公开(公告)号：US11826560B2

公开(公告)日：2023-11-28

申请号：US17999708

申请日：2021-05-19

Applicant: RaySearch Laboratories AB

Inventor： Tianfang Zhang

IPC: A61N5/10 ,  G16H20/40

CPC classification number: A61N5/1039 ,  A61N5/1031 ,  A61N5/1038 ,  G16H20/40 ,  A61N2005/1034

Abstract: A computer-implemented method for generating a radiation therapy treatment plan for a volume of a patient, the method comprising: receiving an image of the volume; receiving at least one dose-distribution-derived function configured to provide a value as an output based on, as input, at least part of a dose distribution defined relative to the image; receiving a first probability distribution and at least a second, different, probability distribution, the first and at least second probability distributions; defining a multi-criteria optimization problem comprising at least a first objective function based on the at least one dose-distribution-derived function, the first probability distribution and a loss function; and a second objective function based on the at least one dose-distribution-derived function, the second probability distribution and the loss function; and performing a multi-criteria optimization process based on the at least two objective functions to generate at least two output treatment plans.

公开(公告)号：US11798674B2

公开(公告)日：2023-10-24

申请号：US17660425

申请日：2022-04-25

Applicant: RaySearch Laboratories AB

Inventor： Erik Traneus ,  Björn Hårdemark

IPC: G16H20/40 ,  A61N5/10

CPC classification number: G16H20/40 ,  A61N5/103 ,  A61N5/1031 ,  A61N5/1043 ,  A61N2005/1087 ,  A61N2005/1095 ,  A61N2005/1096

Abstract: A compensating device for use in ion-based radiotherapy may comprise a disk with a number of protrusions may be placed in a radiation beam to affect the ions in the beam in different ways to create an irradiation field from a broad beam. This is particularly useful in FLASH therapy because of the limited time available or modulating the beam. A method of designing such a compensating device is proposed, comprising the steps of obtaining characteristics of an actual treatment plan comprising at least one beam, determining at least one parameter characteristic of the desired energy modulation of the actual plan by performing a dose calculation of the initial plan and, based on the at least one parameter, computing a shape for each of the plurality of elongated elements to modulate the dose of the delivery beam to mimic the dose of the initial plan per beam.

公开(公告)号：US20230144962A1

公开(公告)日：2023-05-11

申请号：US17907546

申请日：2021-03-22

Applicant: RaySearch Laboratories AB (Pub)

Inventor： Bjorn ANDERSSON ,  Erik ENGWALL ,  Albin FREDRIKSSON ,  Kjell ERIKSSON

IPC: A61N5/10

CPC classification number: A61N5/1001 ,  A61N5/103 ,  A61N5/1038

Abstract: A computer-based method of optimizing a radiotherapy treatment plan for a patient is proposed, wherein a complete treatment comprising both external beam therapy and brachytherapy is optimized in one procedure using an optimization problem comprising an objective function designed to optimize the total dose distribution as a combination of a first dose distribution to be provided by a first radiation set and a second dose distribution to be provided by a second radiation set. One of the radiation sets is external beam radiotherapy and the other is brachytherapy. The optimization is based on a total desired dose for the whole treatment, images of the patient before the treatment starts and an estimated image of the patient after the first radiation set has been delivered.

公开(公告)号：US20230115222A1

公开(公告)日：2023-04-13

申请号：US17906453

申请日：2021-03-16

Applicant: RaySearch Laboratories AB (Publ)

Inventor： Erik TRANEUS ,  Bjorn HARDEMARK ,  Kjell ERIKSSON

IPC: A61N5/10 ,  G16H20/40

Abstract: A radiotherapy treatment planning method for achieving a FLASH radiotherapy treatment plan involves optimizing the plan using an optimization problem that has been designed to maximize the part of the irradiation that will be delivered under FLASH conditions, in particular to an organ at risk, to minimize the damage to the organ at risk.

公开(公告)号：US20230112426A1

公开(公告)日：2023-04-13

申请号：US17906439

申请日：2021-03-16

Applicant: RaySearch Laboratories AB (Publ)

Inventor： Martin JANSON ,  Erik TRANEUS

IPC: A61N5/10

Abstract: A method of optimizing a radiotherapy treatment plan for delivering charged particles to a patient by pencil beam scanning, involves optimizing the treatment plan using an optimization problem that is designed to allow spots to differ in at least one of shape and orientation, and optionally also in size. This enables the optimization spots so as to cover the target in the best possible way and with a sharp penumbra along the outer edges of the target. The invention also relates to a computer program product and a computer system for use in such planning and a treatment delivery system for delivering such a plan.

公开(公告)号：US20220344027A1

公开(公告)日：2022-10-27

申请号：US17660425

申请日：2022-04-25

Applicant: RaySearch Laboratories AB

Inventor： Erik TRANEUS ,  Björn HÅRDEMARK

IPC: G16H20/40 ,  A61N5/10

Abstract: A compensating device for use in ion-based radiotherapy may comprise a disk with a number of protrusions may be placed in a radiation beam to affect the ions in the beam in different ways to create an irradiation field from a broad beam. This is particularly useful in FLASH therapy because of the limited time available or modulating the beam. A method of designing such a compensating device is proposed, comprising the steps of obtaining characteristics of an actual treatment plan comprising at least one beam, determining at least one parameter characteristic of the desired energy modulation of the actual plan by performing a dose calculation of the initial plan and, based on the at least one parameter, computing a shape for each of the plurality of elongated elements to modulate the dose of the delivery beam to mimic the dose of the initial plan per beam.

公开(公告)号：US20220257981A1

公开(公告)日：2022-08-18

申请号：US17627222

申请日：2020-07-08

Applicant: RaySearch Laboratories AB

Inventor： Erik TRANEUS

IPC: A61N5/10

Abstract: The trajectory of a beam of charged particles within a patient may be changed by the application of a magnetic field. In that way, the position of the beam's Bragg peak may be controlled for a beam having a specific direction and energy.

公开(公告)号：US20220257976A1

公开(公告)日：2022-08-18

申请号：US17627389

申请日：2020-07-08

Applicant: RaySearch Laboratories AB

Inventor： Erik TRANEUS

IPC: A61N5/10

Abstract: A radiotherapy treatment plan for grid therapy in which a patient is radiated from a source of radiation with a set of spatially fractionated beams of charged particles such as protons, including varying the direction of each beam in the set of beams. Generating the plan comprises the steps of determining a first path through the patient to a first Bragg peak position and determining a second path through the patient, at least a part of the second path being directed at an angle from the first path to a first deflected Bragg peak position. The beam directions may be varied by means of magnetic fields or by varying the relative angle between the gantry and the patient.

公开(公告)号：US11224762B2

公开(公告)日：2022-01-18

申请号：US16500204

申请日：2018-04-04

Applicant: RaySearch Laboratories AB

Inventor： Albin Fredriksson

IPC: A61N5/10

Abstract: A method of radiotherapy treatment planning comprises optimizing a treatment plan based on at least one proposed dose map according to a set of clinical goals The resulting dose distribution is compared to the at least one clinical goal, and if the optimized dose distribution does not fulfil the at least one clinical goal, continuing with step d the dose map is adjusted before a new treatment plan is optimized. When the optimized dose distribution fulfils the clinical goals, the treatment plan is accepted.

公开(公告)号：US20210220671A1

公开(公告)日：2021-07-22

申请号：US15733906

申请日：2019-06-25

Applicant: RaySearch Laboratories AB

Inventor： Kjell ERIKSSON

IPC: A61N5/10

Abstract: A method of radiotherapy treatment planning involves dynamic target tracking and beam redirection. A set of 3D images of a patient reflecting a movement of the patient is obtained, and each image is deformably registered with one reference image. The accumulated dose is calculated as the sum of the dose distribution over all phases in dependence of the patient movement and the model of the delivery machine, the dose distribution for each phase being deformed by means of the deformation map for the respective phase, to match the reference image.