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公开(公告)号：US12186477B2
公开(公告)日：2025-01-07
申请号：US18304854
申请日：2023-04-21
Applicant: Stamford Devices Limited
Inventor： Joseph Grehan , Niall Smith
IPC: A61M11/00 , B05B15/14 , B05B17/00 , B05B17/06 , B06B1/02 , G01N29/22 , G01N29/42 , G16H20/10 , G16H20/13 , B05B12/00 , B05B12/08
Abstract: A nebulizer has an aperture plate, a mounting, an actuator, and an aperture plate drive circuit (2-4). A controller measures an electrical drive parameter at each of a plurality of measuring points, each measuring point having a drive frequency; and based on the values of the parameter at the measuring points makes a determination of optimum drive frequency and also an end-of-dose prediction. The controller performs a short scan at regular sub-second intervals at which drive current is measured at two measuring points with different drive frequencies. According to drive parameter measurements at these points the controller determines if a full scan sweeping across a larger number of measuring points should be performed. The full scan provides the optimum drive frequency for the device and also an end of dose indication.
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公开(公告)号：US20240066542A1
公开(公告)日：2024-02-29
申请号：US18495066
申请日：2023-10-26
Applicant: STAMFORD DEVICES LIMITED
Inventor： Joseph GREHAN , Noel COYLE , Russell GREANEY , Stephen THORNTON
CPC classification number: B05B12/081 , A61M11/005 , A61M15/0085 , B05B17/0646 , B05B17/0669 , A61M2205/3317 , A61M2205/50
Abstract: An aerosol delivery system has an aerosol generator with a vibrating aperture plate (10) and an actuator (11, 16, 17, 19), a controller (18, 19). The controller in real time monitors (201) the aerosol generator as it is driven for vibration of the aperture plate, and detects (202) a change in an electrical characteristic in response to a transition from a wet state to a dry state of the aperture plate. It automatically modifies (203, 205, 206), during the transition, operation of the aerosol generator in response to the detected change. The modification includes reducing applied power (203). The controller continues (204) to monitor during the transition, including monitoring the aperture plate for presence of residual liquid on the aperture plate first surface. The controller monitors at a number of drive frequencies and maintains data representing trends in a combination of the electrical characteristic signals at the different frequencies, and identifies a start of a transition if a calculated value rises above a threshold. There is one threshold for triggering a check scan for residual volume and a higher threshold to trigger an immediate shut down.
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公开(公告)号：US11833310B2
公开(公告)日：2023-12-05
申请号：US16750507
申请日：2020-01-23
Applicant: Stamford Devices Limited
Inventor： Ronan MacLoughlin , Niall Smith
IPC: A61M16/08 , A61M16/06 , A61M16/16 , A61M16/20 , A61M11/00 , A61M15/08 , A61M16/14 , A61M16/10 , A61M16/00
CPC classification number: A61M16/16 , A61M11/00 , A61M15/08 , A61M16/0666 , A61M16/0833 , A61M16/0866 , A61M16/0875 , A61M16/1095 , A61M16/14 , A61M16/202 , A61M2016/0018 , A61M2016/0027 , A61M2016/0033 , A61M2016/0036 , A61M2205/33 , A61M2205/3334
Abstract: A high flow nasal therapy system (1) has a gas supply (2), a nebulizer (12), and a nasal interface (7). There are two branches (11, 10) and a valve (6) linked with the controller, the branches including a first branch (11) for delivery of aerosol and a second branch (10) for delivery of non-aerosolized gas. The controller controls delivery into the branches (11, 10), in which flow is unidirectional in the first and second branches, from the gas supply towards the nasal interface. The first branch (11) includes the nebulizer (12) and a line configured to store a bolus of aerosol during flow through the second branch (10). The valve (6) comprises a Y-junction between the gas inlet on one side and the branches on the other side.
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公开(公告)号：US11806478B2
公开(公告)日：2023-11-07
申请号：US17015179
申请日：2020-09-09
Applicant: Stamford Devices Limited
Inventor： John Sylvester Power , James B. Fink , Conor Paul Duffy , Trevor Stephen Fahy
IPC: A61M16/00 , A61M16/14 , A61M15/00 , A61M11/00 , A61M16/06 , A61M16/08 , A61M16/16 , B05B12/08 , B05B17/00 , B05B17/06
CPC classification number: A61M16/14 , A61M11/002 , A61M11/003 , A61M11/005 , A61M15/0085 , A61M16/0057 , A61M16/0666 , A61M16/0672 , A61M16/0833 , A61M16/0875 , A61M16/147 , A61M16/16 , A61M16/0808 , A61M2202/0208 , A61M2206/14 , B05B12/081 , B05B17/0646 , B05B17/0669
Abstract: A supplemental oxygen delivery system is described in which Aerosol is delivered into a housing 10, 20, which sits in the circuit from the supplemental oxygen supply and optional humidifier. The supplemental oxygen passes through this chamber 10, 20 in which the aerosol is located, and collects the aerosol transporting it to a patient via a nasal cannula 3 or a face mask 4. An aerosol generator 9 is mounted to the housing 10, 20 and delivers aerosol into an oxygen stream 13 flowing between an inlet 14 and an outlet 15 of the housing 10. The housing 10 also has a removable plug 16 in the base 17 thereof for draining any liquid that accumulates in the housing 10. There is no disruption of oxygen delivery to patients using nasal cannulas who currently have to use a separate face-mask when receiving nebulized medication.
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公开(公告)号：US20230248921A1
公开(公告)日：2023-08-10
申请号：US18304854
申请日：2023-04-21
Applicant: Stamford Devices Limited
Inventor： Joseph GREHAN , Niall SMITH
IPC: A61M11/00 , G01N29/22 , G01N29/42 , B05B17/00 , B05B17/06 , B06B1/02 , B05B15/14 , G16H20/10 , G16H20/13
CPC classification number: A61M11/005 , A61M11/001 , G01N29/22 , G01N29/42 , B05B17/0646 , B05B17/0669 , B06B1/0253 , B05B15/14 , G16H20/10 , G16H20/13 , B05B12/004
Abstract: A nebulizer has an aperture plate, a mounting, an actuator, and an aperture plate drive circuit (2-4). A controller measures an electrical drive parameter at each of a plurality of measuring points, each measuring point having a drive frequency; and based on the values of the parameter at the measuring points makes a determination of optimum drive frequency and also an end-of-dose prediction. The controller performs a short scan at regular sub-second intervals at which drive current is measured at two measuring points with different drive frequencies. According to drive parameter measurements at these points the controller determines if a full scan sweeping across a larger number of measuring points should be performed. The full scan provides the optimum drive frequency for the device and also an end of dose indication.
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Patent Agency Ranking
公开(公告)号：US11679209B2
公开(公告)日：2023-06-20
申请号：US16686286
申请日：2019-11-18
Applicant: Stamford Devices Limited
Inventor： Brendan Hogan
CPC classification number: A61M11/003 , A61M11/005 , C25D1/08 , C25D7/00 , B05B17/0646 , C25D3/567
Abstract: A photo-resist (21) is applied in a pattern or vertical columns having the dimensions of holes or pores of the aperture plate to be produced. This mask pattern provides the apertures which define the aerosol particle size, having up to 2500 holes per square mm. There is electro-deposition of metal (22) into the spaces around the columns (21). There is further application of a second photo-resist mask (25) of much larger (wider and taller) columns, encompassing the area of a number of first columns (21). The hole diameter in the second plating layer is chosen according to a desired flow rate.
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公开(公告)号：US11648580B2
公开(公告)日：2023-05-16
申请号：US17888334
申请日：2022-08-15
Applicant: Stamford Devices Limited
Inventor： Brendan Hogan , Kieran Hyland , Anthony Redmond
CPC classification number: B05B17/0646 , A61M11/001 , A61M11/005 , A61M15/0085 , B05B17/0653
Abstract: An aerosol generator with electrical power conducting pins has a vibratable plate with apertures therein and an annular piezo. An annular support member supports the piezo and the vibratable plate. A first electrical power conducting pin engages directly with a first, top, surface of the piezo. A second electrical power conducting pin indirectly conducts electrical power to a second surface of the piezo, by contacting an extension tab. There is a film of cured epoxy adhesive on the tab. The aerosol generator avoids need for soldered joints for electrical contact, and the pins are conveniently mounted parallel to each on the same lateral and top side of the piezo and support member. The pins may have multi-point tips for particularly effective electrical contact.
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公开(公告)号：US20230080331A1
公开(公告)日：2023-03-16
申请号：US17808432
申请日：2022-06-23
Applicant: Stamford Devices Limited
Inventor： Hong XU
IPC: C25D7/00 , B41J2/16 , C25D5/02 , C25D5/10 , C25D1/00 , C25D5/00 , A61M11/00 , C25D5/54 , B05B17/00 , C25D3/38 , C25D3/46 , C25D3/48 , C25D3/54 , C25D5/34 , C25D5/48
Abstract: In one embodiment, a method for manufacturing an aperture plate includes depositing a releasable seed layer above a substrate, applying a first patterned photolithography mask above the releasable seed layer, the first patterned photolithography mask having a negative pattern to a desired aperture pattern, electroplating a first material above the exposed portions of the releasable seed layer and defined by the first mask, applying a second photolithography mask above the first material, the second photolithography mask having a negative pattern to a first cavity, electroplating a second material above the exposed portions of the first material and defined by the second mask, removing both masks, and etching the releasable seed layer to release the first material and the second material. The first and second material form an aperture plate for use in aerosolizing a liquid. Other aperture plates and methods of producing aperture plates are described according to other embodiments.
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公开(公告)号：US20230032517A1
公开(公告)日：2023-02-02
申请号：US17818484
申请日：2022-08-09
Applicant: Stamford Devices Limited
Inventor： Brendan HOGAN , Hong XU
Abstract: An aperture plate is manufactured by plating metal around a mask of resist columns having a desired size, pitch, and profile, which yields a wafer about 60 μm thickness. This is approximately the full desired target aperture plate thickness. The plating is continued so that the metal overlies the top surfaces of the columns until the desired apertures are achieved. This needs only one masking/plating cycle to achieve the desired plate thickness. Also, the plate has passageways formed beneath the apertures, formed as an integral part of the method, by mask material removal. These are suitable for entrainment of aerosolized droplets exiting the apertures.
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公开(公告)号：US20210370336A1
公开(公告)日：2021-12-02
申请号：US17179950
申请日：2021-02-19
Applicant: Stamford Devices Limited
Inventor： Ronan MACLOUGHLIN , Conor Paul Duffy , Brendan HOGAN , Patrick Martin Kelly
Abstract: A method for aerosolising a liquid comprises the steps of: providing an aperture plate having at least 100 outlet holes per mm2; delivering liquid to the aperture plate; and vibrating the aperture plate to produce an aerosol. The viscosity of the liquid is in the range of from 1 to15 cP and the surface tension of the liquid is in the range of from 72 to 0.5 mN/m. The output rate of the generated aerosol is greater than 0.01 mL/min.
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