公开(公告)号：US08264684B2

公开(公告)日：2012-09-11

申请号：US13031784

申请日：2011-02-22

Applicant: Richard Livingston

Inventor： Richard Livingston

IPC: G01N21/00

CPC classification number: G01N21/6428 ,  B01L3/5085 ,  B01L2300/0654 ,  B01L2300/0829 ,  G01N15/14 ,  G01N15/1429 ,  G01N15/1434 ,  G01N15/1456 ,  G01N15/1463 ,  G01N21/64 ,  G01N21/645 ,  G01N21/6452 ,  G01N21/6458 ,  G01N33/53 ,  G01N2015/0038 ,  G01N2015/1402 ,  G01N2015/1447 ,  G01N2015/1452 ,  G01N2201/02 ,  G01N2201/06113 ,  G01N2201/062 ,  G01N2201/0697

Abstract: The invention encompasses analyzers and analyzer systems that include a single molecule analyzer, methods of using the analyzer and analyzer systems to analyze samples, either for single molecules or for molecular complexes. The single molecule uses electromagnetic radiation that is translated through the sample to detect the presence or absence of a single molecule. The single molecule analyzer provided herein is useful for diagnostics because the analyzer detects single molecules with zero carryover between samples.

Abstract translation: 本发明包括分析仪和分析仪系统，其包括单分子分析仪，使用分析仪和分析仪系统分析样品的单分子或分子复合物的方法。 单分子使用通过样品翻译的电磁辐射来检测单个分子的存在或不存在。 本文提供的单分子分析仪可用于诊断，因为分析仪检测样品之间具有零携带的单分子。

公开(公告)号：US20110192248A1

公开(公告)日：2011-08-11

申请号：US13022353

申请日：2011-02-07

Applicant: Omar Daniel LOPEZ ,  Gary Wiederrecht ,  David J. Gosztola ,  Derrick C. Mancini

Inventor： Omar Daniel LOPEZ ,  Gary Wiederrecht ,  David J. Gosztola ,  Derrick C. Mancini

IPC: B81B7/02

CPC classification number: H02N1/008 ,  B25J7/00 ,  G01N21/658 ,  G01N2201/02 ,  G02B5/008 ,  G02F1/17 ,  Y10T74/20354 ,  Y10T74/2036

Abstract: A nanopositioning system for producing a coupling interaction between a first nanoparticle and a second nanoparticle. A first MEMS positioning assembly includes an electro-static comb drive actuator configured to selectively displace a first nanoparticle in a first dimension and an electrode configured to selectively displace the first nanoparticle in a second dimensions. Accordingly, the first nanoparticle may be selectively positioned in two dimensions to modulate the distance between the first nanoparticle and a second nanoparticle that may be coupled to a second MEMS positioning assembly. Modulating the distance between the first and second nanoparticles obtains a coupling interaction between the nanoparticles that alters at least one material property of the nanoparticles applicable to a variety of sensing and control applications.

Abstract translation: 一种用于产生第一纳米颗粒和第二纳米颗粒之间的偶联相互作用的纳米定位系统。 第一MEMS定位组件包括静电梳状驱动致动器，其被配置为选择性地置换第一尺寸中的第一纳米颗粒和被配置成在第二维度中选择性地置换第一纳米颗粒的电极。 因此，第一纳米颗粒可以被选择性地定位在二维上以调节第一纳米颗粒和第二纳米颗粒之间的距离，第二纳米颗粒可以耦合到第二MEMS定位组件。 调节第一和第二纳米颗粒之间的距离获得纳米颗粒之间的耦合相互作用，其改变适用于各种感测和控制应用的纳米颗粒的至少一种材料性质。

公开(公告)号：US07872734B2

公开(公告)日：2011-01-18

申请号：US12815372

申请日：2010-06-14

Applicant: James R. Braig ,  Peter Rule ,  Phillip C. Hartstein ,  Bernhard B. Sterling ,  Jennifer H. Gable ,  Kenneth I. Li

Inventor： James R. Braig ,  Peter Rule ,  Phillip C. Hartstein ,  Bernhard B. Sterling ,  Jennifer H. Gable ,  Kenneth I. Li

IPC: G01N33/48

CPC classification number: A61B5/157 ,  A61B5/01 ,  A61B5/1411 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/150022 ,  A61B5/150083 ,  A61B5/150213 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150458 ,  A61B5/150503 ,  A61B5/150618 ,  A61B5/150717 ,  A61B5/15087 ,  A61B5/151 ,  A61B5/15107 ,  A61B5/15136 ,  A61B5/1514 ,  A61B5/15194 ,  A61B5/6826 ,  A61B5/6838 ,  A61B10/0045 ,  A61B2562/0295 ,  A61B2562/12 ,  G01N21/03 ,  G01N21/0332 ,  G01N21/35 ,  G01N21/3577 ,  G01N21/3581 ,  G01N33/49 ,  G01N33/66 ,  G01N2021/0389 ,  G01N2201/02 ,  G01N2201/068

Abstract: A reagentless whole-blood analyte detection system that is capable of being deployed near a patient has a source capable of emitting a beam of radiation that includes a spectral band. The whole-blood system also has a detector in an optical path of the beam. The whole-blood system also has a housing that is configured to house the source and the detector. The whole-blood system also has a sample element that is situated in the optical path of the beam. The sample element has a sample cell and a sample cell wall that does not eliminate transmittance of the beam of radiation in the spectral band.

公开(公告)号：US07746465B2

公开(公告)日：2010-06-29

申请号：US11966557

申请日：2007-12-28

Applicant: Douglas C. Mark

Inventor： Douglas C. Mark

IPC: G01N21/01

CPC classification number: G01N21/23 ,  G01N21/01 ,  G01N2021/0339 ,  G01N2201/02

Abstract: The sample holder includes support having a thickness and an aperture through the thickness of the support. A tilt mechanism is connected to the support for controlled tilting of the support, and the aperture through the support is configured to have a diameter that increases in a direction through the thickness of the support. This arrangement enables a light beam to pass through the same given area of the sample, irrespective of whether the sample is held perpendicular to the beam or held at a tilted position relative to the beam. In one embodiment, the holder includes an efficient magnetic clamp mechanism for securing the sample to the holder. The holder compactly integrates with tilting mechanisms a sample rotation mechanism.

Abstract translation: 样品保持器包括具有穿过支撑件的厚度的厚度和孔径的支撑件。 倾斜机构连接到支撑件以用于支撑件的受控倾斜，并且通过支撑件的孔被构造成具有在穿过支撑件的厚度的方向上增加的直径。 这种布置使得光束能够通过样品的相同的给定区域，而不管样品是保持垂直于光束还是保持在相对于光束的倾斜位置。 在一个实施例中，保持器包括用于将样品固定到保持器的有效的磁性夹紧机构。 夹持器与倾斜机构紧密地集成了样品旋转机构。

公开(公告)号：US20100035358A1

公开(公告)日：2010-02-11

申请号：US12575004

申请日：2009-10-07

Applicant: Dennis A. Lehto ,  Steven J. Boege

Inventor： Dennis A. Lehto ,  Steven J. Boege

IPC: G01N31/00 ,  G01N21/00

CPC classification number: C12Q1/6874 ,  B01J2219/00286 ,  B01J2219/00306 ,  B01J2219/005 ,  B01J2219/00533 ,  B01J2219/00596 ,  B01J2219/00648 ,  B01L3/502 ,  B01L3/50851 ,  B01L7/00 ,  B01L7/52 ,  B01L9/527 ,  B01L2200/10 ,  B01L2300/043 ,  B01L2300/0822 ,  B01L2300/0877 ,  B01L2300/1805 ,  B01L2300/1811 ,  B01L2300/1894 ,  G01N15/1459 ,  G01N15/1463 ,  G01N15/1484 ,  G01N21/0332 ,  G01N21/05 ,  G01N2021/0346 ,  G01N2021/058 ,  G01N2201/02 ,  G03B27/42

Abstract: A device for performing biological sample reactions may include a plurality of flow cells configured to be mounted to a common microscope translation stage, wherein each flow cell is configured to receive at least one sample holder containing biological sample. Each flow cell also may be configured to be selectively placed in an open position for positioning the at least one sample holder into the flow cell and a closed position for reacting biological sample contained in the at least one sample holder. The plurality of flow cells may be configured to be selectively placed in the open position and the closed position independently of each other.

Abstract translation: 用于进行生物样品反应的装置可以包括多个流动池，其构造成安装到普通的显微镜平移台上，其中每个流动池被构造成容纳至少一个含有生物样品的样品架。 每个流动池还可以被配置为选择性地放置在打开位置，用于将至少一个样品保持器定位到流动室中，以及用于使包含在至少一个样品保持器中的生物样品反应的关闭位置。 多个流动池可以被配置为被选择性地彼此相对放置在打开位置和关闭位置。

公开(公告)号：US07619752B2

公开(公告)日：2009-11-17

申请号：US11980262

申请日：2007-10-30

Applicant: Martin M. Liphardt ,  Christopher A. Goeden

Inventor： Martin M. Liphardt ,  Christopher A. Goeden

IPC: G01B11/14

CPC classification number: G01N21/211 ,  G01N21/47 ,  G01N21/55 ,  G01N2201/02

Abstract: System and method for orienting the tilt and vertical position of samples in ellipsometer and the like systems.

Abstract translation: 用于定位椭偏仪等样品的倾斜和垂直位置的系统和方法。

公开(公告)号：US20090213360A1

公开(公告)日：2009-08-27

申请号：US12343218

申请日：2008-12-23

Applicant: James R. Braig ,  Peter Rule ,  Philip C. Hartstein ,  Bernhard B. Sterling ,  Jennifer H. Gable ,  Kenneth I. Li

Inventor： James R. Braig ,  Peter Rule ,  Philip C. Hartstein ,  Bernhard B. Sterling ,  Jennifer H. Gable ,  Kenneth I. Li

IPC: G01N33/48

CPC classification number: A61B5/157 ,  A61B5/01 ,  A61B5/1411 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/150022 ,  A61B5/150083 ,  A61B5/150213 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150458 ,  A61B5/150503 ,  A61B5/150618 ,  A61B5/150717 ,  A61B5/15087 ,  A61B5/151 ,  A61B5/15107 ,  A61B5/15136 ,  A61B5/1514 ,  A61B5/15194 ,  A61B5/6826 ,  A61B5/6838 ,  A61B10/0045 ,  A61B2562/0295 ,  A61B2562/12 ,  G01N21/03 ,  G01N21/0332 ,  G01N21/35 ,  G01N21/3577 ,  G01N21/3581 ,  G01N33/49 ,  G01N33/66 ,  G01N2021/0389 ,  G01N2201/02 ,  G01N2201/068

Abstract: A reagentless whole-blood analyte detection system that is capable of being deployed near a patient has a source capable of emitting a beam of radiation that includes a spectral band. The whole-blood system also has a detector in an optical path of the beam. The whole-blood system also has a housing that is configured to house the source and the detector. The whole-blood system also has a sample element that is situated in the optical path of the beam. The sample element has a sample cell and a sample cell wall that does not eliminate transmittance of the beam of radiation in the spectral band.

Abstract translation: 能够在患者附近部署的无试剂全血分析物检测系统具有能够发射包括光谱带的辐射束的源。 全血系统还具有光束的光路中的检测器。 全血系统还具有容纳源和检测器的壳体。 全血系统还具有位于束的光路中的样品元件。 样品元件具有不消除光谱带中的辐射束的透射率的样品池和样品池壁。

公开(公告)号：US20090139311A1

公开(公告)日：2009-06-04

申请号：US12244701

申请日：2008-10-02

Applicant: Dennis A. Lehto ,  Steven J. Boege

Inventor： Dennis A. Lehto ,  Steven J. Boege

IPC: G01N30/00 ,  B01L3/00

CPC classification number: C12Q1/6874 ,  B01J2219/00286 ,  B01J2219/00306 ,  B01J2219/005 ,  B01J2219/00533 ,  B01J2219/00596 ,  B01J2219/00648 ,  B01L3/502 ,  B01L3/50851 ,  B01L7/00 ,  B01L7/52 ,  B01L9/527 ,  B01L2200/10 ,  B01L2300/043 ,  B01L2300/0822 ,  B01L2300/0877 ,  B01L2300/1805 ,  B01L2300/1811 ,  B01L2300/1894 ,  G01N15/1459 ,  G01N15/1463 ,  G01N15/1484 ,  G01N21/0332 ,  G01N21/05 ,  G01N2021/0346 ,  G01N2021/058 ,  G01N2201/02 ,  G03B27/42

Abstract: A device for performing biological sample reactions may include a plurality of flow cells configured to be mounted to a common microscope translation stage, wherein each flow cell is configured to receive at least one sample holder containing biological sample. Each flow cell also may be configured to be selectively placed in an open position for positioning the at least one sample holder into the flow cell and a closed position for reacting biological sample contained in the at least one sample holder. The plurality of flow cells may be configured to be selectively placed in the open position and the closed position independently of each other.

Abstract translation: 用于进行生物样品反应的装置可以包括多个流动池，其构造成安装到普通的显微镜平移台上，其中每个流动池被构造成容纳至少一个含有生物样品的样品架。 每个流动池还可以被配置为选择性地放置在打开位置，用于将至少一个样品保持器定位到流动室中，以及用于使包含在至少一个样品保持器中的生物样品反应的关闭位置。 多个流动池可以被配置为被选择性地彼此相对放置在打开位置和关闭位置。

公开(公告)号：US07481787B2

公开(公告)日：2009-01-27

申请号：US11316672

申请日：2005-12-21

Applicant: Jennifer H. Gable ,  James R. Braig ,  Kenneth I. Li ,  Mark Wechsler ,  Peng Zheng ,  Richard Keenan

Inventor： Jennifer H. Gable ,  James R. Braig ,  Kenneth I. Li ,  Mark Wechsler ,  Peng Zheng ,  Richard Keenan

IPC: A61N1/30

CPC classification number: A61B5/157 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0086 ,  A61B5/1411 ,  A61B5/1427 ,  A61B5/1451 ,  A61B5/14517 ,  A61B5/14532 ,  A61B5/14535 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/15003 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150267 ,  A61B5/150358 ,  A61B5/150755 ,  A61B5/150862 ,  A61B5/150992 ,  A61B5/153 ,  A61B5/155 ,  A61B5/4839 ,  A61B10/0064 ,  A61B2560/0443 ,  A61M5/14212 ,  A61M5/14232 ,  A61M5/16854 ,  A61M5/1723 ,  A61M5/365 ,  A61M5/38 ,  A61M2205/12 ,  A61M2205/3306 ,  A61M2230/20 ,  A61M2230/201 ,  G01N21/03 ,  G01N21/3577 ,  G01N2021/3595 ,  G01N2201/02 ,  G01N2201/061 ,  G06F19/00 ,  Y10T137/4478 ,  Y10T137/7722 ,  Y10T137/86485 ,  Y10T436/111666 ,  Y10T436/2575

Abstract: A fluid handling module is configured for removable engagement with a reusable main fluid handling instrument. The module includes a module housing and a first fluid passageway extending from the module housing. The first fluid passageway has a patient end remote from the housing. The first fluid passageway is configured to provide fluid communication with a bodily fluid in a patient. A fluid component separator is in fluid communication with the first fluid passageway. The fluid component separator is configured to separate at least one component from a portion of the bodily fluid drawn from the patient. A spectroscopic sample cell is configured to hold at least a portion of the first component.

Abstract translation: 流体处理模块被配置为可移除地与可重复使用的主流体处理装置接合。 模块包括模块壳体和从模块壳体延伸的第一流体通道。 第一流体通道具有远离壳体的患者端。 第一流体通道被配置为提供与患者体内的体液的流体连通。 流体组分分离器与第一流体通道流体连通。 流体组分分离器构造成将至少一种组分与从患者抽出的体液的一部分分离。 光谱样品池被配置为保持第一组分的至少一部分。

公开(公告)号：US20030086074A1

公开(公告)日：2003-05-08

申请号：US10219625

申请日：2002-08-14

Inventor： James R. Braig ,  Peter Rule ,  Philip C. Hartstein

IPC: G01N033/48

CPC classification number: A61B5/157 ,  A61B5/01 ,  A61B5/1411 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/150022 ,  A61B5/150083 ,  A61B5/150213 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150458 ,  A61B5/150503 ,  A61B5/150618 ,  A61B5/150717 ,  A61B5/15087 ,  A61B5/151 ,  A61B5/15107 ,  A61B5/15136 ,  A61B5/1514 ,  A61B5/15194 ,  A61B5/6826 ,  A61B5/6838 ,  A61B10/0045 ,  A61B2562/0295 ,  A61B2562/12 ,  G01N21/03 ,  G01N21/0332 ,  G01N21/35 ,  G01N21/3577 ,  G01N21/3581 ,  G01N33/49 ,  G01N33/66 ,  G01N2021/0389 ,  G01N2201/02 ,  G01N2201/068

Abstract: A reagentless whole-blood analyte detection system that is capable of being deployed near a patient has a source capable of emitting a beam of radiation that includes a spectral band. The whole-blood system also has a detector in an optical path of the beam. The whole-blood system also has a housing that is configured to house the source and the detector. The whole-blood system also has a sample element that is situated in the optical path of the beam. The sample element has a sample cell and a sample cell wall that does not eliminate transmittance of the beam of radiation in the spectral band.