合颗粒,其中每个复合颗粒包括由非磁性材料制成的导热颗粒 主体和通过粘合剂粘附到导热颗粒的表面的磁性颗粒和绝缘无机颗粒。 可以通过使用搅拌造粒机搅拌含有导热颗粒粉末,磁性颗粒粉末,绝缘无机颗粒粉末和粘合剂的粉末原料来制备复合颗粒粉末。

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