公开(公告)号：US12036407B2

公开(公告)日：2024-07-16

申请号：US17472753

申请日：2021-09-13

Applicant: SPR Therapeutics, Inc.

Inventor： Joseph W. Boggs, II ,  Maria E. Bennett ,  Amorn Wongsarnpigoon ,  John Chae ,  Warren M. Grill ,  Kathryn Stager ,  Rosemary Zang

IPC: A61N1/36 ,  A61B17/34 ,  A61N1/05

CPC classification number: A61N1/36021 ,  A61B17/3468 ,  A61N1/0502 ,  A61N1/0558 ,  A61N1/36017 ,  A61N1/36071

Abstract: It has been discovered that pain felt in a given region of the body can be treated by stimulating a peripheral nerve at a therapeutically effective distance from the region where pain is felt to generate a comfortable sensation (i.e., paresthesia) overlapping the regions of pain. A method has been developed to reduce pain in a painful region following limb joint replacement by stimulating a peripheral nerve innervating the painful region with an electrode inserted into tissue and spaced from the peripheral nerve. This method may be used to help alleviate postoperative pain in patients following total knee arthroplasty surgery or other limb joint replacement surgeries.

公开(公告)号：US20240157138A1

公开(公告)日：2024-05-16

申请号：US18423623

申请日：2024-01-26

Applicant: SPR Therapeutics, Inc.

Inventor： Joseph W. Boggs, II ,  Robert B. Strother ,  Kathryn W. Stager ,  Jonathan L. Sakai ,  Amorn Wongsarnpigoon ,  Matthew deBock ,  Devin Sell ,  Meredith McGee

IPC: A61N1/36 ,  A61N1/05

CPC classification number: A61N1/36017 ,  A61N1/05 ,  A61N1/0502 ,  A61N1/36021 ,  A61N1/3752

Abstract: Neurostimulation assemblies, systems, and methods make possible the providing of short-term therapy or diagnostic testing by providing electrical connections between muscles and/or nerves inside the body and stimulus generators and/or recording instruments mounted on the surface of the skin or carried outside the body. The assembly affords maximum patient mobility and comfort through differentiated components having minimal profiles and connected by way of detachable and adjustable connections.

公开(公告)号：US20240115861A1

公开(公告)日：2024-04-11

申请号：US18502142

申请日：2023-11-06

Applicant: SPR Therapeutics, INC.

Inventor： Meredith McGee ,  Joseph W. Boggs ,  John Chae ,  Amorn Wongsarnpigoon ,  Maria E. Bennett

IPC: A61N1/36 ,  A61N1/05

CPC classification number: A61N1/36071 ,  A61N1/0551 ,  A61N1/0558 ,  A61N1/36017 ,  A61N1/36021

Abstract: The present invention reduces pain and improves function long-term in persons with back pain using electrical stimulation in the back. This approach involves an electrical stimulation device including at least one electrode adapted for insertion within an animal body with back pain and at least one pulse generator operatively coupled with the at least one electrode, wherein the pulse generator delivers electrical stimulation activating at least a nerve innervating at least a paraspinal muscle in a back of the animal body for pain relief.

公开(公告)号：US20230414935A1

公开(公告)日：2023-12-28

申请号：US18241333

申请日：2023-09-01

Applicant: SPR Therapeutics, Inc.

Inventor： Joseph W. Boggs ,  Amorn Wongsarnpigoon ,  Matthew G. deBock ,  Meredith J. McGee ,  Devin Sell ,  Robert B. Strother

IPC: A61N1/05 ,  A61N1/36 ,  A61B17/34 ,  A61N1/372

CPC classification number: A61N1/0558 ,  A61N1/36071 ,  A61N1/0551 ,  A61B17/3468 ,  A61N1/0502 ,  A61N1/36017 ,  A61N1/37205 ,  A61N1/37211 ,  A61N1/3787

Abstract: An introducing device for locating a tissue region and deploying an electrode is shown and described. The introducing device may include an outer sheath. An inner sheath may be disposed within the outer sheath. The inner sheath may be configured to engage an implantable electrode. In an example, the inner sheath may comprise a stimulation probe having an uninsulated portion at or near a distal end of the delivery sheath. The outer sheath may be coupled to a power source or stimulation signal generating circuitry at a proximal end. A clinician may control application of the stimulation signal to a tissue region via the outer sheath.

公开(公告)号：US11771891B2

公开(公告)日：2023-10-03

申请号：US17338754

申请日：2021-06-04

Applicant: SPR THERAPEUTICS, INC.

Inventor： Joseph W. Boggs ,  Rosemary H. Zang

IPC: A61N1/36 ,  A61N1/05 ,  A61N1/04 ,  A61B5/06

CPC classification number: A61N1/0551 ,  A61N1/0456 ,  A61N1/0502 ,  A61N1/0558 ,  A61N1/36021 ,  A61N1/36071 ,  A61B5/061 ,  A61N1/36017

Abstract: Systems and methods are provided for applying electrical stimulation to a body by an electrode spaced from a target nerve of passage. It has been discovered that pain felt, or perceived to be felt, in a given region of the body can be treated by stimulating muscle close to a “nerve of passage” in a region that is superior (i.e., cranial or upstream toward the spinal column) to the region where pain is felt, such as in a case of post-amputation residual limb pain, or purportedly felt in the case of post-amputation phantom limb pain.

公开(公告)号：US20220362544A1

公开(公告)日：2022-11-17

申请号：US17875744

申请日：2022-07-28

Applicant: SPR Therapeutics, Inc.

Inventor： Joseph W. Boggs, II ,  Amorn Wongsarnpigoon ,  Matthew G. deBock ,  Meredith J. McGee ,  Devin Sell ,  Robert B. Strother, JR.

IPC: A61N1/05 ,  A61N1/36 ,  A61N1/372 ,  A61B17/34

Abstract: An introducing device for locating a tissue region and deploying an electrode is shown and described. The introducing device may include an outer sheath. An inner sheath may be disposed within the outer sheath. The inner sheath may be configured to engage an implantable electrode. In an example, the inner sheath may comprise a stimulation probe having an uninsulated portion at or near a distal end of the delivery sheath. The outer sheath may be coupled to a power source or stimulation signal generating circuitry at a proximal end. A clinician may control application of the stimulation signal to a tissue region via the outer sheath.

公开(公告)号：US20220288394A1

公开(公告)日：2022-09-15

申请号：US17824981

申请日：2022-05-26

Applicant: SPR Therapeutics, Inc.

Inventor： Maria E. Bennett ,  Joseph W. Boggs ,  Warren M. Grill ,  John Chae

IPC: A61N1/36

Abstract: Embodiments of the present invention provide systems and methods for the treatment of pain through activation of select neural fibers. The neural fibers may comprise one or more afferent neural fibers and/or one or more efferent neural fibers. If afferent fibers are stimulated, alone or in combination with efferent fibers, a therapeutically effective amount of electrical stimulation is applied to activate afferent pathways in a manner approximating natural afferent activity. The afferent fibers may be associated with primary receptors of muscle spindles, golgi tendon organs, secondary, receptors of muscle spindles, joint receptors, touch receptors, and other types of mechanoreceptors and/or proprioceptors. If efferent fibers are stimulated, alone or in combination with afferent fibers, a therapeutically effective amount of electrical stimulation is applied to activate intrafusal and/or extrafusal muscle fibers, which results in an indirect activation of afferent fibers associated therewith.

公开(公告)号：US20220257947A1

公开(公告)日：2022-08-18

申请号：US17727883

申请日：2022-04-25

Applicant: SPR THERAPEUTICS, INC.

Inventor： Joseph W. Boggs, II

IPC: A61N1/36

Abstract: It has been discovered that pain felt in a given region of the body can be treated, not by motor point stimulation of muscle in the local region where pain is felt, but by stimulating muscle spaced from a “nerve of passage” in a region that is superior (i.e., cranial or upstream toward the spinal column) to the region where pain is felt. Spinal nerves such as the intercostal nerves or nerves passing through a nerve plexus, which comprise trunks that divide by divisions and/or cords into branches, comprise “nerves of passage.”

公开(公告)号：US11413450B2

公开(公告)日：2022-08-16

申请号：US16052089

申请日：2018-08-01

Applicant: SPR Therapeutics, Inc.

Inventor： Joseph W. Boggs, II ,  Amorn Wongsarnpigoon ,  Matthew G. deBock ,  Meredith J. McGee ,  Devin Sell ,  Robert B. Strother, Jr.

IPC: A61N1/05 ,  A61N1/36 ,  A61N1/372 ,  A61B17/34

Abstract: An introducing device for locating a tissue region and deploying an electrode is shown and described. The introducing device may include an outer sheath. An inner sheath may be disposed within the outer sheath. The inner sheath may be configured to engage an implantable electrode. In an example, the inner sheath may comprise a stimulation probe having an uninsulated portion at or near a distal end of the delivery sheath. The outer sheath may be coupled to a power source or stimulation signal generating circuitry at a proximal end. A clinician may control application of the stimulation signal to a tissue region via the outer sheath.

公开(公告)号：US20220111199A1

公开(公告)日：2022-04-14

申请号：US17555602

申请日：2021-12-20

Applicant: SPR Therapeutics, Inc.

Inventor： Joseph W. Boggs, II ,  Amorn Wongsarnpigoon

IPC: A61N1/05 ,  A61N1/36

Abstract: The present disclosure generally relates to a system for treating headaches and other pain associated with the occipital nerves. More particularly, the disclosure relates to a system of treating pain by selectively activating specific nerve fibers with a single, fault-resistant contact situated proximate to, but not in direct contact with, portions of one or more the occipital nerves. Additional measures ensure the lead does not migrate or fracture, resulting in long-lasting pain relief.