公开(公告)号：US06699275B1

公开(公告)日：2004-03-02

申请号：US10269878

申请日：2002-10-11

Applicant: Mark B. Knudson ,  John P. Sopp ,  Timothy R. Conrad

Inventor： Mark B. Knudson ,  John P. Sopp ,  Timothy R. Conrad

IPC: A61F206

CPC classification number: A61F2/91 ,  A61F2/848 ,  A61F2/915 ,  A61F2/95 ,  A61F2/958 ,  A61F2/966 ,  A61F2002/91541 ,  A61F2002/9155 ,  A61F2250/0068

Abstract: An intraluminal stent comprises a reticulated tube having an un-deployed diameter and expandable to an enlarged diameter. When the tube is at the un-deployed diameter, the tube has cell-defining portions with opposing surfaces defining an open cell bounded by the cell-defining portions.

Abstract translation: 管腔内支架包括具有未展开直径并可扩张至扩大直径的网状管。 当管处于未展开的直径时，管具有细胞限定部分，其具有限定由细胞限定部分限定的开放细胞的相对表面。

公开(公告)号：US06634362B2

公开(公告)日：2003-10-21

申请号：US10036915

申请日：2002-01-03

Applicant: Timothy R. Conrad ,  Mark B. Knudson

Inventor： Timothy R. Conrad ,  Mark B. Knudson

IPC: A61B1900

CPC classification number: A61F5/566

Abstract: A method and apparatus for treating snoring of a patient includes providing an implant for altering a dynamic response of a soft palate of the patient to airflow past the soft palate. The implant is embedded in the soft palate to alter the dynamic response. The implant has multiple fibers braided along a length of the implant.

公开(公告)号：US06601585B1

公开(公告)日：2003-08-05

申请号：US09872789

申请日：2001-06-01

Applicant: Timothy R. Conrad ,  Mark B. Knudson ,  Jerry C. Griffin

Inventor： Timothy R. Conrad ,  Mark B. Knudson ,  Jerry C. Griffin

IPC: A61B1900

CPC classification number: A61F5/566

Abstract: A method and apparatus for treating snoring of a patient includes providing an implant for altering a dynamic response of a soft palate of the patient to airflow past the soft palate. The implant is embedded in the soft palate to alter the dynamic response. For example, the implant has a mass, stiffness or dampening sufficient to alter the dynamic response following the implantation without substantially impairing a function of the soft palate to close a nasal passage of the patient during swallowing.

Abstract translation: 用于治疗患者打鼾的方法和装置包括提供植入物，用于改变患者的软腭的动态响应以使气流通过软腭。 植入物嵌入软腭以改变动态反应。 例如，植入物具有足以改变植入后的动态响应的质量，刚度或阻尼，而基本上不会损伤软腭在吞咽期间关闭患者鼻通道的功能。

公开(公告)号：US06578580B2

公开(公告)日：2003-06-17

申请号：US10121166

申请日：2002-04-11

Applicant: Timothy R. Conrad ,  Mark B. Knudson

Inventor： Timothy R. Conrad ,  Mark B. Knudson

IPC: A61B1900

CPC classification number: A61F2/00 ,  A61F2/0059 ,  A61F5/566

Abstract: An apparatus for use in treating snoring of a patient suffering from snoring includes an implant of bio-compatible material sized to be embedded within the soft palate. The implant is disposed within a bore of a distal tip of a needle for penetration into the soft palate. The bore is sized to receive a rod from a proximal end of the needle with the rod opposing the implant to eject the implant from the distal tip upon relative sliding movement of said needle and said rod. The needle at the distal tip is perforated for fluid to flow through a wall of the needle into engagement with the implant. The implant is selected to altering a dynamic response of the soft palate to airflow past the soft palate.

公开(公告)号：US06523541B2

公开(公告)日：2003-02-25

申请号：US09815154

申请日：2001-03-21

Applicant: Mark B. Knudson ,  Timothy R. Conrad

Inventor： Mark B. Knudson ,  Timothy R. Conrad

IPC: A61B1900

CPC classification number: A61F5/566 ,  A61F2/00 ,  A61F2/0059 ,  A61F2/0077 ,  A61F2/20 ,  A61F5/56

Abstract: A delivery system for delivering an implant into a soft palate of a patient for treatment of snoring includes an implant and a delivery tool. The implant is formed from a sheet of flexible, bio-compatible material sized to be inserted into the soft palate. The delivery tool includes a penetrating member with a distal end for penetration into the soft palate through a small penetration wound. The implant is carried in the distal end of the penetrating member. A flattening tool is contained within the penetration member and constrained by the penetrating member against a bias for a distal tip of the tool to expand beyond a size of the penetration wound to approximately a width of the implant. The flattening tool is retractable between an extended position and a retracted position with the distal tip of the tool in the retracted position being smaller than the penetration wound. The penetrating member is retractable relative to the flattening tool when the flattening tool is in the extended position.

Abstract translation: 用于将植入物输送到患者的软腭中用于治疗打鼾的递送系统包括植入物和递送工具。 植入物由尺寸适于插入软腭的柔性，生物相容性材料片形成。 输送工具包括具有远端的穿透构件，用于通过小的穿透伤口穿透软腭。 植入物被携带在穿透构件的远端。 平整工具包含在穿透构件内并且被穿透构件约束以抵抗用于工具的远侧末端的偏压，以扩展超过穿透伤口的大小至植入物的大致宽度。 平坦化工具在延伸位置和缩回位置之间缩回，其中工具的远端在缩回位置小于穿透伤口。 当平整工具处于伸展位置时，穿透构件相对于压扁工具可缩回。

公开(公告)号：US06450169B1

公开(公告)日：2002-09-17

申请号：US09513432

申请日：2000-02-25

Applicant: Timothy R. Conrad ,  Mark B. Knudson

Inventor： Timothy R. Conrad ,  Mark B. Knudson

IPC: A61B1900

CPC classification number: A61F5/566

Abstract: A method and apparatus for treating snoring of a patient includes providing an implant for altering a dynamic response of a soft palate of the patient to airflow past the soft palate. The implant is embedded in the soft palate to alter the dynamic response. The implant has multiple fibers braided along a length of the implant.

Abstract translation: 用于治疗患者打鼾的方法和装置包括提供植入物，用于改变患者的软腭的动态响应以使气流通过软腭。 植入物嵌入软腭以改变动态反应。 植入物沿着植入物的长度编织多根纤维。

公开(公告)号：US06250307B1

公开(公告)日：2001-06-26

申请号：US09398991

申请日：1999-09-17

Applicant: Timothy R. Conrad ,  Mark B. Knudson ,  Jerry C. Griffin

Inventor： Timothy R. Conrad ,  Mark B. Knudson ,  Jerry C. Griffin

IPC: A61B1900

CPC classification number: A61F5/566

Abstract: A method and apparatus for treating snoring of a patient includes providing an implant for altering a dynamic response of a soft palate of the patient to airflow past the soft palate. The implant is embedded in the soft palate to alter the dynamic response. For example, the implant has a mass, stiffness or dampening sufficient to alter the dynamic response following the implantation without substantially impairing a function of the soft palate to close a nasal passage of the patient during swallowing.

Abstract translation: 用于治疗患者打鼾的方法和装置包括提供植入物，用于改变患者的软腭的动态响应以使气流通过软腭。 植入物嵌入软腭以改变动态反应。 例如，植入物具有足以改变植入后的动态响应的质量，刚度或阻尼，而基本上不会损伤软腭的功能，以在吞咽期间闭合患者的鼻通道。

公开(公告)号：US06214041B1

公开(公告)日：2001-04-10

申请号：US09009674

申请日：1998-01-20

Applicant: Katherine S. Tweden ,  Timothy R. Conrad

Inventor： Katherine S. Tweden ,  Timothy R. Conrad

IPC: A61F206

CPC classification number: A61F2/94 ,  A61F2/2493 ,  A61F2220/0008

Abstract: A transmyocardial implant includes a hollow rigid conduit having a first portion and a second portion. The first portion is sized to be received within a coronary vessel lumen. The first portion has an axial dimension aligned with an axis of the vessel. The second portion is sized to extend from the vessel through a myocardium into a heart chamber. The conduit has open first and second ends on axial ends of respective ones of the first and second portions to define a blood flow pathway within an interior of the conduit between the first and second ends. The first portion has at least one radial opening formed therethrough for blood to flow radially outward of the first portion proximally to the first end.

Abstract translation: 经心肌植入物包括具有第一部分和第二部分的中空刚性导管。 第一部分的尺寸被设计成能够接收在冠状血管腔内。 第一部分具有与容器的轴线对准的轴向尺寸。 第二部分的尺寸设计成从血管延伸通过心肌进入心室。 导管在第一和第二部分中的相应的第一和第二部分的轴向端部上具有打开的第一和第二端，以在第一和第二端之间的导管内部限定血液流动通路。 第一部分具有穿过其形成的至少一个径向开口，用于血液从第一部分的径向向外向近端流动到第一端。

公开(公告)号：US08538542B2

公开(公告)日：2013-09-17

申请号：US13188293

申请日：2011-07-21

Applicant: Mark B. Knudson ,  Richard R. Wilson ,  Katherine S. Tweden ,  Timothy R. Conrad

Inventor： Mark B. Knudson ,  Richard R. Wilson ,  Katherine S. Tweden ,  Timothy R. Conrad

IPC: A61N1/08 ,  A61N1/36

CPC classification number: A61N1/36007 ,  A61N1/05 ,  A61N1/0551 ,  A61N1/321 ,  A61N1/36053 ,  A61N1/3606 ,  A61N1/36071

Abstract: Systems and methods of using a system for treating a gastrointestinal disorder characterized by dysmotility of a gastrointestinal organ. A system comprises a first electrode adapted for placement on the vagus nerve at a stimulation site proximal to at least one site of vagal innervation of a gastrointestinal organ, a second electrode adapted for placement on the vagus nerve at a site proximal to the stimulation site, a third electrode adapted for placement on the vagus nerve at a distal blocking site distal to the stimulation site, an implantable controller comprising at least one circuit for generating a neural conduction blocking signal connected to the second and third electrode, at least one circuit for generating a neural conduction stimulating signal connected to the first electrode; and an external programmer configured to communicate at least one parameter for the neural conduction blocking signal to the implantable controller; and an external coil adapted to be worn by the patient, wherein the external coil is connected to the external programmer, and is adapted to inductively couple to the implantable controller.

Abstract translation: 使用系统治疗以胃肠器官发育不良为特征的胃肠道疾病的系统和方法。 系统包括适于放置在迷走神经附近的刺激部位的第一电极，所述刺激部位接近胃肠器官的迷走神经支配的至少一个部位，适于放置在靠近刺激部位的部位的迷走神经上的第二电极， 适于放置在远离刺激部位的远端阻塞位置处的迷走神经上的第三电极，可植入控制器，包括用于产生连接到第二和第三电极的神经传导阻断信号的至少一个电路，至少一个用于产生 连接到第一电极的神经传导刺激信号; 以及外部编程器，被配置为将至少一个神经传导阻断信号的参数传送到所述可植入控制器; 以及适于由患者佩戴的外部线圈，其中所述外部线圈连接到所述外部编程器，并且适于感应地耦合到所述可植入控制器。

公开(公告)号：US08413662B2

公开(公告)日：2013-04-09

申请号：US13276146

申请日：2011-10-18

Applicant: Anja K. Metzger ,  Brian J. Erickson ,  John P. Sopp ,  Mark B. Knudson ,  Timothy R. Conrad

Inventor： Anja K. Metzger ,  Brian J. Erickson ,  John P. Sopp ,  Mark B. Knudson ,  Timothy R. Conrad

IPC: A61F5/56

CPC classification number: A61F5/56 ,  A61F2/04 ,  A61F2/20 ,  A61F2002/046 ,  A61M31/002 ,  A61M37/00

Abstract: A pharyngeal airway having a pharyngeal wall of a patient at least partially surrounding and defining the airway is treated by selecting an implant dimensioned so as to be implanted at or beneath a mucosal layer of the pharyngeal wall and extending transverse to said wall. The implant has mechanical characteristics for the implant, at least in combination with a fibrotic tissue response induced by the implant, to stiffen said pharyngeal wall to resist radial collapse. The implant is implanted into the pharyngeal wall transverse to a longitudinal axis of the airway.