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    IN SITU HYBRIDIZATION DETECTION METHOD
    61.
    发明申请
    IN SITU HYBRIDIZATION DETECTION METHOD 审中-公开
    原位杂交检测方法

    公开(公告)号：US20160273035A1

    公开(公告)日：2016-09-22

    申请号：US14659847

    申请日：2015-03-17

    Applicant: DAKO DENMARK A/S

    Inventor： Lars Winther ,  Jesper Lohse ,  Susanne Gabs ,  Kenneth Heesche Petersen

    IPC: C12Q1/68

    CPC classification number: C12Q1/6876 ,  C12Q1/6841 ,  C12Q2525/161 ,  C12Q2565/40

    Abstract: The invention provides compositions and methods for the detection of targets in a sample; in particular, an in situ hybridization (ISH) sample. Probes and detectable labels may be provided in multiple layers in order to increase the flexibility of a detection system, and to allow for amplification to enhance the signal from a target. The layers may be created by incorporating probes and detectable labels into larger molecular units that interact through nucleic acids base-pairing, including peptide-nucleic acid (PNA) base-pairing. Optional non-natural bases allow for degenerate base pairing schemes. The compositions and methods are also compatible with immunohistochemistry (IHC), immunocytochemistry (ICC), flow cytometry, enzyme immuno-assays (EIA), enzyme linked immuno-assays (ELISA), blotting methods (e.g. Western, Southern, and Northern), labeling inside electrophoresis systems or on surfaces or arrays, and precipitation, among other general detection assay formats. The invention is also compatible with many different types of targets, probes, and detectable labels.

    Abstract translation: 本发明提供用于检测样品中靶标的组合物和方法; 特别是原位杂交（ISH）样品。 可以以多层提供探针和可检测标记，以便增加检测系统的灵活性，并允许放大以增强来自靶的信号。 可以通过将探针和可检测标记掺入通过核酸碱基配对（包括肽 - 核酸（PNA）碱基配对）相互作用的较大分子单元中来产生层。 可选的非天然碱基允许简并碱基配对方案。 组合物和方法还与免疫组化（IHC），免疫细胞化学（ICC），流式细胞术，酶免疫测定（EIA），酶联免疫测定（ELISA），印迹方法（例如西方，南方和北方）相兼容， 标记电泳系统或表面或阵列，以及其他一般检测测定形式的沉淀。 本发明还与许多​​不同类型的靶，探针和可检测标记相兼容。

    Tissue processing apparatus
    63.
    发明授权
    Tissue processing apparatus 有权
    组织处理装置

    公开(公告)号：US09182323B2

    公开(公告)日：2015-11-10

    申请号：US14503925

    申请日：2014-10-01

    Applicant: DAKO DENMARK A/S

    Inventor： Tim Svenstrup Poulsen ,  Steen Hauge Matthiesen

    IPC: B01L3/02 ,  G01N1/30 ,  G01N1/28 ,  G01N1/31

    CPC classification number: G01N1/2813 ,  G01N1/30 ,  G01N1/312

    Abstract: An apparatus for processing a biological sample is provided. The biological sample being arranged on a first planar surface of a carrier, the apparatus having a second planar surface arranged substantially parallel to said first planar surface and at a first distance from said first planar surface. The first planar surface and said second planar surface are arranged at an angle (A) greater than zero degree from the horizontal plane (HP). The apparatus having a supply for supplying an amount of a liquid that is to be applied to said biological sample. The first planar surface and said second planar surface are configured to be arranged at a second distance from each other, said second distance being such that said supplied amount of liquid is distributed over said biological sample when said first planar surface and said second planar surface are brought to said second distance from each other.

    Abstract translation: 提供了一种用于处理生物样品的装置。 生物样品布置在载体的第一平坦表面上，该装置具有基本上平行于所述第一平坦表面并且距离所述第一平面的第一距离布置的第二平坦表面。 第一平坦表面和所述第二平坦表面以与水平面（HP）大于零度的角度（A）布置。 该装置具有用于供应一定量待应用于所述生物样品的液体的供给装置。 第一平坦表面和第二平坦表面被配置为彼此间隔开第二距离，所述第二距离使得当所述第一平面和所述第二平面是所述第一平面和所述第二平面时，所述供应量的液体分布在所述生物样品上 带到彼此的第二距离。

    ANTIBODY COCKTAIL
    64.
    发明申请
    ANTIBODY COCKTAIL 有权
    抗体蛋白

    公开(公告)号：US20150301054A1

    公开(公告)日：2015-10-22

    申请号：US14693084

    申请日：2015-04-22

    Applicant: DAKO DENMARK A/S

    Inventor： Zhiming LIAO ,  Jeanette MUSSER

    IPC: G01N33/574

    CPC classification number: G01N33/57434 ,  G01N2333/47 ,  G01N2333/4742 ,  G01N2333/99 ,  G01N2800/52

    Abstract: The present invention relates to a composition comprising at least three primary antibodies or fragments thereof, wherein the at least three antibodies or fragments thereof binds specifically to at least three different proteins, and wherein the at least three different proteins are AMCAR, CK 5/6, and HMWC. Methods for using the composition in diagnosis, prognosis, and assessing efficacy of treatment is further included as well as kits comprising said composition, and optionally, instructions of its use.

    Abstract translation: 本发明涉及包含至少三种一抗或其片段的组合物，其中所述至少三种抗体或其片段特异性结合至少三种不同的蛋白质，并且其中所述至少三种不同的蛋白质是AMCAR，CK5 / 6 ，和HMWC。 进一步包括在组合物诊断，预后和评价治疗功效中使用该组合物的方法以及包含所述组合物和任选的其使用说明书的试剂盒。

    METHOD FOR DETECTION OF L523S EXPRESSION IN BIOLOGICAL SAMPLES
    65.
    发明申请
    METHOD FOR DETECTION OF L523S EXPRESSION IN BIOLOGICAL SAMPLES 有权
    用于检测生物样品中L523S表达的方法

    公开(公告)号：US20150072891A1

    公开(公告)日：2015-03-12

    申请号：US14492171

    申请日：2014-09-22

    Applicant: DAKO DENMARK A/S

    Inventor： Katherine Marks SOJKA ,  Elizabeth Oliver SPAULDING

    IPC: G01N33/574

    CPC classification number: G01N33/57476 ,  G01N33/5743

    Abstract: The present invention discloses methods for differentiating between normal or reactive cells and malignant cells in biological samples comprising: exposing the biological sample to an antibody to L523S protein and detecting the presence of the antibody bound to L523S protein within the malignant cells, in embodiments, such methods may further comprise: exposing the biological sample to an antibody to a second protein that is a marker of cell lineage and detecting the presence of the antibody to the second protein within cells corresponding to a particular ceil lineage and/or may comprise: exposing the biological sample to an antibody to a third protein which is a marker of cells that are normal or reactive and detecting the presence of the antibody to the third protein within cells that are normal or reactive.

    Abstract translation: 本发明公开了用于区分生物样品中的正常或反应性细胞与恶性细胞的方法，包括：将生物样品暴露于L523S蛋白的抗体，并检测在恶性细胞内与L523S蛋白结合的抗体的存在， 方法可以进一步包括：将生物样品暴露于作为细胞谱系标志物的第二蛋白质的抗体，并检测在对应于特定细胞谱系的细胞内第二种蛋白质的抗体的存在和/或可以包括： 生物样品与第三种蛋白质的抗体，其是正常或反应性细胞的标志物，并检测在正常或反应性细胞内第三种蛋白质的存在。

    HYBRIDIZATION COMPOSITIONS AND METHODS USING FORMAMIDE
    66.
    发明申请
    HYBRIDIZATION COMPOSITIONS AND METHODS USING FORMAMIDE 审中-公开
    杂化组合物和使用甲酰胺的方法

    公开(公告)号：US20140234844A1

    公开(公告)日：2014-08-21

    申请号：US14348134

    申请日：2012-09-28

    Applicant: DAKO DENMARK A/S

    Inventor： Steen Hauge Matthiesen

    IPC: C12Q1/68

    CPC classification number: C12Q1/6832 ,  C12Q1/6841 ,  C12Q1/6876 ,  C12Q2523/113 ,  C12Q2527/125 ,  C12Q2527/137

    Abstract: The invention provides methods and compositions for hybridizing at least one molecule to a target. The composition comprises at least one nucleic acid sequence, formamide, and a hybridization solution, wherein the concentration of formamide is less than or equal to 25%.

    Abstract translation: 本发明提供了用于将至少一种分子与目标物杂交的方法和组合物。 组合物包含至少一种核酸序列，甲酰胺和杂交溶液，其中甲酰胺的浓度小于或等于25％。

    SYSTEMS AND METHODS FOR TRACKING AND PROVIDING WORKFLOW INFORMATION
    70.
    发明申请
    SYSTEMS AND METHODS FOR TRACKING AND PROVIDING WORKFLOW INFORMATION 有权

    公开(公告)号：US20130166345A1

    公开(公告)日：2013-06-27

    申请号：US13690032

    申请日：2012-11-30

    Applicant: DAKO DENMARK A/S

    Inventor： Laura Chirica ,  Mats Grahn ,  Stephen Jones

    IPC: G06Q10/06

    CPC classification number: G06Q10/0633 ,  G06F19/00 ,  G06Q10/06 ,  G16H10/40 ,  G16H40/20 ,  G16H40/67

    Abstract: A tangible computer-readable storage device storing computer-executable program instructions that generate a user interface for displaying workflow information associated with a tissue specimen in a pathology laboratory. The program instructions may be configured to perform a method including displaying a virtual laboratory component representing a physical pathology laboratory having one or more laboratory stations for processing the tissue specimen, wherein the tissue specimen is processed by the one or more laboratory stations according to a workflow, and displaying a specimen indicator that indicates a current specimen state based on a current relationship of the tissue specimen to the workflow. The method may further include enabling a first active component associated with the virtual laboratory component, wherein the first active component is configured to receive a user selection of a laboratory station and generating a supplemental view component of the selected laboratory station in response to the user selection, wherein the supplemental view provides supplemental information on processing by the selected laboratory station of the tissue specimen.

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